Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages

Infection and Immunity

Volumn 83, Issue 12, 2015, Pages 4740-4749

  Finethy, Ryan ^a   Jorgensen, Ine ^b   Haldar, Arun K ^a   De Zoete, Marcel R ^c   Strowig, Till ^c,d   Flavell, Richard A ^c   Yamamoto, Masahiro ^e   Nagarajan, Uma M ^b   Miao, Edward A ^b   Coers, Jörn ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AIM2 PROTEIN; CASPASE 11; CELL PROTEIN; CRYOPYRIN; GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; AIM2 PROTEIN, HUMAN; CARRIER PROTEIN; CASP11 PROTEIN, MOUSE; CASPASE; DNA BINDING PROTEIN; GBP1 PROTEIN, MOUSE; GBP2 PROTEIN, MOUSE; NLRP3 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACTERIAL GROWTH; CELL INCLUSION; CELL VACUOLE; CHLAMYDIA MURIDARUM; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONTROLLED STUDY; CYTOKINE RELEASE; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; INFLAMMATION; KNOCKOUT MOUSE; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PATHOGEN CONTAINING VACUOLE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PYROPTOSIS; REGULATORY MECHANISM; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CASPASES; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; CHLAMYDIA TRACHOMATIS; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HOST-PATHOGEN INTERACTIONS; INCLUSION BODIES; INFLAMMASOMES; INTERFERON-GAMMA; INTERLEUKIN-18; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; VACUOLES;

EID: 84949652170     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00856-15     Document Type: Article

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