Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 1, 2013, Pages 294-299

  Degrandi, Daniel ^a   Kravets, Elisabeth ^a   Konermann, Carolin ^a   Beuter Gunia, Cornelia ^a   Klum̈pers, Verena ^a   Lahme, Sarah ^a   Wischmann, Eva ^a   Mausberg, Anne K ^a   Beer Hammer, Sandra ^a,b   Pfeffer, Klaus ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cell autonomous immunity; Host pathogen interaction; Pathogen defense

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MURINE GUANYLATE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; CELL PROLIFERATION; CELL STIMULATION; CELL TYPE; CONTROLLED STUDY; LISTERIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PRENYLATION; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; FLUORESCENT ANTIBODY TECHNIQUE; GTP-BINDING PROTEINS; HOST-PATHOGEN INTERACTIONS; INTERFERON-GAMMA; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NIH 3T3 CELLS; REPRODUCTION; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL;

LISTERIA MONOCYTOGENES; MURINAE; MUS; TOXOPLASMA GONDII;

EID: 84871941976     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205635110     Document Type: Article

References (38)

1. Huang S, et al. (1993) Immune response in mice that lack the interferon-gamma receptor. Science 259(5102):1742-1745. (Pubitemid 23114659)
2. Pfeffer K, et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73(3):457-467. (Pubitemid 23143346)
3. Endres R, et al. (1997) Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity 7(3):419-432. (Pubitemid 27446016)
4. Boehm U, Klamp T, Groot M, Howard JC (1997) Cellular responses to interferon-gamma. Annu Rev Immunol 15:749-795.
5. Martens S, Howard J (2006) The interferon-inducible GTPases. Annu Rev Cell Dev Biol 22:559-589.
6. Shenoy AR, et al. (2007) Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology 212(9-10):771-784. (Pubitemid 350246255)
7. Taylor GA, Feng CG, Sher A (2007) Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). Microbes Infect 9 (14-15):1644-1651. (Pubitemid 350225741)
8. Haller O, Stertz S, Kochs G (2007) The Mx GTPase family of interferon-induced antiviral proteins. Microbes Infect 9(14-15):1636- 1643.
9. Haller O, Kochs G (2002) Interferon-induced mx proteins: Dynamin-like GTPases with antiviral activity. Traffic 3(10):710-717.
10. Gao S, et al. (2011) Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity 35(4):514-525.
11. Bekpen C, et al. (2005) The interferon-inducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol 6 (11):R92.
12. Taylor GA, Feng CG, Sher A (2004) p47 GTPases: regulators of immunity to intracellular pathogens. Nat Rev Immunol 4(2):100-109. (Pubitemid 38209204)
13. Olszewski MA, Gray J, Vestal DJ (2006) In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. J Interferon Cytokine Res 26 (5):328-352. (Pubitemid 43801016)
14. Kresse A, et al. (2008) Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 9:158.
15. Tripal P, et al. (2007) Unique features of different members of the human guanylate-binding protein family. J Interferon Cytokine Res 27(1):44-52. (Pubitemid 46185061)
16. Cheng YS, Colonno RJ, Yin FH (1983) Interferon induction of fibroblast proteins with guanylate binding activity. J Biol Chem 258(12):7746-7750. (Pubitemid 13038014)
17. Boehm U, et al. (1998) Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol 161(12):6715-6723. (Pubitemid 28562214)
18. Nguyen TT, Hu Y, Widney DP, Mar RA, Smith JB (2002) Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro. J Interferon Cytokine Res 22(8):899-909. (Pubitemid 35217522)
19. Degrandi D, et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179(11):7729-7740.
20. Konermann C, et al. (2007) In silico and in vitro characterization of mGBP4 splice variants. DNA Cell Biol 26(12):847-851. (Pubitemid 350274410)
21. Anderson SL, Carton JM, Lou J, Xing L, Rubin BY (1999) Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus. Virology 256(1):8-14. (Pubitemid 29391821)
22. Carter CC, Gorbacheva VY, Vestal DJ (2005) Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: Differential requirement for wild-type GTP binding domain. Arch Virol 150(6):1213- 1220.
23. Kim BH, et al. (2011) A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Science 332(6030):717-721.
24. Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C (2000) Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Nature 403(6769):567-571. (Pubitemid 30082205)
25. Sinensky M, Lutz RJ (1992) The prenylation of proteins. Bioessays 14(1):25-31.
26. Stickney JT, Buss JE (2000) Murine guanylate-binding protein: Incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding protein. Mol Biol Cell 11(7):2191-2200. (Pubitemid 30489907)
27. Zhang SY, et al. (2008) Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev 226:29-40.
28. Scharton-Kersten TM, Yap G, Magram J, Sher A (1997) Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med 185(7):1261-1273. (Pubitemid 27172907)
29. Howard JC, Hunn JP, Steinfeldt T (2011) The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii. Curr Opin Microbiol 14(4):414-421.
30. Martens S, et al. (2005) Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. PLoS Pathog 1(3):e24.
31. Yamamoto M, et al. (2012) A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity 37(2):302-313.
32. Collazo CM, et al. (2001) Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med 194(2):181- 188.
33. Halonen SK, Weiss LM (2000) Investigation into the mechanism of gamma interferon-mediated inhibition of Toxoplasma gondii in murine astrocytes. Infect Immun 68(6):3426-3430. (Pubitemid 30340440)
34. Subauste CS (2009) Autophagy in immunity against Toxoplasma gondii. Curr Top Microbiol Immunol 335:251-265.
35. Hunn JP, Feng CG, Sher A, Howard JC (2011) The immunity-related GTPases in mammals: A fast-evolving cell-autonomous resistance system against intracellular pathogens. Mamm Genome 22(1-2):43-54.
36. Praefcke GJ, McMahon HT (2004) The dynamin superfamily: Universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol 5(2):133-147. (Pubitemid 38160256)
37. Balasubramanian S, Messmer-Blust AF, Jeyaratnam JA, Vestal DJ (2011) Role of GTP binding, isoprenylation, and the C-terminal alpha-helices in the inhibition of cell spreading by the interferon-induced GTPase, Mouse Guanylate-Binding Protein-2. J Interferon Cytokine Res 31(3):291-298.
38. Kravets E, et al. (2012) The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii. J Biol Chem 287(33):27452-27466.