Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gamma

Microbes and Infection

Volumn 12, Issue 1, 2010, Pages 28-36

  Elkins, Karen L ^a   Colombini, Susan M ^a   Meierovics, Anda I ^a   Chu, May C ^b   Chou, Alicia Y ^a   Cowley, Siobhán C ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Francisella; Interferon gamma; Macrophages; Mice; T lymphocytes; Vaccination

Indexed keywords

BACTERIAL PROTEIN; GAMMA INTERFERON; LIVE VACCINE; PROTEIN MGLA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; CELLULAR IMMUNITY; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; FRANCISELLA; FRANCISELLA NOVICIDA; FRANCISELLA TULARENSIS; IN VIVO STUDY; KNOCKOUT MOUSE; LOW DRUG DOSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIMED LYMPHOCYTE TYPING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROVOCATION TEST; SECONDARY IMMUNE RESPONSE; SPLEEN CELL; T LYMPHOCYTE; TULAREMIA;

ADOPTIVE TRANSFER; ANIMALS; BACTERIAL VACCINES; FRANCISELLA TULARENSIS; INTERFERON-GAMMA; LETHAL DOSE 50; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; SURVIVAL ANALYSIS; TULAREMIA; VACCINATION;

FRANCISELLA; FRANCISELLA TULARENSIS; MUS;

EID: 73149121346     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2009.09.012     Document Type: Article

References (31)

1. Schoenborn J.R., and Wilson C.B. Regulation of interferon-gamma during innate and adaptive immune responses. Adv. Immunol 96 (2007) 41-101
2. Haverkamp M.H., van Dissel J.T., and Holland S.M. Human host genetic factors in nontuberculous mycobacterial infection: lessons from single gene disorders affecting innate and adaptive immunity and lessons from molecular defects in interferon-gamma-dependent signaling. Microbes Infect 8 (2006) 1157-1166
3. Schaible U.E., Collins H.L., and Kaufmann S.H. Confrontation between intracellular bacteria and the immune system. Adv. Immunol 71 (1999) 267-377
4. Flynn J.L., and Chan J. Immunology of tuberculosis. Ann. Rev. Immunol 19 (2001) 93-129
5. +T cells and protective memory against tuberculosis. Tuberculosis (Edinb.) 87 (2007) 465-473
6. Mittrucker H.W., Steinhoff U., Kohler A., Krause M., Lazar D., Mex P., Miekley D., and Kaufmann S.H. Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. Proc. Natl. Acad. Sci. USA 104 (2007) 12434-12439
7. Haring J.S., and Harty J.T. Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor. Infect. Immun 74 (2006) 6252-6263
8. Elkins K.L., Cowley S.C., and Bosio C.M. Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain. Microbes Infect 5 (2003) 132-142
9. Conlan J.W., Shen H., Kuolee R., Zhao X., and Chen W. Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an α/β T cell- and interferon gamma-dependent mechanism. Vaccine 23 (2005) 2477-2485
10. Wu T.H., Hutt J.A., Garrison K.A., Berliba L.S., Zhou Y., and Lyons C.R. Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A. Infect. Immun 73 (2005) 2644-2654
11. Elkins K.L., Cooper A., Colombini S.M., Cowley S.C., and Kieffer T.L. In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of Interleukin-12 (IL-12) but not on IL-12 p70. Infect. Immun 70 (2002) 1936-1948
12. Sjöstedt A., North R.J., and Conlan J.W. The requirement of tumour necrosis factor-alpha and interferon-gamma for the expression of protective immunity to secondary murine tularaemia depends on the size of the challenge inoculum. Microbiology 142 (1996) 1369-1374
13. Conlan J.W., KuoLee R., Shen H., and Webb A. Different host defences are required to protect mice from primary systemic vs pulmonary infection with the facultative intracellular bacterial pathogen, Francisella tularensis LVS. Microb. Pathog 32 (2002) 127-134
14. Cowley S.C., and Elkins K.L. Multiple T cell subsets control Francisella tularensis LVS intracellular growth without stimulation through macrophage interferon gamma receptors. J. Exp. Med 198 (2003) 379-389
15. Elkins K.L., Rhinehart-Jones T.R., Culkin S.J., Yee D., and Winegar R.K. Minimal requirements for murine resistance to infection with Francisella tularensis LVS. Infect. Immun 64 (1996) 3288-3293
16. Baron G.S., and Nano F.E. MglA and MglB are required for the intramacrophage growth of Francisella novicida. Mol. Micro 29 (1998) 247-259
17. Thomas R., Johansson A., Neeson B., Isherwood K., Sjostedt A., Ellis J., and Titball R.W. Discrimination of human pathogenic subspecies of Francisella tularensis by using restriction fragment length polymorphism. J. Clin. Microbiol. 41 (2003) 50-57
18. Rhinehart-Jones T.R., Fortier A.H., and Elkins K.L. Transfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cells. Infect. Immun 62 (1994) 3129-3137
19. Carlson Jr. P.E., Carroll J.A., O'Dee D.M., and Nau G.J. Modulation of virulence factors in Francisella tularensis determines human macrophage responses. Microb. Pathog 42 (2007) 204-214
20. Cherwonogrodzky J.W., Knodel M.H., and Spence M.R. Increased encapsulation and virulence of Francisella tularensis live vaccine strain (LVS) by subculturing on synthetic medium. Vaccine 12 (1994) 773-775
21. Sändstrom G. The tularemia vaccine. J. Chem. Tech. Biotechnol 59 (1994) 315-320
22. Collazo C.M., Meierovics A.I., De Pascalis R., Wu T.H., Lyons C.R., and Elkins K.L. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect. Immun 77 (2009) 2010-2021
23. Shen H., Chen W., and Conlan J.W. Mice sublethally infected with Francisella novicida U112 develop only marginal protective immunity against systemic or aerosol challenge with virulent type A or B strains of F. tularensis. Microb. Pathog 37 (2004) 107-110
24. Titball R.W. Vaccines against intracellular bacterial pathogens. Drug Discov. Today 13 (2008) 596-600
25. Pammit M.A., Raulie E.K., Lauriano C.M., Klose K.E., and Arulanandam B.P. Intranasal vaccination with a defined attenuated Francisella novicida strain induces gamma interferon-dependent antibody-mediated protection against tularemia. Infect. Immun 74 (2006) 2063-2071
26. +T cells are required during priming but not the effector phase of antibody-mediated IFN-gamma-dependent protective immunity against pulmonary Francisella novicida infection. Immunol. Cell Biol. 86 (2008) 515-522
27. 2 that blocks T cell proliferation and promotes a Th2-like response. J. Immunol 178 (2007) 2065-2074
28. Parsa K.V., Butchar J.P., Rajaram M.V., Cremer T.J., Gunn J.S., Schlesinger L.S., and Tridandapani S. Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFN gamma response. Mol. Immunol 45 (2008) 3428-3437
29. Chiavolini D., Alroy J., King C.A., Jorth P., Weir S., Madico G., Murphy J.R., and Wetzler L.M. Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia. Infect. Immun 76 (2008) 486-496
30. +T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. J. Exp. Med 192 (2000) 347-358
31. Bokhari S.M., Kim K.J., Pinson D.M., Slusser J., Yeh H.W., and Parmely M.J. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect. Immun 76 (2008) 1379-1389