Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

Nature

Volumn 403, Issue 6769, 2000, Pages 567-571

  Prakash, Balaji ^a   Praefcke, Gerrit J K ^a   Renault, Louis ^a   Wittinghofer, Alfred ^a   Herrmann, Christian ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; RAS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; GENE INSERTION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; DYNAMINS; ESCHERICHIA COLI; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0034598734     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35000617     Document Type: Article

References (30)

1. Cheng, Y.-S. E., Colonno, R. J. & Yin, F. H. Interferon induction of fibroblast proteins with guanylate binding activity J. Biol. Chem. 258, 7746-7750 (1983).
2. Cheng, Y.-S. E., Patterson, C. E. & Staeheli, P. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP Mol. Cell. Biol. 11, 4717-4725 (1991).
3. Schwemmle, M. & Staeheli, P. The interferon-induced 67-kDa guanylate-binding protein (hGBP1) is a GTPase that converts GTP to GMP J. biol. Chem. 269, 11299-11305 (1994).
4. Anderson, S. L., Carton, J. M., Lou, J., Xing, L. & Rubin, B. Y. Interferon-induced guanylate-binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalo-myocarditis virus Virology 256, 8-14 (1999).
5. van der Bliek, A. M. Functional diversity in the dynamin family Trends Cell Biol. 9, 96-102 (1999).
6. Boehm, U. et al. Two families of GTPases dominate the complex cellular response to IFN-γ J. Immunol. 161, 6715-6723 (1998).
7. Staeheli, P., Pitossi, F. & Pavlovic, J. Mx proteins: GTPases with antiviral activity Trends Cell Biol. 3, 268-272 (1993).
8. Praefcke, G. J. K., Geyer, M., Schwemmle, M., Kalbitzer, H. R. & Herrmann, C. Nucleotide-binding characteristics of human guanylate-binding protein 1 and identification of the third canonical GTP-binding motif J. Mol. Biol. 292, 321-332 (1999)
9. Weijland, A. & Parmeggiani, A. Towards a model for the interaction between elongation factor Tu and the ribosome Science 259, 1311-1314 (1993)
10. Saraste, M., Sibbald, P. R. & Wittinghofer, A. The P-loop - a common motif in ATP-and GTP-binding proteins Trends. Biochem. Sci. 15, 430-434 (1990).
11. Boriack-Sjodin, P. A., Margarit, S. M., Barsagi, D. & Kuriyan, J. The structural basis of the activation of Ras by Sos Nature 394, 337-343 (1998).
12. Scheffzek, K., Ahmadian, M. R. & Wittinghofer, A. GTPase activating proteins: helping hands to complement an active site Trends Biochem. Sci. 23, 257-262 (1998).
13. Warnock, D. E., Hinshaw, J. E. & Schmid, S. L. Dynamin self-assembly stimulates its GTPase activity J. Biol. Chem. 271, 22310-22314 (1996)
14. Sever, S., Muhlberg, A. B. & Schmid, S. L. Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis. Nature 398, 481-486 (1999).
15. Stowell, M. H. B., Marks, B., Wigge, P. & McMahon, H. T. Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring Nature Cell Biol. 1, 27-32 (1999).
16. Schwemmle, M., Richter, M. F., Herrmann, C., Nassar, N. & Staeheli, P. Unexpected structural requirements for GTPase activity of the interferon-induced MxA protein J. Biol. Chem. 270, 13518-13523 (1995).
17. Schumacher, B. & Staeheli, P. Domains mediating intramolecular folding and oligomerization of MxA GTPase J. Biol. Chem. 273, 28365-28370 (1998).
18. Smirnova, E., Shurland, D-L., Newman-Smith, E. D., Pishvaee, B. & van der Bliek, A. M. A model for dynamin self-assembly based on binding between three different protein domains J. Biol. Chem. 274, 14942-14947 (1999)
19. Okamoto, P. M., Tripet, B., Litowski, J., Hodges, R. S. & Vallee, R. B. Multiple distinct coiled-coils are involved in dynamin self-assembly J. Biol. Chem. 274, 10277-10286 (1999).
20. Collaborative Computational project, N.4. The CCP4 suite: programs for protein crystallography Acta Crystallogr. D 50, 760-763 (1994).
21. Kochs, G. & Haller, O. GTP-bound Human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae) J. Biol. Chem. 274, 4370-4376 (1999)
22. Terwilliger, T. C. & Berendzen, J. Correlated phasing of multiple isomorphous replacement data Acta Crystallogr. D 52, 749-757 (1996).
23. Perrakis, A., Sixma, T. K., Wilson, K. S. & Lamzin, V. S. wARP:improvement and extension of crystallographic phases by weighted averaging of multiple refined dummy atomic models Acta Crystallogr. D 53, 448-455 (1997).
24. Jones, T. A. & Kjeldgaard, M. Electron-density map interpretation Methods Enzymol. 277, 173-208 (1997).
25. Brunger, A. T. et al. Crystallography and NMR system: a new software system for macromolecular structure determination Acta Crystallogr. D 54, 905-921 (1998).
26. Kraulis, P. J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures J. Appl. Crystallogr. 24, 946-950 (1991).
27. Merrit, E. A. & Murphy, M. E. P. Raster3D version 2.0. A program for photorealistic molecular graphics Acta Crystallogr. D 50, 869-873 (1994).
28. Nicholls, A., Sharp, K. A. & Honig, B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons Proteins 11, 281-296 (1991)
29. Kabsch, W. & Sander, C. Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features Biopolymers 22, 2577-2637 (1983)
30. Pai, E. F. et at. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35Ȧ resolution: implications for the mechanism of GTP hydrolysis EMBO J. 9, 2351-2359 (1990).