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Volumn 280, Issue 1, 2017, Pages 231-248

Immunomodulation by ionizing radiation—impact for design of radio-immunotherapies and for treatment of inflammatory diseases

Author keywords

immunogenic cancer cell death; immunomonitoring; in situ vaccination; inflammation; ionizing radiation; radio immunotherapy

Indexed keywords

APOPTOSIS INHIBITOR; LIPOCORTIN 5; PHOSPHATIDYLSERINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 85031119484     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12572     Document Type: Review
Times cited : (137)

References (210)
  • 1
    • 84870454408 scopus 로고    scopus 로고
    • Image-guided radiotherapy: From current concept to future perspectives
    • Jaffray DA. Image-guided radiotherapy: From current concept to future perspectives. Nat Rev Clin Oncol. 2012;9:688-699.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 688-699
    • Jaffray, D.A.1
  • 2
    • 84941751878 scopus 로고    scopus 로고
    • Non-targeted effects of radiation exposure: Recent advances and implications
    • Kadhim MA, Hill MA. Non-targeted effects of radiation exposure: Recent advances and implications. Radiat Prot Dosimetry. 2015;166:118-124.
    • (2015) Radiat Prot Dosimetry , vol.166 , pp. 118-124
    • Kadhim, M.A.1    Hill, M.A.2
  • 3
    • 84941876964 scopus 로고    scopus 로고
    • Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases
    • Frey B, Hehlgans S, Rodel F, Gaipl US. Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases. Cancer Lett. 2015;368:230-237.
    • (2015) Cancer Lett , vol.368 , pp. 230-237
    • Frey, B.1    Hehlgans, S.2    Rodel, F.3    Gaipl, U.S.4
  • 4
    • 84992156227 scopus 로고    scopus 로고
    • Reactive oxygen species formation and bystander effects in gradient irradiation on human breast cancer cells
    • Zhang D, Zhou T, He F, et al. Reactive oxygen species formation and bystander effects in gradient irradiation on human breast cancer cells. Oncotarget. 2016;7:41622-41636.
    • (2016) Oncotarget , vol.7 , pp. 41622-41636
    • Zhang, D.1    Zhou, T.2    He, F.3
  • 5
    • 85014352562 scopus 로고    scopus 로고
    • Impact of particle irradiation on the immune system: From the clinic to mars
    • Fernandez-Gonzalo R, Baatout S, Moreels M. Impact of particle irradiation on the immune system: From the clinic to mars. Front Immunol. 2017;8:177.
    • (2017) Front Immunol , vol.8 , pp. 177
    • Fernandez-Gonzalo, R.1    Baatout, S.2    Moreels, M.3
  • 9
    • 78649321892 scopus 로고    scopus 로고
    • Current status of biodosimetry based on standard cytogenetic methods
    • Pinto MM, Santos NF, Amaral A. Current status of biodosimetry based on standard cytogenetic methods. Radiat Environ Biophys. 2010;49:567-581.
    • (2010) Radiat Environ Biophys , vol.49 , pp. 567-581
    • Pinto, M.M.1    Santos, N.F.2    Amaral, A.3
  • 10
    • 84942154980 scopus 로고    scopus 로고
    • Radiation environment at aviation altitudes and in space
    • Sihver L, Ploc O, Puchalska M, et al. Radiation environment at aviation altitudes and in space. Radiat Prot Dosimetry. 2015;164:477-483.
    • (2015) Radiat Prot Dosimetry , vol.164 , pp. 477-483
    • Sihver, L.1    Ploc, O.2    Puchalska, M.3
  • 11
    • 84895923545 scopus 로고    scopus 로고
    • Current concepts in clinical radiation oncology
    • Orth M, Lauber K, Niyazi M, et al. Current concepts in clinical radiation oncology. Radiat Environ Biophys. 2014;53:1-29.
    • (2014) Radiat Environ Biophys , vol.53 , pp. 1-29
    • Orth, M.1    Lauber, K.2    Niyazi, M.3
  • 13
    • 84901458582 scopus 로고    scopus 로고
    • Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells
    • Heylmann D, Rodel F, Kindler T, Kaina B. Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells. Biochem Biophys Acta. 2014;1846:121-129.
    • (2014) Biochem Biophys Acta , vol.1846 , pp. 121-129
    • Heylmann, D.1    Rodel, F.2    Kindler, T.3    Kaina, B.4
  • 14
    • 0032916590 scopus 로고    scopus 로고
    • Impact of localized radiotherapy on blood immune cells counts and function in humans
    • Belka C, Ottinger H, Kreuzfelder E, et al. Impact of localized radiotherapy on blood immune cells counts and function in humans. Radiother Oncol. 1999;50:199-204.
    • (1999) Radiother Oncol , vol.50 , pp. 199-204
    • Belka, C.1    Ottinger, H.2    Kreuzfelder, E.3
  • 15
    • 79952366675 scopus 로고    scopus 로고
    • High-mobility group box 1, oxidative stress, and disease
    • Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal. 2011;14:1315-1335.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1315-1335
    • Tang, D.1    Kang, R.2    Zeh, H.J.3    Lotze, M.T.4
  • 16
    • 84992377460 scopus 로고    scopus 로고
    • Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET)
    • Nikitaki Z, Nikolov V, Mavragani IV, et al. Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET). Free Radical Res. 2016;50:S64-s78.
    • (2016) Free Radical Res , vol.50 , pp. S64-s78
    • Nikitaki, Z.1    Nikolov, V.2    Mavragani, I.V.3
  • 18
    • 84255210700 scopus 로고    scopus 로고
    • Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
    • Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012;19:107-120.
    • (2012) Cell Death Differ , vol.19 , pp. 107-120
    • Galluzzi, L.1    Vitale, I.2    Abrams, J.M.3
  • 19
    • 84877273607 scopus 로고    scopus 로고
    • Dying cell clearance and its impact on the outcome of tumor radiotherapy
    • Lauber K, Ernst A, Orth M, Herrmann M, Belka C. Dying cell clearance and its impact on the outcome of tumor radiotherapy. Front Oncol. 2012;2:116.
    • (2012) Front Oncol , vol.2 , pp. 116
    • Lauber, K.1    Ernst, A.2    Orth, M.3    Herrmann, M.4    Belka, C.5
  • 20
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 2011;144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 21
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M, Cho RW, Lobo NA, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009;458:780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 22
    • 85014095449 scopus 로고    scopus 로고
    • Cold atmospheric plasma, a novel promising anti-cancer treatment modality
    • Yan D, Sherman JH, Keidar M. Cold atmospheric plasma, a novel promising anti-cancer treatment modality. Oncotarget. 2016;8:15977-15995.
    • (2016) Oncotarget , vol.8 , pp. 15977-15995
    • Yan, D.1    Sherman, J.H.2    Keidar, M.3
  • 23
    • 84912575835 scopus 로고    scopus 로고
    • Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status
    • Klammer H, Mladenov E, Li F, Iliakis G. Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status. Cancer Lett. 2015;356:58-71.
    • (2015) Cancer Lett , vol.356 , pp. 58-71
    • Klammer, H.1    Mladenov, E.2    Li, F.3    Iliakis, G.4
  • 24
    • 84958569020 scopus 로고    scopus 로고
    • Systemic mechanisms and effects of ionizing radiation: A new ‘old’ paradigm of how the bystanders and distant can become the players
    • Nikitaki Z, Mavragani IV, Laskaratou DA, et al. Systemic mechanisms and effects of ionizing radiation: A new ‘old’ paradigm of how the bystanders and distant can become the players. Semin Cancer Biol. 2016;37–38:77-95.
    • (2016) Semin Cancer Biol , vol.37-38 , pp. 77-95
    • Nikitaki, Z.1    Mavragani, I.V.2    Laskaratou, D.A.3
  • 25
    • 84891849910 scopus 로고    scopus 로고
    • Antitumor immune responses induced by ionizing irradiation and further immune stimulation
    • Frey B, Rubner Y, Kulzer L, et al. Antitumor immune responses induced by ionizing irradiation and further immune stimulation. Cancer Immunol Immunother. 2014;63:29-36.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 29-36
    • Frey, B.1    Rubner, Y.2    Kulzer, L.3
  • 26
    • 1242315588 scopus 로고    scopus 로고
    • Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    • Demaria S, Ng B, Devitt ML, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys. 2004;58:862-870.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 862-870
    • Demaria, S.1    Ng, B.2    Devitt, M.L.3
  • 28
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P. The danger model: A renewed sense of self. Science. 2002;296:301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 30
    • 84973866691 scopus 로고    scopus 로고
    • Balancing efficacy of and host immune responses to cancer therapy: The yin and yang effects
    • Shaked Y. Balancing efficacy of and host immune responses to cancer therapy: The yin and yang effects. Nat Rev Clin Oncol. 2016;13:611-626.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 611-626
    • Shaked, Y.1
  • 31
    • 0037942745 scopus 로고    scopus 로고
    • Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
    • Chakraborty M, Abrams SI, Camphausen K, et al. Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy. J Immunol. 2003;170:6338-6347.
    • (2003) J Immunol , vol.170 , pp. 6338-6347
    • Chakraborty, M.1    Abrams, S.I.2    Camphausen, K.3
  • 32
    • 84896724517 scopus 로고    scopus 로고
    • Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing
    • Gameiro SR, Jammeh ML, Wattenberg MM, Tsang KY, Ferrone S, Hodge JW. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing. Oncotarget. 2014;5:403-416.
    • (2014) Oncotarget , vol.5 , pp. 403-416
    • Gameiro, S.R.1    Jammeh, M.L.2    Wattenberg, M.M.3    Tsang, K.Y.4    Ferrone, S.5    Hodge, J.W.6
  • 34
    • 65949111072 scopus 로고    scopus 로고
    • The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells
    • Gehrmann M, Radons J, Molls M, Multhoff G. The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells. Cell Stress Chaperones. 2008;13:1-10.
    • (2008) Cell Stress Chaperones , vol.13 , pp. 1-10
    • Gehrmann, M.1    Radons, J.2    Molls, M.3    Multhoff, G.4
  • 35
    • 0028953056 scopus 로고
    • A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells
    • Multhoff G, Botzler C, Wiesnet M, et al. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer. 1995;61:272-279.
    • (1995) Int J Cancer , vol.61 , pp. 272-279
    • Multhoff, G.1    Botzler, C.2    Wiesnet, M.3
  • 36
    • 0030454056 scopus 로고    scopus 로고
    • Heat-shock protein 72 cell-surface expression on human lung carcinoma cells in associated with an increased sensitivity to lysis mediated by adherent natural killer cells
    • Botzler C, Issels R, Multhoff G. Heat-shock protein 72 cell-surface expression on human lung carcinoma cells in associated with an increased sensitivity to lysis mediated by adherent natural killer cells. Cancer Immunol Immunother. 1996;43:226-230.
    • (1996) Cancer Immunol Immunother , vol.43 , pp. 226-230
    • Botzler, C.1    Issels, R.2    Multhoff, G.3
  • 37
    • 84926683486 scopus 로고    scopus 로고
    • Heat shock protein 70 (Hsp70) peptide activated natural killer (NK) cells for the treatment of patients with Non-Small Cell Lung Cancer (NSCLC) after radiochemotherapy (RCTx) – From preclinical studies to a clinical phase II trial
    • Specht HM, Ahrens N, Blankenstein C, et al. Heat shock protein 70 (Hsp70) peptide activated natural killer (NK) cells for the treatment of patients with Non-Small Cell Lung Cancer (NSCLC) after radiochemotherapy (RCTx) – From preclinical studies to a clinical phase II trial. Front Immunol. 2015;6:162.
    • (2015) Front Immunol , vol.6 , pp. 162
    • Specht, H.M.1    Ahrens, N.2    Blankenstein, C.3
  • 38
    • 33644535813 scopus 로고    scopus 로고
    • Dendritic cell infiltration and prognosis of human hepatocellular carcinoma
    • Cai XY, Gao Q, Qiu SJ, et al. Dendritic cell infiltration and prognosis of human hepatocellular carcinoma. J Cancer Res Clin Oncol. 2006;132:293-301.
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 293-301
    • Cai, X.Y.1    Gao, Q.2    Qiu, S.J.3
  • 39
    • 34447277894 scopus 로고    scopus 로고
    • Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    • Gao Q, Qiu SJ, Fan J, et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 2007;25:2586-2593.
    • (2007) J Clin Oncol , vol.25 , pp. 2586-2593
    • Gao, Q.1    Qiu, S.J.2    Fan, J.3
  • 40
    • 0033120990 scopus 로고    scopus 로고
    • Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
    • Arnold-Schild D, Hanau D, Spehner D, et al. Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells. J Immunol. 1999;162:3757-3760.
    • (1999) J Immunol , vol.162 , pp. 3757-3760
    • Arnold-Schild, D.1    Hanau, D.2    Spehner, D.3
  • 41
    • 67949102158 scopus 로고    scopus 로고
    • Activation of natural killer cells by heat shock protein 70. 2002
    • Multhoff G. Activation of natural killer cells by heat shock protein 70. 2002. Int J Hyperth. 2009;25:169-175.
    • (2009) Int J Hyperth , vol.25 , pp. 169-175
    • Multhoff, G.1
  • 42
    • 0031945664 scopus 로고    scopus 로고
    • Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response
    • Botzler C, Li G, Issels RD, Multhoff G. Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response. Cell Stress Chaperones. 1998;3:6-11.
    • (1998) Cell Stress Chaperones , vol.3 , pp. 6-11
    • Botzler, C.1    Li, G.2    Issels, R.D.3    Multhoff, G.4
  • 43
    • 80655127833 scopus 로고    scopus 로고
    • Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages
    • Schildkopf P, Frey B, Ott OJ, et al. Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages. Radiother Oncol. 2011;101:109-115.
    • (2011) Radiother Oncol , vol.101 , pp. 109-115
    • Schildkopf, P.1    Frey, B.2    Ott, O.J.3
  • 44
    • 77950256166 scopus 로고    scopus 로고
    • Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation
    • Matsumura S, Demaria S. Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation. Radiat Res. 2010;173:418-425.
    • (2010) Radiat Res , vol.173 , pp. 418-425
    • Matsumura, S.1    Demaria, S.2
  • 46
    • 64949109089 scopus 로고    scopus 로고
    • Hyperthermia in combination with X-irradiation induces inflammatory forms of cell death
    • Schildkopf P, Holmer R, Sieber R, et al. Hyperthermia in combination with X-irradiation induces inflammatory forms of cell death. Autoimmunity. 2009;42:311-313.
    • (2009) Autoimmunity , vol.42 , pp. 311-313
    • Schildkopf, P.1    Holmer, R.2    Sieber, R.3
  • 47
    • 33646704729 scopus 로고    scopus 로고
    • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
    • Reits EA, Hodge JW, Herberts CA, et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med. 2006;203:1259-1271.
    • (2006) J Exp Med , vol.203 , pp. 1259-1271
    • Reits, E.A.1    Hodge, J.W.2    Herberts, C.A.3
  • 48
    • 84865318455 scopus 로고    scopus 로고
    • Old and new facts about hyperthermia-induced modulations of the immune system
    • Frey B, Weiss EM, Rubner Y, et al. Old and new facts about hyperthermia-induced modulations of the immune system. Int J Hyperth. 2012;28:528-542.
    • (2012) Int J Hyperth , vol.28 , pp. 528-542
    • Frey, B.1    Weiss, E.M.2    Rubner, Y.3
  • 49
    • 84945460646 scopus 로고    scopus 로고
    • Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future
    • Datta NR, Ordonez SG, Gaipl US, et al. Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future. Cancer Treat Rev. 2015;41:742-753.
    • (2015) Cancer Treat Rev , vol.41 , pp. 742-753
    • Datta, N.R.1    Ordonez, S.G.2    Gaipl, U.S.3
  • 50
    • 79960003299 scopus 로고    scopus 로고
    • Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
    • Krawczyk PM, Eppink B, Essers J, et al. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc Natl Acad Sci USA. 2011;108:9851-9856.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9851-9856
    • Krawczyk, P.M.1    Eppink, B.2    Essers, J.3
  • 51
    • 77955622857 scopus 로고    scopus 로고
    • Biological rationales and clinical applications of temperature controlled hyperthermia–implications for multimodal cancer treatments
    • Schildkopf P, Ott OJ, Frey B, et al. Biological rationales and clinical applications of temperature controlled hyperthermia–implications for multimodal cancer treatments. Curr Med Chem. 2010;17:3045-3057.
    • (2010) Curr Med Chem , vol.17 , pp. 3045-3057
    • Schildkopf, P.1    Ott, O.J.2    Frey, B.3
  • 52
    • 78650176575 scopus 로고    scopus 로고
    • Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells
    • Mantel F, Frey B, Haslinger S, et al. Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells. Strahlenther Onkol. 2010;186:587-599.
    • (2010) Strahlenther Onkol , vol.186 , pp. 587-599
    • Mantel, F.1    Frey, B.2    Haslinger, S.3
  • 53
    • 33847177938 scopus 로고    scopus 로고
    • The role of annexin A5 in the modulation of the immune response against dying and dead cells
    • Munoz LE, Frey B, Pausch F, et al. The role of annexin A5 in the modulation of the immune response against dying and dead cells. Curr Med Chem. 2007;14:271-277.
    • (2007) Curr Med Chem , vol.14 , pp. 271-277
    • Munoz, L.E.1    Frey, B.2    Pausch, F.3
  • 54
    • 37349051718 scopus 로고    scopus 로고
    • Molecular characteristics of immunogenic cancer cell death
    • Tesniere A, Panaretakis T, Kepp O, et al. Molecular characteristics of immunogenic cancer cell death. Cell Death Differ. 2008;15:3-12.
    • (2008) Cell Death Differ , vol.15 , pp. 3-12
    • Tesniere, A.1    Panaretakis, T.2    Kepp, O.3
  • 55
    • 72949113212 scopus 로고    scopus 로고
    • Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells
    • Schildkopf P, Frey B, Mantel F, et al. Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells. Biochem Biophys Res Comm. 2010;391:1014-1020.
    • (2010) Biochem Biophys Res Comm , vol.391 , pp. 1014-1020
    • Schildkopf, P.1    Frey, B.2    Mantel, F.3
  • 56
    • 84960352394 scopus 로고    scopus 로고
    • Combination of ionising radiation with hyperthermia increases the immunogenic potential of B16-F10 melanoma cells in vitro and in vivo
    • Werthmoller N, Frey B, Ruckert M, Lotter M, Fietkau R, Gaipl US. Combination of ionising radiation with hyperthermia increases the immunogenic potential of B16-F10 melanoma cells in vitro and in vivo. Int J Hyperth. 2016;32:23-30.
    • (2016) Int J Hyperth , vol.32 , pp. 23-30
    • Werthmoller, N.1    Frey, B.2    Ruckert, M.3    Lotter, M.4    Fietkau, R.5    Gaipl, U.S.6
  • 57
    • 84985032779 scopus 로고    scopus 로고
    • High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy
    • Parker KH, Horn LA, Ostrand-Rosenberg S. High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy. J Leukoc Biol. 2016;100:463-470.
    • (2016) J Leukoc Biol , vol.100 , pp. 463-470
    • Parker, K.H.1    Horn, L.A.2    Ostrand-Rosenberg, S.3
  • 58
    • 84957310840 scopus 로고    scopus 로고
    • Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner
    • Werthmoller N, Frey B, Wunderlich R, Fietkau R, Gaipl US. Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner. Cell Death Dis. 2015;6:e1761.
    • (2015) Cell Death Dis , vol.6
    • Werthmoller, N.1    Frey, B.2    Wunderlich, R.3    Fietkau, R.4    Gaipl, U.S.5
  • 59
    • 84939201459 scopus 로고    scopus 로고
    • Enhanced tumour regression in a patient of liposarcoma treated with radiotherapy and hyperthermia: Hint for dynamic immunomodulation by hyperthermia
    • Datta NR, Grobholz R, Puric E, et al. Enhanced tumour regression in a patient of liposarcoma treated with radiotherapy and hyperthermia: Hint for dynamic immunomodulation by hyperthermia. Int J Hyperth. 2015;31:574-577.
    • (2015) Int J Hyperth , vol.31 , pp. 574-577
    • Datta, N.R.1    Grobholz, R.2    Puric, E.3
  • 60
    • 85031092114 scopus 로고    scopus 로고
    • Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements
    • Trefna HD, Crezee H, Schmidt M, et al. Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements. Int J Hyperth. 2017;31:1-12.
    • (2017) Int J Hyperth , vol.31 , pp. 1-12
    • Trefna, H.D.1    Crezee, H.2    Schmidt, M.3
  • 61
    • 85014069907 scopus 로고    scopus 로고
    • Quality assurance guidelines for superficial hyperthermia clinical trials: II. Technical requirements for heating devices
    • Dobsicek Trefna H, Crezee J, Schmidt M, et al. Quality assurance guidelines for superficial hyperthermia clinical trials: II. Technical requirements for heating devices. Strahlenther Onkol. 2017;193:351-366.
    • (2017) Strahlenther Onkol , vol.193 , pp. 351-366
    • Dobsicek Trefna, H.1    Crezee, J.2    Schmidt, M.3
  • 63
    • 84865138542 scopus 로고    scopus 로고
    • Immunogenic tumor cell death induced by chemoradiotherapy in patients with esophageal squamous cell carcinoma
    • Suzuki Y, Mimura K, Yoshimoto Y, et al. Immunogenic tumor cell death induced by chemoradiotherapy in patients with esophageal squamous cell carcinoma. Can Res. 2012;72:3967-3976.
    • (2012) Can Res , vol.72 , pp. 3967-3976
    • Suzuki, Y.1    Mimura, K.2    Yoshimoto, Y.3
  • 64
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med. 2007;13:1050-1059.
    • (2007) Nat Med , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3
  • 65
    • 75749147533 scopus 로고    scopus 로고
    • Immunogenic death of colon cancer cells treated with oxaliplatin
    • Tesniere A, Schlemmer F, Boige V, et al. Immunogenic death of colon cancer cells treated with oxaliplatin. Oncogene. 2010;29:482-491.
    • (2010) Oncogene , vol.29 , pp. 482-491
    • Tesniere, A.1    Schlemmer, F.2    Boige, V.3
  • 66
    • 84923247523 scopus 로고    scopus 로고
    • Consensus guidelines for the detection of immunogenic cell death
    • Kepp O, Senovilla L, Vitale I, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 2014;3:e955691.
    • (2014) Oncoimmunology , vol.3
    • Kepp, O.1    Senovilla, L.2    Vitale, I.3
  • 67
    • 84959386808 scopus 로고    scopus 로고
    • Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma
    • Vandenberk L, Garg AD, Verschuere T, et al. Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma. Oncoimmunology. 2016;5:e1083669.
    • (2016) Oncoimmunology , vol.5
    • Vandenberk, L.1    Garg, A.D.2    Verschuere, T.3
  • 68
    • 85027933609 scopus 로고    scopus 로고
    • The immune functions of phosphatidylserine in membranes of dying cells and microvesicles
    • Frey B, Gaipl US. The immune functions of phosphatidylserine in membranes of dying cells and microvesicles. Semin Immunopathol. 2011;33:497-516.
    • (2011) Semin Immunopathol , vol.33 , pp. 497-516
    • Frey, B.1    Gaipl, U.S.2
  • 69
    • 70450219473 scopus 로고    scopus 로고
    • AnnexinA5 renders dead tumor cells immunogenic–implications for multimodal cancer therapies
    • Frey B, Schildkopf P, Rodel F, et al. AnnexinA5 renders dead tumor cells immunogenic–implications for multimodal cancer therapies. J Immunotoxicol. 2009;6:209-216.
    • (2009) J Immunotoxicol , vol.6 , pp. 209-216
    • Frey, B.1    Schildkopf, P.2    Rodel, F.3
  • 70
    • 8644274867 scopus 로고    scopus 로고
    • Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo
    • Bondanza A, Zimmermann VS, Rovere-Querini P, et al. Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. J Exp Med. 2004;200:1157-1165.
    • (2004) J Exp Med , vol.200 , pp. 1157-1165
    • Bondanza, A.1    Zimmermann, V.S.2    Rovere-Querini, P.3
  • 71
    • 68149180347 scopus 로고    scopus 로고
    • The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype
    • Frey B, Munoz LE, Pausch F, et al. The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype. J Cell Mol Med. 2009;13:1391-1399.
    • (2009) J Cell Mol Med , vol.13 , pp. 1391-1399
    • Frey, B.1    Munoz, L.E.2    Pausch, F.3
  • 72
    • 68849112162 scopus 로고    scopus 로고
    • Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells
    • Schilling D, Gehrmann M, Steinem C, et al. Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. FASEB J. 2009;23:2467-2477.
    • (2009) FASEB J , vol.23 , pp. 2467-2477
    • Schilling, D.1    Gehrmann, M.2    Steinem, C.3
  • 73
    • 77958197104 scopus 로고    scopus 로고
    • Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques
    • van Tilborg GA, Vucic E, Strijkers GJ, et al. Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques. Bioconjug Chem. 2010;21:1794-1803.
    • (2010) Bioconjug Chem , vol.21 , pp. 1794-1803
    • van Tilborg, G.A.1    Vucic, E.2    Strijkers, G.J.3
  • 74
    • 80255124055 scopus 로고    scopus 로고
    • In search of a novel target – Phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy
    • Riedl S, Rinner B, Asslaber M, et al. In search of a novel target – Phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy. Biochem Biophys Acta. 2011;1808:2638-2645.
    • (2011) Biochem Biophys Acta , vol.1808 , pp. 2638-2645
    • Riedl, S.1    Rinner, B.2    Asslaber, M.3
  • 75
    • 18544381354 scopus 로고    scopus 로고
    • Surface exposure of phosphatidylserine in pathological cells
    • Zwaal RF, Comfurius P, Bevers EM. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci. 2005;62:971-988.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 971-988
    • Zwaal, R.F.1    Comfurius, P.2    Bevers, E.M.3
  • 76
    • 77956914523 scopus 로고    scopus 로고
    • Phosphatidylserine targeting for diagnosis and treatment of human diseases
    • Schutters K, Reutelingsperger C. Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis. 2010;15:1072-1082.
    • (2010) Apoptosis , vol.15 , pp. 1072-1082
    • Schutters, K.1    Reutelingsperger, C.2
  • 77
    • 79953155957 scopus 로고    scopus 로고
    • Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motif
    • Rosenbaum S, Kreft S, Etich J, et al. Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motif. J Biol Chem. 2011;286:5708-5716.
    • (2011) J Biol Chem , vol.286 , pp. 5708-5716
    • Rosenbaum, S.1    Kreft, S.2    Etich, J.3
  • 78
    • 84945445347 scopus 로고    scopus 로고
    • (99 m)Tc-Annexin A5 quantification of apoptotic tumor response: A systematic review and meta-analysis of clinical imaging trials
    • Belhocine TZ, Blankenberg FG, Kartachova MS, et al. (99 m)Tc-Annexin A5 quantification of apoptotic tumor response: A systematic review and meta-analysis of clinical imaging trials. Eur J Nucl Med Mol Imaging. 2015;42:2083-2097.
    • (2015) Eur J Nucl Med Mol Imaging , vol.42 , pp. 2083-2097
    • Belhocine, T.Z.1    Blankenberg, F.G.2    Kartachova, M.S.3
  • 79
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-128.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 80
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415-421.
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 81
    • 84966769739 scopus 로고    scopus 로고
    • Targeting the heterogeneity of cancer with individualized neoepitope vaccines
    • Tureci O, Vormehr M, Diken M, Kreiter S, Huber C, Sahin U. Targeting the heterogeneity of cancer with individualized neoepitope vaccines. Clin Cancer Res. 2016;22:1885-1896.
    • (2016) Clin Cancer Res , vol.22 , pp. 1885-1896
    • Tureci, O.1    Vormehr, M.2    Diken, M.3    Kreiter, S.4    Huber, C.5    Sahin, U.6
  • 82
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature. 2009;461:788-792.
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 83
    • 84958978461 scopus 로고    scopus 로고
    • Radiotherapy combined with novel STING-targeting oligonucleotides results in regression of established tumors
    • Baird JR, Friedman D, Cottam B, et al. Radiotherapy combined with novel STING-targeting oligonucleotides results in regression of established tumors. Can Res. 2016;76:50-61.
    • (2016) Can Res , vol.76 , pp. 50-61
    • Baird, J.R.1    Friedman, D.2    Cottam, B.3
  • 84
    • 84911461919 scopus 로고    scopus 로고
    • Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells
    • Kulzer L, Rubner Y, Deloch L, et al. Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells. J Immunotoxicol. 2014;11:328-336.
    • (2014) J Immunotoxicol , vol.11 , pp. 328-336
    • Kulzer, L.1    Rubner, Y.2    Deloch, L.3
  • 85
    • 84955621208 scopus 로고    scopus 로고
    • Immune contexture, immunoscore, and malignant cell molecular subgroups for prognostic and theranostic classifications of cancers
    • Becht E, Giraldo NA, Germain C, et al. Immune contexture, immunoscore, and malignant cell molecular subgroups for prognostic and theranostic classifications of cancers. Adv Immunol. 2016;130:95-190.
    • (2016) Adv Immunol , vol.130 , pp. 95-190
    • Becht, E.1    Giraldo, N.A.2    Germain, C.3
  • 86
    • 84900881554 scopus 로고    scopus 로고
    • The immune microenvironment: A major player in human cancers
    • Fridman WH, Remark R, Goc J, et al. The immune microenvironment: A major player in human cancers. Int Arch Allergy Immunol. 2014;164:13-26.
    • (2014) Int Arch Allergy Immunol , vol.164 , pp. 13-26
    • Fridman, W.H.1    Remark, R.2    Goc, J.3
  • 87
    • 84892946785 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
    • Balermpas P, Michel Y, Wagenblast J, et al. Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer. Br J Cancer. 2014;110:501-509.
    • (2014) Br J Cancer , vol.110 , pp. 501-509
    • Balermpas, P.1    Michel, Y.2    Wagenblast, J.3
  • 88
    • 84944255998 scopus 로고    scopus 로고
    • CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG)
    • Balermpas P, Rodel F, Rodel C, et al. CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG). Int J Cancer. 2016;138:171-181.
    • (2016) Int J Cancer , vol.138 , pp. 171-181
    • Balermpas, P.1    Rodel, F.2    Rodel, C.3
  • 89
    • 84900301377 scopus 로고    scopus 로고
    • Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
    • Tran E, Turcotte S, Gros A, et al. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science. 2014;344:641-645.
    • (2014) Science , vol.344 , pp. 641-645
    • Tran, E.1    Turcotte, S.2    Gros, A.3
  • 90
    • 85017277731 scopus 로고    scopus 로고
    • Hypofractionated irradiation has immune stimulatory potential and induces a timely restricted infiltration of immune cells in colon cancer tumors
    • Frey B, Ruckert M, Weber J, et al. Hypofractionated irradiation has immune stimulatory potential and induces a timely restricted infiltration of immune cells in colon cancer tumors. Front Immunol. 2017;8:231.
    • (2017) Front Immunol , vol.8 , pp. 231
    • Frey, B.1    Ruckert, M.2    Weber, J.3
  • 91
    • 84974822460 scopus 로고    scopus 로고
    • The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia
    • Finkel P, Frey B, Mayer F, et al. The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia. Oncoimmunology. 2016;5:e1101206.
    • (2016) Oncoimmunology , vol.5
    • Finkel, P.1    Frey, B.2    Mayer, F.3
  • 92
    • 84902654063 scopus 로고    scopus 로고
    • Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1
    • Crouse J, Bedenikovic G, Wiesel M, et al. Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1. Immunity. 2014;40:961-973.
    • (2014) Immunity , vol.40 , pp. 961-973
    • Crouse, J.1    Bedenikovic, G.2    Wiesel, M.3
  • 93
    • 84984919506 scopus 로고    scopus 로고
    • Cancer cell death-inducing radiotherapy: Impact on local tumour control, tumour cell proliferation and induction of systemic anti-tumour immunity
    • Frey B, Derer A, Scheithauer H, Wunderlich R, Fietkau R, Gaipl US. Cancer cell death-inducing radiotherapy: Impact on local tumour control, tumour cell proliferation and induction of systemic anti-tumour immunity. Adv Exp Med Biol. 2016;930:151-172.
    • (2016) Adv Exp Med Biol , vol.930 , pp. 151-172
    • Frey, B.1    Derer, A.2    Scheithauer, H.3    Wunderlich, R.4    Fietkau, R.5    Gaipl, U.S.6
  • 94
  • 95
    • 0028177037 scopus 로고
    • Transforming growth factor-beta activation in irradiated murine mammary gland
    • Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA. Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest. 1994;93:892-899.
    • (1994) J Clin Invest , vol.93 , pp. 892-899
    • Barcellos-Hoff, M.H.1    Derynck, R.2    Tsang, M.L.3    Weatherbee, J.A.4
  • 96
    • 78149361497 scopus 로고    scopus 로고
    • Discontinuous induction of X-linked inhibitor of apoptosis in EA.hy.926 endothelial cells is linked to NF-kappaB activation and mediates the anti-inflammatory properties of low-dose ionising-radiation
    • Rodel F, Frey B, Capalbo G, et al. Discontinuous induction of X-linked inhibitor of apoptosis in EA.hy.926 endothelial cells is linked to NF-kappaB activation and mediates the anti-inflammatory properties of low-dose ionising-radiation. Radiother Oncol. 2010;97:346-351.
    • (2010) Radiother Oncol , vol.97 , pp. 346-351
    • Rodel, F.1    Frey, B.2    Capalbo, G.3
  • 97
    • 79959526395 scopus 로고    scopus 로고
    • TGF-beta signaling in breast cancer cell invasion and bone metastasis
    • Drabsch Y, ten Dijke P. TGF-beta signaling in breast cancer cell invasion and bone metastasis. J Mammary Gland Biol Neoplasia. 2011;16:97-108.
    • (2011) J Mammary Gland Biol Neoplasia , vol.16 , pp. 97-108
    • Drabsch, Y.1    ten Dijke, P.2
  • 98
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN
    • Fridlender ZG, Sun J, Kim S, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN. Cancer Cell. 2009;16:183-194.
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1    Sun, J.2    Kim, S.3
  • 99
    • 84982279514 scopus 로고    scopus 로고
    • TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype
    • Zhang F, Wang H, Wang X, et al. TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype. Oncotarget. 2016;7:52294-52306.
    • (2016) Oncotarget , vol.7 , pp. 52294-52306
    • Zhang, F.1    Wang, H.2    Wang, X.3
  • 100
    • 84929366910 scopus 로고    scopus 로고
    • TGFbeta is a master regulator of radiation therapy-induced antitumor immunity
    • Vanpouille-Box C, Diamond JM, Pilones KA, et al. TGFbeta is a master regulator of radiation therapy-induced antitumor immunity. Can Res. 2015;75:2232-2242.
    • (2015) Can Res , vol.75 , pp. 2232-2242
    • Vanpouille-Box, C.1    Diamond, J.M.2    Pilones, K.A.3
  • 101
    • 78649402748 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity
    • Tanaka H, Shinto O, Yashiro M, et al. Transforming growth factor beta signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity. Oncol Rep. 2010;24:1637-1643.
    • (2010) Oncol Rep , vol.24 , pp. 1637-1643
    • Tanaka, H.1    Shinto, O.2    Yashiro, M.3
  • 102
    • 48549086258 scopus 로고    scopus 로고
    • Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta
    • Wei S, Shreiner AB, Takeshita N, Chen L, Zou W, Chang AE. Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta. Can Res. 2008;68:5432-5438.
    • (2008) Can Res , vol.68 , pp. 5432-5438
    • Wei, S.1    Shreiner, A.B.2    Takeshita, N.3    Chen, L.4    Zou, W.5    Chang, A.E.6
  • 103
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236:219-242.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 104
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat Med. 2002;8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 105
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res. 2014;20:5064-5074.
    • (2014) Clin Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3
  • 106
    • 84939263638 scopus 로고    scopus 로고
    • Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy
    • Adachi K, Tamada K. Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Cancer Sci. 2015;106:945-950.
    • (2015) Cancer Sci , vol.106 , pp. 945-950
    • Adachi, K.1    Tamada, K.2
  • 107
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 108
    • 85019182007 scopus 로고    scopus 로고
    • Prognostic significance of PD-L1 in solid tumor: An updated meta-analysis
    • Wang Q, Liu F, Liu L. Prognostic significance of PD-L1 in solid tumor: An updated meta-analysis. Medicine. 2017;96:e6369.
    • (2017) Medicine , vol.96
    • Wang, Q.1    Liu, F.2    Liu, L.3
  • 109
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 110
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014;124:687-695.
    • (2014) J Clin Invest , vol.124 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3
  • 111
    • 85009375159 scopus 로고    scopus 로고
    • Chemoradiation increases PD-L1 expression in certain melanoma and glioblastoma cells
    • Derer A, Spiljar M, Baumler M, et al. Chemoradiation increases PD-L1 expression in certain melanoma and glioblastoma cells. Front Immunol. 2016;7:610.
    • (2016) Front Immunol , vol.7 , pp. 610
    • Derer, A.1    Spiljar, M.2    Baumler, M.3
  • 112
    • 85019900256 scopus 로고    scopus 로고
    • Combined radiotherapy and anti-PD-L1 antibody synergistically enhances anti-tumor effect in non-small cell lung cancer
    • Gong X, Li X, Jiang T, et al. Combined radiotherapy and anti-PD-L1 antibody synergistically enhances anti-tumor effect in non-small cell lung cancer. J Thorac Oncol. 2017;12:1085-1097.
    • (2017) J Thorac Oncol , vol.12 , pp. 1085-1097
    • Gong, X.1    Li, X.2    Jiang, T.3
  • 113
    • 84978173628 scopus 로고    scopus 로고
    • Novel technique for high-precision stereotactic irradiation of mouse brains
    • Hartmann J, Wolfelschneider J, Stache C, et al. Novel technique for high-precision stereotactic irradiation of mouse brains. Strahlenther Onkol. 2016;192:806-814.
    • (2016) Strahlenther Onkol , vol.192 , pp. 806-814
    • Hartmann, J.1    Wolfelschneider, J.2    Stache, C.3
  • 114
    • 85002194582 scopus 로고    scopus 로고
    • Drug priming enhances radiosensitivity of adamantinomatous craniopharyngioma via downregulation of survivin
    • Stache C, Bils C, Fahlbusch R, et al. Drug priming enhances radiosensitivity of adamantinomatous craniopharyngioma via downregulation of survivin. Neurosurg Focus. 2016;41:E14.
    • (2016) Neurosurg Focus , vol.41
    • Stache, C.1    Bils, C.2    Fahlbusch, R.3
  • 115
    • 84923090821 scopus 로고    scopus 로고
    • Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma
    • Ritprajak P, Azuma M. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. Oral Oncol. 2015;51:221-228.
    • (2015) Oral Oncol , vol.51 , pp. 221-228
    • Ritprajak, P.1    Azuma, M.2
  • 117
    • 84946434271 scopus 로고    scopus 로고
    • The increase of circulating PD-L1-expressing CD68(+) macrophage in ovarian cancer
    • Qu QX, Huang Q, Shen Y, Zhu YB, Zhang XG. The increase of circulating PD-L1-expressing CD68(+) macrophage in ovarian cancer. Tumour Biol. 2016;37:5031-5037.
    • (2016) Tumour Biol , vol.37 , pp. 5031-5037
    • Qu, Q.X.1    Huang, Q.2    Shen, Y.3    Zhu, Y.B.4    Zhang, X.G.5
  • 118
    • 84865313261 scopus 로고    scopus 로고
    • Combined treatment of human colorectal tumor cell lines with chemotherapeutic agents and ionizing irradiation can in vitro induce tumor cell death forms with immunogenic potential
    • Frey B, Stache C, Rubner Y, et al. Combined treatment of human colorectal tumor cell lines with chemotherapeutic agents and ionizing irradiation can in vitro induce tumor cell death forms with immunogenic potential. J Immunotoxicol. 2012;9:301-313.
    • (2012) J Immunotoxicol , vol.9 , pp. 301-313
    • Frey, B.1    Stache, C.2    Rubner, Y.3
  • 119
    • 84960490927 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes, forkhead box P3, programmed death ligand-1, and cytotoxic T lymphocyte-associated antigen-4 expressions before and after neoadjuvant chemoradiation in rectal cancer
    • Teng F, Meng X, Kong L, et al. Tumor-infiltrating lymphocytes, forkhead box P3, programmed death ligand-1, and cytotoxic T lymphocyte-associated antigen-4 expressions before and after neoadjuvant chemoradiation in rectal cancer. Transl Res. 2015;166(721–732):e721.
    • (2015) Transl Res , vol.166 , Issue.721-732
    • Teng, F.1    Meng, X.2    Kong, L.3
  • 120
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14:1014-1022.
    • (2013) Nat Immunol , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 121
    • 82255195940 scopus 로고    scopus 로고
    • gamma-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo
    • Sharma A, Bode B, Wenger RH, et al. gamma-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PLoS ONE. 2011;6:e28217.
    • (2011) PLoS ONE , vol.6
    • Sharma, A.1    Bode, B.2    Wenger, R.H.3
  • 122
    • 84949554848 scopus 로고    scopus 로고
    • Correlation of Hsp70 serum levels with gross tumor volume and composition of lymphocyte subpopulations in patients with squamous cell and adeno non-small cell lung cancer
    • Gunther S, Ostheimer C, Stangl S, et al. Correlation of Hsp70 serum levels with gross tumor volume and composition of lymphocyte subpopulations in patients with squamous cell and adeno non-small cell lung cancer. Front Immunol. 2015;6:556.
    • (2015) Front Immunol , vol.6 , pp. 556
    • Gunther, S.1    Ostheimer, C.2    Stangl, S.3
  • 123
    • 84867829868 scopus 로고    scopus 로고
    • Dual role of heat shock proteins (HSPs) in anti-tumor immunity
    • Multhoff G, Pockley AG, Streffer C, Gaipl US. Dual role of heat shock proteins (HSPs) in anti-tumor immunity. Curr Mol Med. 2012;12:1174-1182.
    • (2012) Curr Mol Med , vol.12 , pp. 1174-1182
    • Multhoff, G.1    Pockley, A.G.2    Streffer, C.3    Gaipl, U.S.4
  • 124
    • 84872026647 scopus 로고    scopus 로고
    • Radiation therapy to convert the tumor into an in situ vaccine
    • Formenti SC, Demaria S. Radiation therapy to convert the tumor into an in situ vaccine. Int J Radiat Oncol Biol Phys. 2012;84:879-880.
    • (2012) Int J Radiat Oncol Biol Phys , vol.84 , pp. 879-880
    • Formenti, S.C.1    Demaria, S.2
  • 125
    • 84947773168 scopus 로고    scopus 로고
    • Immune-modulating properties of ionizing radiation: Rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors
    • Derer A, Frey B, Fietkau R, Gaipl US. Immune-modulating properties of ionizing radiation: Rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors. Cancer Immunol Immunother. 2016;65:779-786.
    • (2016) Cancer Immunol Immunother , vol.65 , pp. 779-786
    • Derer, A.1    Frey, B.2    Fietkau, R.3    Gaipl, U.S.4
  • 126
    • 85014380761 scopus 로고    scopus 로고
    • The immunoregulatory potential of particle radiation in cancer therapy
    • Ebner DK, Tinganelli W, Helm A, et al. The immunoregulatory potential of particle radiation in cancer therapy. Front Immunol. 2017;8:99.
    • (2017) Front Immunol , vol.8 , pp. 99
    • Ebner, D.K.1    Tinganelli, W.2    Helm, A.3
  • 127
    • 84955417454 scopus 로고    scopus 로고
    • In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment
    • Vanpouille-Box C, Pilones KA, Wennerberg E, Formenti SC, Demaria S. In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment. Vaccine. 2015;33:7415-7422.
    • (2015) Vaccine , vol.33 , pp. 7415-7422
    • Vanpouille-Box, C.1    Pilones, K.A.2    Wennerberg, E.3    Formenti, S.C.4    Demaria, S.5
  • 129
    • 84992013320 scopus 로고    scopus 로고
    • Radiotherapy combination opportunities leveraging immunity for the next oncology practice
    • Herrera FG, Bourhis J, Coukos G. Radiotherapy combination opportunities leveraging immunity for the next oncology practice. Cancer J Clin. 2017;67:65-85.
    • (2017) Cancer J Clin , vol.67 , pp. 65-85
    • Herrera, F.G.1    Bourhis, J.2    Coukos, G.3
  • 130
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39:782-795.
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1    Mlecnik, B.2    Tosolini, M.3
  • 131
    • 85029636194 scopus 로고    scopus 로고
    • Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
    • Carstens JL, Correa de Sampaio P, Yang D, et al. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer. Nat Commun. 2017;8:15095.
    • (2017) Nat Commun , vol.8 , pp. 15095
    • Carstens, J.L.1    Correa de Sampaio, P.2    Yang, D.3
  • 133
    • 84978370380 scopus 로고    scopus 로고
    • Tumour and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy
    • Yamamoto Y, Offord CP, Kimura G, et al. Tumour and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy. Br J Cancer. 2016;115:195-202.
    • (2016) Br J Cancer , vol.115 , pp. 195-202
    • Yamamoto, Y.1    Offord, C.P.2    Kimura, G.3
  • 134
    • 84982084027 scopus 로고    scopus 로고
    • Checkpoint antibodies but not T cell-recruiting diabodies effectively synergize with TIL-inducing gamma-irradiation
    • Hettich M, Lahoti J, Prasad S, Niedermann G. Checkpoint antibodies but not T cell-recruiting diabodies effectively synergize with TIL-inducing gamma-irradiation. Can Res. 2016;76:4673-4683.
    • (2016) Can Res , vol.76 , pp. 4673-4683
    • Hettich, M.1    Lahoti, J.2    Prasad, S.3    Niedermann, G.4
  • 135
    • 84887561907 scopus 로고    scopus 로고
    • Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy
    • Klug F, Prakash H, Huber PE, et al. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell. 2013;24:589-602.
    • (2013) Cancer Cell , vol.24 , pp. 589-602
    • Klug, F.1    Prakash, H.2    Huber, P.E.3
  • 136
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • Ganss R, Ryschich E, Klar E, Arnold B, Hammerling GJ. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Can Res. 2002;62:1462-1470.
    • (2002) Can Res , vol.62 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3    Arnold, B.4    Hammerling, G.J.5
  • 137
    • 84974803082 scopus 로고    scopus 로고
    • Radiotherapy: Changing the game in immunotherapy
    • Demaria S, Coleman CN, Formenti SC. Radiotherapy: Changing the game in immunotherapy. Trends Cancer. 2016;2:286-294.
    • (2016) Trends Cancer , vol.2 , pp. 286-294
    • Demaria, S.1    Coleman, C.N.2    Formenti, S.C.3
  • 138
    • 84989863126 scopus 로고    scopus 로고
    • Stereotactic ablative radiotherapy and immunotherapy combinations: Turning the future into systemic therapy?
    • Walshaw RC, Honeychurch J, Illidge TM. Stereotactic ablative radiotherapy and immunotherapy combinations: Turning the future into systemic therapy? Br J Radiol. 2016;89:20160472.
    • (2016) Br J Radiol , vol.89 , pp. 20160472
    • Walshaw, R.C.1    Honeychurch, J.2    Illidge, T.M.3
  • 139
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
    • Zeng J, See AP, Phallen J, et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys. 2013;86:343-349.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 343-349
    • Zeng, J.1    See, A.P.2    Phallen, J.3
  • 140
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009;15:5379-5388.
    • (2009) Clin Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3
  • 141
    • 79953295544 scopus 로고    scopus 로고
    • The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity
    • Burnette BC, Liang H, Lee Y, et al. The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity. Can Res. 2011;71:2488-2496.
    • (2011) Can Res , vol.71 , pp. 2488-2496
    • Burnette, B.C.1    Liang, H.2    Lee, Y.3
  • 142
    • 85006746576 scopus 로고    scopus 로고
    • Combining type I interferons and 5-aza-2′-deoxycitidine to improve anti-tumor response against melanoma
    • Lucarini V, Buccione C, Ziccheddu G, et al. Combining type I interferons and 5-aza-2′-deoxycitidine to improve anti-tumor response against melanoma. J Invest Dermatol. 2017;137:159-169.
    • (2017) J Invest Dermatol , vol.137 , pp. 159-169
    • Lucarini, V.1    Buccione, C.2    Ziccheddu, G.3
  • 143
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: Changing strategies for cancer treatment
    • Lee Y, Auh SL, Wang Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: Changing strategies for cancer treatment. Blood. 2009;114:589-595.
    • (2009) Blood , vol.114 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3
  • 144
    • 85031085588 scopus 로고    scopus 로고
    • Tumor abolition and antitumor immunostimulation by physico-chemical tumor ablation
    • Keisari Y. Tumor abolition and antitumor immunostimulation by physico-chemical tumor ablation. Front Biosci. 2017;22:310-347.
    • (2017) Front Biosci , vol.22 , pp. 310-347
    • Keisari, Y.1
  • 147
    • 84860503128 scopus 로고    scopus 로고
    • Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation – Implications for cancer therapies
    • Frey B, Rubner Y, Wunderlich R, et al. Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation – Implications for cancer therapies. Curr Med Chem. 2012;19:1751-1764.
    • (2012) Curr Med Chem , vol.19 , pp. 1751-1764
    • Frey, B.1    Rubner, Y.2    Wunderlich, R.3
  • 149
    • 42549138499 scopus 로고    scopus 로고
    • Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
    • Melief CJ, van der Burg SH. Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines. Nat Rev Cancer. 2008;8:351-360.
    • (2008) Nat Rev Cancer , vol.8 , pp. 351-360
    • Melief, C.J.1    van der Burg, S.H.2
  • 150
    • 84945906575 scopus 로고    scopus 로고
    • Sipuleucel-T (Provenge((R)))-autopsy of an innovative paradigm change in cancer treatment: Why a single-product biotech company failed to capitalize on its breakthrough invention
    • Jaroslawski S, Toumi M. Sipuleucel-T (Provenge((R)))-autopsy of an innovative paradigm change in cancer treatment: Why a single-product biotech company failed to capitalize on its breakthrough invention. BioDrugs. 2015;29:301-307.
    • (2015) BioDrugs , vol.29 , pp. 301-307
    • Jaroslawski, S.1    Toumi, M.2
  • 151
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: A proof-of-principle trial
    • Golden EB, Chhabra A, Chachoua A, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: A proof-of-principle trial. Lancet Oncol. 2015;16:795-803.
    • (2015) Lancet Oncol , vol.16 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3
  • 152
    • 84942108093 scopus 로고    scopus 로고
    • Synergy of radiotherapy and a cancer vaccine for the treatment of HPV-associated head and neck cancer
    • Mondini M, Nizard M, Tran T, et al. Synergy of radiotherapy and a cancer vaccine for the treatment of HPV-associated head and neck cancer. Mol Cancer Ther. 2015;14:1336-1345.
    • (2015) Mol Cancer Ther , vol.14 , pp. 1336-1345
    • Mondini, M.1    Nizard, M.2    Tran, T.3
  • 153
    • 84945188232 scopus 로고    scopus 로고
    • Clinically feasible approaches to potentiating cancer cell-based immunotherapies
    • Seledtsov VI, Goncharov AG, Seledtsova GV. Clinically feasible approaches to potentiating cancer cell-based immunotherapies. Human Vaccin Immunother. 2015;11:851-869.
    • (2015) Human Vaccin Immunother , vol.11 , pp. 851-869
    • Seledtsov, V.I.1    Goncharov, A.G.2    Seledtsova, G.V.3
  • 154
    • 85015853519 scopus 로고    scopus 로고
    • Food processing by high hydrostatic pressure
    • Yamamoto K. Food processing by high hydrostatic pressure. Biosci Biotechnol Biochem. 2017;81:672-679.
    • (2017) Biosci Biotechnol Biochem , vol.81 , pp. 672-679
    • Yamamoto, K.1
  • 155
    • 0028220701 scopus 로고
    • Proteins under pressure. The influence of high hydrostatic pressure on structure, function and assembly of proteins and protein complexes
    • Gross M, Jaenicke R. Proteins under pressure. The influence of high hydrostatic pressure on structure, function and assembly of proteins and protein complexes. Eur J Biochem. 1994;221:617-630.
    • (1994) Eur J Biochem , vol.221 , pp. 617-630
    • Gross, M.1    Jaenicke, R.2
  • 156
    • 55249091823 scopus 로고    scopus 로고
    • Cells under pressure – Treatment of eukaryotic cells with high hydrostatic pressure, from physiologic aspects to pressure induced cell death
    • Frey B, Janko C, Ebel N, et al. Cells under pressure – Treatment of eukaryotic cells with high hydrostatic pressure, from physiologic aspects to pressure induced cell death. Curr Med Chem. 2008;15:2329-2336.
    • (2008) Curr Med Chem , vol.15 , pp. 2329-2336
    • Frey, B.1    Janko, C.2    Ebel, N.3
  • 157
    • 21644476266 scopus 로고    scopus 로고
    • Hydrostatic pressure induced death of mammalian cells engages pathways related to apoptosis or necrosis
    • Frey B, Franz S, Sheriff A, et al. Hydrostatic pressure induced death of mammalian cells engages pathways related to apoptosis or necrosis. Cell Mol Biol. 2004;50:459-467.
    • (2004) Cell Mol Biol , vol.50 , pp. 459-467
    • Frey, B.1    Franz, S.2    Sheriff, A.3
  • 158
    • 21644467346 scopus 로고    scopus 로고
    • High hydrostatic pressure inactivated human tumour cells preserve their immunogenicity
    • Korn A, Frey B, Sheriff A, et al. High hydrostatic pressure inactivated human tumour cells preserve their immunogenicity. Cell Mol Biol. 2004;50:469-477.
    • (2004) Cell Mol Biol , vol.50 , pp. 469-477
    • Korn, A.1    Frey, B.2    Sheriff, A.3
  • 159
    • 77954934585 scopus 로고    scopus 로고
    • High hydrostatic pressure treatment generates inactivated mammalian tumor cells with immunogeneic features
    • Weiss EM, Meister S, Janko C, et al. High hydrostatic pressure treatment generates inactivated mammalian tumor cells with immunogeneic features. J Immunotoxicol. 2010;7:194-204.
    • (2010) J Immunotoxicol , vol.7 , pp. 194-204
    • Weiss, E.M.1    Meister, S.2    Janko, C.3
  • 160
    • 84879554009 scopus 로고    scopus 로고
    • Selected anti-tumor vaccines merit a place in multimodal tumor therapies
    • Weiss EM, Wunderlich R, Ebel N, et al. Selected anti-tumor vaccines merit a place in multimodal tumor therapies. Front Oncol. 2012;2:132.
    • (2012) Front Oncol , vol.2 , pp. 132
    • Weiss, E.M.1    Wunderlich, R.2    Ebel, N.3
  • 161
    • 84902543448 scopus 로고    scopus 로고
    • High hydrostatic pressure induces immunogenic cell death in human tumor cells
    • Fucikova J, Moserova I, Truxova I, et al. High hydrostatic pressure induces immunogenic cell death in human tumor cells. Int J Cancer. 2014;135:1165-1177.
    • (2014) Int J Cancer , vol.135 , pp. 1165-1177
    • Fucikova, J.1    Moserova, I.2    Truxova, I.3
  • 162
    • 84959020402 scopus 로고    scopus 로고
    • Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy
    • Mikyskova R, Stepanek I, Indrova M, et al. Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy. Int J Oncol. 2016;48:953-964.
    • (2016) Int J Oncol , vol.48 , pp. 953-964
    • Mikyskova, R.1    Stepanek, I.2    Indrova, M.3
  • 163
    • 85019120416 scopus 로고    scopus 로고
    • High hydrostatic pressure affects antigenic pool in tumor cells: Implication for dendritic cell-based cancer immunotherapy
    • Urbanova L, Hradilova N, Moserova I, et al. High hydrostatic pressure affects antigenic pool in tumor cells: Implication for dendritic cell-based cancer immunotherapy. Immunol Lett. 2017;187:27-34.
    • (2017) Immunol Lett , vol.187 , pp. 27-34
    • Urbanova, L.1    Hradilova, N.2    Moserova, I.3
  • 164
    • 84958213866 scopus 로고    scopus 로고
    • Exploiting the immunogenic potential of cancer cells for improved dendritic cell vaccines
    • Vandenberk L, Belmans J, Van Woensel M, Riva M, Van Gool SW. Exploiting the immunogenic potential of cancer cells for improved dendritic cell vaccines. Front Immunol. 2015;6:663.
    • (2015) Front Immunol , vol.6 , pp. 663
    • Vandenberk, L.1    Belmans, J.2    Van Woensel, M.3    Riva, M.4    Van Gool, S.W.5
  • 165
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: A magic bullet?
    • Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: A magic bullet? Science. 2013;339:286-291.
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 166
    • 70749153336 scopus 로고
    • Über Heilung des Gelenkrheumatismus durch Röntgenstrahlung bei Kindern
    • Schmid-Monnard C. Über Heilung des Gelenkrheumatismus durch Röntgenstrahlung bei Kindern. Fortschr Röntgenstr. 1898;1:209.
    • (1898) Fortschr Röntgenstr , vol.1 , pp. 209
    • Schmid-Monnard, C.1
  • 167
    • 84940453217 scopus 로고    scopus 로고
    • DEGRO practical guidelines for radiotherapy of non-malignant disorders: Part I: Physical principles, radiobiological mechanisms, and radiogenic risk
    • Reichl B, Block A, Schafer U, et al. DEGRO practical guidelines for radiotherapy of non-malignant disorders: Part I: Physical principles, radiobiological mechanisms, and radiogenic risk. Strahlenther Onkol. 2015;191:701-709.
    • (2015) Strahlenther Onkol , vol.191 , pp. 701-709
    • Reichl, B.1    Block, A.2    Schafer, U.3
  • 168
    • 34248550946 scopus 로고    scopus 로고
    • Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy
    • Rodel F, Keilholz L, Herrmann M, Sauer R, Hildebrandt G. Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. Int J Radiat Biol. 2007;83:357-366.
    • (2007) Int J Radiat Biol , vol.83 , pp. 357-366
    • Rodel, F.1    Keilholz, L.2    Herrmann, M.3    Sauer, R.4    Hildebrandt, G.5
  • 169
    • 84860520670 scopus 로고    scopus 로고
    • Modulation of inflammatory immune reactions by low-dose ionizing radiation: Molecular mechanisms and clinical application
    • Rodel F, Frey B, Gaipl U, et al. Modulation of inflammatory immune reactions by low-dose ionizing radiation: Molecular mechanisms and clinical application. Curr Med Chem. 2012;19:1741-1750.
    • (2012) Curr Med Chem , vol.19 , pp. 1741-1750
    • Rodel, F.1    Frey, B.2    Gaipl, U.3
  • 170
    • 85031091800 scopus 로고    scopus 로고
    • Interconnection between DNA damage, senescence, inflammation, and cancer
    • Wunderlich R, Ruehle PF, Deloch L, et al. Interconnection between DNA damage, senescence, inflammation, and cancer. Front Biosci. 2017;22:348-369.
    • (2017) Front Biosci , vol.22 , pp. 348-369
    • Wunderlich, R.1    Ruehle, P.F.2    Deloch, L.3
  • 171
    • 84881659842 scopus 로고    scopus 로고
    • Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose x-irradiation
    • Rodel F, Frey B, Manda K, et al. Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose x-irradiation. Front Oncol. 2012;2:120.
    • (2012) Front Oncol , vol.2 , pp. 120
    • Rodel, F.1    Frey, B.2    Manda, K.3
  • 173
    • 84934943164 scopus 로고    scopus 로고
    • Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function
    • Wunderlich R, Ernst A, Rodel F, et al. Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function. Clin Exp Immunol. 2015;179:50-61.
    • (2015) Clin Exp Immunol , vol.179 , pp. 50-61
    • Wunderlich, R.1    Ernst, A.2    Rodel, F.3
  • 174
    • 84880338840 scopus 로고    scopus 로고
    • Reduced secretion of the inflammatory cytokine IL-1beta by stimulated peritoneal macrophages of radiosensitive Balb/c mice after exposure to 0.5 or 0.7 Gy of ionizing radiation
    • Frischholz B, Wunderlich R, Ruhle PF, et al. Reduced secretion of the inflammatory cytokine IL-1beta by stimulated peritoneal macrophages of radiosensitive Balb/c mice after exposure to 0.5 or 0.7 Gy of ionizing radiation. Autoimmunity. 2013;46:323-328.
    • (2013) Autoimmunity , vol.46 , pp. 323-328
    • Frischholz, B.1    Wunderlich, R.2    Ruhle, P.F.3
  • 175
    • 84867017339 scopus 로고    scopus 로고
    • Low dose ionising radiation leads to a NF-kappaB dependent decreased secretion of active IL-1beta by activated macrophages with a discontinuous dose-dependency
    • Lodermann B, Wunderlich R, Frey S, et al. Low dose ionising radiation leads to a NF-kappaB dependent decreased secretion of active IL-1beta by activated macrophages with a discontinuous dose-dependency. Int J Radiat Biol. 2012;88:727-734.
    • (2012) Int J Radiat Biol , vol.88 , pp. 727-734
    • Lodermann, B.1    Wunderlich, R.2    Frey, S.3
  • 177
    • 0036292547 scopus 로고    scopus 로고
    • The effects of low-dose X-irradiation on the oxidative burst in stimulated macrophages
    • Schaue D, Marples B, Trott KR. The effects of low-dose X-irradiation on the oxidative burst in stimulated macrophages. Int J Radiat Biol. 2002;78:567-576.
    • (2002) Int J Radiat Biol , vol.78 , pp. 567-576
    • Schaue, D.1    Marples, B.2    Trott, K.R.3
  • 178
    • 84899131192 scopus 로고    scopus 로고
    • A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species
    • Large M, Reichert S, Hehlgans S, Fournier C, Rodel C, Rodel F. A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species. Radiat Oncol. 2014;9:80.
    • (2014) Radiat Oncol , vol.9 , pp. 80
    • Large, M.1    Reichert, S.2    Hehlgans, S.3    Fournier, C.4    Rodel, C.5    Rodel, F.6
  • 179
    • 85021689237 scopus 로고    scopus 로고
    • Systemic effects of ionizing radiation at the proteome and metabolome levels in the blood of cancer patients treated with radiotherapy: The influence of inflammation and radiation toxicity
    • Jelonek K, Pietrowska M, Widlak P. Systemic effects of ionizing radiation at the proteome and metabolome levels in the blood of cancer patients treated with radiotherapy: The influence of inflammation and radiation toxicity. Int J Radiat Biol. 2017;93:683-696.
    • (2017) Int J Radiat Biol , vol.93 , pp. 683-696
    • Jelonek, K.1    Pietrowska, M.2    Widlak, P.3
  • 180
    • 85020004749 scopus 로고    scopus 로고
    • Basics of radiation biology when treating hyperproliferative benign diseases
    • Rodel F, Fournier C, Wiedemann J, et al. Basics of radiation biology when treating hyperproliferative benign diseases. Front Immunol. 2017;8:519.
    • (2017) Front Immunol , vol.8 , pp. 519
    • Rodel, F.1    Fournier, C.2    Wiedemann, J.3
  • 181
    • 84896372212 scopus 로고    scopus 로고
    • The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome. Long-term results
    • Ott OJ, Hertel S, Gaipl US, Frey B, Schmidt M, Fietkau R. The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome. Long-term results. Strahlenther Onkol. 2014;190:293-297.
    • (2014) Strahlenther Onkol , vol.190 , pp. 293-297
    • Ott, O.J.1    Hertel, S.2    Gaipl, U.S.3    Frey, B.4    Schmidt, M.5    Fietkau, R.6
  • 182
    • 84896909826 scopus 로고    scopus 로고
    • The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder syndrome. Long-term results
    • Ott OJ, Hertel S, Gaipl US, Frey B, Schmidt M, Fietkau R. The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder syndrome. Long-term results. Strahlenther Onkol. 2014;190:394-398.
    • (2014) Strahlenther Onkol , vol.190 , pp. 394-398
    • Ott, O.J.1    Hertel, S.2    Gaipl, U.S.3    Frey, B.4    Schmidt, M.5    Fietkau, R.6
  • 183
    • 84948070022 scopus 로고    scopus 로고
    • Radiotherapy for benign achillodynia. Long-term results of the Erlangen Dose Optimization Trial
    • Ott OJ, Jeremias C, Gaipl US, Frey B, Schmidt M, Fietkau R. Radiotherapy for benign achillodynia. Long-term results of the Erlangen Dose Optimization Trial. Strahlenther Onkol. 2015;191:979-984.
    • (2015) Strahlenther Onkol , vol.191 , pp. 979-984
    • Ott, O.J.1    Jeremias, C.2    Gaipl, U.S.3    Frey, B.4    Schmidt, M.5    Fietkau, R.6
  • 184
    • 84903373968 scopus 로고    scopus 로고
    • Radiotherapy for benign calcaneodynia: Long-term results of the Erlangen Dose Optimization (EDO) trial
    • Ott OJ, Jeremias C, Gaipl US, Frey B, Schmidt M, Fietkau R. Radiotherapy for benign calcaneodynia: Long-term results of the Erlangen Dose Optimization (EDO) trial. Strahlenther Onkol. 2014;190:671-675.
    • (2014) Strahlenther Onkol , vol.190 , pp. 671-675
    • Ott, O.J.1    Jeremias, C.2    Gaipl, U.S.3    Frey, B.4    Schmidt, M.5    Fietkau, R.6
  • 188
    • 84981499980 scopus 로고    scopus 로고
    • Development of a modular assay for detailed immunophenotyping of peripheral human whole blood samples by multicolor flow cytometry
    • Ruhle PF, Fietkau R, Gaipl US, Frey B. Development of a modular assay for detailed immunophenotyping of peripheral human whole blood samples by multicolor flow cytometry. Int J Mol Sci. 2016;17:1-29.
    • (2016) Int J Mol Sci , vol.17 , pp. 1-29
    • Ruhle, P.F.1    Fietkau, R.2    Gaipl, U.S.3    Frey, B.4
  • 189
    • 84947941076 scopus 로고    scopus 로고
    • The immune system in cancer prevention, development and therapy
    • Candeias SM, Gaipl US. The immune system in cancer prevention, development and therapy. Anticancer Agents Med Chem. 2016;16:101-107.
    • (2016) Anticancer Agents Med Chem , vol.16 , pp. 101-107
    • Candeias, S.M.1    Gaipl, U.S.2
  • 190
    • 84866852663 scopus 로고    scopus 로고
    • Cancer classification using the immunoscore: A worldwide task force
    • Galon J, Pages F, Marincola FM, et al. Cancer classification using the immunoscore: A worldwide task force. J Transl Med. 2012;10:205.
    • (2012) J Transl Med , vol.10 , pp. 205
    • Galon, J.1    Pages, F.2    Marincola, F.M.3
  • 191
    • 84925298945 scopus 로고    scopus 로고
    • Prognostic and predictive value of immunological parameters for chemoradioimmunotherapy in patients with pancreatic adenocarcinoma
    • Karakhanova S, Ryschich E, Mosl B, et al. Prognostic and predictive value of immunological parameters for chemoradioimmunotherapy in patients with pancreatic adenocarcinoma. Br J Cancer. 2015;112:1027-1036.
    • (2015) Br J Cancer , vol.112 , pp. 1027-1036
    • Karakhanova, S.1    Ryschich, E.2    Mosl, B.3
  • 192
    • 85021176181 scopus 로고    scopus 로고
    • Implementing liquid biopsies into clinical decision making for cancer immunotherapy
    • Quandt D, Zucht HD, Amann A, et al. Implementing liquid biopsies into clinical decision making for cancer immunotherapy. Oncotarget. 2017;8:48507-48520.
    • (2017) Oncotarget , vol.8 , pp. 48507-48520
    • Quandt, D.1    Zucht, H.D.2    Amann, A.3
  • 193
    • 79551676875 scopus 로고    scopus 로고
    • Changes in peripheral blood level of regulatory T cells in patients with malignant melanoma during treatment with dendritic cell vaccination and low-dose IL-2
    • Bjoern J, Brimnes MK, Andersen MH, Thor Straten P, Svane IM. Changes in peripheral blood level of regulatory T cells in patients with malignant melanoma during treatment with dendritic cell vaccination and low-dose IL-2. Scand J Immunol. 2011;73:222-233.
    • (2011) Scand J Immunol , vol.73 , pp. 222-233
    • Bjoern, J.1    Brimnes, M.K.2    Andersen, M.H.3    Thor Straten, P.4    Svane, I.M.5
  • 194
    • 84865592340 scopus 로고    scopus 로고
    • Cytometry: Today's technology and tomorrow's horizons
    • Chattopadhyay PK, Roederer M. Cytometry: Today's technology and tomorrow's horizons. Methods. 2012;57:251-258.
    • (2012) Methods , vol.57 , pp. 251-258
    • Chattopadhyay, P.K.1    Roederer, M.2
  • 195
    • 84857647499 scopus 로고    scopus 로고
    • Standardizing immunophenotyping for the Human Immunology Project
    • Maecker HT, McCoy JP, Nussenblatt R. Standardizing immunophenotyping for the Human Immunology Project. Nat Rev Immunol. 2012;12:191-200.
    • (2012) Nat Rev Immunol , vol.12 , pp. 191-200
    • Maecker, H.T.1    McCoy, J.P.2    Nussenblatt, R.3
  • 196
    • 85018512066 scopus 로고    scopus 로고
    • Tumor-infiltrating and peripheral blood T cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma
    • Giraldo NA, Becht E, Vano Y, et al. Tumor-infiltrating and peripheral blood T cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma. Clin Cancer Res. 2017;23:4416-4428.
    • (2017) Clin Cancer Res , vol.23 , pp. 4416-4428
    • Giraldo, N.A.1    Becht, E.2    Vano, Y.3
  • 197
    • 66449089455 scopus 로고    scopus 로고
    • Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus
    • Munoz LE, Janko C, Grossmayer GE, et al. Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum. 2009;60:1733-1742.
    • (2009) Arthritis Rheum , vol.60 , pp. 1733-1742
    • Munoz, L.E.1    Janko, C.2    Grossmayer, G.E.3
  • 198
    • 34247590859 scopus 로고    scopus 로고
    • Clearance deficiency and systemic lupus erythematosus (SLE)
    • Gaipl US, Munoz LE, Grossmayer G, et al. Clearance deficiency and systemic lupus erythematosus (SLE). J Autoimmun. 2007;28:114-121.
    • (2007) J Autoimmun , vol.28 , pp. 114-121
    • Gaipl, U.S.1    Munoz, L.E.2    Grossmayer, G.3
  • 199
    • 85006377717 scopus 로고    scopus 로고
    • Immuno-oncology: Allying forces of radio- and immuno-therapy to enhance cancer cell killing
    • Bernier J. Immuno-oncology: Allying forces of radio- and immuno-therapy to enhance cancer cell killing. Crit Rev Oncol Hematol. 2016;108:97-108.
    • (2016) Crit Rev Oncol Hematol , vol.108 , pp. 97-108
    • Bernier, J.1
  • 200
    • 84960158712 scopus 로고    scopus 로고
    • Immunotherapy and stereotactic ablative radiotherapy (ISABR): A curative approach?
    • Bernstein MB, Krishnan S, Hodge JW, Chang JY. Immunotherapy and stereotactic ablative radiotherapy (ISABR): A curative approach? Nat Rev Clin Oncol. 2016;13:516-524.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 516-524
    • Bernstein, M.B.1    Krishnan, S.2    Hodge, J.W.3    Chang, J.Y.4
  • 201
    • 84907486895 scopus 로고    scopus 로고
    • Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade
    • Dovedi SJ, Adlard AL, Lipowska-Bhalla G, et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Can Res. 2014;74:5458-5468.
    • (2014) Can Res , vol.74 , pp. 5458-5468
    • Dovedi, S.J.1    Adlard, A.L.2    Lipowska-Bhalla, G.3
  • 202
    • 84879645728 scopus 로고    scopus 로고
    • Radiation and immunotherapy: A synergistic combination
    • Kalbasi A, June CH, Haas N, Vapiwala N. Radiation and immunotherapy: A synergistic combination. J Clin Invest. 2013;123:2756-2763.
    • (2013) J Clin Invest , vol.123 , pp. 2756-2763
    • Kalbasi, A.1    June, C.H.2    Haas, N.3    Vapiwala, N.4
  • 203
    • 85019382493 scopus 로고    scopus 로고
    • The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
    • Balermpas P, Rodel F, Krause M, et al. The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Int J Cancer. 2017;141:594-603.
    • (2017) Int J Cancer , vol.141 , pp. 594-603
    • Balermpas, P.1    Rodel, F.2    Krause, M.3
  • 204
    • 84942306499 scopus 로고    scopus 로고
    • FcgammaRs modulate the anti-tumor activity of antibodies targeting the PD-1/PD-L1 axis
    • Dahan R, Sega E, Engelhardt J, Selby M, Korman AJ, Ravetch JV. FcgammaRs modulate the anti-tumor activity of antibodies targeting the PD-1/PD-L1 axis. Cancer Cell. 2015;28:285-295.
    • (2015) Cancer Cell , vol.28 , pp. 285-295
    • Dahan, R.1    Sega, E.2    Engelhardt, J.3    Selby, M.4    Korman, A.J.5    Ravetch, J.V.6
  • 205
    • 85020905767 scopus 로고    scopus 로고
    • Immunotherapy for head and neck squamous cell carcinoma: A review of current and emerging therapeutic options
    • Moskovitz JM, Moy J, Seiwert TY, Ferris RL. Immunotherapy for head and neck squamous cell carcinoma: A review of current and emerging therapeutic options. Oncologist. 2017;22:680-693.
    • (2017) Oncologist , vol.22 , pp. 680-693
    • Moskovitz, J.M.1    Moy, J.2    Seiwert, T.Y.3    Ferris, R.L.4
  • 206
    • 84892948376 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer
    • Ward MJ, Thirdborough SM, Mellows T, et al. Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer. Br J Cancer. 2014;110:489-500.
    • (2014) Br J Cancer , vol.110 , pp. 489-500
    • Ward, M.J.1    Thirdborough, S.M.2    Mellows, T.3
  • 207
    • 84938422155 scopus 로고    scopus 로고
    • Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas–an immunohistochemical study
    • Weber M, Moebius P, Buttner-Herold M, et al. Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas–an immunohistochemical study. Br J Cancer. 2015;113:510-519.
    • (2015) Br J Cancer , vol.113 , pp. 510-519
    • Weber, M.1    Moebius, P.2    Buttner-Herold, M.3
  • 208
    • 85020269576 scopus 로고    scopus 로고
    • Integrative analysis identifies a novel AXL-PI3 kinase-PD-L1 signaling axis associated with Radiation Resistance in Head and Neck Cancer
    • Skinner HD, Giri U, Yang LP, et al. Integrative analysis identifies a novel AXL-PI3 kinase-PD-L1 signaling axis associated with Radiation Resistance in Head and Neck Cancer. Clin Cancer Res. 2017;23:2713-2722.
    • (2017) Clin Cancer Res , vol.23 , pp. 2713-2722
    • Skinner, H.D.1    Giri, U.2    Yang, L.P.3
  • 209
    • 84937523796 scopus 로고    scopus 로고
    • Radio-immunotherapy: The focused beam expands
    • Frey B, Gaipl US. Radio-immunotherapy: The focused beam expands. Lancet Oncol. 2015;16:742-743.
    • (2015) Lancet Oncol , vol.16 , pp. 742-743
    • Frey, B.1    Gaipl, U.S.2
  • 210
    • 70349982431 scopus 로고    scopus 로고
    • HMGB1 mediates endogenous TLR2 activation and brain tumor regression
    • Curtin JF, Liu N, Candolfi M, et al. HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS Med. 2009;6:e10.
    • (2009) PLoS Med , vol.6
    • Curtin, J.F.1    Liu, N.2    Candolfi, M.3


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