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Volumn 368, Issue 2, 2015, Pages 230-237

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

Author keywords

Immune biomarkers; Inflammation; Ionizing radiation; Low dose radiation therapy; Tumor associated macrophages; Tumor infiltrating lymphocytes

Indexed keywords

BIOLOGICAL MARKER;

EID: 84941876964     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2015.04.010     Document Type: Review
Times cited : (102)

References (123)
  • 1
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 4
    • 84941880712 scopus 로고    scopus 로고
    • Fundamentals of inflammation
    • Ciaccia L. Fundamentals of inflammation. Yale J. Biol. Med 2001, 84:64-65.
    • (2001) Yale J. Biol. Med , vol.84 , pp. 64-65
    • Ciaccia, L.1
  • 5
    • 33750906418 scopus 로고    scopus 로고
    • The five cardinal signs of inflammation: calor, dolor, rubor, tumor... and penuria (apologies to Aulus Cornelius Celsus, De medicina, c. A.D. 25)
    • Tracy R.P. The five cardinal signs of inflammation: calor, dolor, rubor, tumor... and penuria (apologies to Aulus Cornelius Celsus, De medicina, c. A.D. 25). J. Gerontol. A. Biol Sci. Med Sci 2006, 61:1051-1052.
    • (2006) J. Gerontol. A. Biol Sci. Med Sci , vol.61 , pp. 1051-1052
    • Tracy, R.P.1
  • 6
    • 84941880459 scopus 로고    scopus 로고
    • Springer, Basel, B.B. Aggarwal, B. Sung, S.C. Gupta (Eds.)
    • Inflammation and Cancer 2014, Springer, Basel. B.B. Aggarwal, B. Sung, S.C. Gupta (Eds.).
    • (2014) Inflammation and Cancer
  • 7
    • 84870880129 scopus 로고    scopus 로고
    • Cytokines in radiobiological responses: a review
    • Schaue D., Kachikwu E.L., McBride W.H. Cytokines in radiobiological responses: a review. Radiat. Res 2012, 178:505-523.
    • (2012) Radiat. Res , vol.178 , pp. 505-523
    • Schaue, D.1    Kachikwu, E.L.2    McBride, W.H.3
  • 8
    • 84880269392 scopus 로고    scopus 로고
    • How cytokine networks fuel inflammation: toward a cytokine-based disease taxonomy
    • Schett G., Elewaut D., McInnes I.B., Dayer J.M., Neurath M.F. How cytokine networks fuel inflammation: toward a cytokine-based disease taxonomy. Nat. Med 2013, 19:822-824.
    • (2013) Nat. Med , vol.19 , pp. 822-824
    • Schett, G.1    Elewaut, D.2    McInnes, I.B.3    Dayer, J.M.4    Neurath, M.F.5
  • 11
    • 33746775283 scopus 로고    scopus 로고
    • Evidence-based skin care management in radiation therapy
    • McQuestion M. Evidence-based skin care management in radiation therapy. Semin. Oncol. Nurs 2006, 22:163-173.
    • (2006) Semin. Oncol. Nurs , vol.22 , pp. 163-173
    • McQuestion, M.1
  • 12
    • 43749115744 scopus 로고    scopus 로고
    • A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis
    • Pignol J.P., Olivotto I., Rakovitch E., Gardner S., Sixel K., Beckham W., et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J. Clin. Oncol 2008, 26:2085-2092.
    • (2008) J. Clin. Oncol , vol.26 , pp. 2085-2092
    • Pignol, J.P.1    Olivotto, I.2    Rakovitch, E.3    Gardner, S.4    Sixel, K.5    Beckham, W.6
  • 13
    • 29244432161 scopus 로고    scopus 로고
    • Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006
    • Hymes S.R., Strom E.A., Fife C. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J. Am. Acad. Dermatol 2006, 54:28-46.
    • (2006) J. Am. Acad. Dermatol , vol.54 , pp. 28-46
    • Hymes, S.R.1    Strom, E.A.2    Fife, C.3
  • 15
    • 0018569985 scopus 로고
    • Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma
    • Stone H.B., Peters L.J., Milas L. Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma. J. Natl Cancer Inst 1979, 63:1229-1235.
    • (1979) J. Natl Cancer Inst , vol.63 , pp. 1229-1235
    • Stone, H.B.1    Peters, L.J.2    Milas, L.3
  • 16
    • 84919484600 scopus 로고    scopus 로고
    • Seminars in radiation oncology. Introduction
    • Formenti S.C. Seminars in radiation oncology. Introduction. Semin. Radiat. Oncol 2015, 25:1-3.
    • (2015) Semin. Radiat. Oncol , vol.25 , pp. 1-3
    • Formenti, S.C.1
  • 17
    • 84857141296 scopus 로고    scopus 로고
    • Cancer-related inflammation: common themes and therapeutic opportunities
    • Balkwill F.R., Mantovani A. Cancer-related inflammation: common themes and therapeutic opportunities. Semin. Cancer Biol 2012, 22:33-40.
    • (2012) Semin. Cancer Biol , vol.22 , pp. 33-40
    • Balkwill, F.R.1    Mantovani, A.2
  • 18
    • 0028177037 scopus 로고
    • Transforming growth factor-beta activation in irradiated murine mammary gland
    • Barcellos-Hoff M.H., Derynck R., Tsang M.L., Weatherbee J.A. Transforming growth factor-beta activation in irradiated murine mammary gland. J. Clin. Invest 1994, 93:892-899.
    • (1994) J. Clin. Invest , vol.93 , pp. 892-899
    • Barcellos-Hoff, M.H.1    Derynck, R.2    Tsang, M.L.3    Weatherbee, J.A.4
  • 19
    • 84860501644 scopus 로고    scopus 로고
    • Modulation of the immune system by ionizing irradiation and chemotherapeutic agents - contribution of immune activation and blocking of immune suppression to cancer therapy success
    • Gaipl U.S. Modulation of the immune system by ionizing irradiation and chemotherapeutic agents - contribution of immune activation and blocking of immune suppression to cancer therapy success. Curr. Med. Chem 2012, 19:1739-1740.
    • (2012) Curr. Med. Chem , vol.19 , pp. 1739-1740
    • Gaipl, U.S.1
  • 21
    • 84860503128 scopus 로고    scopus 로고
    • Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation - implications for cancer therapies
    • Frey B., Rubner Y., Wunderlich R., Weiss E.M., Pockley A.G., Fietkau R., et al. Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation - implications for cancer therapies. Curr. Med. Chem 2012, 19:1751-1764.
    • (2012) Curr. Med. Chem , vol.19 , pp. 1751-1764
    • Frey, B.1    Rubner, Y.2    Wunderlich, R.3    Weiss, E.M.4    Pockley, A.G.5    Fietkau, R.6
  • 23
    • 84886090883 scopus 로고    scopus 로고
    • Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model
    • Wada S., Harris T.J., Tryggestad E., Yoshimura K., Zeng J., Yen H.R., et al. Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model. Int. J. Radiat. Oncol. Biol. Phys 2013, 87:769-776.
    • (2013) Int. J. Radiat. Oncol. Biol. Phys , vol.87 , pp. 769-776
    • Wada, S.1    Harris, T.J.2    Tryggestad, E.3    Yoshimura, K.4    Zeng, J.5    Yen, H.R.6
  • 26
    • 34248192226 scopus 로고    scopus 로고
    • Harnessing the immune system to treat cancer
    • Bhardwaj N. Harnessing the immune system to treat cancer. J. Clin. Invest 2007, 117:1130-1136.
    • (2007) J. Clin. Invest , vol.117 , pp. 1130-1136
    • Bhardwaj, N.1
  • 27
    • 84923879744 scopus 로고    scopus 로고
    • TGFbeta1 protects cells from gamma-IR by enhancing the activity of the NHEJ repair pathway
    • Kim M.R., Lee J., An Y.S., Jin Y.B., Park I.C., Chung E., et al. TGFbeta1 protects cells from gamma-IR by enhancing the activity of the NHEJ repair pathway. Mol. Cancer Res 2014, 13(2):319-329.
    • (2014) Mol. Cancer Res , vol.13 , Issue.2 , pp. 319-329
    • Kim, M.R.1    Lee, J.2    An, Y.S.3    Jin, Y.B.4    Park, I.C.5    Chung, E.6
  • 28
    • 84877004454 scopus 로고    scopus 로고
    • Cytokine patterns in patients with cancer: a systematic review
    • Lippitz B.E. Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol 2013, 14:e218-e228.
    • (2013) Lancet Oncol , vol.14 , pp. e218-e228
    • Lippitz, B.E.1
  • 29
    • 84879398211 scopus 로고    scopus 로고
    • TGF-beta signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves
    • Hagler M.A., Hadley T.M., Zhang H., Mehra K., Roos C.M., Schaff H.V., et al. TGF-beta signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves. Cardiovasc. Res 2013, 99:175-184.
    • (2013) Cardiovasc. Res , vol.99 , pp. 175-184
    • Hagler, M.A.1    Hadley, T.M.2    Zhang, H.3    Mehra, K.4    Roos, C.M.5    Schaff, H.V.6
  • 30
    • 84899051060 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes favor the response to chemoradiotherapy of head and neck cancer
    • Balermpas P., Rodel F., Weiss C., Rodel C., Fokas E. Tumor-infiltrating lymphocytes favor the response to chemoradiotherapy of head and neck cancer. Oncoimmunology 2014, 3:e27403.
    • (2014) Oncoimmunology , vol.3 , pp. e27403
    • Balermpas, P.1    Rodel, F.2    Weiss, C.3    Rodel, C.4    Fokas, E.5
  • 31
    • 84892946785 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
    • Balermpas P., Michel Y., Wagenblast J., Seitz O., Weiss C., Rodel F., et al. Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer. Br. J. Cancer 2014, 110:501-509.
    • (2014) Br. J. Cancer , vol.110 , pp. 501-509
    • Balermpas, P.1    Michel, Y.2    Wagenblast, J.3    Seitz, O.4    Weiss, C.5    Rodel, F.6
  • 32
    • 79959745851 scopus 로고    scopus 로고
    • The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis
    • Gooden M.J., de Bock G.H., Leffers N., Daemen T., Nijman H.W. The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br. J. Cancer 2011, 105:93-103.
    • (2011) Br. J. Cancer , vol.105 , pp. 93-103
    • Gooden, M.J.1    de Bock, G.H.2    Leffers, N.3    Daemen, T.4    Nijman, H.W.5
  • 33
    • 84880704621 scopus 로고    scopus 로고
    • The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
    • Galon J., Angell H.K., Bedognetti D., Marincola F.M. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity 2013, 39:11-26.
    • (2013) Immunity , vol.39 , pp. 11-26
    • Galon, J.1    Angell, H.K.2    Bedognetti, D.3    Marincola, F.M.4
  • 34
    • 84922008349 scopus 로고    scopus 로고
    • Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences
    • Balermpas P., Rodel F., Liberz R., Oppermann J., Wagenblast J., Ghanaati S., et al. Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences. Br. J. Cancer 2014, 111:1509-1518.
    • (2014) Br. J. Cancer , vol.111 , pp. 1509-1518
    • Balermpas, P.1    Rodel, F.2    Liberz, R.3    Oppermann, J.4    Wagenblast, J.5    Ghanaati, S.6
  • 35
    • 84862811913 scopus 로고    scopus 로고
    • Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer
    • Chung F.T., Lee K.Y., Wang C.W., Heh C.C., Chan Y.F., Chen H.W., et al. Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer. Int. J. Cancer 2012, 131:E227-E235.
    • (2012) Int. J. Cancer , vol.131 , pp. E227-E235
    • Chung, F.T.1    Lee, K.Y.2    Wang, C.W.3    Heh, C.C.4    Chan, Y.F.5    Chen, H.W.6
  • 36
    • 70249084906 scopus 로고    scopus 로고
    • Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma
    • Jensen T.O., Schmidt H., Moller H.J., Hoyer M., Maniecki M.B., Sjoegren P., et al. Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma. J. Clin. Oncol 2009, 27:3330-3337.
    • (2009) J. Clin. Oncol , vol.27 , pp. 3330-3337
    • Jensen, T.O.1    Schmidt, H.2    Moller, H.J.3    Hoyer, M.4    Maniecki, M.B.5    Sjoegren, P.6
  • 38
    • 84899473274 scopus 로고    scopus 로고
    • The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure
    • Lima L., Oliveira D., Tavares A., Amaro T., Cruz R., Oliveira M.J., et al. The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure. Urol. Oncol 2014, 32:449-457.
    • (2014) Urol. Oncol , vol.32 , pp. 449-457
    • Lima, L.1    Oliveira, D.2    Tavares, A.3    Amaro, T.4    Cruz, R.5    Oliveira, M.J.6
  • 39
    • 84864828790 scopus 로고    scopus 로고
    • The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
    • Medrek C., Ponten F., Jirstrom K., Leandersson K. The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer 2012, 12:306.
    • (2012) BMC Cancer , vol.12 , pp. 306
    • Medrek, C.1    Ponten, F.2    Jirstrom, K.3    Leandersson, K.4
  • 40
    • 77949345555 scopus 로고    scopus 로고
    • Tumor-associated macrophages and survival in classic Hodgkin's lymphoma
    • Steidl C., Lee T., Shah S.P., Farinha P., Han G., Nayar T., et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N. Engl. J. Med 2010, 362:875-885.
    • (2010) N. Engl. J. Med , vol.362 , pp. 875-885
    • Steidl, C.1    Lee, T.2    Shah, S.P.3    Farinha, P.4    Han, G.5    Nayar, T.6
  • 41
    • 84868116570 scopus 로고    scopus 로고
    • Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 intergroup trial
    • Tan K.L., Scott D.W., Hong F., Kahl B.S., Fisher R.I., Bartlett N.L., et al. Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 intergroup trial. Blood 2012, 120:3280-3287.
    • (2012) Blood , vol.120 , pp. 3280-3287
    • Tan, K.L.1    Scott, D.W.2    Hong, F.3    Kahl, B.S.4    Fisher, R.I.5    Bartlett, N.L.6
  • 43
    • 84900564666 scopus 로고    scopus 로고
    • Immunotherapy for solid tumors - a review for surgeons
    • Saied A., Pillarisetty V.G., Katz S.C. Immunotherapy for solid tumors - a review for surgeons. J. Surg. Res 2014, 187:525-535.
    • (2014) J. Surg. Res , vol.187 , pp. 525-535
    • Saied, A.1    Pillarisetty, V.G.2    Katz, S.C.3
  • 44
    • 84889575198 scopus 로고    scopus 로고
    • Modulation of oxidative stress as an anticancer strategy
    • Gorrini C., Harris I.S., Mak T.W. Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov 2013, 12:931-947.
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 931-947
    • Gorrini, C.1    Harris, I.S.2    Mak, T.W.3
  • 45
    • 77957226847 scopus 로고    scopus 로고
    • Effects of low-dose radiation on the immune system of mice after total-body irradiation
    • Bogdandi E.N., Balogh A., Felgyinszki N., Szatmari T., Persa E., Hildebrandt G., et al. Effects of low-dose radiation on the immune system of mice after total-body irradiation. Radiat. Res 2010, 174:480-489.
    • (2010) Radiat. Res , vol.174 , pp. 480-489
    • Bogdandi, E.N.1    Balogh, A.2    Felgyinszki, N.3    Szatmari, T.4    Persa, E.5    Hildebrandt, G.6
  • 47
    • 84916938395 scopus 로고    scopus 로고
    • Low-dose ionizing radiation induces direct activation of natural killer cells and provides a novel approach for adoptive cellular immunotherapy
    • Yang G., Kong Q., Wang G., Jin H., Zhou L., Yu D., et al. Low-dose ionizing radiation induces direct activation of natural killer cells and provides a novel approach for adoptive cellular immunotherapy. Cancer Biother. Radiopharm 2014, 29:428-434.
    • (2014) Cancer Biother. Radiopharm , vol.29 , pp. 428-434
    • Yang, G.1    Kong, Q.2    Wang, G.3    Jin, H.4    Zhou, L.5    Yu, D.6
  • 49
    • 0032727033 scopus 로고    scopus 로고
    • Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells
    • Multhoff G., Mizzen L., Winchester C.C., Milner C.M., Wenk S., Eissner G., et al. Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp. Hematol 1999, 27:1627-1636.
    • (1999) Exp. Hematol , vol.27 , pp. 1627-1636
    • Multhoff, G.1    Mizzen, L.2    Winchester, C.C.3    Milner, C.M.4    Wenk, S.5    Eissner, G.6
  • 50
    • 84941880491 scopus 로고    scopus 로고
    • The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation
    • Multhoff G., Pockley A.G., Schmid T.E., Schilling D. The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation. Cancer Lett 2015.
    • (2015) Cancer Lett
    • Multhoff, G.1    Pockley, A.G.2    Schmid, T.E.3    Schilling, D.4
  • 51
  • 52
    • 83455209199 scopus 로고    scopus 로고
    • NK cell-based immunotherapy for treating cancer: will it be promising?
    • Cho D., Kim S.K., Carson W.E. NK cell-based immunotherapy for treating cancer: will it be promising?. Korean J. Hematol 2011, 46:3-5.
    • (2011) Korean J. Hematol , vol.46 , pp. 3-5
    • Cho, D.1    Kim, S.K.2    Carson, W.E.3
  • 53
    • 84924955889 scopus 로고    scopus 로고
    • Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors
    • Scholch S., Rauber C., Tietz A., Rahbari N.N., Bork U., Schmidt T., et al. Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors. Oncotarget 2015, 6:4663-4676.
    • (2015) Oncotarget , vol.6 , pp. 4663-4676
    • Scholch, S.1    Rauber, C.2    Tietz, A.3    Rahbari, N.N.4    Bork, U.5    Schmidt, T.6
  • 54
    • 84926683486 scopus 로고    scopus 로고
    • Review article: heat shock protein 70 (Hsp70) peptide activated Natural Killer (NK) cells for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCTx) - from preclinical studies to a clinical phase II trial
    • Specht H.M., Ahrens N., Blankenstein C., Duell T., Fietkau R., Gaipl U.S., et al. Review article: heat shock protein 70 (Hsp70) peptide activated Natural Killer (NK) cells for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCTx) - from preclinical studies to a clinical phase II trial. Front. Immunol 2015, 6:1-9.
    • (2015) Front. Immunol , vol.6 , pp. 1-9
    • Specht, H.M.1    Ahrens, N.2    Blankenstein, C.3    Duell, T.4    Fietkau, R.5    Gaipl, U.S.6
  • 55
    • 0025400477 scopus 로고
    • The structure and signalling functions of the invariant T cell receptor components
    • Frank S.J., Samelson L.E., Klausner R.D. The structure and signalling functions of the invariant T cell receptor components. Semin. Immunol 1990, 2:89-97.
    • (1990) Semin. Immunol , vol.2 , pp. 89-97
    • Frank, S.J.1    Samelson, L.E.2    Klausner, R.D.3
  • 56
    • 0024472148 scopus 로고
    • Surface molecules involved in the activation and regulation of T or natural killer lymphocytes in humans
    • Moretta A., Ciccone E., Pantaleo G., Tambussi G., Bottino C., Melioli G., et al. Surface molecules involved in the activation and regulation of T or natural killer lymphocytes in humans. Immunol. Rev 1989, 111:145-175.
    • (1989) Immunol. Rev , vol.111 , pp. 145-175
    • Moretta, A.1    Ciccone, E.2    Pantaleo, G.3    Tambussi, G.4    Bottino, C.5    Melioli, G.6
  • 57
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 2005, 5:263-274.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 58
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med 2004, 10:942-949.
    • (2004) Nat. Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 59
    • 79955892681 scopus 로고    scopus 로고
    • Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer
    • Yasuda K., Nirei T., Sunami E., Nagawa H., Kitayama J. Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer. Radiat. Oncol 2011, 6:49.
    • (2011) Radiat. Oncol , vol.6 , pp. 49
    • Yasuda, K.1    Nirei, T.2    Sunami, E.3    Nagawa, H.4    Kitayama, J.5
  • 62
    • 84863619632 scopus 로고    scopus 로고
    • Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation
    • Gupta A., Probst H.C., Vuong V., Landshammer A., Muth S., Yagita H., et al. Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation. J. Immunol 2012, 189:558-566.
    • (2012) J. Immunol , vol.189 , pp. 558-566
    • Gupta, A.1    Probst, H.C.2    Vuong, V.3    Landshammer, A.4    Muth, S.5    Yagita, H.6
  • 63
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M., Lewis C.E. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 2013, 23:277-286.
    • (2013) Cancer Cell , vol.23 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 64
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian B.Z., Pollard J.W. Macrophage diversity enhances tumor progression and metastasis. Cell 2010, 141:39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 65
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • Gordon S., Martinez F.O. Alternative activation of macrophages: mechanism and functions. Immunity 2010, 32:593-604.
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 66
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol 2011, 11:723-737.
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 67
    • 84871076444 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in tissue repair and remodelling
    • Mantovani A., Biswas S.K., Galdiero M.R., Sica A., Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J. Pathol 2013, 229:176-185.
    • (2013) J. Pathol , vol.229 , pp. 176-185
    • Mantovani, A.1    Biswas, S.K.2    Galdiero, M.R.3    Sica, A.4    Locati, M.5
  • 68
    • 79960997061 scopus 로고    scopus 로고
    • The interplay between macrophages and angiogenesis in development, tissue injury and regeneration
    • Nucera S., Biziato D., De Palma M. The interplay between macrophages and angiogenesis in development, tissue injury and regeneration. Int. J. Dev. Biol 2011, 55:495-503.
    • (2011) Int. J. Dev. Biol , vol.55 , pp. 495-503
    • Nucera, S.1    Biziato, D.2    De Palma, M.3
  • 69
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • Biswas S.K., Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol 2010, 11:889-896.
    • (2010) Nat. Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 70
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C., Muthana M., Coffelt S.B., Lewis C.E. The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 2008, 8:618-631.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 71
    • 84884566959 scopus 로고    scopus 로고
    • The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery
    • Russell J.S., Brown J.M. The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery. Front. Physiol 2013, 4:157.
    • (2013) Front. Physiol , vol.4 , pp. 157
    • Russell, J.S.1    Brown, J.M.2
  • 73
    • 39049141295 scopus 로고    scopus 로고
    • Indirect macrophage responses to ionizing radiation: implications for genotype-dependent bystander signaling
    • Coates P.J., Rundle J.K., Lorimore S.A., Wright E.G. Indirect macrophage responses to ionizing radiation: implications for genotype-dependent bystander signaling. Cancer Res 2008, 68:450-456.
    • (2008) Cancer Res , vol.68 , pp. 450-456
    • Coates, P.J.1    Rundle, J.K.2    Lorimore, S.A.3    Wright, E.G.4
  • 74
    • 0028092762 scopus 로고
    • Production of 13-hydroxyoctadecadienoic acid and tumor necrosis factor-alpha by murine peritoneal macrophages in response to irradiation
    • Iwamoto K.S., McBride W.H. Production of 13-hydroxyoctadecadienoic acid and tumor necrosis factor-alpha by murine peritoneal macrophages in response to irradiation. Radiat. Res 1994, 139:103-108.
    • (1994) Radiat. Res , vol.139 , pp. 103-108
    • Iwamoto, K.S.1    McBride, W.H.2
  • 76
    • 34247844643 scopus 로고    scopus 로고
    • Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth
    • Tsai C.S., Chen F.H., Wang C.C., Huang H.L., Jung S.M., Wu C.J., et al. Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth. Int. J. Radiat. Oncol. Biol. Phys 2007, 68:499-507.
    • (2007) Int. J. Radiat. Oncol. Biol. Phys , vol.68 , pp. 499-507
    • Tsai, C.S.1    Chen, F.H.2    Wang, C.C.3    Huang, H.L.4    Jung, S.M.5    Wu, C.J.6
  • 78
    • 84904447687 scopus 로고    scopus 로고
    • Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes - an immunohistochemical study
    • Wehrhan F., Buttner-Herold M., Hyckel P., Moebius P., Preidl R., Distel L., et al. Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes - an immunohistochemical study. BMC Cancer 2014, 14:522.
    • (2014) BMC Cancer , vol.14 , pp. 522
    • Wehrhan, F.1    Buttner-Herold, M.2    Hyckel, P.3    Moebius, P.4    Preidl, R.5    Distel, L.6
  • 79
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich D.I., Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol 2009, 9:162-174.
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 80
    • 78650474985 scopus 로고    scopus 로고
    • Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13
    • Highfill S.L., Rodriguez P.C., Zhou Q., Goetz C.A., Koehn B.H., Veenstra R., et al. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 2010, 116:5738-5747.
    • (2010) Blood , vol.116 , pp. 5738-5747
    • Highfill, S.L.1    Rodriguez, P.C.2    Zhou, Q.3    Goetz, C.A.4    Koehn, B.H.5    Veenstra, R.6
  • 81
    • 84869791457 scopus 로고    scopus 로고
    • Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma
    • Kodumudi K.N., Weber A., Sarnaik A.A., Pilon-Thomas S. Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma. J. Immunol 2012, 189:5147-5154.
    • (2012) J. Immunol , vol.189 , pp. 5147-5154
    • Kodumudi, K.N.1    Weber, A.2    Sarnaik, A.A.3    Pilon-Thomas, S.4
  • 82
    • 84887561907 scopus 로고    scopus 로고
    • Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy
    • Klug F., Prakash H., Huber P.E., Seibel T., Bender N., Halama N., et al. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 2013, 24:589-602.
    • (2013) Cancer Cell , vol.24 , pp. 589-602
    • Klug, F.1    Prakash, H.2    Huber, P.E.3    Seibel, T.4    Bender, N.5    Halama, N.6
  • 83
    • 84877273607 scopus 로고    scopus 로고
    • Dying cell clearance and its impact on the outcome of tumor radiotherapy
    • Lauber K., Ernst A., Orth M., Herrmann M., Belka C. Dying cell clearance and its impact on the outcome of tumor radiotherapy. Front. Oncol 2012, 2:116.
    • (2012) Front. Oncol , vol.2 , pp. 116
    • Lauber, K.1    Ernst, A.2    Orth, M.3    Herrmann, M.4    Belka, C.5
  • 84
    • 84912525332 scopus 로고    scopus 로고
    • The impact of radiation therapy on the antitumor immunity: local effects and systemic consequences
    • Lumniczky K., Safrany G. The impact of radiation therapy on the antitumor immunity: local effects and systemic consequences. Cancer Lett 2015, 356:114-125.
    • (2015) Cancer Lett , vol.356 , pp. 114-125
    • Lumniczky, K.1    Safrany, G.2
  • 86
    • 84919464054 scopus 로고    scopus 로고
    • Radiotherapy and immunogenic cell death
    • Golden E.B., Apetoh L. Radiotherapy and immunogenic cell death. Semin. Radiat. Oncol 2015, 25:11-17.
    • (2015) Semin. Radiat. Oncol , vol.25 , pp. 11-17
    • Golden, E.B.1    Apetoh, L.2
  • 88
    • 84899138473 scopus 로고    scopus 로고
    • Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines
    • Rubner Y., Muth C., Strnad A., Derer A., Sieber R., Buslei R., et al. Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines. Radiat. Oncol 2014, 9:89.
    • (2014) Radiat. Oncol , vol.9 , pp. 89
    • Rubner, Y.1    Muth, C.2    Strnad, A.3    Derer, A.4    Sieber, R.5    Buslei, R.6
  • 89
    • 84902517902 scopus 로고    scopus 로고
    • Immunogenic cell death in radiation therapy
    • Galluzzi L., Kepp O., Kroemer G. Immunogenic cell death in radiation therapy. Oncoimmunology 2013, 2:e26536.
    • (2013) Oncoimmunology , vol.2 , pp. e26536
    • Galluzzi, L.1    Kepp, O.2    Kroemer, G.3
  • 90
    • 80455144497 scopus 로고    scopus 로고
    • TGFbeta1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo
    • Bouquet F., Pal A., Pilones K.A., Demaria S., Hann B., Akhurst R.J., et al. TGFbeta1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin. Cancer Res 2011, 17:6754-6765.
    • (2011) Clin. Cancer Res , vol.17 , pp. 6754-6765
    • Bouquet, F.1    Pal, A.2    Pilones, K.A.3    Demaria, S.4    Hann, B.5    Akhurst, R.J.6
  • 92
    • 85027933550 scopus 로고    scopus 로고
    • [Radiotherapy of non-malignant diseases. Past, present and future]
    • Seegenschmiedt M.H., Micke O. [Radiotherapy of non-malignant diseases. Past, present and future]. Strahlenther. Onkol 2012, 188(Suppl. 3):272-290.
    • (2012) Strahlenther. Onkol , vol.188 , pp. 272-290
    • Seegenschmiedt, M.H.1    Micke, O.2
  • 93
    • 84896909826 scopus 로고    scopus 로고
    • The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder syndrome. Long-term results
    • Ott O.J., Hertel S., Gaipl U.S., Frey B., Schmidt M., Fietkau R. The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder syndrome. Long-term results. Strahlenther. Onkol 2014, 190:394-398.
    • (2014) Strahlenther. Onkol , vol.190 , pp. 394-398
    • Ott, O.J.1    Hertel, S.2    Gaipl, U.S.3    Frey, B.4    Schmidt, M.5    Fietkau, R.6
  • 94
    • 84881659842 scopus 로고    scopus 로고
    • Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose x-irradiation
    • Rodel F., Frey B., Manda K., Hildebrandt G., Hehlgans S., Keilholz L., et al. Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose x-irradiation. Front. Oncol 2012, 2:120.
    • (2012) Front. Oncol , vol.2 , pp. 120
    • Rodel, F.1    Frey, B.2    Manda, K.3    Hildebrandt, G.4    Hehlgans, S.5    Keilholz, L.6
  • 95
    • 34248675793 scopus 로고    scopus 로고
    • Radiotherapy of non-malignant disorders: where do we stand?
    • Leer J.W., van Houtte P., Seegenschmiedt H. Radiotherapy of non-malignant disorders: where do we stand?. Radiother. Oncol 2007, 83:175-177.
    • (2007) Radiother. Oncol , vol.83 , pp. 175-177
    • Leer, J.W.1    van Houtte, P.2    Seegenschmiedt, H.3
  • 96
    • 40949111841 scopus 로고    scopus 로고
    • Low-dose hyper-radiosensitivity: past, present, and future
    • Marples B., Collis S.J. Low-dose hyper-radiosensitivity: past, present, and future. Int. J. Radiat. Oncol. Biol. Phys 2008, 70:1310-1318.
    • (2008) Int. J. Radiat. Oncol. Biol. Phys , vol.70 , pp. 1310-1318
    • Marples, B.1    Collis, S.J.2
  • 97
    • 2442693184 scopus 로고    scopus 로고
    • Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells
    • Marples B., Wouters B.G., Collis S.J., Chalmers A.J., Joiner M.C. Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells. Radiat. Res 2004, 161:247-255.
    • (2004) Radiat. Res , vol.161 , pp. 247-255
    • Marples, B.1    Wouters, B.G.2    Collis, S.J.3    Chalmers, A.J.4    Joiner, M.C.5
  • 98
    • 84860520670 scopus 로고    scopus 로고
    • Modulation of inflammatory immune reactions by low-dose ionizing radiation: molecular mechanisms and clinical application
    • Rodel F., Frey B., Gaipl U., Keilholz L., Fournier C., Manda K., et al. Modulation of inflammatory immune reactions by low-dose ionizing radiation: molecular mechanisms and clinical application. Curr. Med. Chem 2012, 19:1741-1750.
    • (2012) Curr. Med. Chem , vol.19 , pp. 1741-1750
    • Rodel, F.1    Frey, B.2    Gaipl, U.3    Keilholz, L.4    Fournier, C.5    Manda, K.6
  • 99
    • 0017133958 scopus 로고
    • Secretory function of mononuclear phagocytes: a review
    • Unanue E.R. Secretory function of mononuclear phagocytes: a review. Am. J. Pathol 1976, 83:396-418.
    • (1976) Am. J. Pathol , vol.83 , pp. 396-418
    • Unanue, E.R.1
  • 102
    • 0742304419 scopus 로고    scopus 로고
    • Low-dose radiotherapy (LD-RT) and the modulation of iNOS expression in adjuvant-induced arthritis in rats
    • Hildebrandt G., Radlingmayr A., Rosenthal S., Rothe R., Jahns J., Hindemith M., et al. Low-dose radiotherapy (LD-RT) and the modulation of iNOS expression in adjuvant-induced arthritis in rats. Int. J. Radiat. Biol 2003, 79:993-1001.
    • (2003) Int. J. Radiat. Biol , vol.79 , pp. 993-1001
    • Hildebrandt, G.1    Radlingmayr, A.2    Rosenthal, S.3    Rothe, R.4    Jahns, J.5    Hindemith, M.6
  • 104
    • 0036292547 scopus 로고    scopus 로고
    • The effects of low-dose X-irradiation on the oxidative burst in stimulated macrophages
    • Schaue D., Marples B., Trott K.R. The effects of low-dose X-irradiation on the oxidative burst in stimulated macrophages. Int. J. Radiat. Biol 2002, 78:567-576.
    • (2002) Int. J. Radiat. Biol , vol.78 , pp. 567-576
    • Schaue, D.1    Marples, B.2    Trott, K.R.3
  • 105
    • 12144290656 scopus 로고    scopus 로고
    • Dose-dependent biphasic induction and transcriptional activity of nuclear factor kappa B (NF-kappaB) in EA.hy.926 endothelial cells after low-dose X-irradiation
    • Rodel F., Hantschel M., Hildebrandt G., Schultze-Mosgau S., Rodel C., Herrmann M., et al. Dose-dependent biphasic induction and transcriptional activity of nuclear factor kappa B (NF-kappaB) in EA.hy.926 endothelial cells after low-dose X-irradiation. Int. J. Radiat. Biol 2004, 80:115-123.
    • (2004) Int. J. Radiat. Biol , vol.80 , pp. 115-123
    • Rodel, F.1    Hantschel, M.2    Hildebrandt, G.3    Schultze-Mosgau, S.4    Rodel, C.5    Herrmann, M.6
  • 106
    • 70749120798 scopus 로고    scopus 로고
    • Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells
    • Rodel F., Keilholz L., Herrmann M., Weiss C., Frey B., Voll R., et al. Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells. Autoimmunity 2009, 42:343-345.
    • (2009) Autoimmunity , vol.42 , pp. 343-345
    • Rodel, F.1    Keilholz, L.2    Herrmann, M.3    Weiss, C.4    Frey, B.5    Voll, R.6
  • 107
    • 1842765587 scopus 로고    scopus 로고
    • The induction of TGF-beta(1) and NF-kappaB parallels a biphasic time course of leukocyte/endothelial cell adhesion following low-dose X-irradiation
    • Rodel F., Schaller U., Schultze-Mosgau S., Beuscher H.U., Keilholz L., Herrmann M., et al. The induction of TGF-beta(1) and NF-kappaB parallels a biphasic time course of leukocyte/endothelial cell adhesion following low-dose X-irradiation. Strahlenther. Onkol 2004, 180:194-200.
    • (2004) Strahlenther. Onkol , vol.180 , pp. 194-200
    • Rodel, F.1    Schaller, U.2    Schultze-Mosgau, S.3    Beuscher, H.U.4    Keilholz, L.5    Herrmann, M.6
  • 108
    • 84867017339 scopus 로고    scopus 로고
    • Low dose ionising radiation leads to a NF-kappaB dependent decreased secretion of active IL-1beta by activated macrophages with a discontinuous dose-dependency
    • Lodermann B., Wunderlich R., Frey S., Schorn C., Stangl S., Rodel F., et al. Low dose ionising radiation leads to a NF-kappaB dependent decreased secretion of active IL-1beta by activated macrophages with a discontinuous dose-dependency. Int. J. Radiat. Biol 2012, 88:727-734.
    • (2012) Int. J. Radiat. Biol , vol.88 , pp. 727-734
    • Lodermann, B.1    Wunderlich, R.2    Frey, S.3    Schorn, C.4    Stangl, S.5    Rodel, F.6
  • 109
    • 77955906264 scopus 로고    scopus 로고
    • The nuclear factor NF-kappaB pathway in inflammation
    • Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb. Perspect. Biol 2009, 1:a001651.
    • (2009) Cold Spring Harb. Perspect. Biol , vol.1 , pp. a001651
    • Lawrence, T.1
  • 110
    • 84934943164 scopus 로고    scopus 로고
    • Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function
    • Wunderlich R., Ernst A., Rodel F., Fietkau R., Ott O., Lauber K., et al. Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function. Clin. Exp. Immunol 2015, 179:50-61.
    • (2015) Clin. Exp. Immunol , vol.179 , pp. 50-61
    • Wunderlich, R.1    Ernst, A.2    Rodel, F.3    Fietkau, R.4    Ott, O.5    Lauber, K.6
  • 111
    • 78149361497 scopus 로고    scopus 로고
    • Discontinuous induction of X-linked inhibitor of apoptosis in EA.hy.926 endothelial cells is linked to NF-kappaB activation and mediates the anti-inflammatory properties of low-dose ionising-radiation
    • Rodel F., Frey B., Capalbo G., Gaipl U., Keilholz L., Voll R., et al. Discontinuous induction of X-linked inhibitor of apoptosis in EA.hy.926 endothelial cells is linked to NF-kappaB activation and mediates the anti-inflammatory properties of low-dose ionising-radiation. Radiother. Oncol 2010, 97:346-351.
    • (2010) Radiother. Oncol , vol.97 , pp. 346-351
    • Rodel, F.1    Frey, B.2    Capalbo, G.3    Gaipl, U.4    Keilholz, L.5    Voll, R.6
  • 112
    • 84899131192 scopus 로고    scopus 로고
    • A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species
    • Large M., Reichert S., Hehlgans S., Fournier C., Rodel C., Rodel F. A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species. Radiat. Oncol 2014, 9:80.
    • (2014) Radiat. Oncol , vol.9 , pp. 80
    • Large, M.1    Reichert, S.2    Hehlgans, S.3    Fournier, C.4    Rodel, C.5    Rodel, F.6
  • 113
    • 84896372212 scopus 로고    scopus 로고
    • The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome
    • Ott O.J., Hertel S., Gaipl U.S., Frey B., Schmidt M., Fietkau R. The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome. Strahlenther. Onkol 2014, 190:293-297.
    • (2014) Strahlenther. Onkol , vol.190 , pp. 293-297
    • Ott, O.J.1    Hertel, S.2    Gaipl, U.S.3    Frey, B.4    Schmidt, M.5    Fietkau, R.6
  • 114
    • 84903373968 scopus 로고    scopus 로고
    • Radiotherapy for benign calcaneodynia: long-term results of the Erlangen Dose Optimization (EDO) trial
    • Ott O.J., Jeremias C., Gaipl U.S., Frey B., Schmidt M., Fietkau R. Radiotherapy for benign calcaneodynia: long-term results of the Erlangen Dose Optimization (EDO) trial. Strahlenther. Onkol 2014, 190:671-675.
    • (2014) Strahlenther. Onkol , vol.190 , pp. 671-675
    • Ott, O.J.1    Jeremias, C.2    Gaipl, U.S.3    Frey, B.4    Schmidt, M.5    Fietkau, R.6
  • 115
    • 84941875274 scopus 로고    scopus 로고
    • Locally restricted low-dose irradiation of human TNF-alpha transgenic mice with 0.5 Gy reduces bone-loss and inflammation in vivo
    • Deloch L., Derer A., Ruhle P.F., Ott O., Fietkau R., Frey B., et al. Locally restricted low-dose irradiation of human TNF-alpha transgenic mice with 0.5 Gy reduces bone-loss and inflammation in vivo. Strahlenther. Onkol 2014, 190:92.
    • (2014) Strahlenther. Onkol , vol.190 , pp. 92
    • Deloch, L.1    Derer, A.2    Ruhle, P.F.3    Ott, O.4    Fietkau, R.5    Frey, B.6
  • 116
    • 84887559345 scopus 로고    scopus 로고
    • Anthracyclines induce DNA damage response-mediated protection against severe sepsis
    • Figueiredo N., Chora A., Raquel H., Pejanovic N., Pereira P., Hartleben B., et al. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity 2013, 39:874-884.
    • (2013) Immunity , vol.39 , pp. 874-884
    • Figueiredo, N.1    Chora, A.2    Raquel, H.3    Pejanovic, N.4    Pereira, P.5    Hartleben, B.6
  • 117
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 118
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 119
    • 85027919856 scopus 로고    scopus 로고
    • [History of German radiation oncology]
    • Heilmann H.P. [History of German radiation oncology]. Strahlenther. Onkol 2012, 188(Suppl. 3):220-226.
    • (2012) Strahlenther. Onkol , vol.188 , pp. 220-226
    • Heilmann, H.P.1
  • 120
  • 121
    • 84934441514 scopus 로고    scopus 로고
    • Radiotherapy and the tumor microenvironment: mutual influence and clinical implications
    • Thompson R.F., Maity A. Radiotherapy and the tumor microenvironment: mutual influence and clinical implications. Adv. Exp. Med. Biol 2014, 772:147-165.
    • (2014) Adv. Exp. Med. Biol , vol.772 , pp. 147-165
    • Thompson, R.F.1    Maity, A.2


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