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Volumn 7, Issue DEC, 2016, Pages

Chemoradiation increases PD-L1 expression in certain melanoma and glioblastoma cells

Author keywords

Checkpoint inhibitor; Fractionated radiotherapy; Glioblastoma; IFN gamma; IL 6; Immunotherapy; Melanoma; PD L1

Indexed keywords

DACARBAZINE; FLUORESCEIN ISOTHIOCYANATE; FLUOROURACIL; GAMMA INTERFERON; INTERLEUKIN 6; IRINOTECAN; LIPOCORTIN 5; OXALIPLATIN; PROGRAMMED DEATH 1 LIGAND 1; TEMOZOLOMIDE;

EID: 85009375159     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00610     Document Type: Article
Times cited : (113)

References (44)
  • 1
    • 0032916590 scopus 로고    scopus 로고
    • Impact of localized radiotherapy on blood immune cells counts and function in humans
    • Belka C, Ottinger H, Kreuzfelder E, Weinmann M, Lindemann M, Lepple-Wienhues A, et al. Impact of localized radiotherapy on blood immune cells counts and function in humans. Radiother Oncol (1999) 50(2):199-204. doi:10.1016/S0167-8140(98)00130-3
    • (1999) Radiother Oncol , vol.50 , Issue.2 , pp. 199-204
    • Belka, C.1    Ottinger, H.2    Kreuzfelder, E.3    Weinmann, M.4    Lindemann, M.5    Lepple-Wienhues, A.6
  • 2
    • 42649099297 scopus 로고    scopus 로고
    • Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy
    • Teitz-Tennenbaum S, Li Q, Okuyama R, Davis MA, Sun R, Whitfield J, et al. Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy. J Immunother (2008) 31(4):345-58. doi:10.1097/CJI.0b013e318163628c
    • (2008) J Immunother , vol.31 , Issue.4 , pp. 345-358
    • Teitz-Tennenbaum, S.1    Li, Q.2    Okuyama, R.3    Davis, M.A.4    Sun, R.5    Whitfield, J.6
  • 3
    • 41549145181 scopus 로고    scopus 로고
    • Immunogenicity of anthracyclines: moving towards more personalized medicine
    • Apetoh L, Mignot G, Panaretakis T, Kroemer G, Zitvogel L. Immunogenicity of anthracyclines: moving towards more personalized medicine. Trends Mol Med (2008) 14(4):141-51. doi:10.1016/j.molmed.2008.02.002
    • (2008) Trends Mol Med , vol.14 , Issue.4 , pp. 141-151
    • Apetoh, L.1    Mignot, G.2    Panaretakis, T.3    Kroemer, G.4    Zitvogel, L.5
  • 4
    • 84947773168 scopus 로고    scopus 로고
    • Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors
    • Derer A, Frey B, Fietkau R, Gaipl US. Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors. Cancer Immunol Immunother (2016) 65(7):779-86. doi:10.1007/s00262-015-1771-8
    • (2016) Cancer Immunol Immunother , vol.65 , Issue.7 , pp. 779-786
    • Derer, A.1    Frey, B.2    Fietkau, R.3    Gaipl, U.S.4
  • 5
    • 84959209617 scopus 로고    scopus 로고
    • Primary glioblastoma multiforme tumors and recurrence: comparative analysis of the danger signals HMGB1, HSP70, and calreticulin
    • Muth C, Rubner Y, Semrau S, Ruhle PF, Frey B, Strnad A, et al. Primary glioblastoma multiforme tumors and recurrence: comparative analysis of the danger signals HMGB1, HSP70, and calreticulin. Strahlenther Onkol (2016) 192(3):146-55. doi:10.1007/s00066-015-0926-z
    • (2016) Strahlenther Onkol , vol.192 , Issue.3 , pp. 146-155
    • Muth, C.1    Rubner, Y.2    Semrau, S.3    Ruhle, P.F.4    Frey, B.5    Strnad, A.6
  • 6
    • 84902076277 scopus 로고    scopus 로고
    • Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy
    • Gaipl US, Multhoff G, Scheithauer H, Lauber K, Hehlgans S, Frey B, et al. Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy. Immunotherapy (2014) 6(5):597-610. doi:10.2217/imt.14.38
    • (2014) Immunotherapy , vol.6 , Issue.5 , pp. 597-610
    • Gaipl, U.S.1    Multhoff, G.2    Scheithauer, H.3    Lauber, K.4    Hehlgans, S.5    Frey, B.6
  • 7
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev (2010) 236:219-42. doi:10.1111/j.1600-065X.2010.00923.x
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 8
    • 84921448324 scopus 로고    scopus 로고
    • The evolution of checkpoint blockade as a cancer therapy: what's here, what's next?
    • Shin DS, Ribas A. The evolution of checkpoint blockade as a cancer therapy: what's here, what's next? Curr Opin Immunol (2015) 33:23-35. doi:10.1016/j.coi.2015.01.006
    • (2015) Curr Opin Immunol , vol.33 , pp. 23-35
    • Shin, D.S.1    Ribas, A.2
  • 9
    • 84879579673 scopus 로고    scopus 로고
    • At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy
    • Intlekofer AM, Thompson CB. At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. J Leukoc Biol (2013) 94(1):25-39. doi:10.1189/jlb.1212621
    • (2013) J Leukoc Biol , vol.94 , Issue.1 , pp. 25-39
    • Intlekofer, A.M.1    Thompson, C.B.2
  • 10
    • 84939456588 scopus 로고    scopus 로고
    • Development of PD-1/PD-L1 pathway in tumor immune microenvironment and treatment for non-small cell lung cancer
    • He J, Hu Y, Hu M, Li B. Development of PD-1/PD-L1 pathway in tumor immune microenvironment and treatment for non-small cell lung cancer. Sci Rep (2015) 5:13110. doi:10.1038/srep13110
    • (2015) Sci Rep , vol.5 , pp. 13110
    • He, J.1    Hu, Y.2    Hu, M.3    Li, B.4
  • 11
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med (2002) 8(8):793-800. doi:10.1038/nm730
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 12
    • 13844294372 scopus 로고    scopus 로고
    • PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
    • Iwai Y, Terawaki S, Honjo T. PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int Immunol (2005) 17(2):133-44. doi:10.1093/intimm/dxh194
    • (2005) Int Immunol , vol.17 , Issue.2 , pp. 133-144
    • Iwai, Y.1    Terawaki, S.2    Honjo, T.3
  • 14
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQM, Hwu W-J, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med (2012) 366(26):2455-65. doi:10.1056/NEJMoa1200694
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.M.3    Hwu, W.-J.4    Topalian, S.L.5    Hwu, P.6
  • 15
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol (2014) 32(10):1020-30. doi:10.1200/jco.2013.53.0105
    • (2014) J Clin Oncol , vol.32 , Issue.10 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6
  • 16
    • 84904855312 scopus 로고    scopus 로고
    • Immunologic and clinical effects of targeting PD-1 in lung cancer
    • Harvey RD. Immunologic and clinical effects of targeting PD-1 in lung cancer. Clin Pharmacol Ther (2014) 96(2):214-23. doi:10.1038/clpt.2014.74
    • (2014) Clin Pharmacol Ther , vol.96 , Issue.2 , pp. 214-223
    • Harvey, R.D.1
  • 17
    • 84879288623 scopus 로고    scopus 로고
    • Immunotherapeutic approaches in triple-negative breast cancer: latest research and clinical prospects
    • Stagg J, Allard B. Immunotherapeutic approaches in triple-negative breast cancer: latest research and clinical prospects. Ther Adv Med Oncol (2013) 5(3):169-81. doi:10.1177/1758834012475152
    • (2013) Ther Adv Med Oncol , vol.5 , Issue.3 , pp. 169-181
    • Stagg, J.1    Allard, B.2
  • 18
    • 84906517328 scopus 로고    scopus 로고
    • PD-L1 expression and tumor-infiltrating lymphocytes: revisiting the antitumor immune response potential in breast cancer
    • Schalper KA. PD-L1 expression and tumor-infiltrating lymphocytes: revisiting the antitumor immune response potential in breast cancer. Oncoimmunology (2014) 3:e29288. doi:10.4161/onci.29288
    • (2014) Oncoimmunology , vol.3
    • Schalper, K.A.1
  • 19
    • 77954938867 scopus 로고    scopus 로고
    • Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy
    • Mangsbo SM, Sandin LC, Anger K, Korman AJ, Loskog A, Totterman TH. Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy. J Immunother (2010) 33(3):225-35. doi:10.1097/CJI.0b013e3181c01fcb
    • (2010) J Immunother , vol.33 , Issue.3 , pp. 225-235
    • Mangsbo, S.M.1    Sandin, L.C.2    Anger, K.3    Korman, A.J.4    Loskog, A.5    Totterman, T.H.6
  • 20
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer (2012) 12(4):252-64. doi:10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 21
    • 84939227614 scopus 로고    scopus 로고
    • Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers
    • Carbognin L, Pilotto S, Milella M, Vaccaro V, Brunelli M, Caliò A, et al. Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PLoS One (2015) 10(6):e0130142. doi:10.1371/journal.pone.0130142
    • (2015) PLoS One , vol.10 , Issue.6
    • Carbognin, L.1    Pilotto, S.2    Milella, M.3    Vaccaro, V.4    Brunelli, M.5    Caliò, A.6
  • 22
    • 84907486895 scopus 로고    scopus 로고
    • Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade
    • Dovedi SJ, Adlard AL, Lipowska-Bhalla G, McKenna C, Jones S, Cheadle EJ, et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res (2014) 74(19):5458-68. doi:10.1158/0008-5472.can-14-1258
    • (2014) Cancer Res , vol.74 , Issue.19 , pp. 5458-5468
    • Dovedi, S.J.1    Adlard, A.L.2    Lipowska-Bhalla, G.3    McKenna, C.4    Jones, S.5    Cheadle, E.J.6
  • 23
    • 84918532590 scopus 로고    scopus 로고
    • Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer
    • Parikh F, Duluc D, Imai N, Clark A, Misiukiewicz K, Bonomi M, et al. Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer. Cancer Res (2014) 74(24):7205-16. doi:10.1158/0008-5472.can-14-1913
    • (2014) Cancer Res , vol.74 , Issue.24 , pp. 7205-7216
    • Parikh, F.1    Duluc, D.2    Imai, N.3    Clark, A.4    Misiukiewicz, K.5    Bonomi, M.6
  • 24
    • 85027933609 scopus 로고    scopus 로고
    • The immune functions of phosphatidylserine in membranes of dying cells and microvesicles
    • Frey B, Gaipl US. The immune functions of phosphatidylserine in membranes of dying cells and microvesicles. Semin Immunopathol (2011) 33(5):497-516. doi:10.1007/s00281-010-0228-6
    • (2011) Semin Immunopathol , vol.33 , Issue.5 , pp. 497-516
    • Frey, B.1    Gaipl, U.S.2
  • 25
    • 84921792710 scopus 로고    scopus 로고
    • Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma
    • Wong SQ, Behren A, Mar VJ, Woods K, Li J, Martin C, et al. Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma. Oncotarget (2015) 6(2):1115-27. doi:10.18632/oncotarget.2747
    • (2015) Oncotarget , vol.6 , Issue.2 , pp. 1115-1127
    • Wong, S.Q.1    Behren, A.2    Mar, V.J.3    Woods, K.4    Li, J.5    Martin, C.6
  • 26
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science (2015) 348(6230):124-8. doi:10.1126/science.aaa1348
    • (2015) Science , vol.348 , Issue.6230 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6
  • 28
    • 84957310840 scopus 로고    scopus 로고
    • Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide-and T-cell-dependent manner
    • Werthmoller N, Frey B, Wunderlich R, Fietkau R, Gaipl US. Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide-and T-cell-dependent manner. Cell Death Dis (2015) 6:e1761. doi:10.1038/cddis.2015.129
    • (2015) Cell Death Dis , vol.6
    • Werthmoller, N.1    Frey, B.2    Wunderlich, R.3    Fietkau, R.4    Gaipl, U.S.5
  • 29
    • 84892866206 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or-naive melanoma
    • Weber JS, Kudchadkar RR, Yu B, Gallenstein D, Horak CE, Inzunza HD, et al. Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or-naive melanoma. J Clin Oncol (2013) 31(34):4311-8. doi:10.1200/JCO.2013.51.4802
    • (2013) J Clin Oncol , vol.31 , Issue.34 , pp. 4311-4318
    • Weber, J.S.1    Kudchadkar, R.R.2    Yu, B.3    Gallenstein, D.4    Horak, C.E.5    Inzunza, H.D.6
  • 30
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res (2014) 20(19):5064-74. doi:10.1158/1078-0432.CCR-13-3271
    • (2014) Clin Cancer Res , vol.20 , Issue.19 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3    Xu, H.4    Pan, X.5    Kim, J.H.6
  • 31
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature (2014) 515(7528):563-7. doi:10.1038/nature14011
    • (2014) Nature , vol.515 , Issue.7528 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3    Fine, G.D.4    Hamid, O.5    Gordon, M.S.6
  • 32
    • 84949548456 scopus 로고    scopus 로고
    • Radio-immunotherapy-induced immunogenic cancer cells as basis for induction of systemic anti-tumor immune responses-pre-clinical evidence and ongoing clinical applications
    • Derer A, Deloch L, Rubner Y, Fietkau R, Frey B, Gaipl US. Radio-immunotherapy-induced immunogenic cancer cells as basis for induction of systemic anti-tumor immune responses-pre-clinical evidence and ongoing clinical applications. Front Immunol (2015) 6:505. doi:10.3389/fimmu.2015.00505
    • (2015) Front Immunol , vol.6 , pp. 505
    • Derer, A.1    Deloch, L.2    Rubner, Y.3    Fietkau, R.4    Frey, B.5    Gaipl, U.S.6
  • 33
    • 84928773222 scopus 로고    scopus 로고
    • IFN-[gamma] from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer
    • Abiko K, Matsumura N, Hamanishi J, Horikawa N, Murakami R, Yamaguchi K, et al. IFN-[gamma] from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer. Br J Cancer (2015) 112(9):1501-9. doi:10.1038/bjc.2015.101
    • (2015) Br J Cancer , vol.112 , Issue.9 , pp. 1501-1509
    • Abiko, K.1    Matsumura, N.2    Hamanishi, J.3    Horikawa, N.4    Murakami, R.5    Yamaguchi, K.6
  • 34
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
    • Lee Y, Auh SL, Wang Y, Burnette B, Wang Y, Meng Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood (2009) 114(3):589-95. doi:10.1182/blood-2009-02-206870
    • (2009) Blood , vol.114 , Issue.3 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3    Burnette, B.4    Wang, Y.5    Meng, Y.6
  • 35
    • 20444406500 scopus 로고    scopus 로고
    • Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor
    • Lugade AA, Moran JP, Gerber SA, Rose RC, Frelinger JG, Lord EM. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol (2005) 174(12):7516-23. doi:10.4049/jimmunol.174.12.7516
    • (2005) J Immunol , vol.174 , Issue.12 , pp. 7516-7523
    • Lugade, A.A.1    Moran, J.P.2    Gerber, S.A.3    Rose, R.C.4    Frelinger, J.G.5    Lord, E.M.6
  • 36
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan MZ, Galloway AE, Kawashima N, Dewyngaert JK, Babb JS, Formenti SC, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res (2009) 15(17):5379-88. doi:10.1158/1078-0432.CCR-09-0265
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3    Dewyngaert, J.K.4    Babb, J.S.5    Formenti, S.C.6
  • 37
    • 84946434271 scopus 로고    scopus 로고
    • The increase of circulating PD-L1-expressing CD68(+) macrophage in ovarian cancer
    • Qu QX, Huang Q, Shen Y, Zhu YB, Zhang XG. The increase of circulating PD-L1-expressing CD68(+) macrophage in ovarian cancer. Tumour Biol (2016) 37(4):5031-7. doi:10.1007/s13277-015-4066-y
    • (2016) Tumour Biol , vol.37 , Issue.4 , pp. 5031-5037
    • Qu, Q.X.1    Huang, Q.2    Shen, Y.3    Zhu, Y.B.4    Zhang, X.G.5
  • 38
    • 0018875598 scopus 로고
    • Establishment of mouse colonic carcinoma cell lines with different metastatic properties
    • Brattain MG, Strobel-Stevens J, Fine D, Webb M, Sarrif AM. Establishment of mouse colonic carcinoma cell lines with different metastatic properties. Cancer Res (1980) 40(7):2142-6.
    • (1980) Cancer Res , vol.40 , Issue.7 , pp. 2142-2146
    • Brattain, M.G.1    Strobel-Stevens, J.2    Fine, D.3    Webb, M.4    Sarrif, A.M.5
  • 39
    • 84905663507 scopus 로고    scopus 로고
    • Sinister self-sacrifice: the contribution of apoptosis to malignancy
    • Willems JJ, Arnold BP, Gregory CD. Sinister self-sacrifice: the contribution of apoptosis to malignancy. Front Immunol (2014) 5:299. doi:10.3389/fimmu.2014.00299
    • (2014) Front Immunol , vol.5 , pp. 299
    • Willems, J.J.1    Arnold, B.P.2    Gregory, C.D.3
  • 40
    • 84899061145 scopus 로고    scopus 로고
    • Exomics and immunogenics: bridging mutational load and immune checkpoints efficacy
    • Champiat S, Ferte C, Lebel-Binay S, Eggermont A, Soria JC. Exomics and immunogenics: bridging mutational load and immune checkpoints efficacy. Oncoimmunology (2014) 3(1):e27817. doi:10.4161/onci.27817
    • (2014) Oncoimmunology , vol.3 , Issue.1
    • Champiat, S.1    Ferte, C.2    Lebel-Binay, S.3    Eggermont, A.4    Soria, J.C.5
  • 41
    • 84999142201 scopus 로고    scopus 로고
    • Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors
    • Danilova L, Wang H, Sunshine J, Kaunitz GJ, Cottrell TR, Xu H, et al. Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors. Proc Natl Acad Sci U S A (2016) 113(48):E7769-77. doi:10.1073/pnas.1607836113
    • (2016) Proc Natl Acad Sci U S A , vol.113 , Issue.48 , pp. E7769-E7777
    • Danilova, L.1    Wang, H.2    Sunshine, J.3    Kaunitz, G.J.4    Cottrell, T.R.5    Xu, H.6
  • 42
    • 84982792265 scopus 로고    scopus 로고
    • Modern radiotherapy concepts and the impact of radiation on immune activation
    • Deloch L, Derer A, Hartmann J, Frey B, Fietkau R, Gaipl US. Modern radiotherapy concepts and the impact of radiation on immune activation. Front Oncol (2016) 6:141. doi:10.3389/fonc.2016.00141
    • (2016) Front Oncol , vol.6 , pp. 141
    • Deloch, L.1    Derer, A.2    Hartmann, J.3    Frey, B.4    Fietkau, R.5    Gaipl, U.S.6
  • 43
    • 84860503128 scopus 로고    scopus 로고
    • Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation-implications for cancer therapies
    • Frey B, Rubner Y, Wunderlich R, Weiss EM, Pockley AG, Fietkau R, et al. Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation-implications for cancer therapies. Curr Med Chem (2012) 19(12):1751-64. doi:10.2174/092986712800099811
    • (2012) Curr Med Chem , vol.19 , Issue.12 , pp. 1751-1764
    • Frey, B.1    Rubner, Y.2    Wunderlich, R.3    Weiss, E.M.4    Pockley, A.G.5    Fietkau, R.6
  • 44
    • 84911805773 scopus 로고    scopus 로고
    • Increased skin and mucosal toxicity in the combination of vemurafenib with radiation therapy
    • Merten R, Hecht M, Haderlein M, Distel L, Fietkau R, Heinzerling L, et al. Increased skin and mucosal toxicity in the combination of vemurafenib with radiation therapy. Strahlenther Onkol (2014) 190(12):1169-72. doi:10.1007/s00066-014-0698-x
    • (2014) Strahlenther Onkol , vol.190 , Issue.12 , pp. 1169-1172
    • Merten, R.1    Hecht, M.2    Haderlein, M.3    Distel, L.4    Fietkau, R.5    Heinzerling, L.6


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