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Volumn 1, Issue , 2017, Pages 99-117

Analyzing tumor metabolism in vivo

Author keywords

Cancer metabolism; Magnetic resonance imaging; Mass spectrometry; Metabolic flux analysis; Metabolomics; Positron emission tomography

Indexed keywords


EID: 85030558263     PISSN: None     EISSN: 24723428     Source Type: Book Series    
DOI: 10.1146/annurev-cancerbio-050216-121954     Document Type: Article
Times cited : (33)

References (109)
  • 2
    • 84855710482 scopus 로고    scopus 로고
    • Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
    • Andronesi OC, Kim GS, Gerstner E, Batchelor T, Tzika AA, et al. 2012. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci. Transl. Med. 4:116ra4
    • (2012) Sci. Transl. Med , vol.4 , pp. 116ra4
    • Andronesi, O.C.1    Kim, G.S.2    Gerstner, E.3    Batchelor, T.4    Tzika, A.A.5
  • 3
    • 84933050304 scopus 로고    scopus 로고
    • The tumour microenvironment after radiotherapy: Mechanisms of resistance and recurrence
    • Barker HE, Paget JT, Khan AA, Harrington KJ. 2015. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat. Rev. Cancer 15:409-25
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 409-425
    • Barker, H.E.1    Paget, J.T.2    Khan, A.A.3    Harrington, K.J.4
  • 4
    • 84874686616 scopus 로고    scopus 로고
    • Vivo MRS of locally advanced breast cancer: Characteristics related to negative or positive choline detection and early monitoring of treatment response
    • Bathen TF, Heldahl MG, Sitter B, Vettukattil R, Bofin A, et al. 2011. In vivo MRS of locally advanced breast cancer: characteristics related to negative or positive choline detection and early monitoring of treatment response. MAGMA 24:347-57
    • (2011) MAGMA , vol.24 , pp. 347-357
    • Bathen, T.F.1    Heldahl, M.G.2    Sitter, B.3    Vettukattil, R.4    Bofin, A.5
  • 6
    • 84955239068 scopus 로고    scopus 로고
    • A systematic review on [18F]FLT-PET uptake as a measure of treatment response in cancer patients
    • Bollineni VR, Kramer GM, Jansma EP, Liu Y, Oyen WJ. 2016. A systematic review on [18F]FLT-PET uptake as a measure of treatment response in cancer patients. Eur. J. Cancer 55:81-97
    • (2016) Eur. J. Cancer , vol.55 , pp. 81-97
    • Bollineni, V.R.1    Kramer, G.M.2    Jansma, E.P.3    Liu, Y.4    Oyen, W.J.5
  • 7
    • 84925969707 scopus 로고    scopus 로고
    • Metabolic pathways promoting cancer cell survival and growth
    • Boroughs LK, DeBerardinis RJ. 2015. Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol. 17:351-59
    • (2015) Nat. Cell Biol , vol.17 , pp. 351-359
    • Boroughs, L.K.1    Deberardinis, R.J.2
  • 9
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell RA,McGranahanN, Bartek J, Swanton C. 2013. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501:338-45
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 11
    • 84897524498 scopus 로고    scopus 로고
    • Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas
    • Castro-Vega LJ, Buffet A, De Cubas AA, Cascon A,MenaraM, et al. 2014. Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas. Hum. Mol. Genet. 23:2440-46
    • (2014) Hum. Mol. Genet , vol.23 , pp. 2440-2446
    • Castro-Vega, L.J.1    Buffet, A.2    De Cubas, A.A.3    Cascon, A.4    Menara, M.5
  • 13
    • 79957774646 scopus 로고    scopus 로고
    • Pyruvate carboxylase is required for glutamineindependent growth of tumor cells
    • Cheng T, Sudderth J, Yang C,Mullen AR, Jin ES, et al. 2011. Pyruvate carboxylase is required for glutamineindependent growth of tumor cells. PNAS 108:8674-79
    • (2011) PNAS , vol.108 , pp. 8674-8679
    • Cheng, T.1    Sudderth, J.2    Yang, C.3    Mullen, A.R.4    Jin, E.S.5
  • 14
    • 84862776826 scopus 로고    scopus 로고
    • 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
    • Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, et al. 2012. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat. Med. 18:624-29
    • (2012) Nat. Med , vol.18 , pp. 624-629
    • Choi, C.1    Ganji, S.K.2    Deberardinis, R.J.3    Hatanpaa, K.J.4    Rakheja, D.5
  • 17
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-Associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, Bennett BD, Bittinger MA, et al. 2009. Cancer-Associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:739-44
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3    Bennett, B.D.4    Bittinger, M.A.5
  • 19
    • 85084407098 scopus 로고    scopus 로고
    • Analyzingmetabolism in biological systems. in
    • Cold Spring Harbor, NY: Cold Spring Harb. Lab. Press
    • DeBerardinis RJ. 2015. Analyzingmetabolism in biological systems. In Navigating Metabolism, ed.NSChandel, pp. 223-31. Cold Spring Harbor, NY: Cold Spring Harb. Lab. Press
    • (2015) Navigating Metabolism, Ed.NSChandel , pp. 223-231
    • Deberardinis, R.J.1
  • 20
    • 75149148563 scopus 로고    scopus 로고
    • Q?s next: The diverse functions of glutamine in metabolism, cell biology and cancer
    • DeBerardinis RJ, Cheng T. 2010. Q?s next: The diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 29:313-24
    • (2010) Oncogene , vol.29 , pp. 313-324
    • Deberardinis, R.J.1    Cheng, T.2
  • 21
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutaminemetabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ,Mancuso A, Daikhin E, Nissim I, YudkoffM, et al. 2007. Beyond aerobic glycolysis: Transformed cells can engage in glutaminemetabolism that exceeds the requirement for protein and nucleotide synthesis. PNAS 104:19345-50
    • (2007) PNAS , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5
  • 25
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
    • Fan TW, Lane AN, Higashi RM, Farag MA, Gao H, et al. 2009. Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 8:41
    • (2009) Mol. Cancer , vol.8 , pp. 41
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3    Farag, M.A.4    Gao, H.5
  • 26
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-Aminopteroyl-glutamic acid (aminopterin)
    • Farber S, DiamondLK, Mercer RD, SylvesterRF Jr.,Wolff JA. 1948. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-Aminopteroyl-glutamic acid (aminopterin). N. Engl. J. Med. 238:787-93
    • (1948) N. Engl. J. Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2    Mercer, R.D.3    Sylvester, R.F.4    Wolff, J.A.5
  • 27
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disruptTET2function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, et al. 2010. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disruptTET2function, and impair hematopoietic differentiation. Cancer Cell 18:553-67
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5
  • 28
    • 49049096675 scopus 로고    scopus 로고
    • 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine
    • Gallagher FA, Kettunen MI, Day SE, Lerche M, Brindle KM. 2008. 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine. Magn. Reson. Med. 60:253-57
    • (2008) Magn. Reson. Med , vol.60 , pp. 253-257
    • Gallagher, F.A.1    Kettunen, M.I.2    Day, S.E.3    Lerche, M.4    Brindle, K.M.5
  • 29
    • 73949133557 scopus 로고    scopus 로고
    • Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors
    • Gallagher FA, Kettunen MI, Hu DE, Jensen PR, Zandt RI, et al. 2009. Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors. PNAS 106:19801-6
    • (2009) PNAS , vol.106 , pp. 19801-19806
    • Gallagher, F.A.1    Kettunen, M.I.2    Hu, D.E.3    Jensen, P.R.4    Zandt, R.I.5
  • 30
    • 0036717382 scopus 로고    scopus 로고
    • Molecular imaging of cancer with positron emission tomography
    • Gambhir SS. 2002. Molecular imaging of cancer with positron emission tomography. Nat. Rev. Cancer 2:683-93
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 683-693
    • Gambhir, S.S.1
  • 31
    • 23844457954 scopus 로고    scopus 로고
    • Vivo magnetic resonance spectroscopy in cancer
    • Gillies RJ, Morse DL. 2005. In vivo magnetic resonance spectroscopy in cancer. Annu. Rev. Biomed. Eng. 7:287-326
    • (2005) Annu. Rev. Biomed. Eng , vol.7 , pp. 287-326
    • Gillies, R.J.1    Morse, D.L.2
  • 32
    • 79952154676 scopus 로고    scopus 로고
    • Metabolic tumor imaging using magnetic resonance spectroscopy
    • Glunde K, Bhujwalla ZM. 2011. Metabolic tumor imaging using magnetic resonance spectroscopy. Semin. Oncol. 38:26-41
    • (2011) Semin. Oncol , vol.38 , pp. 26-41
    • Glunde, K.1    Bhujwalla, Z.M.2
  • 35
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D,Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell 144:646-74
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 36
    • 84862183974 scopus 로고    scopus 로고
    • Regional cell proliferation inmicrodissected human prostate specimens after heavy water labeling in vivo: Correlation with prostate epithelial cells isolated from seminal fluid
    • HayesGM,Simko J, Holochwost D, KuchinskyK, Busch R, et al. 2012. Regional cell proliferation inmicrodissected human prostate specimens after heavy water labeling in vivo: correlation with prostate epithelial cells isolated from seminal fluid. Clin. Cancer Res. 18:3250-60
    • (2012) Clin. Cancer Res , vol.18 , pp. 3250-3260
    • Hayes, G.M.1    Simko, J.2    Holochwost, D.3    Kuchinsky, K.4    Busch, R.5
  • 39
    • 84944076036 scopus 로고    scopus 로고
    • Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
    • Herranz D, Ambesi-Impiombato A, Sudderth J, Sanchez-Martin M, Belver L, et al. 2015. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat. Med. 21:1182-89
    • (2015) Nat. Med , vol.21 , pp. 1182-1189
    • Herranz, D.1    Ambesi-Impiombato, A.2    Sudderth, J.3    Sanchez-Martin, M.4    Belver, L.5
  • 40
    • 84959280789 scopus 로고    scopus 로고
    • Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
    • Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, et al. 2016. Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells. Dev. Cell 36:540-49
    • (2016) Dev. Cell , vol.36 , pp. 540-549
    • Hosios, A.M.1    Hecht, V.C.2    Danai, L.V.3    Johnson, M.O.4    Rathmell, J.C.5
  • 41
    • 84957567984 scopus 로고    scopus 로고
    • Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma
    • Hu LS, Ning S, Eschbacher JM, Gaw N, Dueck AC, et al. 2015. Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma. PLOS ONE 10:e0141506
    • (2015) PLOS ONE , vol.10 , pp. e0141506
    • Hu, L.S.1    Ning, S.2    Eschbacher, J.M.3    Gaw, N.4    Dueck, A.C.5
  • 42
    • 79960006190 scopus 로고    scopus 로고
    • 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    • Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, et al. 2011. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 14:131-42
    • (2011) Cell Metab , vol.14 , pp. 131-142
    • Hu, S.1    Balakrishnan, A.2    Bok, R.A.3    Anderton, B.4    Larson, P.E.5
  • 43
    • 23644448721 scopus 로고    scopus 로고
    • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
    • Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, et al. 2005. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8:143-53
    • (2005) Cancer Cell , vol.8 , pp. 143-153
    • Isaacs, J.S.1    Jung, Y.J.2    Mole, D.R.3    Lee, S.4    Torres-Cabala, C.5
  • 44
    • 84964374713 scopus 로고    scopus 로고
    • Reductive carboxylation supports redox homeostasis during anchorage-independent growth
    • Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, et al. 2016. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature 532:255-58
    • (2016) Nature , vol.532 , pp. 255-258
    • Jiang, L.1    Shestov, A.A.2    Swain, P.3    Yang, C.4    Parker, S.J.5
  • 45
    • 84873678601 scopus 로고    scopus 로고
    • Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
    • Jiang P, Du W, Mancuso A, Wellen KE, Yang X. 2013. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493:689-93
    • (2013) Nature , vol.493 , pp. 689-693
    • Jiang, P.1    Du, W.2    Mancuso, A.3    Wellen, K.E.4    Yang, X.5
  • 46
    • 84875755814 scopus 로고    scopus 로고
    • Influence of metabolism on epigenetics and disease
    • Kaelin WG Jr., McKnight SL. 2013. Influence of metabolism on epigenetics and disease. Cell 153:56-69
    • (2013) Cell , vol.153 , pp. 56-69
    • Kaelin, W.G.1    McKnight, S.L.2
  • 47
    • 84878464291 scopus 로고    scopus 로고
    • Hypoxic and Ras-Transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
    • Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, et al. 2013. Hypoxic and Ras-Transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. PNAS 110:8882-87
    • (2013) PNAS , vol.110 , pp. 8882-8887
    • Kamphorst, J.J.1    Cross, J.R.2    Fan, J.3    De Stanchina, E.4    Mathew, R.5
  • 48
    • 81755187045 scopus 로고    scopus 로고
    • Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
    • Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. 2011. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. PNAS 108:18606-11
    • (2011) PNAS , vol.108 , pp. 18606-18611
    • Keshari, K.R.1    Kurhanewicz, J.2    Bok, R.3    Larson, P.E.4    Vigneron, D.B.5    Wilson, D.M.6
  • 49
    • 84973502636 scopus 로고    scopus 로고
    • Assessment of invasive breast cancer heterogeneity using whole-Tumor magnetic resonance imaging texture analysis: Correlations with detailed pathological findings
    • Ko ES, Kim JH, Lim Y, Han BK, Cho EY, Nam SJ. 2016. Assessment of invasive breast cancer heterogeneity using whole-Tumor magnetic resonance imaging texture analysis: correlations with detailed pathological findings. Medicine 95:e2453
    • (2016) Medicine , vol.95 , pp. e2453
    • Ko, E.S.1    Kim, J.H.2    Lim, Y.3    Han, B.K.4    Cho, E.Y.5    Nam, S.J.6
  • 50
    • 79951507755 scopus 로고    scopus 로고
    • Analysis of cancer metabolism by imaging hyperpolarized nuclei: Prospects for translation to clinical research
    • Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, et al. 2011. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia 13:81-97
    • (2011) Neoplasia , vol.13 , pp. 81-97
    • Kurhanewicz, J.1    Vigneron, D.B.2    Brindle, K.3    Chekmenev, E.Y.4    Comment, A.5
  • 51
    • 0030056928 scopus 로고    scopus 로고
    • Three-dimensional H-1MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution
    • Kurhanewicz J, VigneronDB, Hricak H, Narayan P, Carroll P, Nelson SJ. 1996. Three-dimensional H-1MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution. Radiology 198:795-805
    • (1996) Radiology , vol.198 , pp. 795-805
    • Kurhanewicz, J.1    Vigneron, D.B.2    Hricak, H.3    Narayan, P.4    Carroll, P.5    Nelson, S.J.6
  • 52
    • 84919776459 scopus 로고    scopus 로고
    • Comparative evaluation of extraction methods for simultaneous mass-spectrometric analysis of complex lipids and primary metabolites from human blood plasma
    • Lee DY, Kind T, Yoon YR, Fiehn O, Liu KH. 2014. Comparative evaluation of extraction methods for simultaneous mass-spectrometric analysis of complex lipids and primary metabolites from human blood plasma. Anal. Bioanal. Chem. 406:7275-86
    • (2014) Anal. Bioanal. Chem , vol.406 , pp. 7275-7286
    • Lee, D.Y.1    Kind, T.2    Yoon, Y.R.3    Fiehn, O.4    Liu, K.H.5
  • 53
  • 54
    • 84907272714 scopus 로고    scopus 로고
    • Fructose-1,6-bisphosphatase opposes renal carcinoma progression
    • Li B, Qiu B, Lee DS,Walton ZE, Ochocki JD, et al. 2014. Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513:251-55
    • (2014) Nature , vol.513 , pp. 251-255
    • Li, B.1    Qiu, B.2    Lee Dswalton, Z.E.3    Ochocki, J.D.4
  • 55
    • 83755168277 scopus 로고    scopus 로고
    • PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine
    • Lieberman BP, Ploessl K, Wang L, Qu W, Zha Z, et al. 2011. PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine. J. Nucl. Med. 52:1947-55
    • (2011) J. Nucl. Med , vol.52 , pp. 1947-1955
    • Lieberman, B.P.1    Ploessl, K.2    Wang, L.3    Qu, W.4    Zha, Z.5
  • 56
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, et al. 2012. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483:474-78
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3    Rohle, D.4    Turcan, S.5
  • 57
    • 48749132804 scopus 로고    scopus 로고
    • Analytical strategies for LC-MS-based targeted metabolomics
    • Lu W, Bennett BD, Rabinowitz JD. 2008. Analytical strategies for LC-MS-based targeted metabolomics. J. Chromatogr. B. 871:236-42
    • (2008) J. Chromatogr. B , vol.871 , pp. 236-242
    • Lu, W.1    Bennett, B.D.2    Rabinowitz, J.D.3
  • 58
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, et al. 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120:237-48
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5
  • 59
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG. 2011. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol. 27:441-64
    • (2011) Annu. Rev. Cell Dev. Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 60
    • 84919905682 scopus 로고    scopus 로고
    • Acetate fuels the cancer engine
    • Lyssiotis CA, Cantley LC. 2014. Acetate fuels the cancer engine. Cell 159:1492-94
    • (2014) Cell , vol.159 , pp. 1492-1494
    • Lyssiotis, C.A.1    Cantley, L.C.2
  • 62
    • 84862016091 scopus 로고    scopus 로고
    • Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
    • Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, et al. 2012. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab. 15:827-37
    • (2012) Cell Metab , vol.15 , pp. 827-837
    • Marin-Valencia, I.1    Yang, C.2    Mashimo, T.3    Cho, S.4    Baek, H.5
  • 63
    • 84919903877 scopus 로고    scopus 로고
    • Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
    • Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, et al. 2014. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 159:1603-14
    • (2014) Cell , vol.159 , pp. 1603-1614
    • Mashimo, T.1    Pichumani, K.2    Vemireddy, V.3    Hatanpaa, K.J.4    Singh, D.K.5
  • 64
    • 84867139220 scopus 로고    scopus 로고
    • Genetically-defined metabolic reprogramming in cancer
    • Mullen AR, DeBerardinis RJ. 2012. Genetically-defined metabolic reprogramming in cancer. Trends Endocrinol. Metab. 23:552-59
    • (2012) Trends Endocrinol. Metab , vol.23 , pp. 552-559
    • Mullen, A.R.1    Deberardinis, R.J.2
  • 66
    • 84878458746 scopus 로고    scopus 로고
    • Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging
    • O?Brien PJ, LeeM, Spilker ME, Zhang CC, Yan Z, et al. 2013. Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging. Cancer Metab. 1:4
    • (2013) Cancer Metab , vol.1 , pp. 4
    • Obrien, P.J.1    Lee, M.2    Spilker, M.E.3    Zhang, C.C.4    Yan, Z.5
  • 69
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, et al. 2008. An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-12
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5
  • 70
    • 84955326448 scopus 로고    scopus 로고
    • The emerging hallmarks of cancer metabolism
    • Pavlova NN, Thompson CB. 2016. The emerging hallmarks of cancer metabolism. Cell Metab. 23:27-47
    • (2016) Cell Metab , vol.23 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 71
    • 0348107409 scopus 로고    scopus 로고
    • The TCA cycle and tumorigenesis: The examples of fumarate hydratase and succinate dehydrogenase
    • Pollard PJ, Wortham NC, Tomlinson IP. 2003. The TCA cycle and tumorigenesis: The examples of fumarate hydratase and succinate dehydrogenase. Ann. Med. 35:632-39
    • (2003) Ann. Med , vol.35 , pp. 632-639
    • Pollard, P.J.1    Wortham, N.C.2    Tomlinson, I.P.3
  • 72
    • 84858603856 scopus 로고    scopus 로고
    • Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
    • Pope WB, Prins RM, Thomas MA, Nagarajan R, Yen KE, et al. 2012. Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. J. Neuro-Oncology 107:197-205
    • (2012) J. Neuro-Oncology , vol.107 , pp. 197-205
    • Pope, W.B.1    Prins, R.M.2    Thomas, M.A.3    Nagarajan, R.4    Yen, K.E.5
  • 73
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz JD, White E. 2010. Autophagy and metabolism. Science 330:1344-48
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 76
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, et al. 2013. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340:626-30
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3    Turcan, S.4    Grommes, C.5
  • 77
    • 84908213474 scopus 로고    scopus 로고
    • Mitochondrial ROS in cancer: Initiators, amplifiers or an Achilles heel?
    • Sabharwal SS, Schumacker PT. 2014. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles? heel? Nat. Rev. Cancer 14:709-21
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 709-721
    • Sabharwal, S.S.1    Schumacker, P.T.2
  • 78
    • 84944751731 scopus 로고    scopus 로고
    • Combined use of 18F-FDG and 18F-FMISO in unresectable non-small cell lung cancer patients planned for radiotherapy: A dynamic PET/CT study
    • Sachpekidis C, Thieke C, Askoxylakis V, Nicolay NH, Huber PE, et al. 2015. Combined use of 18F-FDG and 18F-FMISO in unresectable non-small cell lung cancer patients planned for radiotherapy: A dynamic PET/CT study. Am. J. Nucl. Med. Mol. Imaging 5:127-42
    • (2015) Am. J. Nucl. Med. Mol. Imaging , vol.5 , pp. 127-142
    • Sachpekidis, C.1    Thieke, C.2    Askoxylakis, V.3    Nicolay, N.H.4    Huber, P.E.5
  • 79
    • 29444442413 scopus 로고    scopus 로고
    • Diagnostic architectural and dynamic features at breast MR imaging: Multicenter study
    • Schnall MD, Blume J, Bluemke DA, DeAngelis GA, DeBruhl N, et al. 2006. Diagnostic architectural and dynamic features at breast MR imaging: multicenter study. Radiology 238:42-53
    • (2006) Radiology , vol.238 , pp. 42-53
    • Schnall, M.D.1    Blume, J.2    Bluemke, D.A.3    Deangelis, G.A.4    Debruhl, N.5
  • 80
    • 84947648620 scopus 로고    scopus 로고
    • Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
    • Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, et al. 2015. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 27:57-71
    • (2015) Cancer Cell , vol.27 , pp. 57-71
    • Schug, Z.T.1    Peck, B.2    Jones, D.T.3    Zhang, Q.4    Grosskurth, S.5
  • 81
    • 84989159124 scopus 로고    scopus 로고
    • Fumarate is an epigenetic modifier that elicits epithelial-To-mesenchymal transition
    • In press
    • Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, Henriques da Costa AS, et al. 2016. Fumarate is an epigenetic modifier that elicits epithelial-To-mesenchymal transition. Nature. In press. doi: 10.1038/nature19353
    • (2016) Nature
    • Sciacovelli, M.1    Gonçalves, E.2    Johnson, T.I.3    Zecchini, V.R.4    Da Costa, H.A.S.5
  • 82
    • 19944433653 scopus 로고    scopus 로고
    • Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-αprolyl hydroxylase
    • Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, et al. 2005. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-αprolyl hydroxylase. Cancer Cell 7:77-85
    • (2005) Cancer Cell , vol.7 , pp. 77-85
    • Selak, M.A.1    Armour, S.M.2    Mackenzie, E.D.3    Boulahbel, H.4    Watson, D.G.5
  • 83
    • 84961287801 scopus 로고    scopus 로고
    • Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation
    • Sellers K, Fox MP, Bousamra M, Slone SP, Higashi RM, et al. 2015. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J. Clin. Investig. 125:687-98
    • (2015) J. Clin. Investig , vol.125 , pp. 687-698
    • Sellers, K.1    Fox, M.P.2    Bousamra, M.3    Slone, S.P.4    Higashi, R.M.5
  • 84
    • 84930216252 scopus 로고    scopus 로고
    • MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
    • Shroff EH, Eberlin LS, Dang VM, Gouw AM, Gabay M, et al. 2015. MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism. PNAS 112:6539-44
    • (2015) PNAS , vol.112 , pp. 6539-6544
    • Shroff, E.H.1    Eberlin, L.S.2    Dang, V.M.3    Gouw, A.M.4    Gabay, M.5
  • 85
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux P, Vegran F, Schroeder T,Wergin MC, Verrax J, et al. 2008. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Investig. 118:3930-42
    • (2008) J. Clin. Investig , vol.118 , pp. 3930-3942
    • Sonveaux, P.1    Vegran, F.2    Schroeder, T.3    Wergin, M.C.4    Verrax, J.5
  • 86
    • 60149091657 scopus 로고    scopus 로고
    • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    • Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, et al. 2009. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457:910-14
    • (2009) Nature , vol.457 , pp. 910-914
    • Sreekumar, A.1    Poisson, L.M.2    Rajendiran, T.M.3    Khan, A.P.4    Cao, Q.5
  • 87
    • 0037214241 scopus 로고    scopus 로고
    • Value of FDG-PET in the management of non-small cell lung cancer
    • Stroobants S, Verschakelen J, Vansteenkiste J. 2003. Value of FDG-PET in the management of non-small cell lung cancer. Eur. J. Radiol. 45:49-59
    • (2003) Eur. J. Radiol , vol.45 , pp. 49-59
    • Stroobants, S.1    Verschakelen, J.2    Vansteenkiste, J.3
  • 88
    • 85060496113 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species and cancer
    • Sullivan LB, Chandel NS. 2014. Mitochondrial reactive oxygen species and cancer. Cancer Metab. 2:17
    • (2014) Cancer Metab , vol.2 , pp. 17
    • Sullivan, L.B.1    Chandel, N.S.2
  • 89
    • 84883753045 scopus 로고    scopus 로고
    • A prospective clinical trial of tumor hypoxia imaging with 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) before and during radiation therapy
    • Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, et al. 2013. A prospective clinical trial of tumor hypoxia imaging with 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) before and during radiation therapy. J. Radiat. Res. 54:1078-84
    • (2013) J. Radiat. Res , vol.54 , pp. 1078-1084
    • Tachibana, I.1    Nishimura, Y.2    Shibata, T.3    Kanamori, S.4    Nakamatsu, K.5
  • 90
    • 84948701108 scopus 로고    scopus 로고
    • Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
    • Tardito S,Oudin A, Ahmed SU, Fack F, Keunen O, et al. 2015. Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nat. Cell Biol. 17:1556-68
    • (2015) Nat. Cell Biol , vol.17 , pp. 1556-1568
    • Tardito, S.1    Oudin, A.2    Ahmed, S.U.3    Fack, F.4    Keunen, O.5
  • 92
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, et al. 2002. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat. Genet. 30:406-10
    • (2002) Nat. Genet , vol.30 , pp. 406-410
    • Tomlinson, I.P.1    Alam, N.A.2    Rowan, A.J.3    Barclay, E.4    Jaeger, E.E.5
  • 93
    • 84955304990 scopus 로고    scopus 로고
    • Small molecule MALDI MS imaging: Current technologies and future challenges
    • Trim PJ, Snel MF. 2016. Small molecule MALDI MS imaging: current technologies and future challenges. Methods 104:127-41
    • (2016) Methods , vol.104 , pp. 127-141
    • Trim, P.J.1    Snel, M.F.2
  • 94
    • 84926661140 scopus 로고    scopus 로고
    • Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
    • Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, et al. 2015. Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Sci. Transl. Med. 7:274ra17
    • (2015) Sci. Transl. Med , vol.7 , pp. 274ra17
    • Venneti, S.1    Dunphy, M.P.2    Zhang, H.3    Pitter, K.L.4    Zanzonico, P.5
  • 95
    • 0027442958 scopus 로고
    • Metabolic monitoring of breast cancer chemohormonotherapy using positron emission tomography: Initial evaluation
    • Wahl RL, Zasadny K, Helvie M, Hutchins GD, Weber B, Cody R. 1993. Metabolic monitoring of breast cancer chemohormonotherapy using positron emission tomography: initial evaluation. J. Clin. Oncol. 11:2101-11
    • (1993) J. Clin. Oncol , vol.11 , pp. 2101-2111
    • Wahl, R.L.1    Zasadny, K.2    Helvie, M.3    Hutchins, G.D.4    Weber, B.5    Cody, R.6
  • 96
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, et al. 2013. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 340:622-26
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1    Travins, J.2    Delabarre, B.3    Penard-Lacronique, V.4    Schalm, S.5
  • 97
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. 1956. On the origin of cancer cells. Science 123:309-14
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 99
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
    • Ward PS, Thompson CB. 2012. Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate. Cancer Cell 21:297-308
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 100
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, et al. 2008. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.PNAS105:18782-87
    • (2008) PNAS105 , pp. 18782-18787
    • Wise, D.R.1    Deberardinis, R.J.2    Mancuso, A.3    Sayed, N.4    Zhang, X.Y.5
  • 101
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • Xiao M, Yang H, Xu W, Ma S, LinH, et al. 2012. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26:1326-38
    • (2012) Genes Dev , vol.26 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5
  • 102
    • 0029071943 scopus 로고
    • High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue
    • Yamada S, Kubota K, Kubota R, Ido T, Tamahashi N. 1995. High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue. J. Nucl. Med. 36:1301-6
    • (1995) J. Nucl. Med , vol.36 , pp. 1301-1306
    • Yamada, S.1    Kubota, K.2    Kubota, R.3    Ido, T.4    Tamahashi, N.5
  • 104
    • 84965079350 scopus 로고    scopus 로고
    • Exogenous fatty acids are the preferred source of membrane lipids in proliferating fibroblasts
    • Yao CH, Fowle-Grider R, Mahieu NG, Liu GY, Chen YJ, et al. 2016. Exogenous fatty acids are the preferred source of membrane lipids in proliferating fibroblasts. Cell Chem. Biol. 23:483-93
    • (2016) Cell Chem. Biol , vol.23 , pp. 483-493
    • Yao, C.H.1    Fowle-Grider, R.2    Mahieu, N.G.3    Liu, G.Y.4    Chen, Y.J.5
  • 105
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, et al. 2012. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149:656-70
    • (2012) Cell , vol.149 , pp. 656-670
    • Ying, H.1    Kimmelman, A.C.2    Lyssiotis, C.A.3    Hua, S.4    Chu, G.C.5
  • 106
    • 84899511589 scopus 로고    scopus 로고
    • INCA: A computational platform for isotopically non-stationary metabolic flux analysis
    • Young JD. 2014. INCA: A computational platform for isotopically non-stationary metabolic flux analysis. Bioinformatics 30:1333-35
    • (2014) Bioinformatics , vol.30 , pp. 1333-1335
    • Young, J.D.1
  • 107
    • 84877984661 scopus 로고    scopus 로고
    • Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
    • Young RM, Ackerman D, Quinn ZL, Mancuso A, Gruber M, et al. 2013. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev. 27:1115-31
    • (2013) Genes Dev , vol.27 , pp. 1115-1131
    • Young, R.M.1    Ackerman, D.2    Quinn, Z.L.3    Mancuso, A.4    Gruber, M.5
  • 108
    • 84863011452 scopus 로고    scopus 로고
    • The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
    • Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, et al. 2012. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab. 15:157-70
    • (2012) Cell Metab , vol.15 , pp. 157-170
    • Yuneva, M.O.1    Fan, T.W.2    Allen, T.D.3    Higashi, R.M.4    Ferraris, D.V.5
  • 109
    • 84964445423 scopus 로고    scopus 로고
    • Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
    • Zhao H, Yang L, Baddour J, Achreja A, Bernard V, et al. 2016. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. eLife 5:e10250
    • (2016) ELife , vol.5 , pp. e10250
    • Zhao, H.1    Yang, L.2    Baddour, J.3    Achreja, A.4    Bernard, V.5


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