Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 46, 2011, Pages 18606-18611

  Keshari, Kayvan R ^a   Kurhanewicz, John ^a   Bok, Robert ^a   Larson, Peder E Z ^a   Vigneron, Daniel B ^a   Wilson, David M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Kinetics; Molecular imaging; MRI; Probe

Indexed keywords

ASCORBIC ACID; CARBON 13; DEHYDROASCORBIC ACID; DEHYDROASCORBIC ACID C 13; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CARBON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; HYPERPOLARIZATION; IN VIVO METABOLIC IMAGING; KIDNEY; LIVER; MOLECULAR IMAGING; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PANCREAS CANCER; POLARIZATION; PRIORITY JOURNAL; SENSOR; SYNTHESIS; ANIMAL; ANISOTROPY; CHEMISTRY; KINETICS; METABOLISM; METHODOLOGY; NEOPLASM; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TISSUE DISTRIBUTION;

MURINAE;

ANIMALS; ANISOTROPY; ASCORBIC ACID; BRAIN; CARBON ISOTOPES; DEHYDROASCORBIC ACID; GLUTATHIONE; KIDNEY; KINETICS; LIVER; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NEOPLASMS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; TISSUE DISTRIBUTION;

EID: 81755187045     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106920108     Document Type: Article

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