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Volumn 1024, Issue , 2017, Pages 175-194

cGAS-STING activation in the tumor microenvironment and its role in cancer immunity

Author keywords

Cancer; cGAMP; cGAS; Connexin; Interferon; STING

Indexed keywords

ANTINEOPLASTIC AGENT; CELL DNA; CYCLIC GMP AMP SYNTHETASE; GAP JUNCTION PROTEIN; INTERFERON; PATHOGEN ASSOCIATED MOLECULAR PATTERN; SYNTHETASE; TUMOR PROTEIN; UNCLASSIFIED DRUG; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE;

EID: 85029704354     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-981-10-5987-2_8     Document Type: Chapter
Times cited : (38)

References (100)
  • 1
    • 84920019524 scopus 로고    scopus 로고
    • Potential therapeutic targets in the process of nucleic acid recognition: Opportunities and challenges
    • He S, Mao X, Sun H, Shirakawa T, Zhang H, Wang X (2015) Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges. Trends Pharmacol Sci 36(1):51–64. doi:10.1016/j.tips.2014.10.013
    • (2015) Trends Pharmacol Sci , vol.36 , Issue.1 , pp. 51-64
    • He, S.1    Mao, X.2    Sun, H.3    Shirakawa, T.4    Zhang, H.5    Wang, X.6
  • 2
    • 84991214605 scopus 로고    scopus 로고
    • Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system
    • Luecke S, Paludan SR (2016) Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system. Cytokine. doi:10.1016/j.cyto.2016.10.003
    • (2016) Cytokine
    • Luecke, S.1    Paludan, S.R.2
  • 4
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • Ishikawa H, Barber GN (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455(7213):674–678. doi:10.1038/nature07317
    • (2008) Nature , vol.455 , Issue.7213 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 5
    • 66649109939 scopus 로고    scopus 로고
    • ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
    • Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A 106(21):8653–8658. doi:10.1073/pnas.0900850106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.21 , pp. 8653-8658
    • Sun, W.1    Li, Y.2    Chen, L.3    Chen, H.4    You, F.5    Zhou, X.6    Zhou, Y.7    Zhai, Z.8    Chen, D.9    Jiang, Z.10
  • 6
    • 53349168904 scopus 로고    scopus 로고
    • The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    • Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29(4):538–550. doi:10.1016/j.immuni.2008.09.003
    • (2008) Immunity , vol.29 , Issue.4 , pp. 538-550
    • Zhong, B.1    Yang, Y.2    Li, S.3    Wang, Y.Y.4    Li, Y.5    Diao, F.6    Lei, C.7    He, X.8    Zhang, L.9    Tien, P.10    Shu, H.B.11
  • 7
    • 49449115516 scopus 로고    scopus 로고
    • MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
    • Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC (2008) MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol 28(16):5014–5026. doi:10.1128/MCB.00640-08
    • (2008) Mol Cell Biol , vol.28 , Issue.16 , pp. 5014-5026
    • Jin, L.1    Waterman, P.M.2    Jonscher, K.R.3    Short, C.M.4    Reisdorph, N.A.5    Cambier, J.C.6
  • 8
    • 84857937262 scopus 로고    scopus 로고
    • STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
    • Tanaka Y, Chen ZJ (2012) STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal 5(214):ra20. doi:10.1126/scisignal.2002521
    • (2012) Sci Signal , vol.5 , Issue.214
    • Tanaka, Y.1    Chen, Z.J.2
  • 9
    • 84924778328 scopus 로고    scopus 로고
    • Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
    • Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347(6227):aaa2630. doi:10.1126/science.aaa2630
    • (2015) Science , vol.347 , Issue.6227
    • Liu, S.1    Cai, X.2    Wu, J.3    Cong, Q.4    Chen, X.5    Li, T.6    Du, F.7    Ren, J.8    Yt, W.9    Grishin, N.V.10    Chen, Z.J.11
  • 10
    • 84940000532 scopus 로고    scopus 로고
    • A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis
    • Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR (2015) A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis. Nat Med 21(4):401–406. doi:10.1038/nm.3813
    • (2015) Nat Med , vol.21 , Issue.4 , pp. 401-406
    • Dey, B.1    Dey, R.J.2    Cheung, L.S.3    Pokkali, S.4    Guo, H.5    Lee, J.H.6    Bishai, W.R.7
  • 11
    • 77954070545 scopus 로고    scopus 로고
    • C-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response
    • Woodward JJ, Iavarone AT, Portnoy DA (2010) c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328(5986):1703–1705. doi:10.1126/science.1189801
    • (2010) Science , vol.328 , Issue.5986 , pp. 1703-1705
    • Woodward, J.J.1    Iavarone, A.T.2    Portnoy, D.A.3
  • 12
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H, Ma Z, Barber GN (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461(7265):788–792. doi:10.1038/nature08476
    • (2009) Nature , vol.461 , Issue.7265 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 13
    • 84893934506 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA by cGAS and other STING-dependent sensors
    • Bhat N, Fitzgerald KA (2014) Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur J Immunol 44(3):634–640. doi:10.1002/eji.201344127
    • (2014) Eur J Immunol , vol.44 , Issue.3 , pp. 634-640
    • Bhat, N.1    Fitzgerald, K.A.2
  • 14
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • Sun L, Wu J, Du F, Chen X, Chen ZJ (2013) Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339(6121):786–791. doi:10.1126/science.1232458
    • (2013) Science , vol.339 , Issue.6121 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 15
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339(6121):826–830. doi:10.1126/science.1229963
    • (2013) Science , vol.339 , Issue.6121 , pp. 826-830
    • Wu, J.1    Sun, L.2    Chen, X.3    Du, F.4    Shi, H.5    Chen, C.6    Chen, Z.J.7
  • 19
    • 84880508067 scopus 로고    scopus 로고
    • Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
    • Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell 51(2):226–235. doi:10.1016/j.molcel.2013.05.022
    • (2013) Mol Cell , vol.51 , Issue.2 , pp. 226-235
    • Zhang, X.1    Shi, H.2    Wu, J.3    Zhang, X.4    Sun, L.5    Chen, C.6    Chen, Z.J.7
  • 25
    • 84940121945 scopus 로고    scopus 로고
    • Cutting edge: CGAS Is required for lethal autoimmune disease in the trex1-deficient mouse model of aicardi-goutieres syndrome
    • Gray EE, Treuting PM, Woodward JJ, Stetson DB (2015) Cutting edge: cGAS Is required for lethal autoimmune disease in the trex1-deficient mouse model of aicardi-goutieres syndrome. J Immunol 195(5):1939–1943. doi:10.4049/jimmunol.1500969
    • (2015) J Immunol , vol.195 , Issue.5 , pp. 1939-1943
    • Gray, E.E.1    Treuting, P.M.2    Woodward, J.J.3    Stetson, D.B.4
  • 26
    • 84908120748 scopus 로고    scopus 로고
    • Intrinsic self-DNA triggers inflammatory disease dependent on STING
    • Ahn J, Ruiz P, Barber GN (2014) Intrinsic self-DNA triggers inflammatory disease dependent on STING. J Immunol 193(9):4634–4642. doi:10.4049/jimmunol.1401337
    • (2014) J Immunol , vol.193 , Issue.9 , pp. 4634-4642
    • Ahn, J.1    Ruiz, P.2    Barber, G.N.3
  • 30
    • 80355136945 scopus 로고    scopus 로고
    • Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8(alpha)+ dendritic cells
    • Fuertes MB, Kacha AK, Kline J, Woo SR, Kranz DM, Murphy KM, Gajewski TF (2011) Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8(alpha)+ dendritic cells. J Exp Med 208(10):2005–2016. doi:10.1084/jem.20101159
    • (2011) J Exp Med , vol.208 , Issue.10 , pp. 2005-2016
    • Fuertes, M.B.1    Kacha, A.K.2    Kline, J.3    Woo, S.R.4    Kranz, D.M.5    Murphy, K.M.6    Gajewski, T.F.7
  • 31
    • 84916894965 scopus 로고    scopus 로고
    • STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells
    • Klarquist J, Hennies CM, Lehn MA, Reboulet RA, Feau S, Janssen EM (2014) STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells. J Immunol 193(12):6124–6134. doi:10.4049/jimmunol.1401869
    • (2014) J Immunol , vol.193 , Issue.12 , pp. 6124-6134
    • Klarquist, J.1    Hennies, C.M.2    Lehn, M.A.3    Reboulet, R.A.4    Feau, S.5    Janssen, E.M.6
  • 34
    • 84997810104 scopus 로고    scopus 로고
    • Current clinical trials testing the combination of immunotherapy with radiotherapy
    • Kang J, Demaria S, Formenti S (2016) Current clinical trials testing the combination of immunotherapy with radiotherapy. J Immunother Cancer 4:51. doi:10.1186/s40425-016-0156-7
    • (2016) J Immunother Cancer , vol.4 , pp. 51
    • Kang, J.1    Demaria, S.2    Formenti, S.3
  • 35
    • 84964698449 scopus 로고    scopus 로고
    • STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment
    • Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H (2014) STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res 2(12):1199–1208. doi:10.1158/2326-6066. CIR-14-0099
    • (2014) Cancer Immunol Res , vol.2 , Issue.12 , pp. 1199-1208
    • Ohkuri, T.1    Ghosh, A.2    Kosaka, A.3    Zhu, J.4    Ikeura, M.5    David, M.6    Watkins, S.C.7    Sarkar, S.N.8    Okada, H.9
  • 36
    • 84970963467 scopus 로고    scopus 로고
    • Agonist-mediated activation of STING induces apoptosis in malignant B cells
    • Tang CH, Zundell JA, Ranatunga S, Lin C, Nefedova Y, Del Valle JR, Hu CC (2016) Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res 76(8):2137–2152. doi:10.1158/0008-5472.CAN-15-1885
    • (2016) Cancer Res , vol.76 , Issue.8 , pp. 2137-2152
    • Tang, C.H.1    Zundell, J.A.2    Ranatunga, S.3    Lin, C.4    Nefedova, Y.5    Del Valle, J.R.6    Cc, H.7
  • 38
    • 80051638135 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadi-mezan (ASA404) in advanced non-small-cell lung cancer
    • Epub 2011 Jun 27
    • Lara PN Jr, Douillard JY, Nakagawa K, von Pawel J, McKeage MJ, Albert I, Losonczy G, Reck M, Heo DS, Fan X, Fandi A, Scagliotti G (2011) Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadi-mezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol 29(22):2965–2971. doi:10.1200/JCO.2011.35.0660. Epub 2011 Jun 27.
    • (2011) J Clin Oncol , vol.29 , Issue.22 , pp. 2965-2971
    • Lara, P.N.1    Douillard, J.Y.2    Nakagawa, K.3    Von Pawel, J.4    McKeage, M.J.5    Albert, I.6    Losonczy, G.7    Reck, M.8    Heo, D.S.9    Fan, X.10    Fandi, A.11    Scagliotti, G.12
  • 39
    • 84949096097 scopus 로고    scopus 로고
    • Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy
    • Corrales L, Gajewski TF (2016) Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy. Cytokine 77:245–247. doi:10.1016/j.cyto.2015.08.258
    • (2016) Cytokine , vol.77 , pp. 245-247
    • Corrales, L.1    Gajewski, T.F.2
  • 40
    • 84940172128 scopus 로고    scopus 로고
    • Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma
    • Nakamura T, Miyabe H, Hyodo M, Sato Y, Hayakawa Y, Harashima H (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release 216:149–157. doi:10.1016/j.jconrel.2015.08.026
    • (2015) J Control Release , vol.216 , pp. 149-157
    • Nakamura, T.1    Miyabe, H.2    Hyodo, M.3    Sato, Y.4    Hayakawa, Y.5    Harashima, H.6
  • 41
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • Topalian SL, Drake CG, Pardoll DM (2015) Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27(4):450–461. doi:10.1016/j. ccell.2015.03.001
    • (2015) Cancer Cell , vol.27 , Issue.4 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 43
    • 85016106531 scopus 로고    scopus 로고
    • Established T cell-inflamed tumors rejected after adaptive resistance was reversed by combination STING activation and PD-1 pathway blockade
    • Moore E, Clavijo PE, Davis R, Cash H, Van Waes C, Kim Y, Allen C (2016) Established T cell-inflamed tumors rejected after adaptive resistance was reversed by combination STING activation and PD-1 pathway blockade. Cancer Immunol Res 4(12):1061–1071. doi:10.1158/2326-6066.CIR-16-0104
    • (2016) Cancer Immunol Res , vol.4 , Issue.12 , pp. 1061-1071
    • Moore, E.1    Clavijo, P.E.2    Davis, R.3    Cash, H.4    Van Waes, C.5    Kim, Y.6    Allen, C.7
  • 45
    • 84965032473 scopus 로고    scopus 로고
    • STING promotes the growth of tumors characterized by low antigenicity via IDO activation
    • Lemos H, Mohamed E, Huang L, Ou R, Pacholczyk G, Arbab AS, Munn D, Mellor AL (2016) STING promotes the growth of tumors characterized by low antigenicity via IDO activation. Cancer Res 76(8):2076–2081. doi:10.1158/0008-5472.CAN-15-1456
    • (2016) Cancer Res , vol.76 , Issue.8 , pp. 2076-2081
    • Lemos, H.1    Mohamed, E.2    Huang, L.3    Ou, R.4    Pacholczyk, G.5    Arbab, A.S.6    Munn, D.7    Mellor, A.L.8
  • 49
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson DB, Medzhitov R (2006) Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24(1):93–103. doi:10.1016/j.immuni.2005.12.003
    • (2006) Immunity , vol.24 , Issue.1 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 50
    • 84888637695 scopus 로고    scopus 로고
    • Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
    • Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V (2013) Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503(7477):530–534. doi:10.1038/nature12640
    • (2013) Nature , vol.503 , Issue.7477 , pp. 530-534
    • Ablasser, A.1    Schmid-Burgk, J.L.2    Hemmerling, I.3    Horvath, G.L.4    Schmidt, T.5    Latz, E.6    Hornung, V.7
  • 51
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R (2008) Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134(4):587–598. doi:10.1016/j.cell.2008.06.032
    • (2008) Cell , vol.134 , Issue.4 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 52
    • 84907996785 scopus 로고    scopus 로고
    • Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
    • Lan YY, Londono D, Bouley R, Rooney MS, Hacohen N (2014) Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Rep 9(1):180–192. doi:10.1016/j.celrep.2014.08.074
    • (2014) Cell Rep , vol.9 , Issue.1 , pp. 180-192
    • Lan, Y.Y.1    Londono, D.2    Bouley, R.3    Rooney, M.S.4    Hacohen, N.5
  • 54
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
    • Gehrke N, Mertens C, Zillinger T, Wenzel J, Bald T, Zahn S, Tuting T, Hartmann G, Barchet W (2013) Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 39(3):482–495. doi:10.1016/j.immuni.2013.08.004
    • (2013) Immunity , vol.39 , Issue.3 , pp. 482-495
    • Gehrke, N.1    Mertens, C.2    Zillinger, T.3    Wenzel, J.4    Bald, T.5    Zahn, S.6    Tuting, T.7    Hartmann, G.8    Barchet, W.9
  • 57
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646– 674. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 61
    • 84966929800 scopus 로고    scopus 로고
    • The DNA structure-specific endonuclease MUS81 mediates DNA sensor STING-dependent host rejection of prostate cancer cells
    • Ho SS, Zhang WY, Tan NY, Khatoo M, Suter MA, Tripathi S, Cheung FS, Lim WK, Tan PH, Ngeow J, Gasser S (2016) The DNA structure-specific endonuclease MUS81 mediates DNA sensor STING-dependent host rejection of prostate cancer cells. Immunity 44(5):1177–1189. doi:10.1016/j.immuni.2016.04.010
    • (2016) Immunity , vol.44 , Issue.5 , pp. 1177-1189
    • Ho, S.S.1    Zhang, W.Y.2    Tan, N.Y.3    Khatoo, M.4    Suter, M.A.5    Tripathi, S.6    Cheung, F.S.7    Lim, W.K.8    Tan, P.H.9    Ngeow, J.10    Gasser, S.11
  • 62
    • 84955365022 scopus 로고    scopus 로고
    • Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis
    • Xia T, Konno H, Ahn J, Barber GN (2016) Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis. Cell Rep 14(2):282–297. doi:10.1016/j.celrep.2015.12.029
    • (2016) Cell Rep , vol.14 , Issue.2 , pp. 282-297
    • Xia, T.1    Konno, H.2    Ahn, J.3    Barber, G.N.4
  • 63
    • 84995477297 scopus 로고    scopus 로고
    • Recurrent loss of STING signaling in melanoma correlates with susceptibility to viral oncolysis
    • Xia T, Konno H, Barber GN (2016) Recurrent loss of STING signaling in melanoma correlates with susceptibility to viral oncolysis. Cancer Res. doi:10.1158/0008-5472.CAN-16-1404
    • (2016) Cancer Res. Doi
    • Xia, T.1    Konno, H.2    Barber, G.N.3
  • 64
    • 84856301080 scopus 로고    scopus 로고
    • Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    • Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB (2012) Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36(1):120–131. doi:10.1016/j. immuni.2011.11.018
    • (2012) Immunity , vol.36 , Issue.1 , pp. 120-131
    • Gall, A.1    Treuting, P.2    Elkon, K.B.3    Loo, Y.M.4    Gale, M.5    Barber, G.N.6    Stetson, D.B.7
  • 65
    • 33646271857 scopus 로고    scopus 로고
    • Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment
    • Gajewski TF (2006) Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment. Clin Cancer Res 12(7 Pt 2):2326s–2330s. doi:10.1158/1078-0432.CCR-05-2517
    • (2006) Clin Cancer Res , vol.12 , Issue.7 , pp. 2326s-2330s
    • Gajewski, T.F.1
  • 66
    • 84856021596 scopus 로고    scopus 로고
    • Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis
    • Hwang WT, Adams SF, Tahirovic E, Hagemann IS, Coukos G (2012) Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis. Gynecol Oncol 124(2):192– 198. doi:10.1016/j.ygyno.2011.09.039
    • (2012) Gynecol Oncol , vol.124 , Issue.2 , pp. 192-198
    • Hwang, W.T.1    Adams, S.F.2    Tahirovic, E.3    Hagemann, I.S.4    Coukos, G.5
  • 70
    • 85008350932 scopus 로고    scopus 로고
    • DNA-sensing and nuclease gene expressions as markers for colorectal cancer progression
    • Yang CA, Huang HY, Chang YS, Lin CL, Lai IL, Chang JG (2017) DNA-sensing and nuclease gene expressions as markers for colorectal cancer progression. Oncology 92(2):115–124. doi:10.1159/000452281
    • (2017) Oncology , vol.92 , Issue.2 , pp. 115-124
    • Yang, C.A.1    Huang, H.Y.2    Chang, Y.S.3    Lin, C.L.4    Lai, I.L.5    Chang, J.G.6
  • 71
    • 84922575712 scopus 로고    scopus 로고
    • Induction of PLSCR1 in a STING/IRF3-dependent manner upon vector transfection in ovarian epithelial cells
    • Kodigepalli KM, Nanjundan M (2015) Induction of PLSCR1 in a STING/IRF3-dependent manner upon vector transfection in ovarian epithelial cells. PLoS One 10(2):e0117464. doi:10.1371/journal.pone.0117464
    • (2015) Plos One , vol.10 , Issue.2
    • Kodigepalli, K.M.1    Nanjundan, M.2
  • 75
    • 84945353895 scopus 로고    scopus 로고
    • DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
    • Lau L, Gray EE, Brunette RL, Stetson DB (2015) DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway. Science 350(6260):568–571. doi:10.1126/science. aab3291
    • (2015) Science , vol.350 , Issue.6260 , pp. 568-571
    • Lau, L.1    Gray, E.E.2    Brunette, R.L.3    Stetson, D.B.4
  • 77
    • 0014021760 scopus 로고
    • Intercellular communication and the control of tissue growth: Lack of communication between cancer cells
    • Loewenstein WR, Kanno Y (1966) Intercellular communication and the control of tissue growth: lack of communication between cancer cells. Nature 209(5029):1248–1249
    • (1966) Nature , vol.209 , Issue.5029 , pp. 1248-1249
    • Loewenstein, W.R.1    Kanno, Y.2
  • 78
    • 84992345174 scopus 로고    scopus 로고
    • Gap junctions and cancer: Communicating for 50 years
    • Aasen T, Mesnil M, Naus CC, Lampe PD, Laird DW (2016) Gap junctions and cancer: communicating for 50 years. Nat Rev Cancer 16(12):775–788. doi:10.1038/nrc.2016.105
    • (2016) Nat Rev Cancer , vol.16 , Issue.12 , pp. 775-788
    • Aasen, T.1    Mesnil, M.2    Naus, C.C.3    Lampe, P.D.4    Laird, D.W.5
  • 79
    • 84994052397 scopus 로고    scopus 로고
    • Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
    • Xu N, Chen HJ, Chen SH, Xue XY, Chen H, Zheng QS, Wei Y, Li XD, Huang JB, Cai H, Sun XL (2016) Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer. Oncotarget 7(41):67476–67484. doi:10.18632/oncotarget.11231
    • (2016) Oncotarget , vol.7 , Issue.41 , pp. 67476-67484
    • Xu, N.1    Chen, H.J.2    Chen, S.H.3    Xue, X.Y.4    Chen, H.5    Zheng, Q.S.6    Wei, Y.7    Li, X.D.8    Huang, J.B.9    Cai, H.10    Sun, X.L.11
  • 81
    • 0023142165 scopus 로고
    • A survey of human cancers for human papillomavirus DNA by filter hybridization
    • Ostrow RS, Manias DA, Fong WJ, Zachow KR, Faras AJ (1987) A survey of human cancers for human papillomavirus DNA by filter hybridization. Cancer 59(3):429–434
    • (1987) Cancer , vol.59 , Issue.3 , pp. 429-434
    • Ostrow, R.S.1    Manias, D.A.2    Fong, W.J.3    Zachow, K.R.4    Faras, A.J.5
  • 84
    • 84864550842 scopus 로고    scopus 로고
    • Suppression of CX43 expression by miR-20a in the progression of human prostate cancer
    • Li X, Pan JH, Song B, Xiong EQ, Chen ZW, Zhou ZS, Su YP (2012) Suppression of CX43 expression by miR-20a in the progression of human prostate cancer. Cancer Biol Ther 13(10):890–898. doi:10.4161/cbt.20841
    • (2012) Cancer Biol Ther , vol.13 , Issue.10 , pp. 890-898
    • Li, X.1    Pan, J.H.2    Song, B.3    Xiong, E.Q.4    Chen, Z.W.5    Zhou, Z.S.6    Yp, S.7
  • 85
    • 0037047365 scopus 로고    scopus 로고
    • Retroviral delivery of Connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication
    • Qin H, Shao Q, Curtis H, Galipeau J, Belliveau DJ, Wang T, Alaoui-Jamali MA, Laird DW (2002) Retroviral delivery of Connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. J Biol Chem 277(32):29132–29138. doi:10.1074/jbc.M200797200
    • (2002) J Biol Chem , vol.277 , Issue.32 , pp. 29132-29138
    • Qin, H.1    Shao, Q.2    Curtis, H.3    Galipeau, J.4    Belliveau, D.J.5    Wang, T.6    Alaoui-Jamali, M.A.7    Laird, D.W.8
  • 86
    • 84978153222 scopus 로고    scopus 로고
    • Qigesan inhibits migration and invasion of esopha-geal cancer cells via inducing connexin expression and enhancing gap junction function
    • Shi H, Shi D, Wu Y, Shen Q, Li J (2016) Qigesan inhibits migration and invasion of esopha-geal cancer cells via inducing connexin expression and enhancing gap junction function. Cancer Lett 380(1):184–190. doi:10.1016/j.canlet.2016.06.015
    • (2016) Cancer Lett , vol.380 , Issue.1 , pp. 184-190
    • Shi, H.1    Shi, D.2    Wu, Y.3    Shen, Q.4    Li, J.5
  • 87
    • 84947810412 scopus 로고    scopus 로고
    • Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer
    • Stewart MK, Bechberger JF, Welch I, Naus CC, Laird DW (2015) Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer. Oncotarget 6(35):37185–37199. doi:10.18632/oncotarget.5953
    • (2015) Oncotarget , vol.6 , Issue.35 , pp. 37185-37199
    • Stewart, M.K.1    Bechberger, J.F.2    Welch, I.3    Naus, C.C.4    Laird, D.W.5
  • 90
    • 84929629984 scopus 로고    scopus 로고
    • Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration
    • Zhang A, Hitomi M, Bar-Shain N, Dalimov Z, Ellis L, Velpula KK, Fraizer GC, Gourdie RG, Lathia JD (2015) Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration. Oncotarget 6(13):11640–11651. doi:10.18632/oncotarget.3449
    • (2015) Oncotarget , vol.6 , Issue.13 , pp. 11640-11651
    • Zhang, A.1    Hitomi, M.2    Bar-Shain, N.3    Dalimov, Z.4    Ellis, L.5    Velpula, K.K.6    Fraizer, G.C.7    Gourdie, R.G.8    Lathia, J.D.9
  • 92
    • 84992365439 scopus 로고    scopus 로고
    • Gap junction composed of con-nexin43 modulates 5fluorouracil, oxaliplatin and irinotecan resistance on colorectal cancers
    • Zou ZW, Chen HJ, Yu JL, Huang ZH, Fang S, Lin XH (2016) Gap junction composed of con-nexin43 modulates 5fluorouracil, oxaliplatin and irinotecan resistance on colorectal cancers. Mol Med Rep 14(5):4893–4900. doi:10.3892/mmr.2016.5812
    • (2016) Mol Med Rep , vol.14 , Issue.5 , pp. 4893-4900
    • Zou, Z.W.1    Chen, H.J.2    Jl, Y.3    Huang, Z.H.4    Fang, S.5    Lin, X.H.6
  • 93
    • 84956955274 scopus 로고    scopus 로고
    • Impaired gap junctions in human hepatocellular carcinoma limit intrinsic oxaliplatin chemosensitivity: A key role of connexin 26
    • Yang Y, Zhu J, Zhang N, Zhao Y, Li WY, Zhao FY, Ou YR, Qin SK, Wu Q (2016) Impaired gap junctions in human hepatocellular carcinoma limit intrinsic oxaliplatin chemosensitivity: a key role of connexin 26. Int J Oncol 48(2):703–713. doi:10.3892/ijo.2015.3266
    • (2016) Int J Oncol , vol.48 , Issue.2 , pp. 703-713
    • Yang, Y.1    Zhu, J.2    Zhang, N.3    Zhao, Y.4    Li, W.Y.5    Zhao, F.Y.6    Yr, O.7    Qin, S.K.8    Wu, Q.9
  • 95
    • 84946729972 scopus 로고    scopus 로고
    • Interferons and the immunogenic effects of cancer therapy
    • Minn AJ (2015) Interferons and the immunogenic effects of cancer therapy. Trends Immunol 36(11):725–737. doi:10.1016/j.it.2015.09.007
    • (2015) Trends Immunol , vol.36 , Issue.11 , pp. 725-737
    • Minn, A.J.1
  • 96
    • 84910031744 scopus 로고    scopus 로고
    • Inflammation-driven carcinogenesis is mediated through STING
    • Ahn J, Xia T, Konno H, Konno K, Ruiz P, Barber GN (2014) Inflammation-driven carcinogenesis is mediated through STING. Nat Commun 5:5166. doi:10.1038/ncomms6166
    • (2014) Nat Commun , vol.5 , pp. 5166
    • Ahn, J.1    Xia, T.2    Konno, H.3    Konno, K.4    Ruiz, P.5    Barber, G.N.6
  • 97
    • 85014610090 scopus 로고    scopus 로고
    • DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity
    • Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T (2017) DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity. J Immunol 198(4):1649– 1659. doi:10.4049/jimmunol.1601694
    • (2017) J Immunol , vol.198 , Issue.4 , pp. 1649-1659
    • Kitai, Y.1    Kawasaki, T.2    Sueyoshi, T.3    Kobiyama, K.4    Ishii, K.J.5    Zou, J.6    Akira, S.7    Matsuda, T.8    Kawai, T.9
  • 99
    • 85015752214 scopus 로고    scopus 로고
    • A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
    • Erdal E, Haider S, Rehwinkel J, Harris AL, McHugh PJ (2017) A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1. Genes Dev 31(4):353–369. doi:10.1101/gad.289769.116
    • (2017) Genes Dev , vol.31 , Issue.4 , pp. 353-369
    • Erdal, E.1    Haider, S.2    Rehwinkel, J.3    Harris, A.L.4    McHugh, P.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.