Potential therapeutic targets in the process of nucleic acid recognition: Opportunities and challenges

Trends in Pharmacological Sciences

Volumn 36, Issue 1, 2015, Pages 51-64

  He, Shaoheng ^a   Mao, Xiaoquan ^a,b   Sun, Hongzhi ^a   Shirakawa, Taro ^a,b   Zhang, Huiyun ^a   Wang, Xiangdong ^c  

^a JINZHOU MEDICAL UNIVERSITY   (China)

^b Institute of Frontier Medicine Shirokanekai Medical Association ^*  (Japan)

^c FUDAN UNIVERSITY   (China)

Author keywords

DAMPs; DNA and RNA sensing; Innate immunity; PAMPs; Pattern recognition receptor; Toll like receptor

Indexed keywords

BIOLOGICAL FACTOR; CPG OLIGODEOXYNUCLEOTIDE; CYCLIC GMP AMP SYNTHASE; DAMAGE ASSOCIATED MOLECULAR PATTERN; DNA HELICASE; MYELOID DIFFERENTIATION FACTOR 88; NUCLEIC ACID; PATHOGEN ASSOCIATED MOLECULAR PATTERN; POLYINOSINIC POLYCYTIDYLIC ACID; RNA HELICASE; STIMULATOR OF INTERFERON GENE; SYNTHETASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR AFFECTING AGENT; TOLL LIKE RECEPTOR AGONIST; TOLL LIKE RECEPTOR ANTAGONIST; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; PATTERN RECOGNITION RECEPTOR;

BACTERIAL INFECTION; CANCER RISK; CATALYSIS; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; DRUG METABOLISM; DRUG RESEARCH; DRUG TARGETING; GENETIC VARIABILITY; GENOTOXICITY; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; INFECTION; INNATE IMMUNITY; MALARIA; NONHUMAN; NUCLEIC ACID RECOGNITION; NUCLEIC ACID SENSING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; REVIEW; SEPSIS; SIGNAL TRANSDUCTION; TH1 TH2 BALANCE; VACCINATION; VIRUS INFECTION; ANIMAL; IMMUNOLOGY; METABOLISM; TH1 CELL; TH2 CELL;

ANIMALS; DNA HELICASES; HUMANS; IMMUNITY, INNATE; MEMBRANE PROTEINS; NUCLEIC ACIDS; NUCLEOTIDYLTRANSFERASES; RECEPTORS, PATTERN RECOGNITION; RNA HELICASES; TH1 CELLS; TH2 CELLS;

EID: 84920019524     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.10.013     Document Type: Review

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