A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

Genes and Development

Volumn 31, Issue 4, 2017, Pages 353-369

  Erdal, Erkin ^a   Haider, Syed ^a   Rehwinkel, Jan ^a   Harris, Adrian L ^a   McHugh, Peter J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cancer; DNA damage; DNA repair; Interferon; Nucleases

Indexed keywords

BLOOM SYNDROME HELICASE; BST2 PROTEIN; CISPLATIN; DNA; DNA FRAGMENT; DNA2 PROTEIN; EXONUCLEASE; EXONUCLEASE 1; IFI44 PROTEIN; IFI6 PROTEIN; IFIT1 PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; ISG15 PROTEIN; MITOMYCIN; MX1 PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOTIDE; OAS1 PROTEIN; STAT1 PROTEIN; TREX1 PROTEIN; UNCLASSIFIED DRUG; EXODEOXYRIBONUCLEASE; MUTAGENIC AGENT; PHOSPHOPROTEIN; REACTIVE OXYGEN METABOLITE; SINGLE STRANDED DNA; THREE PRIME REPAIR EXONUCLEASE 1;

ANIMAL CELL; ARTICLE; BREAST CANCER CELL LINE; CANCER PATIENT; CANCER SURVIVAL; CELL CYCLE PROGRESSION; CELL FRACTIONATION; CELL NUCLEUS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RESPONSE; CYTOSOL; DNA DAMAGE; DNA REPAIR; ELECTRON MICROSCOPY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INNATE IMMUNITY; MCF-7 CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SURVIVAL RATE; X IRRADIATION; ANIMAL; BREAST NEOPLASMS; CYTOPLASM; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IONIZING RADIATION; METABOLISM; MORTALITY; MOUSE; RADIATION TOLERANCE; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CYTOPLASM; DNA DAMAGE; DNA, SINGLE-STRANDED; EXODEOXYRIBONUCLEASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNITY, INNATE; INTERFERONS; MCF-7 CELLS; MICE; MUTAGENS; PHOSPHOPROTEINS; RADIATION TOLERANCE; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 85015752214     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.289769.116     Document Type: Article

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