cGAS is essential for the antitumor effect of immune checkpoint blockade

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages 1637-1642

  Wang, Hua ^a   Hu, Shuiqing ^a   Chen, Xiang ^a   Shi, Heping ^a,b   Chen, Chuo ^b   Sun, Lijun ^a   Chen, Zhijian J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cancer; cGAMP; cGAS; PD L1; STING

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIC GMP AMP; CYCLIC GMP AMP SYNTHASE; PROGRAMMED DEATH LIGAND 1 ANTIBODY; PROTEIN ANTIBODY; SYNTHETASE; TUMOR ANTIGEN; UNCLASSIFIED DRUG; ANTIBODY; CD274 PROTEIN, MOUSE; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE; PROGRAMMED DEATH 1 LIGAND 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CROSS PRESENTATION; DENDRITIC CELL; MELANOMA B16; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; EXPERIMENTAL MELANOMA; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; METABOLISM; SURVIVAL ANALYSIS; TUMOR CELL LINE;

ANIMALS; ANTIBODIES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; B7-H1 ANTIGEN; CELL LINE, TUMOR; CELLS, CULTURED; CROSS-PRIMING; DENDRITIC CELLS; IMMUNITY, INNATE; MELANOMA, EXPERIMENTAL; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEOTIDES, CYCLIC; NUCLEOTIDYLTRANSFERASES; SURVIVAL ANALYSIS;

EID: 85013115769     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1621363114     Document Type: Article

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