-
1
-
-
0020358296
-
Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells
-
Greenburg, G., Hay, E.D., Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J. Cell Biol. 95 (1982), 333–339.
-
(1982)
J. Cell Biol.
, vol.95
, pp. 333-339
-
-
Greenburg, G.1
Hay, E.D.2
-
2
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery, J.P., et al. Epithelial-mesenchymal transitions in development and disease. Cell 139 (2009), 871–890.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
-
3
-
-
77957551870
-
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
-
Li, R., et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7 (2010), 51–63.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 51-63
-
-
Li, R.1
-
4
-
-
77956320116
-
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
-
Samavarchi-Tehrani, P., et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 7 (2010), 64–77.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 64-77
-
-
Samavarchi-Tehrani, P.1
-
5
-
-
84857817163
-
Slug and Sox9 cooperatively determine the mammary stem cell state
-
Guo, W., et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 148 (2012), 1015–1028.
-
(2012)
Cell
, vol.148
, pp. 1015-1028
-
-
Guo, W.1
-
6
-
-
84887456252
-
The epigenetics of epithelial-mesenchymal plasticity in cancer
-
Tam, W.L., Weinberg, R.A., The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat. Med. 19 (2013), 1438–1449.
-
(2013)
Nat. Med.
, vol.19
, pp. 1438-1449
-
-
Tam, W.L.1
Weinberg, R.A.2
-
7
-
-
84976539958
-
EMT: 2016
-
Nieto, M.A., et al. EMT: 2016. Cell 166 (2016), 21–45.
-
(2016)
Cell
, vol.166
, pp. 21-45
-
-
Nieto, M.A.1
-
8
-
-
84941000153
-
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease
-
Grande, M.T., et al. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat. Med. 21 (2015), 989–997.
-
(2015)
Nat. Med.
, vol.21
, pp. 989-997
-
-
Grande, M.T.1
-
9
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
Thiery, J.P., Sleeman, J.P., Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7 (2006), 131–142.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
10
-
-
84993965417
-
Post-translational modifications of EMT transcriptional factors in cancer metastasis
-
Chang, R., et al. Post-translational modifications of EMT transcriptional factors in cancer metastasis. Open Life Sci. 11 (2016), 237–243.
-
(2016)
Open Life Sci.
, vol.11
, pp. 237-243
-
-
Chang, R.1
-
11
-
-
84873050284
-
Regulatory networks defining EMT during cancer initiation and progression
-
De Craene, B., Berx, G., Regulatory networks defining EMT during cancer initiation and progression. Nat. Rev. Cancer 13 (2013), 97–110.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 97-110
-
-
De Craene, B.1
Berx, G.2
-
12
-
-
57349114162
-
The cell-cell adhesion molecule E-cadherin
-
van Roy, F., Berx, G., The cell-cell adhesion molecule E-cadherin. Cell. Mol. Life Sci. 65 (2008), 3756–3788.
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 3756-3788
-
-
van Roy, F.1
Berx, G.2
-
13
-
-
0033789680
-
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
-
Batlle, E., et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2 (2000), 84–89.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 84-89
-
-
Batlle, E.1
-
14
-
-
0034964418
-
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
-
Comijn, J., et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 7 (2001), 1267–1278.
-
(2001)
Mol. Cell
, vol.7
, pp. 1267-1278
-
-
Comijn, J.1
-
15
-
-
0037086277
-
The SLUG zinc-finger protein represses E-cadherin in breast cancer
-
Hajra, K.M., et al. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62 (2002), 1613–1618.
-
(2002)
Cancer Res.
, vol.62
, pp. 1613-1618
-
-
Hajra, K.M.1
-
16
-
-
38349023012
-
Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
-
Vesuna, F., et al. Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer. Biochem. Biophys. Res. Commun. 367 (2008), 235–241.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.367
, pp. 235-241
-
-
Vesuna, F.1
-
17
-
-
0033784843
-
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
-
Cano, A., et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2 (2000), 76–83.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 76-83
-
-
Cano, A.1
-
18
-
-
20144388095
-
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
-
Eger, A., et al. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24 (2005), 2375–2385.
-
(2005)
Oncogene
, vol.24
, pp. 2375-2385
-
-
Eger, A.1
-
19
-
-
29144485712
-
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
-
Vandewalle, C., et al. SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res. 33 (2005), 6566–6578.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 6566-6578
-
-
Vandewalle, C.1
-
20
-
-
34249289041
-
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
-
Peinado, H., et al. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat. Rev. Cancer 7 (2007), 415–428.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 415-428
-
-
Peinado, H.1
-
21
-
-
84894593599
-
Molecular mechanisms of epithelial-mesenchymal transition
-
Lamouille, S., et al. Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 15 (2014), 178–196.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 178-196
-
-
Lamouille, S.1
-
22
-
-
84958555092
-
ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
-
Lehmann, W., et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat. Commun., 7, 2016, 10498.
-
(2016)
Nat. Commun.
, vol.7
, pp. 10498
-
-
Lehmann, W.1
-
23
-
-
3042796204
-
Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and delta EF1/ZEB1
-
Ponticos, M., et al. Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and delta EF1/ZEB1. Mol. Cell. Biol. 24 (2004), 6151–6161.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6151-6161
-
-
Ponticos, M.1
-
24
-
-
0344699350
-
T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer
-
Gregoire, J.M., Romeo, P.H., T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer. J. Biol. Chem. 274 (1999), 6567–6578.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6567-6578
-
-
Gregoire, J.M.1
Romeo, P.H.2
-
25
-
-
0038324070
-
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
-
Postigo, A.A., et al. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 22 (2003), 2453–2462.
-
(2003)
EMBO J.
, vol.22
, pp. 2453-2462
-
-
Postigo, A.A.1
-
26
-
-
0033513540
-
Independent repressor domains in ZEB regulate muscle and T-cell differentiation
-
Postigo, A.A., Dean, D.C., Independent repressor domains in ZEB regulate muscle and T-cell differentiation. Mol. Cell. Biol. 19 (1999), 7961–7971.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 7961-7971
-
-
Postigo, A.A.1
Dean, D.C.2
-
27
-
-
77956230322
-
The ZEB/miR-200 feedback loop – a motor of cellular plasticity in development and cancer?
-
Brabletz, S., Brabletz, T., The ZEB/miR-200 feedback loop – a motor of cellular plasticity in development and cancer?. EMBO Rep. 11 (2010), 670–677.
-
(2010)
EMBO Rep.
, vol.11
, pp. 670-677
-
-
Brabletz, S.1
Brabletz, T.2
-
28
-
-
84856102456
-
MiR-34 and SNAIL: another double-negative feedback loop controlling cellular plasticity/EMT governed by p53
-
Brabletz, T., MiR-34 and SNAIL: another double-negative feedback loop controlling cellular plasticity/EMT governed by p53. Cell Cycle 11 (2012), 215–216.
-
(2012)
Cell Cycle
, vol.11
, pp. 215-216
-
-
Brabletz, T.1
-
29
-
-
84970967206
-
Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape
-
Liu, F., et al. Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape. Nat. Rev. Cancer 16 (2016), 359–372.
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 359-372
-
-
Liu, F.1
-
30
-
-
80053305896
-
Signaling epigenetics: novel insights on cell signaling and epigenetic regulation
-
Arzate-Mejia, R.G., et al. Signaling epigenetics: novel insights on cell signaling and epigenetic regulation. IUBMB Life 63 (2011), 881–895.
-
(2011)
IUBMB Life
, vol.63
, pp. 881-895
-
-
Arzate-Mejia, R.G.1
-
31
-
-
0036144048
-
DNA methylation patterns and epigenetic memory
-
Bird, A., DNA methylation patterns and epigenetic memory. Genes Dev. 16 (2002), 6–21.
-
(2002)
Genes Dev.
, vol.16
, pp. 6-21
-
-
Bird, A.1
-
32
-
-
80052933429
-
DNA demethylation dynamics
-
Bhutani, N., et al. DNA demethylation dynamics. Cell 146 (2011), 866–872.
-
(2011)
Cell
, vol.146
, pp. 866-872
-
-
Bhutani, N.1
-
33
-
-
57249103576
-
Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter
-
2140. e1–e8
-
Lim, S.O., et al. Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 135 (2008), 2128–2140 2140. e1–e8.
-
(2008)
Gastroenterology
, vol.135
, pp. 2128-2140
-
-
Lim, S.O.1
-
34
-
-
82255185588
-
Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context
-
Espada, J., et al. Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context. Nucleic Acids Res. 39 (2011), 9194–9205.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 9194-9205
-
-
Espada, J.1
-
35
-
-
85005916226
-
deltaEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells
-
Fukagawa, A., et al. deltaEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells. Cancer Med. 4 (2015), 125–135.
-
(2015)
Cancer Med.
, vol.4
, pp. 125-135
-
-
Fukagawa, A.1
-
36
-
-
85002194595
-
Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells
-
Stryjewska, A., et al. Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells. Stem Cells 35 (2016), 611–625.
-
(2016)
Stem Cells
, vol.35
, pp. 611-625
-
-
Stryjewska, A.1
-
37
-
-
84921825783
-
TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer
-
Galvan, J.A., et al. TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. Oncotarget 6 (2015), 874–885.
-
(2015)
Oncotarget
, vol.6
, pp. 874-885
-
-
Galvan, J.A.1
-
38
-
-
79957897561
-
SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation
-
Acun, T., et al. SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. BMC Cancer, 11, 2011, 223.
-
(2011)
BMC Cancer
, vol.11
, pp. 223
-
-
Acun, T.1
-
39
-
-
77954354936
-
Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels
-
Li, A., et al. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res. 70 (2010), 5226–5237.
-
(2010)
Cancer Res.
, vol.70
, pp. 5226-5237
-
-
Li, A.1
-
40
-
-
84872498754
-
DNA methylation is associated with transcription of Snail and Slug genes
-
Chen, Y., et al. DNA methylation is associated with transcription of Snail and Slug genes. Biochem. Biophys. Res. Commun. 430 (2013), 1083–1090.
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.430
, pp. 1083-1090
-
-
Chen, Y.1
-
41
-
-
77956243561
-
Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells
-
Neves, R., et al. Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells. BMC Res. Notes, 3, 2010, 219.
-
(2010)
BMC Res. Notes
, vol.3
, pp. 219
-
-
Neves, R.1
-
42
-
-
85014924343
-
The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia
-
Li, H., et al. The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. Blood 129 (2017), 497–508.
-
(2017)
Blood
, vol.129
, pp. 497-508
-
-
Li, H.1
-
43
-
-
84879863078
-
Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state
-
Lim, Y.Y., et al. Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. J. Cell Sci. 126 (2013), 2256–2266.
-
(2013)
J. Cell Sci.
, vol.126
, pp. 2256-2266
-
-
Lim, Y.Y.1
-
44
-
-
79952534189
-
Regulation of chromatin by histone modifications
-
Bannister, A.J., Kouzarides, T., Regulation of chromatin by histone modifications. Cell Res. 21 (2011), 381–395.
-
(2011)
Cell Res.
, vol.21
, pp. 381-395
-
-
Bannister, A.J.1
Kouzarides, T.2
-
45
-
-
79961023271
-
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
-
McDonald, O.G., et al. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 18 (2011), 867–874.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 867-874
-
-
McDonald, O.G.1
-
46
-
-
84880719085
-
The histone LSD1 demethylase in stemness and cancer transcription programs
-
Amente, S., et al. The histone LSD1 demethylase in stemness and cancer transcription programs. Biochim. Biophys. Acta 1829 (2013), 981–986.
-
(2013)
Biochim. Biophys. Acta
, vol.1829
, pp. 981-986
-
-
Amente, S.1
-
47
-
-
77953107054
-
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
-
Lin, Y., et al. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J. 29 (2010), 1803–1816.
-
(2010)
EMBO J.
, vol.29
, pp. 1803-1816
-
-
Lin, Y.1
-
48
-
-
84984621961
-
Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer
-
Feng, J., et al. Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer. Breast Cancer Res. Treat. 159 (2016), 443–456.
-
(2016)
Breast Cancer Res. Treat.
, vol.159
, pp. 443-456
-
-
Feng, J.1
-
49
-
-
84964837453
-
LSD1-mediated epigenetic modification contributes to ovarian cancer cell migration and invasion
-
Li, Y., et al. LSD1-mediated epigenetic modification contributes to ovarian cancer cell migration and invasion. Oncol. Rep. 35 (2016), 3586–3592.
-
(2016)
Oncol. Rep.
, vol.35
, pp. 3586-3592
-
-
Li, Y.1
-
50
-
-
84879500615
-
Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer
-
Jie, D., et al. Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer. Dig. Dis. Sci. 58 (2013), 1581–1589.
-
(2013)
Dig. Dis. Sci.
, vol.58
, pp. 1581-1589
-
-
Jie, D.1
-
51
-
-
84871956221
-
Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion
-
Ferrari-Amorotti, G., et al. Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion. Cancer Res. 73 (2013), 235–245.
-
(2013)
Cancer Res.
, vol.73
, pp. 235-245
-
-
Ferrari-Amorotti, G.1
-
52
-
-
34247348215
-
Opposing LSD1 complexes function in developmental gene activation and repression programmes
-
882–827
-
Wang, J., et al. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature, 446, 2007 882–827.
-
(2007)
Nature
, vol.446
-
-
Wang, J.1
-
53
-
-
85014942819
-
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia
-
Goossens, S., et al. Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia. Blood 129 (2017), 981–990.
-
(2017)
Blood
, vol.129
, pp. 981-990
-
-
Goossens, S.1
-
54
-
-
41849121175
-
Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex
-
Verstappen, G., et al. Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex. Hum. Mol. Genet. 17 (2008), 1175–1183.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 1175-1183
-
-
Verstappen, G.1
-
55
-
-
79651474948
-
The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
-
Fu, J., et al. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res. 21 (2011), 275–289.
-
(2011)
Cell Res.
, vol.21
, pp. 275-289
-
-
Fu, J.1
-
56
-
-
84979763263
-
Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination
-
Wu, L.M., et al. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat. Neurosci. 19 (2016), 1060–1072.
-
(2016)
Nat. Neurosci.
, vol.19
, pp. 1060-1072
-
-
Wu, L.M.1
-
57
-
-
84930576402
-
Dysfunction of the reciprocal feedback loop between GATA3- and ZEB2-nucleated repression programs contributes to breast cancer metastasis
-
Si, W., et al. Dysfunction of the reciprocal feedback loop between GATA3- and ZEB2-nucleated repression programs contributes to breast cancer metastasis. Cancer Cell 27 (2015), 822–836.
-
(2015)
Cancer Cell
, vol.27
, pp. 822-836
-
-
Si, W.1
-
58
-
-
0346363757
-
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
-
Peinado, H., et al. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 24 (2004), 306–319.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 306-319
-
-
Peinado, H.1
-
59
-
-
84891022708
-
Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1
-
Javaid, S., et al. Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1. Cell Rep. 5 (2013), 1679–1689.
-
(2013)
Cell Rep.
, vol.5
, pp. 1679-1689
-
-
Javaid, S.1
-
60
-
-
84897957021
-
Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells
-
Xiao, W., et al. Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. J. Cell. Mol. Med. 18 (2014), 646–655.
-
(2014)
J. Cell. Mol. Med.
, vol.18
, pp. 646-655
-
-
Xiao, W.1
-
61
-
-
77953743748
-
ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
-
Sanchez-Tillo, E., et al. ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene 29 (2010), 3490–3500.
-
(2010)
Oncogene
, vol.29
, pp. 3490-3500
-
-
Sanchez-Tillo, E.1
-
62
-
-
84880651479
-
SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling
-
Jordan, N.V., et al. SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling. Mol. Cell. Biol. 33 (2013), 3011–3025.
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 3011-3025
-
-
Jordan, N.V.1
-
63
-
-
85006515707
-
Downregulation of Bmi-1 suppresses epithelial mesenchymal transition in melanoma
-
Liu, Y., et al. Downregulation of Bmi-1 suppresses epithelial mesenchymal transition in melanoma. Oncol. Rep. 37 (2017), 139–146.
-
(2017)
Oncol. Rep.
, vol.37
, pp. 139-146
-
-
Liu, Y.1
-
64
-
-
84986878113
-
Bmi-1 promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin
-
Zhang, Z., et al. Bmi-1 promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin. Int. J. Mol. Med. 38 (2016), 1199–1207.
-
(2016)
Int. J. Mol. Med.
, vol.38
, pp. 1199-1207
-
-
Zhang, Z.1
-
65
-
-
84922594763
-
Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog
-
Paranjape, A.N., et al. Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog. BMC Cancer, 14, 2014, 785.
-
(2014)
BMC Cancer
, vol.14
, pp. 785
-
-
Paranjape, A.N.1
-
66
-
-
84938093618
-
Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma
-
Liu, K., et al. Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma. Int. J. Mol. Med. 36 (2015), 783–791.
-
(2015)
Int. J. Mol. Med.
, vol.36
, pp. 783-791
-
-
Liu, K.1
-
67
-
-
84899532574
-
Is density of neighbourhood restaurants associated with BMI in rural Chinese adults? A longitudinal study from the China Health and Nutrition Survey
-
Du, W., et al. Is density of neighbourhood restaurants associated with BMI in rural Chinese adults? A longitudinal study from the China Health and Nutrition Survey. BMJ Open, 4, 2014, e004528.
-
(2014)
BMJ Open
, vol.4
-
-
Du, W.1
-
68
-
-
84908349815
-
EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-beta
-
Oktyabri, D., et al. EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-beta. Biochem. Biophys. Res. Commun. 453 (2014), 124–130.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.453
, pp. 124-130
-
-
Oktyabri, D.1
-
69
-
-
84919917039
-
JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines
-
Tange, S., et al. JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. PLoS One, 9, 2014, e115684.
-
(2014)
PLoS One
, vol.9
-
-
Tange, S.1
-
70
-
-
77956547097
-
Loss of miR-200 inhibition of Suz12 leads to Polycomb-mediated repression required for the formation and maintenance of cancer stem cells
-
Iliopoulos, D., et al. Loss of miR-200 inhibition of Suz12 leads to Polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol. Cell 39 (2010), 761–772.
-
(2010)
Mol. Cell
, vol.39
, pp. 761-772
-
-
Iliopoulos, D.1
-
71
-
-
84922496665
-
Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development
-
Tien, C.L., et al. Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development. Development 142 (2015), 722–731.
-
(2015)
Development
, vol.142
, pp. 722-731
-
-
Tien, C.L.1
-
72
-
-
47949125993
-
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor
-
Herranz, N., et al. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol. Cell. Biol. 28 (2008), 4772–4781.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4772-4781
-
-
Herranz, N.1
-
73
-
-
84856533341
-
EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin
-
Tong, Z.T., et al. EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene 31 (2012), 583–594.
-
(2012)
Oncogene
, vol.31
, pp. 583-594
-
-
Tong, Z.T.1
-
74
-
-
85020467572
-
Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition
-
Yang, J., et al. Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. Nat. Microbiol., 2, 2017, 17086.
-
(2017)
Nat. Microbiol.
, vol.2
, pp. 17086
-
-
Yang, J.1
-
75
-
-
77957583439
-
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition
-
Yang, M.H., et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat. Cell Biol. 12 (2010), 982–992.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 982-992
-
-
Yang, M.H.1
-
76
-
-
84905966696
-
Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells
-
Chen, J., et al. Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells. Cancer Res. 74 (2014), 4353–4363.
-
(2014)
Cancer Res.
, vol.74
, pp. 4353-4363
-
-
Chen, J.1
-
77
-
-
72849130207
-
The Polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
-
Song, L.B., et al. The Polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J. Clin. Invest. 119 (2009), 3626–3636.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3626-3636
-
-
Song, L.B.1
-
78
-
-
84894224148
-
The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression
-
Liu, Y., et al. The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression. J. Biol. Chem. 289 (2014), 4116–4125.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 4116-4125
-
-
Liu, Y.1
-
79
-
-
84885393469
-
Transcriptional regulation by Polycomb group proteins
-
Di Croce, L., Helin, K., Transcriptional regulation by Polycomb group proteins. Nat. Struct. Mol. Biol. 20 (2013), 1147–1155.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 1147-1155
-
-
Di Croce, L.1
Helin, K.2
-
80
-
-
81355142141
-
Non-coding RNAs in human disease
-
Esteller, M., Non-coding RNAs in human disease. Nat. Rev. Genet. 12 (2011), 861–874.
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 861-874
-
-
Esteller, M.1
-
81
-
-
84984537201
-
miR-544a induces epithelial-mesenchymal transition through the activation of WNT signaling pathway in gastric cancer
-
Yanaka, Y., et al. miR-544a induces epithelial-mesenchymal transition through the activation of WNT signaling pathway in gastric cancer. Carcinogenesis 36 (2015), 1363–1371.
-
(2015)
Carcinogenesis
, vol.36
, pp. 1363-1371
-
-
Yanaka, Y.1
-
82
-
-
84937960845
-
MicroRNA-21 regulates biological behavior by inducing EMT in human cholangiocarcinoma
-
Liu, Z., et al. MicroRNA-21 regulates biological behavior by inducing EMT in human cholangiocarcinoma. Int. J. Clin. Exp. Pathol. 8 (2015), 4684–4694.
-
(2015)
Int. J. Clin. Exp. Pathol.
, vol.8
, pp. 4684-4694
-
-
Liu, Z.1
-
83
-
-
84892376937
-
A core microRNA signature associated with inducers of the epithelial-to-mesenchymal transition
-
Diaz-Martin, J., et al. A core microRNA signature associated with inducers of the epithelial-to-mesenchymal transition. J. Pathol. 232 (2014), 319–329.
-
(2014)
J. Pathol.
, vol.232
, pp. 319-329
-
-
Diaz-Martin, J.1
-
84
-
-
41649091906
-
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
-
Park, S.M., et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 22 (2008), 894–907.
-
(2008)
Genes Dev.
, vol.22
, pp. 894-907
-
-
Park, S.M.1
-
85
-
-
84055184850
-
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
-
Siemens, H., et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 10 (2011), 4256–4271.
-
(2011)
Cell Cycle
, vol.10
, pp. 4256-4271
-
-
Siemens, H.1
-
86
-
-
84930999448
-
Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma
-
Li, T., et al. Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma. Oncogene 35 (2016), 1575–1584.
-
(2016)
Oncogene
, vol.35
, pp. 1575-1584
-
-
Li, T.1
-
87
-
-
41149112564
-
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition
-
Beltran, M., et al. A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev. 22 (2008), 756–769.
-
(2008)
Genes Dev.
, vol.22
, pp. 756-769
-
-
Beltran, M.1
-
88
-
-
85062189204
-
Long non-coding RNAs as key regulators of cancer metastasis
-
Koirala, P., et al. Long non-coding RNAs as key regulators of cancer metastasis. J. Cancer Metastasis Treat. 2 (2016), 1–10.
-
(2016)
J. Cancer Metastasis Treat.
, vol.2
, pp. 1-10
-
-
Koirala, P.1
-
89
-
-
84979641106
-
The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
-
Battistelli, C., et al. The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition. Oncogene 36 (2016), 942–955.
-
(2016)
Oncogene
, vol.36
, pp. 942-955
-
-
Battistelli, C.1
-
90
-
-
84942857000
-
LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer
-
Liu, Y.W., et al. LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer. Cell Death Dis., 6, 2015, e1802.
-
(2015)
Cell Death Dis.
, vol.6
-
-
Liu, Y.W.1
-
91
-
-
85009273122
-
MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines
-
Terashima, M., et al. MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines. J. Biol. Chem. 292 (2017), 82–99.
-
(2017)
J. Biol. Chem.
, vol.292
, pp. 82-99
-
-
Terashima, M.1
-
92
-
-
84962086887
-
Endogenous microRNA sponges: evidence and controversy
-
Thomson, D.W., Dinger, M.E., Endogenous microRNA sponges: evidence and controversy. Nat. Rev. Genet. 17 (2016), 272–283.
-
(2016)
Nat. Rev. Genet.
, vol.17
, pp. 272-283
-
-
Thomson, D.W.1
Dinger, M.E.2
-
93
-
-
85011095959
-
Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis
-
Xu, Q., et al. Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis. Cell Death Dis., 7, 2016, e2254.
-
(2016)
Cell Death Dis.
, vol.7
-
-
Xu, Q.1
-
94
-
-
84955619540
-
Epithelial-mesenchymal transition: a new target in anticancer drug discovery
-
Marcucci, F., et al. Epithelial-mesenchymal transition: a new target in anticancer drug discovery. Nat. Rev. Drug Discov. 15 (2016), 311–325.
-
(2016)
Nat. Rev. Drug Discov.
, vol.15
, pp. 311-325
-
-
Marcucci, F.1
-
95
-
-
84863247475
-
A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma
-
Chua, K.N., et al. A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma. PLoS One, 7, 2012, e33183.
-
(2012)
PLoS One
, vol.7
-
-
Chua, K.N.1
-
96
-
-
84945144045
-
Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma
-
Chua, K.N., et al. Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma. Oncotarget 6 (2015), 29991–30005.
-
(2015)
Oncotarget
, vol.6
, pp. 29991-30005
-
-
Chua, K.N.1
-
97
-
-
84998854239
-
HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer
-
Rumman, M., et al. HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer. Oncotarget 7 (2016), 78029–78047.
-
(2016)
Oncotarget
, vol.7
, pp. 78029-78047
-
-
Rumman, M.1
-
98
-
-
84939783826
-
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
-
Herbertz, S., et al. Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Des. Dev. Ther. 9 (2015), 4479–4499.
-
(2015)
Drug Des. Dev. Ther.
, vol.9
, pp. 4479-4499
-
-
Herbertz, S.1
-
99
-
-
84874607100
-
TGF-beta inhibition enhances chemotherapy action against triple-negative breast cancer
-
Bhola, N.E., et al. TGF-beta inhibition enhances chemotherapy action against triple-negative breast cancer. J. Clin. Invest. 123 (2013), 1348–1358.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1348-1358
-
-
Bhola, N.E.1
-
100
-
-
0028151343
-
Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
-
Juttermann, R., et al. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl. Acad. Sci. U. S. A. 91 (1994), 11797–11801.
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 11797-11801
-
-
Juttermann, R.1
-
101
-
-
0031964055
-
Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines
-
Bender, C.M., et al. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res. 58 (1998), 95–101.
-
(1998)
Cancer Res.
, vol.58
, pp. 95-101
-
-
Bender, C.M.1
-
102
-
-
52949144622
-
DNA methylation: its role in cancer development and therapy
-
Kurkjian, C., et al. DNA methylation: its role in cancer development and therapy. Curr. Probl. Cancer 32 (2008), 187–235.
-
(2008)
Curr. Probl. Cancer
, vol.32
, pp. 187-235
-
-
Kurkjian, C.1
-
103
-
-
79960391940
-
miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
-
Eades, G., et al. miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J. Biol. Chem. 286 (2011), 25992–26002.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25992-26002
-
-
Eades, G.1
-
104
-
-
84944462954
-
Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma
-
Bi, C., et al. Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma. Oncotarget 6 (2015), 26508–26518.
-
(2015)
Oncotarget
, vol.6
, pp. 26508-26518
-
-
Bi, C.1
-
105
-
-
84935031617
-
Epigenetic control of EMT/MET dynamics: HNF4alpha impacts DNMT3s through miRs-29
-
Cicchini, C., et al. Epigenetic control of EMT/MET dynamics: HNF4alpha impacts DNMT3s through miRs-29. Biochim. Biophys. Acta 1849 (2015), 919–929.
-
(2015)
Biochim. Biophys. Acta
, vol.1849
, pp. 919-929
-
-
Cicchini, C.1
-
106
-
-
84993964748
-
DNMT1 regulates epithelial-mesenchymal transition and cancer stem cells, which promotes prostate cancer metastasis
-
Lee, E., et al. DNMT1 regulates epithelial-mesenchymal transition and cancer stem cells, which promotes prostate cancer metastasis. Neoplasia 18 (2016), 553–566.
-
(2016)
Neoplasia
, vol.18
, pp. 553-566
-
-
Lee, E.1
-
107
-
-
84954053900
-
A histone deacetylase inhibitor suppresses epithelial-mesenchymal transition and attenuates chemoresistance in biliary tract cancer
-
Sakamoto, T., et al. A histone deacetylase inhibitor suppresses epithelial-mesenchymal transition and attenuates chemoresistance in biliary tract cancer. PLoS One, 11, 2016, e0145985.
-
(2016)
PLoS One
, vol.11
-
-
Sakamoto, T.1
-
108
-
-
85069157892
-
An epithelial marker promoter induction screen identifies histone deacetylase inhibitors to restore epithelial differentiation and abolishes anchorage independence growth in cancers
-
Tang, H.M., et al. An epithelial marker promoter induction screen identifies histone deacetylase inhibitors to restore epithelial differentiation and abolishes anchorage independence growth in cancers. Cell Death Discov., 2, 2016, 16041.
-
(2016)
Cell Death Discov.
, vol.2
, pp. 16041
-
-
Tang, H.M.1
-
109
-
-
84927127599
-
HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells
-
Ji, M., et al. HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. Oncol. Rep. 33 (2015), 2299–2308.
-
(2015)
Oncol. Rep.
, vol.33
, pp. 2299-2308
-
-
Ji, M.1
-
110
-
-
84866419172
-
Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells
-
Kong, D., et al. Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells. PLoS One, 7, 2012, e45045.
-
(2012)
PLoS One
, vol.7
-
-
Kong, D.1
-
111
-
-
84908265816
-
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
-
Falkenberg, K.J., Johnstone, R.W., Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat. Rev. Drug Discov. 13 (2014), 673–691.
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 673-691
-
-
Falkenberg, K.J.1
Johnstone, R.W.2
-
112
-
-
51049100212
-
Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition
-
Shan, B., et al. Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. J. Biol. Chem. 283 (2008), 21065–21073.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 21065-21073
-
-
Shan, B.1
-
113
-
-
84981290368
-
Requirement of HDAC6 for activation of Notch1 by TGF-beta1
-
Deskin, B., et al. Requirement of HDAC6 for activation of Notch1 by TGF-beta1. Sci. Rep., 6, 2016, 31086.
-
(2016)
Sci. Rep.
, vol.6
, pp. 31086
-
-
Deskin, B.1
-
114
-
-
85014562239
-
MAP3K4 controls the chromatin modifier HDAC6 during trophoblast stem cell epithelial-to-mesenchymal transition
-
Mobley, R.J., et al. MAP3K4 controls the chromatin modifier HDAC6 during trophoblast stem cell epithelial-to-mesenchymal transition. Cell Rep. 18 (2017), 2387–2400.
-
(2017)
Cell Rep.
, vol.18
, pp. 2387-2400
-
-
Mobley, R.J.1
-
115
-
-
84930181902
-
ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
-
Meidhof, S., et al. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol. Med 7 (2015), 831–847.
-
(2015)
EMBO Mol. Med
, vol.7
, pp. 831-847
-
-
Meidhof, S.1
-
116
-
-
82655179979
-
Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties
-
Wang, J., et al. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res. 71 (2011), 7238–7249.
-
(2011)
Cancer Res.
, vol.71
, pp. 7238-7249
-
-
Wang, J.1
-
117
-
-
84937429405
-
A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC
-
Mohammad, H.P., et al. A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC. Cancer Cell 28 (2015), 57–69.
-
(2015)
Cancer Cell
, vol.28
, pp. 57-69
-
-
Mohammad, H.P.1
-
118
-
-
84964613530
-
Corrigendum: Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer
-
Song, X., et al. Corrigendum: Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer. Sci. Rep., 6, 2016, 24893.
-
(2016)
Sci. Rep.
, vol.6
, pp. 24893
-
-
Song, X.1
-
119
-
-
84964584345
-
Reversing epigenetic mechanisms of drug resistance in solid tumors using targeted microRNA delivery
-
Berman, M., et al. Reversing epigenetic mechanisms of drug resistance in solid tumors using targeted microRNA delivery. Expert Opin. Drug Deliv. 13 (2016), 987–998.
-
(2016)
Expert Opin. Drug Deliv.
, vol.13
, pp. 987-998
-
-
Berman, M.1
-
120
-
-
79960844248
-
Cancer biology and NuRD: a multifaceted chromatin remodelling complex
-
Lai, A.Y., Wade, P.A., Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat. Rev. Cancer 11 (2011), 588–596.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 588-596
-
-
Lai, A.Y.1
Wade, P.A.2
-
121
-
-
68749108259
-
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
-
Wang, Y., et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 138 (2009), 660–672.
-
(2009)
Cell
, vol.138
, pp. 660-672
-
-
Wang, Y.1
-
122
-
-
84914098166
-
Clinical implications of MTA proteins in human cancer
-
Kaur, E., et al. Clinical implications of MTA proteins in human cancer. Cancer Metastasis Rev. 33 (2014), 1017–1024.
-
(2014)
Cancer Metastasis Rev.
, vol.33
, pp. 1017-1024
-
-
Kaur, E.1
-
123
-
-
33646882068
-
Polycomb complexes repress developmental regulators in murine embryonic stem cells
-
Boyer, L.A., et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441 (2006), 349–353.
-
(2006)
Nature
, vol.441
, pp. 349-353
-
-
Boyer, L.A.1
-
124
-
-
33646865180
-
Control of developmental regulators by Polycomb in human embryonic stem cells
-
Lee, T.I., et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125 (2006), 301–313.
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
-
125
-
-
62149122634
-
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
-
Ezhkova, E., et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136 (2009), 1122–1135.
-
(2009)
Cell
, vol.136
, pp. 1122-1135
-
-
Ezhkova, E.1
-
126
-
-
84982867233
-
Polycomb-mediated repression and Sonic hedgehog signaling interact to regulate Merkel cell specification during skin development
-
Perdigoto, C.N., et al. Polycomb-mediated repression and Sonic hedgehog signaling interact to regulate Merkel cell specification during skin development. PLoS Genet., 12, 2016, e1006151.
-
(2016)
PLoS Genet.
, vol.12
-
-
Perdigoto, C.N.1
-
127
-
-
84989966657
-
Deletion of Polycomb repressive complex 2 from mouse intestine causes loss of stem cells
-
e12
-
Koppens, M.A., et al. Deletion of Polycomb repressive complex 2 from mouse intestine causes loss of stem cells. Gastroenterology 151 (2016), 684–697 e12.
-
(2016)
Gastroenterology
, vol.151
, pp. 684-697
-
-
Koppens, M.A.1
-
128
-
-
84993145020
-
PRC2 preserves intestinal progenitors and restricts secretory lineage commitment
-
Chiacchiera, F., et al. PRC2 preserves intestinal progenitors and restricts secretory lineage commitment. EMBO J. 35 (2016), 2301–2314.
-
(2016)
EMBO J.
, vol.35
, pp. 2301-2314
-
-
Chiacchiera, F.1
-
129
-
-
55949124844
-
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
-
Shen, X., et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 32 (2008), 491–502.
-
(2008)
Mol. Cell
, vol.32
, pp. 491-502
-
-
Shen, X.1
-
130
-
-
34248169728
-
The Polycomb group protein Suz12 is required for embryonic stem cell differentiation
-
Pasini, D., et al. The Polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol. Cell. Biol. 27 (2007), 3769–3779.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3769-3779
-
-
Pasini, D.1
-
131
-
-
8144230178
-
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
-
Pasini, D., et al. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23 (2004), 4061–4071.
-
(2004)
EMBO J.
, vol.23
, pp. 4061-4071
-
-
Pasini, D.1
-
132
-
-
84938212774
-
SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin
-
Xia, R., et al. SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin. Tumour Biol. 36 (2015), 5341–5351.
-
(2015)
Tumour Biol.
, vol.36
, pp. 5341-5351
-
-
Xia, R.1
-
133
-
-
84890819884
-
Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition
-
Malouf, G.G., et al. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biol., 14, 2013, R144.
-
(2013)
Genome Biol.
, vol.14
, pp. R144
-
-
Malouf, G.G.1
-
134
-
-
84870876470
-
PRC2/EED-EZH2 complex is up-regulated in breast cancer lymph node metastasis compared to primary tumor and correlates with tumor proliferation in situ
-
Yu, H., et al. PRC2/EED-EZH2 complex is up-regulated in breast cancer lymph node metastasis compared to primary tumor and correlates with tumor proliferation in situ. PLoS One, 7, 2012, e51239.
-
(2012)
PLoS One
, vol.7
-
-
Yu, H.1
-
135
-
-
66249121737
-
AEBP2 as a potential targeting protein for Polycomb repression complex PRC2
-
Kim, H., et al. AEBP2 as a potential targeting protein for Polycomb repression complex PRC2. Nucleic Acids Res. 37 (2009), 2940–2950.
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 2940-2950
-
-
Kim, H.1
-
136
-
-
34648834735
-
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
-
Nekrasov, M., et al. Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J. 26 (2007), 4078–4088.
-
(2007)
EMBO J.
, vol.26
, pp. 4078-4088
-
-
Nekrasov, M.1
-
137
-
-
77949414371
-
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
-
Pasini, D., et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464 (2010), 306–310.
-
(2010)
Nature
, vol.464
, pp. 306-310
-
-
Pasini, D.1
-
138
-
-
77957946398
-
ARID1A mutations in endometriosis-associated ovarian carcinomas
-
Wiegand, K.C., et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N. Engl. J. Med. 363 (2010), 1532–1543.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1532-1543
-
-
Wiegand, K.C.1
-
139
-
-
2642647094
-
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
-
Versteege, I., et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 394 (1998), 203–206.
-
(1998)
Nature
, vol.394
, pp. 203-206
-
-
Versteege, I.1
-
140
-
-
80052271807
-
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
-
Li, M., et al. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat. Genet. 43 (2011), 828–829.
-
(2011)
Nat. Genet.
, vol.43
, pp. 828-829
-
-
Li, M.1
-
141
-
-
84872810488
-
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
-
Shain, A.H., Pollack, J.R., The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS One, 8, 2013, e55119.
-
(2013)
PLoS One
, vol.8
-
-
Shain, A.H.1
Pollack, J.R.2
-
142
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela, I., et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469 (2011), 539–542.
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
-
143
-
-
84871748359
-
Histone demethylase KDM6B promotes epithelial-mesenchymal transition
-
Ramadoss, S., et al. Histone demethylase KDM6B promotes epithelial-mesenchymal transition. J. Biol. Chem. 287 (2012), 44508–44517.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 44508-44517
-
-
Ramadoss, S.1
-
144
-
-
81255147963
-
KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells
-
Pereira, F., et al. KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. Hum. Mol. Genet. 20 (2011), 4655–4665.
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 4655-4665
-
-
Pereira, F.1
-
145
-
-
84879414983
-
The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer
-
Ezponda, T., et al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene 32 (2013), 2882–2890.
-
(2013)
Oncogene
, vol.32
, pp. 2882-2890
-
-
Ezponda, T.1
-
146
-
-
84937837746
-
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression
-
Cho, M.H., et al. DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nat. Commun., 6, 2015, 7821.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7821
-
-
Cho, M.H.1
-
147
-
-
85007418254
-
EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells
-
Cardenas, H., et al. EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells. Oncotarget 7 (2016), 84453–84467.
-
(2016)
Oncotarget
, vol.7
, pp. 84453-84467
-
-
Cardenas, H.1
-
148
-
-
84976614864
-
RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma
-
Zhou, D., et al. RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma. Exp. Mol. Med., 48, 2016, e238.
-
(2016)
Exp. Mol. Med.
, vol.48
, pp. e238
-
-
Zhou, D.1
-
149
-
-
84893172887
-
RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer
-
Wang, S., et al. RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. PLoS One, 8, 2013, e84735.
-
(2013)
PLoS One
, vol.8
, pp. e84735
-
-
Wang, S.1
-
150
-
-
84879738584
-
KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family
-
Enkhbaatar, Z., et al. KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family. Cell Cycle 12 (2013), 2100–2112.
-
(2013)
Cell Cycle
, vol.12
, pp. 2100-2112
-
-
Enkhbaatar, Z.1
-
151
-
-
85027544634
-
Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis
-
Shao, P., et al. Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis. Nucleic Acids Res. 45 (2017), 1687–1702.
-
(2017)
Nucleic Acids Res.
, vol.45
, pp. 1687-1702
-
-
Shao, P.1
-
152
-
-
84951078433
-
KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer
-
Li, S., et al. KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer. Acta Biochim. Biophys. Sin. (Shanghai) 47 (2015), 997–1004.
-
(2015)
Acta Biochim. Biophys. Sin. (Shanghai)
, vol.47
, pp. 997-1004
-
-
Li, S.1
-
153
-
-
84896536423
-
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells
-
Kim, J.H., et al. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res. 74 (2014), 1705–1717.
-
(2014)
Cancer Res.
, vol.74
, pp. 1705-1717
-
-
Kim, J.H.1
-
154
-
-
84942817510
-
UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1
-
Choi, H.J., et al. UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1. EMBO Rep. 16 (2015), 1288–1298.
-
(2015)
EMBO Rep.
, vol.16
, pp. 1288-1298
-
-
Choi, H.J.1
-
155
-
-
84955468768
-
The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1
-
Gao, Y., et al. The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Sci. Rep., 6, 2016, 19874.
-
(2016)
Sci. Rep.
, vol.6
, pp. 19874
-
-
Gao, Y.1
-
156
-
-
77956571712
-
Histone demethylase JmjD2A regulates neural crest specification
-
Strobl-Mazzulla, P.H., et al. Histone demethylase JmjD2A regulates neural crest specification. Dev. Cell 19 (2010), 460–468.
-
(2010)
Dev. Cell
, vol.19
, pp. 460-468
-
-
Strobl-Mazzulla, P.H.1
-
157
-
-
84867901275
-
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
-
Byles, V., et al. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene 31 (2012), 4619–4629.
-
(2012)
Oncogene
, vol.31
, pp. 4619-4629
-
-
Byles, V.1
-
158
-
-
84942847340
-
Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer
-
Liang, Y., et al. Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer. Cancer Res. 75 (2015), 3672–3680.
-
(2015)
Cancer Res.
, vol.75
, pp. 3672-3680
-
-
Liang, Y.1
-
159
-
-
77956629545
-
Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes
-
Kaimori, A., et al. Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. Hepatology 52 (2010), 1033–1045.
-
(2010)
Hepatology
, vol.52
, pp. 1033-1045
-
-
Kaimori, A.1
-
160
-
-
84991251060
-
Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-beta1 in Airway Epithelium
-
Park, I.H., et al. Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-beta1 in Airway Epithelium. PLoS One, 11, 2016, e0162058.
-
(2016)
PLoS One
, vol.11
, pp. e0162058
-
-
Park, I.H.1
-
161
-
-
77956338683
-
Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
-
Lin, T., et al. Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene 29 (2010), 4896–4904.
-
(2010)
Oncogene
, vol.29
, pp. 4896-4904
-
-
Lin, T.1
-
162
-
-
84859731270
-
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
-
Dong, C., et al. G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J. Clin. Invest 122 (2012), 1469–1486.
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1469-1486
-
-
Dong, C.1
-
163
-
-
84855340668
-
SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
-
Yang, F., et al. SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO J. 31 (2012), 110–123.
-
(2012)
EMBO J.
, vol.31
, pp. 110-123
-
-
Yang, F.1
-
164
-
-
84956875874
-
SET8 induces epithelialmesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1
-
Hou, L., et al. SET8 induces epithelialmesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1. Mol. Med. Rep. 13 (2016), 1681–1688.
-
(2016)
Mol. Med. Rep.
, vol.13
, pp. 1681-1688
-
-
Hou, L.1
-
165
-
-
84861309032
-
Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells
-
Cakouros, D., et al. Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells. Mol. Cell. Biol. 32 (2012), 1433–1441.
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 1433-1441
-
-
Cakouros, D.1
-
166
-
-
84927133961
-
G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma
-
Liu, S., et al. G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma. Oncotarget 6 (2015), 6887–6901.
-
(2015)
Oncotarget
, vol.6
, pp. 6887-6901
-
-
Liu, S.1
-
167
-
-
84875220237
-
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer
-
Dong, C., et al. Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene 32 (2013), 1351–1362.
-
(2013)
Oncogene
, vol.32
, pp. 1351-1362
-
-
Dong, C.1
-
168
-
-
0242669199
-
Coordinated histone modifications mediated by a CtBP co-repressor complex
-
Shi, Y., et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422 (2003), 735–738.
-
(2003)
Nature
, vol.422
, pp. 735-738
-
-
Shi, Y.1
-
169
-
-
43249086048
-
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression
-
Hou, Z., et al. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol. Cell. Biol. 28 (2008), 3198–3207.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3198-3207
-
-
Hou, Z.1
-
170
-
-
84930376615
-
MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition
-
Sun, L., et al. MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition. EMBO Rep. 16 (2015), 689–699.
-
(2015)
EMBO Rep.
, vol.16
, pp. 689-699
-
-
Sun, L.1
-
171
-
-
84867398690
-
A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
-
Strobl-Mazzulla, P.H., Bronner, M.E., A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition. J. Cell Biol. 198 (2012), 999–1010.
-
(2012)
J. Cell Biol.
, vol.198
, pp. 999-1010
-
-
Strobl-Mazzulla, P.H.1
Bronner, M.E.2
-
172
-
-
20444469625
-
Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells
-
Tripathi, M.K., et al. Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. J. Biol. Chem. 280 (2005), 17163–17171.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17163-17171
-
-
Tripathi, M.K.1
-
173
-
-
84857055686
-
Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
-
Aghdassi, A., et al. Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. Gut 61 (2012), 439–448.
-
(2012)
Gut
, vol.61
, pp. 439-448
-
-
Aghdassi, A.1
|