-
1
-
-
79952660821
-
Control of the embryonic stem cell state
-
Young R.A. Control of the embryonic stem cell state. Cell 2011, 144:940-954.
-
(2011)
Cell
, vol.144
, pp. 940-954
-
-
Young, R.A.1
-
2
-
-
79958252915
-
Chromatin connections to pluripotency and cellular reprogramming
-
Orkin S.H., Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell 2011, 145:835-850.
-
(2011)
Cell
, vol.145
, pp. 835-850
-
-
Orkin, S.H.1
Hochedlinger, K.2
-
3
-
-
84863621527
-
Cancer epigenetics: from mechanism to therapy
-
Dawson M.A., Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012, 150:12-27.
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
4
-
-
84876152506
-
Epigenetic regulation of human embryonic stem cells
-
Hu Q., Rosenfeld M.G. Epigenetic regulation of human embryonic stem cells. Front. Genet. 2012, 3:238.
-
(2012)
Front. Genet.
, vol.3
, pp. 238
-
-
Hu, Q.1
Rosenfeld, M.G.2
-
5
-
-
84870375316
-
Histone lysine methylation dynamics: establishment, regulation, and biological impact
-
Black J.C., Van Rechem C., Whetstine J.R. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol. Cell 2012, 48:491-507.
-
(2012)
Mol. Cell
, vol.48
, pp. 491-507
-
-
Black, J.C.1
Van Rechem, C.2
Whetstine, J.R.3
-
6
-
-
84859893371
-
Histone methylation: a dynamic mark in health, disease and inheritance
-
Greer E.L., Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat. Rev. Genet. 2012, 13:343-357.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 343-357
-
-
Greer, E.L.1
Shi, Y.2
-
8
-
-
80054787805
-
Targeting histone demethylases: a new avenue for the fight against cancer
-
Rotili D., Mai A. Targeting histone demethylases: a new avenue for the fight against cancer. Genes Cancer 2011, 2:663-679.
-
(2011)
Genes Cancer
, vol.2
, pp. 663-679
-
-
Rotili, D.1
Mai, A.2
-
9
-
-
35349006314
-
Histone lysine demethylases: emerging roles in development, physiology and disease
-
Shi Y. Histone lysine demethylases: emerging roles in development, physiology and disease. Nat. Rev. Genet. 2007, 8:829-833.
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 829-833
-
-
Shi, Y.1
-
11
-
-
80054788317
-
Histone modifiers in cancer: friends or foes?
-
Cohen I., Poreba E., Kamieniarz K., Schneider R. Histone modifiers in cancer: friends or foes?. Genes Cancer 2011, 2:631-647.
-
(2011)
Genes Cancer
, vol.2
, pp. 631-647
-
-
Cohen, I.1
Poreba, E.2
Kamieniarz, K.3
Schneider, R.4
-
12
-
-
0035794163
-
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1
-
Humphrey G.W., Wang Y., Russanova V.R., Hirai T., Qin J., Nakatani Y., Howard B.H. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J. Biol. Chem. 2001, 276:6817-6824.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6817-6824
-
-
Humphrey, G.W.1
Wang, Y.2
Russanova, V.R.3
Hirai, T.4
Qin, J.5
Nakatani, Y.6
Howard, B.H.7
-
13
-
-
0242669199
-
Coordinated histone modifications mediated by a CtBP co-repressor complex
-
Shi Y., Sawada J., Sui G., Affar el B., Whetstine J.R., Lan F., Ogawa H., Luke M.P., Nakatani Y. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 2003, 422:735-738.
-
(2003)
Nature
, vol.422
, pp. 735-738
-
-
Shi, Y.1
Sawada, J.2
Sui, G.3
Affar El, B.4
Whetstine, J.R.5
Lan, F.6
Ogawa, H.7
Luke, M.P.8
Nakatani, Y.9
-
14
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi Y., Lan F., Matson C., Mulligan P., Whetstine J.R., Cole P.A., Casero R.A. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004, 119:941-953.
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
Lan, F.2
Matson, C.3
Mulligan, P.4
Whetstine, J.R.5
Cole, P.A.6
Casero, R.A.7
-
15
-
-
67650522886
-
A novel mammalian flavin-dependent histone demethylase
-
Karytinos A., Forneris F., Profumo A., Ciossani G., Battaglioli E., Binda C., Mattevi A. A novel mammalian flavin-dependent histone demethylase. J. Biol. Chem. 2009, 284:17775-17782.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 17775-17782
-
-
Karytinos, A.1
Forneris, F.2
Profumo, A.3
Ciossani, G.4
Battaglioli, E.5
Binda, C.6
Mattevi, A.7
-
16
-
-
34250891702
-
Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1
-
Opel M., Lando D., Bonilla C., Trewick S.C., Boukaba A., Walfridsson J., Cauwood J., Werler P.J., Carr A.M., Kouzarides T., Murzina N.V., Allshire R.C., Ekwall K., Laue E.D. Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1. PLoS One 2007, 2:e386.
-
(2007)
PLoS One
, vol.2
-
-
Opel, M.1
Lando, D.2
Bonilla, C.3
Trewick, S.C.4
Boukaba, A.5
Walfridsson, J.6
Cauwood, J.7
Werler, P.J.8
Carr, A.M.9
Kouzarides, T.10
Murzina, N.V.11
Allshire, R.C.12
Ekwall, K.13
Laue, E.D.14
-
17
-
-
34147162969
-
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3
-
Rudolph T., Yonezawa M., Lein S., Heidrich K., Kubicek S., Schafer C., Phalke S., Walther M., Schmidt A., Jenuwein T., Reuter G. Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol. Cell 2007, 26:103-115.
-
(2007)
Mol. Cell
, vol.26
, pp. 103-115
-
-
Rudolph, T.1
Yonezawa, M.2
Lein, S.3
Heidrich, K.4
Kubicek, S.5
Schafer, C.6
Phalke, S.7
Walther, M.8
Schmidt, A.9
Jenuwein, T.10
Reuter, G.11
-
18
-
-
16344368814
-
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process
-
Forneris F., Binda C., Vanoni M.A., Mattevi A., Battaglioli E. Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett. 2005, 579:2203-2207.
-
(2005)
FEBS Lett.
, vol.579
, pp. 2203-2207
-
-
Forneris, F.1
Binda, C.2
Vanoni, M.A.3
Mattevi, A.4
Battaglioli, E.5
-
19
-
-
41549132495
-
LSD1: oxidative chemistry for multifaceted functions in chromatin regulation
-
Forneris F., Binda C., Battaglioli E., Mattevi A. LSD1: oxidative chemistry for multifaceted functions in chromatin regulation. Trends Biochem. Sci. 2008, 33:181-189.
-
(2008)
Trends Biochem. Sci.
, vol.33
, pp. 181-189
-
-
Forneris, F.1
Binda, C.2
Battaglioli, E.3
Mattevi, A.4
-
20
-
-
44649163849
-
Mechanisms involved in the regulation of histone lysine demethylases
-
Lan F., Nottke A.C., Shi Y. Mechanisms involved in the regulation of histone lysine demethylases. Curr. Opin. Cell Biol. 2008, 20:316-325.
-
(2008)
Curr. Opin. Cell Biol.
, vol.20
, pp. 316-325
-
-
Lan, F.1
Nottke, A.C.2
Shi, Y.3
-
21
-
-
29244455626
-
Human histone demethylase LSD1 reads the histone code
-
Forneris F., Binda C., Vanoni M.A., Battaglioli E., Mattevi A. Human histone demethylase LSD1 reads the histone code. J. Biol. Chem. 2005, 280:41360-41365.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 41360-41365
-
-
Forneris, F.1
Binda, C.2
Vanoni, M.A.3
Battaglioli, E.4
Mattevi, A.5
-
22
-
-
33748989795
-
Crystal structure of human histone lysine-specific demethylase 1 (LSD1)
-
Chen Y., Yang Y., Wang F., Wan K., Yamane K., Zhang Y., Lei M. Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc. Natl. Acad. Sci. U. S. A. 2006, 103:13956-13961.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 13956-13961
-
-
Chen, Y.1
Yang, Y.2
Wang, F.3
Wan, K.4
Yamane, K.5
Zhang, Y.6
Lei, M.7
-
23
-
-
33745187327
-
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications
-
Lee M.G., Wynder C., Schmidt D.M., McCafferty D.G., Shiekhattar R. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem. Biol. 2006, 13:563-567.
-
(2006)
Chem. Biol.
, vol.13
, pp. 563-567
-
-
Lee, M.G.1
Wynder, C.2
Schmidt, D.M.3
McCafferty, D.G.4
Shiekhattar, R.5
-
24
-
-
77952355653
-
Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2
-
Binda C., Valente S., Romanenghi M., Pilotto S., Cirilli R., Karytinos A., Ciossani G., Botrugno O.A., Forneris F., Tardugno M., Edmondson D.E., Minucci S., Mattevi A., Mai A. Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. J. Am. Chem. Soc. 2010, 132:6827-6833.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 6827-6833
-
-
Binda, C.1
Valente, S.2
Romanenghi, M.3
Pilotto, S.4
Cirilli, R.5
Karytinos, A.6
Ciossani, G.7
Botrugno, O.A.8
Forneris, F.9
Tardugno, M.10
Edmondson, D.E.11
Minucci, S.12
Mattevi, A.13
Mai, A.14
-
25
-
-
77949421463
-
Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
-
Culhane J.C., Wang D., Yen P.M., Cole P.A. Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J. Am. Chem. Soc. 2010, 132.
-
(2010)
J. Am. Chem. Soc.
, vol.132
-
-
Culhane, J.C.1
Wang, D.2
Yen, P.M.3
Cole, P.A.4
-
26
-
-
24144462170
-
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
-
Metzger E., Wissmann M., Yin N., Muller J.M., Schneider R., Peters A.H., Gunther T., Buettner R., Schule R. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 2005, 437:436-439.
-
(2005)
Nature
, vol.437
, pp. 436-439
-
-
Metzger, E.1
Wissmann, M.2
Yin, N.3
Muller, J.M.4
Schneider, R.5
Peters, A.H.6
Gunther, T.7
Buettner, R.8
Schule, R.9
-
27
-
-
33847392500
-
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
-
Wissmann M., Yin N., Muller J.M., Greschik H., Fodor B.D., Jenuwein T., Vogler C., Schneider R., Gunther T., Buettner R., Metzger E., Schule R. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 2007, 9:347-353.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 347-353
-
-
Wissmann, M.1
Yin, N.2
Muller, J.M.3
Greschik, H.4
Fodor, B.D.5
Jenuwein, T.6
Vogler, C.7
Schneider, R.8
Gunther, T.9
Buettner, R.10
Metzger, E.11
Schule, R.12
-
28
-
-
38149045693
-
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression
-
Perillo B., Ombra M.N., Bertoni A., Cuozzo C., Sacchetti S., Sasso A., Chiariotti L., Malorni A., Abbondanza C., Avvedimento E.V. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 2008, 319:202-206.
-
(2008)
Science
, vol.319
, pp. 202-206
-
-
Perillo, B.1
Ombra, M.N.2
Bertoni, A.3
Cuozzo, C.4
Sacchetti, S.5
Sasso, A.6
Chiariotti, L.7
Malorni, A.8
Abbondanza, C.9
Avvedimento, E.V.10
-
29
-
-
33846690407
-
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors
-
Garcia-Bassets I., Kwon Y.S., Telese F., Prefontaine G.G., Hutt K.R., Cheng C.S., Ju B.G., Ohgi K.A., Wang J., Escoubet-Lozach L., Rose D.W., Glass C.K., Fu X.D., Rosenfeld M.G. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell 2007, 128:505-518.
-
(2007)
Cell
, vol.128
, pp. 505-518
-
-
Garcia-Bassets, I.1
Kwon, Y.S.2
Telese, F.3
Prefontaine, G.G.4
Hutt, K.R.5
Cheng, C.S.6
Ju, B.G.7
Ohgi, K.A.8
Wang, J.9
Escoubet-Lozach, L.10
Rose, D.W.11
Glass, C.K.12
Fu, X.D.13
Rosenfeld, M.G.14
-
30
-
-
77950460256
-
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4
-
Metzger E., Imhof A., Patel D., Kahl P., Hoffmeyer K., Friedrichs N., Muller J.M., Greschik H., Kirfel J., Ji S., Kunowska N., Beisenherz-Huss C., Gunther T., Buettner R., Schule R. Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 2010, 464:792-796.
-
(2010)
Nature
, vol.464
, pp. 792-796
-
-
Metzger, E.1
Imhof, A.2
Patel, D.3
Kahl, P.4
Hoffmeyer, K.5
Friedrichs, N.6
Muller, J.M.7
Greschik, H.8
Kirfel, J.9
Ji, S.10
Kunowska, N.11
Beisenherz-Huss, C.12
Gunther, T.13
Buettner, R.14
Schule, R.15
-
31
-
-
77953121401
-
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity
-
Nair S.S., Nair B.C., Cortez V., Chakravarty D., Metzger E., Schule R., Brann D.W., Tekmal R.R., Vadlamudi R.K. PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. EMBO Rep. 2010, 11:438-444.
-
(2010)
EMBO Rep.
, vol.11
, pp. 438-444
-
-
Nair, S.S.1
Nair, B.C.2
Cortez, V.3
Chakravarty, D.4
Metzger, E.5
Schule, R.6
Brann, D.W.7
Tekmal, R.R.8
Vadlamudi, R.K.9
-
32
-
-
77954053278
-
LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription
-
Amente S., Bertoni A., Morano A., Lania L., Avvedimento E.V., Majello B. LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Oncogene 2010, 29:3691-3702.
-
(2010)
Oncogene
, vol.29
, pp. 3691-3702
-
-
Amente, S.1
Bertoni, A.2
Morano, A.3
Lania, L.4
Avvedimento, E.V.5
Majello, B.6
-
33
-
-
77956853780
-
DNA oxidation drives Myc mediated transcription
-
Amente S., Lania L., Avvedimento E.V., Majello B. DNA oxidation drives Myc mediated transcription. Cell Cycle 2010, 9:3002-3004.
-
(2010)
Cell Cycle
, vol.9
, pp. 3002-3004
-
-
Amente, S.1
Lania, L.2
Avvedimento, E.V.3
Majello, B.4
-
34
-
-
80053140577
-
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes
-
Biswas D., Milne T.A., Basrur V., Kim J., Elenitoba-Johnson K.S., Allis C.D., Roeder R.G. Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:15751-15756.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 15751-15756
-
-
Biswas, D.1
Milne, T.A.2
Basrur, V.3
Kim, J.4
Elenitoba-Johnson, K.S.5
Allis, C.D.6
Roeder, R.G.7
-
35
-
-
18744410349
-
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
-
Nakamura T., Mori T., Tada S., Krajewski W., Rozovskaia T., Wassell R., Dubois G., Mazo A., Croce C.M., Canaani E. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol. Cell 2002, 10:1119-1128.
-
(2002)
Mol. Cell
, vol.10
, pp. 1119-1128
-
-
Nakamura, T.1
Mori, T.2
Tada, S.3
Krajewski, W.4
Rozovskaia, T.5
Wassell, R.6
Dubois, G.7
Mazo, A.8
Croce, C.M.9
Canaani, E.10
-
36
-
-
34548513035
-
P53 is regulated by the lysine demethylase LSD1
-
Huang J., Sengupta R., Espejo A.B., Lee M.G., Dorsey J.A., Richter M., Opravil S., Shiekhattar R., Bedford M.T., Jenuwein T., Berger S.L. p53 is regulated by the lysine demethylase LSD1. Nature 2007, 449:105-108.
-
(2007)
Nature
, vol.449
, pp. 105-108
-
-
Huang, J.1
Sengupta, R.2
Espejo, A.B.3
Lee, M.G.4
Dorsey, J.A.5
Richter, M.6
Opravil, S.7
Shiekhattar, R.8
Bedford, M.T.9
Jenuwein, T.10
Berger, S.L.11
-
37
-
-
34447519212
-
The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners
-
Scoumanne A., Chen X. The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners. J. Biol. Chem. 2007, 282:15471-15475.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 15471-15475
-
-
Scoumanne, A.1
Chen, X.2
-
38
-
-
77958485923
-
Cross-talk between post-translational modifications regulate life or death decisions by E2F1
-
Kontaki H., Talianidis I. Cross-talk between post-translational modifications regulate life or death decisions by E2F1. Cell Cycle 2010, 9:3836-3837.
-
(2010)
Cell Cycle
, vol.9
, pp. 3836-3837
-
-
Kontaki, H.1
Talianidis, I.2
-
39
-
-
77954274181
-
Lysine methylation regulates E2F1-induced cell death
-
Kontaki H., Talianidis I. Lysine methylation regulates E2F1-induced cell death. Mol. Cell 2010, 39:152-160.
-
(2010)
Mol. Cell
, vol.39
, pp. 152-160
-
-
Kontaki, H.1
Talianidis, I.2
-
40
-
-
79551519643
-
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells
-
Cho H.S., Suzuki T., Dohmae N., Hayami S., Unoki M., Yoshimatsu M., Toyokawa G., Takawa M., Chen T., Kurash J.K., Field H.I., Ponder B.A., Nakamura Y., Hamamoto R. Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res. 2011, 71:655-660.
-
(2011)
Cancer Res.
, vol.71
, pp. 655-660
-
-
Cho, H.S.1
Suzuki, T.2
Dohmae, N.3
Hayami, S.4
Unoki, M.5
Yoshimatsu, M.6
Toyokawa, G.7
Takawa, M.8
Chen, T.9
Kurash, J.K.10
Field, H.I.11
Ponder, B.A.12
Nakamura, Y.13
Hamamoto, R.14
-
41
-
-
58149156264
-
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
-
Wang J., Hevi S., Kurash J.K., Lei H., Gay F., Bajko J., Su H., Sun W., Chang H., Xu G., Gaudet F., Li E., Chen T. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat. Genet. 2009, 41:125-129.
-
(2009)
Nat. Genet.
, vol.41
, pp. 125-129
-
-
Wang, J.1
Hevi, S.2
Kurash, J.K.3
Lei, H.4
Gay, F.5
Bajko, J.6
Su, H.7
Sun, W.8
Chang, H.9
Xu, G.10
Gaudet, F.11
Li, E.12
Chen, T.13
-
42
-
-
78049357469
-
Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability
-
Foster C.T., Dovey O.M., Lezina L., Luo J.L., Gant T.W., Barlev N., Bradley A., Cowley S.M. Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol. Cell. Biol. 2010, 30:4851-4863.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 4851-4863
-
-
Foster, C.T.1
Dovey, O.M.2
Lezina, L.3
Luo, J.L.4
Gant, T.W.5
Barlev, N.6
Bradley, A.7
Cowley, S.M.8
-
43
-
-
34247394225
-
Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development
-
Di Stefano L., Ji J.Y., Moon N.S., Herr A., Dyson N. Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development. Curr. Biol. 2007, 17:808-812.
-
(2007)
Curr. Biol.
, vol.17
, pp. 808-812
-
-
Di Stefano, L.1
Ji, J.Y.2
Moon, N.S.3
Herr, A.4
Dyson, N.5
-
44
-
-
64249166375
-
A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory
-
Katz D.J., Edwards T.M., Reinke V., Kelly W.G. A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell 2009, 137:308-320.
-
(2009)
Cell
, vol.137
, pp. 308-320
-
-
Katz, D.J.1
Edwards, T.M.2
Reinke, V.3
Kelly, W.G.4
-
45
-
-
34247348215
-
Opposing LSD1 complexes function in developmental gene activation and repression programmes
-
Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine G.G., Krones A., Ohgi K.A., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes F.L., Korach K.S., Glass C.K., Fu X.D., Rosenfeld M.G. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007, 446:882-887.
-
(2007)
Nature
, vol.446
, pp. 882-887
-
-
Wang, J.1
Scully, K.2
Zhu, X.3
Cai, L.4
Zhang, J.5
Prefontaine, G.G.6
Krones, A.7
Ohgi, K.A.8
Zhu, P.9
Garcia-Bassets, I.10
Liu, F.11
Taylor, H.12
Lozach, J.13
Jayes, F.L.14
Korach, K.S.15
Glass, C.K.16
Fu, X.D.17
Rosenfeld, M.G.18
-
46
-
-
77956913456
-
Histone demethylase LSD1 regulates adipogenesis
-
Musri M.M., Carmona C., Hanzu F.A., Kaliman P., Gomis R., Parrizas M. Histone demethylase LSD1 regulates adipogenesis. J. Biol. Chem. 2010, 285:30034-30041.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 30034-30041
-
-
Musri, M.M.1
Carmona, C.2
Hanzu, F.A.3
Kaliman, P.4
Gomis, R.5
Parrizas, M.6
-
47
-
-
77958152990
-
Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors
-
Choi J., Jang H., Kim H., Kim S.T., Cho E.J., Youn H.D. Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem. Biophys. Res. Commun. 2010, 401:327-332.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.401
, pp. 327-332
-
-
Choi, J.1
Jang, H.2
Kim, H.3
Kim, S.T.4
Cho, E.J.5
Youn, H.D.6
-
48
-
-
79961023271
-
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
-
McDonald O.G., Wu H., Timp W., Doi A., Feinberg A.P. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 2011, 18:867-874.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 867-874
-
-
McDonald, O.G.1
Wu, H.2
Timp, W.3
Doi, A.4
Feinberg, A.P.5
-
49
-
-
77956338683
-
Requirement of the histone demethylase LSD1 in Snail1-mediated transcriptional repression during epithelial-mesenchymal transition
-
Lin T., Ponn A., Hu X., Law B.K., Lu J. Requirement of the histone demethylase LSD1 in Snail1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene 2010, 29:4896-4904.
-
(2010)
Oncogene
, vol.29
, pp. 4896-4904
-
-
Lin, T.1
Ponn, A.2
Hu, X.3
Law, B.K.4
Lu, J.5
-
50
-
-
82255191954
-
Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine
-
Kim J., Orkin S.H. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med. 2011, 3:75.
-
(2011)
Genome Med.
, vol.3
, pp. 75
-
-
Kim, J.1
Orkin, S.H.2
-
51
-
-
25144525014
-
Core transcriptional regulatory circuitry in human embryonic stem cells
-
Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., Gifford D.K., Melton D.A., Jaenisch R., Young R.A. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122:947-956.
-
(2005)
Cell
, vol.122
, pp. 947-956
-
-
Boyer, L.A.1
Lee, T.I.2
Cole, M.F.3
Johnstone, S.E.4
Levine, S.S.5
Zucker, J.P.6
Guenther, M.G.7
Kumar, R.M.8
Murray, H.L.9
Jenner, R.G.10
Gifford, D.K.11
Melton, D.A.12
Jaenisch, R.13
Young, R.A.14
-
52
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen X., Xu H., Yuan P., Fang F., Huss M., Vega V.B., Wong E., Orlov Y.L., Zhang W., Jiang J., Loh Y.H., Yeo H.C., Yeo Z.X., Narang V., Govindarajan K.R., Leong B., Shahab A., Ruan Y., Bourque G., Sung W.K., Clarke N.D., Wei C.L., Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008, 133:1106-1117.
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
Vega, V.B.6
Wong, E.7
Orlov, Y.L.8
Zhang, W.9
Jiang, J.10
Loh, Y.H.11
Yeo, H.C.12
Yeo, Z.X.13
Narang, V.14
Govindarajan, K.R.15
Leong, B.16
Shahab, A.17
Ruan, Y.18
Bourque, G.19
Sung, W.K.20
Clarke, N.D.21
Wei, C.L.22
Ng, H.H.23
more..
-
53
-
-
40749104852
-
An extended transcriptional network for pluripotency of embryonic stem cells
-
Kim J., Chu J., Shen X., Wang J., Orkin S.H. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008, 132:1049-1061.
-
(2008)
Cell
, vol.132
, pp. 1049-1061
-
-
Kim, J.1
Chu, J.2
Shen, X.3
Wang, J.4
Orkin, S.H.5
-
54
-
-
33645381936
-
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
-
Loh Y.H., Wu Q., Chew J.L., Vega V.B., Zhang W., Chen X., Bourque G., George J., Leong B., Liu J., Wong K.Y., Sung K.W., Lee C.W., Zhao X.D., Chiu K.P., Lipovich L., Kuznetsov V.A., Robson P., Stanton L.W., Wei C.L., Ruan Y., Lim B., Ng H.H. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 2006, 38:431-440.
-
(2006)
Nat. Genet.
, vol.38
, pp. 431-440
-
-
Loh, Y.H.1
Wu, Q.2
Chew, J.L.3
Vega, V.B.4
Zhang, W.5
Chen, X.6
Bourque, G.7
George, J.8
Leong, B.9
Liu, J.10
Wong, K.Y.11
Sung, K.W.12
Lee, C.W.13
Zhao, X.D.14
Chiu, K.P.15
Lipovich, L.16
Kuznetsov, V.A.17
Robson, P.18
Stanton, L.W.19
Wei, C.L.20
Ruan, Y.21
Lim, B.22
Ng, H.H.23
more..
-
55
-
-
48449084118
-
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
-
Marson A., Levine S.S., Cole M.F., Frampton G.M., Brambrink T., Johnstone S., Guenther M.G., Johnston W.K., Wernig M., Newman J., Calabrese J.M., Dennis L.M., Volkert T.L., Gupta S., Love J., Hannett N., Sharp P.A., Bartel D.P., Jaenisch R., Young R.A. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008, 134:521-533.
-
(2008)
Cell
, vol.134
, pp. 521-533
-
-
Marson, A.1
Levine, S.S.2
Cole, M.F.3
Frampton, G.M.4
Brambrink, T.5
Johnstone, S.6
Guenther, M.G.7
Johnston, W.K.8
Wernig, M.9
Newman, J.10
Calabrese, J.M.11
Dennis, L.M.12
Volkert, T.L.13
Gupta, S.14
Love, J.15
Hannett, N.16
Sharp, P.A.17
Bartel, D.P.18
Jaenisch, R.19
Young, R.A.20
more..
-
56
-
-
0032127977
-
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
-
Niwa H., Burdon T., Chambers I., Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 1998, 12:2048-2060.
-
(1998)
Genes Dev.
, vol.12
, pp. 2048-2060
-
-
Niwa, H.1
Burdon, T.2
Chambers, I.3
Smith, A.4
-
57
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
Sato N., Meijer L., Skaltsounis L., Greengard P., Brivanlou A.H. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 2004, 10:55-63.
-
(2004)
Nat. Med.
, vol.10
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
59
-
-
79957884078
-
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
-
Adamo A., Sese B., Boue S., Castano J., Paramonov I., Barrero M.J., Izpisua Belmonte J.C. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat. Cell Biol. 2011, 13:652-659.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 652-659
-
-
Adamo, A.1
Sese, B.2
Boue, S.3
Castano, J.4
Paramonov, I.5
Barrero, M.J.6
Izpisua Belmonte, J.C.7
-
60
-
-
84856962477
-
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
-
Whyte W.A., Bilodeau S., Orlando D.A., Hoke H.A., Frampton G.M., Foster C.T., Cowley S.M., Young R.A. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature 2012, 482:221-225.
-
(2012)
Nature
, vol.482
, pp. 221-225
-
-
Whyte, W.A.1
Bilodeau, S.2
Orlando, D.A.3
Hoke, H.A.4
Frampton, G.M.5
Foster, C.T.6
Cowley, S.M.7
Young, R.A.8
-
61
-
-
16844364151
-
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
-
Cartwright P., McLean C., Sheppard A., Rivett D., Jones K., Dalton S. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 2005, 132:885-896.
-
(2005)
Development
, vol.132
, pp. 885-896
-
-
Cartwright, P.1
McLean, C.2
Sheppard, A.3
Rivett, D.4
Jones, K.5
Dalton, S.6
-
62
-
-
77954142510
-
Myc maintains embryonic stem cell pluripotency and self-renewal
-
Varlakhanova N.V., Cotterman R.F., deVries W.N., Morgan J., Donahue L.R., Murray S., Knowles B.B., Knoepfler P.S. myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation 2010, 80:9-19.
-
(2010)
Differentiation
, vol.80
, pp. 9-19
-
-
Varlakhanova, N.V.1
Cotterman, R.F.2
deVries, W.N.3
Morgan, J.4
Donahue, L.R.5
Murray, S.6
Knowles, B.B.7
Knoepfler, P.S.8
-
63
-
-
84856770024
-
Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells
-
Neri F., Zippo A., Krepelova A., Cherubini A., Rocchigiani M., Oliviero S. Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells. Mol. Cell. Biol. 2012, 32:840-851.
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 840-851
-
-
Neri, F.1
Zippo, A.2
Krepelova, A.3
Cherubini, A.4
Rocchigiani, M.5
Oliviero, S.6
-
64
-
-
33845762289
-
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
-
Kahl P., Gullotti L., Heukamp L.C., Wolf S., Friedrichs N., Vorreuther R., Solleder G., Bastian P.J., Ellinger J., Metzger E., Schule R., Buettner R. Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res. 2006, 66:11341-11347.
-
(2006)
Cancer Res.
, vol.66
, pp. 11341-11347
-
-
Kahl, P.1
Gullotti, L.2
Heukamp, L.C.3
Wolf, S.4
Friedrichs, N.5
Vorreuther, R.6
Solleder, G.7
Bastian, P.J.8
Ellinger, J.9
Metzger, E.10
Schule, R.11
Buettner, R.12
-
65
-
-
80255137124
-
Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer
-
Kauffman E.C., Robinson B.D., Downes M.J., Powell L.G., Lee M.M., Scherr D.S., Gudas L.J., Mongan N.P. Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. Mol. Carcinog. 2011, 50:931-944.
-
(2011)
Mol. Carcinog.
, vol.50
, pp. 931-944
-
-
Kauffman, E.C.1
Robinson, B.D.2
Downes, M.J.3
Powell, L.G.4
Lee, M.M.5
Scherr, D.S.6
Gudas, L.J.7
Mongan, N.P.8
-
66
-
-
62449197931
-
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy
-
Schulte J.H., Lim S., Schramm A., Friedrichs N., Koster J., Versteeg R., Ora I., Pajtler K., Klein-Hitpass L., Kuhfittig-Kulle S., Metzger E., Schule R., Eggert A., Buettner R., Kirfel J. Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res. 2009, 69:2065-2071.
-
(2009)
Cancer Res.
, vol.69
, pp. 2065-2071
-
-
Schulte, J.H.1
Lim, S.2
Schramm, A.3
Friedrichs, N.4
Koster, J.5
Versteeg, R.6
Ora, I.7
Pajtler, K.8
Klein-Hitpass, L.9
Kuhfittig-Kulle, S.10
Metzger, E.11
Schule, R.12
Eggert, A.13
Buettner, R.14
Kirfel, J.15
-
67
-
-
84859480637
-
Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer
-
Lv T., Yuan D., Miao X., Lv Y., Zhan P., Shen X., Song Y. Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. PLoS One 2012, 7:e35065.
-
(2012)
PLoS One
, vol.7
-
-
Lv, T.1
Yuan, D.2
Miao, X.3
Lv, Y.4
Zhan, P.5
Shen, X.6
Song, Y.7
-
68
-
-
84892485252
-
Overexpression of LSD1 in hepatocellular carcinoma: a latent target for the diagnosis and therapy of hepatoma
-
Zhao Z.K., Dong P., Gu J., Chen L., Zhuang M., Lu W.J., Wang D.R., Liu Y.B. Overexpression of LSD1 in hepatocellular carcinoma: a latent target for the diagnosis and therapy of hepatoma. Tumour Biol. 2012.
-
(2012)
Tumour Biol.
-
-
Zhao, Z.K.1
Dong, P.2
Gu, J.3
Chen, L.4
Zhuang, M.5
Lu, W.J.6
Wang, D.R.7
Liu, Y.B.8
-
69
-
-
78649815150
-
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
-
Hayami S., Kelly J.D., Cho H.S., Yoshimatsu M., Unoki M., Tsunoda T., Field H.I., Neal D.E., Yamaue H., Ponder B.A., Nakamura Y., Hamamoto R. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int. J. Cancer 2011, 128:574-586.
-
(2011)
Int. J. Cancer
, vol.128
, pp. 574-586
-
-
Hayami, S.1
Kelly, J.D.2
Cho, H.S.3
Yoshimatsu, M.4
Unoki, M.5
Tsunoda, T.6
Field, H.I.7
Neal, D.E.8
Yamaue, H.9
Ponder, B.A.10
Nakamura, Y.11
Hamamoto, R.12
-
70
-
-
84862123313
-
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
-
Harris W.J., Huang X., Lynch J.T., Spencer G.J., Hitchin J.R., Li Y., Ciceri F., Blaser J.G., Greystoke B.F., Jordan A.M., Miller C.J., Ogilvie D.J., Somervaille T.C. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 2012, 21:473-487.
-
(2012)
Cancer Cell
, vol.21
, pp. 473-487
-
-
Harris, W.J.1
Huang, X.2
Lynch, J.T.3
Spencer, G.J.4
Hitchin, J.R.5
Li, Y.6
Ciceri, F.7
Blaser, J.G.8
Greystoke, B.F.9
Jordan, A.M.10
Miller, C.J.11
Ogilvie, D.J.12
Somervaille, T.C.13
-
71
-
-
84862777766
-
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
-
Schenk T., Chen W.C., Gollner S., Howell L., Jin L., Hebestreit K., Klein H.U., Popescu A.C., Burnett A., Mills K., Casero R.A., Marton L., Woster P., Minden M.D., Dugas M., Wang J.C., Dick J.E., Muller-Tidow C., Petrie K., Zelent A. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat. Med. 2012, 18:605-611.
-
(2012)
Nat. Med.
, vol.18
, pp. 605-611
-
-
Schenk, T.1
Chen, W.C.2
Gollner, S.3
Howell, L.4
Jin, L.5
Hebestreit, K.6
Klein, H.U.7
Popescu, A.C.8
Burnett, A.9
Mills, K.10
Casero, R.A.11
Marton, L.12
Woster, P.13
Minden, M.D.14
Dugas, M.15
Wang, J.C.16
Dick, J.E.17
Muller-Tidow, C.18
Petrie, K.19
Zelent, A.20
more..
-
72
-
-
84887603245
-
Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential
-
Vu L.P., Luciani L., Nimer S.D. Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential. Int. J. Hematol. 2013.
-
(2013)
Int. J. Hematol.
-
-
Vu, L.P.1
Luciani, L.2
Nimer, S.D.3
-
73
-
-
84859867217
-
Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML
-
Lokken A.A., Zeleznik-Le N.J. Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML. Cancer Cell 2012, 21:451-453.
-
(2012)
Cancer Cell
, vol.21
, pp. 451-453
-
-
Lokken, A.A.1
Zeleznik-Le, N.J.2
-
74
-
-
80555129351
-
Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think
-
Lobry C., Oh P., Aifantis I. Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J. Exp. Med. 2011, 208:1931-1935.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1931-1935
-
-
Lobry, C.1
Oh, P.2
Aifantis, I.3
-
75
-
-
84869096429
-
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function
-
Yatim A., Benne C., Sobhian B., Laurent-Chabalier S., Deas O., Judde J.G., Lelievre J.D., Levy Y., Benkirane M. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol. Cell 2012, 48:445-458.
-
(2012)
Mol. Cell
, vol.48
, pp. 445-458
-
-
Yatim, A.1
Benne, C.2
Sobhian, B.3
Laurent-Chabalier, S.4
Deas, O.5
Judde, J.G.6
Lelievre, J.D.7
Levy, Y.8
Benkirane, M.9
-
76
-
-
67649834041
-
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
-
Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. USA 2009, 106:10141-10146.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 10141-10146
-
-
Hu, X.1
Li, X.2
Valverde, K.3
Fu, X.4
Noguchi, C.5
Qiu, Y.6
Huang, S.7
-
77
-
-
84870506589
-
Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis
-
Li Y., Deng C., Hu X., Patel B., Fu X., Qiu Y., Brand M., Zhao K., Huang S. Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis. Oncogene 2012, 31:5007-5018.
-
(2012)
Oncogene
, vol.31
, pp. 5007-5018
-
-
Li, Y.1
Deng, C.2
Hu, X.3
Patel, B.4
Fu, X.5
Qiu, Y.6
Brand, M.7
Zhao, K.8
Huang, S.9
|