The polycomb group protein Suz12 is required for embryonic stem cell differentiation

Molecular and Cellular Biology

Volumn 27, Issue 10, 2007, Pages 3769-3779

  Pasini, Diego ^a   Bracken, Adrian P ^a   Hansen, Jacob B ^a   Capillo, Manuela ^b,c   Helin, Kristian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; SUZ12 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; FEMALE; GENE; GENE EXPRESSION; GENE REPRESSION; GENETIC VARIABILITY; MALE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE CULTURE; TRANSCRIPTION INITIATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONES; HOMEODOMAIN PROTEINS; LYSINE; METHYLATION; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; NEURONS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 34248169728     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01432-06     Document Type: Article

References (35)

1. Birve, A., A. K. Sengupta, D. Beuchle, J. Larsson, J. A. Kennison, A. Rasmuson-Lestander, and J. Muller. 2001. Su(z) 12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development 128:3371-3379.
2. Boiani, M., and H. R. Scholer. 2005. Regulatory networks in embryo-derived pluripotent stem cells. Nat. Rev. Mol. Cell. Biol. 6:872-884.
3. Boyer, L. A., T. I. Lee, M. F. Cole, S. E. Johnstone, S. S. Levine, J. P. Zucker, M. G. Guenther, R. M. Kumar, H. L. Murray, R. G. Jenner, D. K. Gifford, D. A. Melton, R. Jaenisch, and R. A. Young. 2005. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947-956.
4. Boyer, L. A., K. Plath, J. Zeitlinger, T. Brambrink, L. A. Medeiros, T. I. Lee, S. S. Levine, M. Wernig, A. Tajonar, M. K. Ray, G. W. Bell, A. P. Otte, M. Vidal, D. K. Gifford, R. A. Young, and R. Jaenisch. 2006. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441:349-353.
5. Bracken, A. P., N. Dietrich, D. Pasini, K. H. Hansen, and K. Helin. 2006. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20:1123-1136.
6. Bracken, A. P., D. Pasini, M. Capra, E. Prosperini, E. Colli, and K. Helin. 2003. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 22:5323-5335.
7. Cao, R., Y. Tsukada, and Y. Zhang. 2005. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20:845-854.
8. Cao, R., L. Wang, H. Wang, L. Xia, H. Erdjument-Bromage, P. Tempst, R. S. Jones, and Y. Zhang. 2002. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298:1039-1043.
9. Cao, R., and Y. Zhang. 2004. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15:57-67.
10. Caretti, G., M. Di Padova, B. Micales, G. E. Lyons, and V. Sartorelli. 2004. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 18:2627-2638.
11. Chambers, I., D. Colby, M. Robertson, J. Nichols, S. Lee, S. Tweedie, and A. Smith. 2003. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113:643-655.
12. Czermin, B., R. Melfi, D. McCabe, V. Seitz, A. Imhof, and V. Pirrotta. 2002. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111:185-196.
13. Erhardt, S., I. H. Su, R. Schneider, S. Barton, A. J. Bannister, L. Perez-Burgos, T. Jenuwein, T. Kouzarides, A. Tarakhovsky, and M. A. Surani. 2003. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130:4235-4248.
14. Erlebacher, A., K. A. Price, and L. H. Glimcher. 2004. Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin. Dev. Biol. 275:158-169.
15. Faust, C., K. A. Lawson, N. J. Schork, B. Thiel, and T. Magnuson. 1998. The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development 125:4495-4506.
16. Faust, C., A. Schumacher, B. Holdener, and T. Magnuson. 1995. The eed mutation disrupts anterior mesoderm production in mice. Development 121:273-285.
17. Hay, D. C., L. Sutherland, J. Clark, and T. Burdon. 2004. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells 22:225-235.
18. Keller, G. M. 1995. In vitro differentiation of embryonic stem cells. Curr. Opin. Cell Biol. 7:862-869.
19. Kuzmichev, A., K. Nishioka, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 2002. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16:2893-2905.
20. LaJeunesse, D., and A. Shearn. 1996. E(z): a polycomb group gene or a trithorax group gene? Development 122:2189-2197.
21. Lee, T. I., R. G. Jenner, L. A. Boyer, M. G. Guenther, S. S. Levine, R. M. Kumar, B. Chevalier, S. E. Johnstone, M. F. Cole, K. Isono, H. Koseki, T. Fuchikami, K. Abe, H. L. Murray, J. P. Zucker, B. Yuan, G. W. Bell, E. Herbolsheimer, N. M. Hannett, K. Sun, D. T. Odom, A. P. Otte, T. L. Volkert, D. P. Bartel, D. A. Melton, D. K. Gifford, R. Jaenisch, and R. A. Young. 2006. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125:301-313.
22. Lin, W., and S. Y. Dent. 2006. Functions of histone-modifying enzymes in development. Curr. Opin. Genet. Dev. 16:137-142.
23. Loh, Y. H., Q. Wu, J. L. Chew, V. B. Vega, W. Zhang, X. Chen, G. Bourque, J. George, B. Leong, J. Liu, K. Y. Wong, K. W. Sung, C. W. Lee, X. D. Zhao, K. P. Chiu, L. Lipovich, V. A. Kuznetsov, P. Robson, L. W. Stanton, C. L. Wei, Y. Ruan, B. Lim, and H. H. Ng. 2006. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38:431-440.
24. Magae, J., C. L. Wu, S. Illenye, E. Harlow, and N. H. Heintz. 1996. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J. Cell Sci. 109:1717-1726.
25. Mitsui, K., Y. Tokuzawa, H. Itoh, K. Segawa, M. Murakami, K. Takahashi, M. Maruyama, M. Maeda, and S. Yamanaka. 2003. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631-642.
26. Montgomery, N. D., D. Yee, A. Chen, S. Kalantry, S. J. Chamberlain, A. P. Otte, and T. Magnuson. 2005. The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr. Biol. 15:942-947.
27. Morin-Kensicki, E. M., C. Faust, C. LaMantia, and T. Magnuson. 2001. Cell and tissue requirements for the gene eed during mouse gastrulation and organogenesis. Genesis 31:142-146.
28. Muller, J., C. M. Hart, N. J. Francis, M. L. Vargas, A. Sengupta, B. Wild, E. L. Miller, M. B. O'Connor, R. E. Kingston, and J. A. Simon. 2002. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111:197-208.
29. Niwa, H., J. Miyazaki, and A. G. Smith. 2000. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24:372-376.
30. O'Carroll, D., S. Erhardt, M. Pagani, S. C. Barton, M. A. Surani, and T. Jenuwein. 2001. The polycomb-group gene Ezh2 is required for early mouse development. Mol. Cell. Biol. 21:4330-4336.
31. Okamoto, I., A. P. Otte, C. D. Allis, D. Reinberg, and E. Heard. 2004. Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303:644-649.
32. Pasini, D., A. P. Bracken, M. R. Jensen, E. L. Denchi, and K. Helin. 2004. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23:4061-4071.
33. Perez-Burgos, L., A. H. Peters, S. Opravil, M. Kauer, K. Mechtler, and T. Jenuwein. 2004. Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol. 376:234-254.
34. Struhl, G. 1981. A gene product required for correct initiation of segmental determination in Drosophila. Nature 293:36-41.
35. Voncken, J. W., D. Schweizer, L. Aagaard, L. Sattler, M. F. Jantsch, and M. van Lohuizen. 1999. Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status. J. Cell Sci. 112:4627-4639.