Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

Gastroenterology

Volumn 151, Issue 4, 2016, Pages 684-697.e12

  Koppens, Martijn A J ^a   Bounova, Gergana ^a   Gargiulo, Gaetano ^a   Tanger, Ellen ^a   Janssen, Hans ^a   Cornelissen Steijger, Paulien ^a   Blom, Marleen ^a   Song, Ji Ying ^a   Wessels, Lodewyk F A ^a,b,c   van Lohuizen, Maarten ^a,c  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c Cancer Genomics Centre Netherlands ^*  (Netherlands)

Author keywords

Development; ISC; PRC1; Small Intestine

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; NOTCH RECEPTOR; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR EZH2; WNT PROTEIN; EED PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CELL ISOLATION; CELL LOSS; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; CRYPT CELL; DATA ANALYSIS; GENE EXPRESSION; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINAL STEM CELL; INTESTINE CRYPT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SECRETORY CELL; WESTERN BLOTTING; WNT SIGNALING PATHWAY; ADULT STEM CELL; ANIMAL; CELL LINEAGE; CYTOLOGY; DEFICIENCY; GENETICS; INTESTINE; KNOCKOUT MOUSE; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ADULT STEM CELLS; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; INTESTINES; MICE; MICE, KNOCKOUT; POLYCOMB REPRESSIVE COMPLEX 2; WNT SIGNALING PATHWAY;

EID: 84989966657     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.06.020     Document Type: Article

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