메뉴 건너뛰기




Volumn 1849, Issue 8, 2015, Pages 919-929

Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29

Author keywords

De novo DNA methylation; Epithelial mesenchymal transition; Hepatocyte; MiR 29; TGF

Indexed keywords

DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MICRORNA 29; MICRORNA 29A; MICRORNA 29B; TRANSFORMING GROWTH FACTOR BETA; DNA (CYTOSINE 5) METHYLTRANSFERASE; HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, MOUSE; MICRORNA; MIRN29 MICRORNA, MOUSE;

EID: 84935031617     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2015.05.005     Document Type: Article
Times cited : (59)

References (34)
  • 1
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    • Acloque H., Adams M.S., Fishwick K., et al. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J. Clin. Invest. 2009 Jun, 119(6):1438-1449.
    • (2009) J. Clin. Invest. , vol.119 , Issue.6 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3
  • 2
    • 0037007175 scopus 로고    scopus 로고
    • Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases
    • Jeltsch A. Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases. Chembiochem 2002 Apr 2, 3(4):274-293.
    • (2002) Chembiochem , vol.3 , Issue.4 , pp. 274-293
    • Jeltsch, A.1
  • 3
    • 0142247187 scopus 로고    scopus 로고
    • Mammalian DNA (cytosine-5) methyltransferases and their expression
    • Pradhan S., Esteve P.O. Mammalian DNA (cytosine-5) methyltransferases and their expression. Clin. Immunol. 2003 Oct, 109(1):6-16.
    • (2003) Clin. Immunol. , vol.109 , Issue.1 , pp. 6-16
    • Pradhan, S.1    Esteve, P.O.2
  • 4
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M., Bell D.W., Haber D.A., et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999 Oct 29, 99(3):247-257.
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3
  • 5
    • 84891826425 scopus 로고    scopus 로고
    • Alterations of epigenetics and microRNA in hepatocellular carcinoma
    • Saito Y., Hibino S., Saito H. Alterations of epigenetics and microRNA in hepatocellular carcinoma. Hepatol. Res. 2014 Jan, 44(1):31-42.
    • (2014) Hepatol. Res. , vol.44 , Issue.1 , pp. 31-42
    • Saito, Y.1    Hibino, S.2    Saito, H.3
  • 6
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y., Kanai Y., Sakamoto M., et al. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 2001 Mar, 33(3):561-568.
    • (2001) Hepatology , vol.33 , Issue.3 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3
  • 7
    • 84874266463 scopus 로고    scopus 로고
    • Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma
    • (Epub 2013 Feb 20)
    • Song M.A., Tiirikainen M., Kwee S., et al. Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. PloS one 2013, 8(2):e55761. (Epub 2013 Feb 20). 10.1371/journal.pone.0055761.
    • (2013) PloS one , vol.8 , Issue.2 , pp. e55761
    • Song, M.A.1    Tiirikainen, M.2    Kwee, S.3
  • 8
    • 84868293073 scopus 로고    scopus 로고
    • MiR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma
    • Ding W., Dang H., You H., et al. miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma. Oncogenesis 2012, 1:e15. 10.1038/oncsis.2012.15.
    • (2012) Oncogenesis , vol.1 , pp. e15
    • Ding, W.1    Dang, H.2    You, H.3
  • 9
    • 84875371295 scopus 로고    scopus 로고
    • 5-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell line HTR8/SVneo
    • Chen Y., Wang K., Leach R. 5-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell line HTR8/SVneo. Biochem. Biophys. Res. Commun. 2013 Mar 1, 432(1):116-122.
    • (2013) Biochem. Biophys. Res. Commun. , vol.432 , Issue.1 , pp. 116-122
    • Chen, Y.1    Wang, K.2    Leach, R.3
  • 10
    • 33644834687 scopus 로고    scopus 로고
    • E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines
    • Lombaerts M., van Wezel T., Philippo K., et al. E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br. J. Cancer 2006 Mar 13, 94(5):661-671.
    • (2006) Br. J. Cancer , vol.94 , Issue.5 , pp. 661-671
    • Lombaerts, M.1    van Wezel, T.2    Philippo, K.3
  • 11
    • 84899572415 scopus 로고    scopus 로고
    • Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer
    • Bedi U., Mishra V.K., Wasilewski D., et al. Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer. Oncotarget 2014 Apr 30, 5(8):2016-2029.
    • (2014) Oncotarget , vol.5 , Issue.8 , pp. 2016-2029
    • Bedi, U.1    Mishra, V.K.2    Wasilewski, D.3
  • 12
    • 84907562669 scopus 로고    scopus 로고
    • A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition
    • Carmona F.J., Davalos V., Vidal E., et al. A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition. Cancer Res. 2014 Oct 1, 74(19):5608-5619.
    • (2014) Cancer Res. , vol.74 , Issue.19 , pp. 5608-5619
    • Carmona, F.J.1    Davalos, V.2    Vidal, E.3
  • 13
    • 0038757830 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis
    • Parviz F., Matullo C., Garrison W.D., et al. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat. Genet. 2003 Jul, 34(3):292-296.
    • (2003) Nat. Genet. , vol.34 , Issue.3 , pp. 292-296
    • Parviz, F.1    Matullo, C.2    Garrison, W.D.3
  • 14
    • 33744795211 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
    • Battle M.A., Konopka G., Parviz F., et al. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc. Natl. Acad. Sci. U. S. A. 2006 May 30, 103(22):8419-8424.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , Issue.22 , pp. 8419-8424
    • Battle, M.A.1    Konopka, G.2    Parviz, F.3
  • 16
    • 79957463762 scopus 로고    scopus 로고
    • The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha
    • Santangelo L., Marchetti A., Cicchini C., et al. The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha. Hepatology 2011 Jun, 53(6):2063-2074.
    • (2011) Hepatology , vol.53 , Issue.6 , pp. 2063-2074
    • Santangelo, L.1    Marchetti, A.2    Cicchini, C.3
  • 17
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M., Garzon R., Cimmino A., et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. U. S. A. 2007 Oct 2, 104(40):15805-15810.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.40 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 18
    • 0031032004 scopus 로고    scopus 로고
    • Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes
    • Amicone L., Spagnoli F.M., Spath G., et al. Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J. 1997 Feb 3, 16(3):495-503.
    • (1997) EMBO J. , vol.16 , Issue.3 , pp. 495-503
    • Amicone, L.1    Spagnoli, F.M.2    Spath, G.3
  • 19
    • 33748279836 scopus 로고    scopus 로고
    • Snail controls differentiation of hepatocytes by repressing HNF4alpha expression
    • Cicchini C., Filippini D., Coen S., et al. Snail controls differentiation of hepatocytes by repressing HNF4alpha expression. J. Cell. Physiol. 2006 Oct, 209(1):230-238.
    • (2006) J. Cell. Physiol. , vol.209 , Issue.1 , pp. 230-238
    • Cicchini, C.1    Filippini, D.2    Coen, S.3
  • 20
    • 84904747598 scopus 로고    scopus 로고
    • Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma
    • Kogure T., Kondo Y., Kazaku E., et al. Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Hepatol. Res. 2014, 44:907-919.
    • (2014) Hepatol. Res. , vol.44 , pp. 907-919
    • Kogure, T.1    Kondo, Y.2    Kazaku, E.3
  • 21
    • 84871194102 scopus 로고    scopus 로고
    • TGFbeta overrides HNF4alpha tumor suppressing activity through GSK3beta inactivation: implication for hepatocellular carcinoma gene therapy
    • Cozzolino A.M., Alonzi T., Santangelo L., et al. TGFbeta overrides HNF4alpha tumor suppressing activity through GSK3beta inactivation: implication for hepatocellular carcinoma gene therapy. J. Hepatol. 2013 Jan, 58(1):65-72.
    • (2013) J. Hepatol. , vol.58 , Issue.1 , pp. 65-72
    • Cozzolino, A.M.1    Alonzi, T.2    Santangelo, L.3
  • 22
    • 0037068379 scopus 로고    scopus 로고
    • 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy
    • Christman J.K. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 2002 Aug 12, 21(35):5483-5495.
    • (2002) Oncogene , vol.21 , Issue.35 , pp. 5483-5495
    • Christman, J.K.1
  • 23
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A., Perez-Moreno M.A., Rodrigo I., et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2000 Feb, 2(2):76-83.
    • (2000) Nat. Cell Biol. , vol.2 , Issue.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3
  • 24
    • 84891022708 scopus 로고    scopus 로고
    • Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1
    • Javaid S., Zhang J., Anderssen E., et al. Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1. Cell Rep. 2013 Dec 26, 5(6):1679-1689.
    • (2013) Cell Rep. , vol.5 , Issue.6 , pp. 1679-1689
    • Javaid, S.1    Zhang, J.2    Anderssen, E.3
  • 25
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • McDonald O.G., Wu H., Timp W., et al. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 2011 Aug, 18(8):867-874.
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , Issue.8 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3
  • 26
    • 84155173213 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection
    • Wu K.J., Yang M.H. Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection. Biosci. Rep. 2011 Dec, 31(6):449-455.
    • (2011) Biosci. Rep. , vol.31 , Issue.6 , pp. 449-455
    • Wu, K.J.1    Yang, M.H.2
  • 27
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li R., Liang J., Ni S., et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010 Jul 2, 7(1):51-63.
    • (2010) Cell Stem Cell , vol.7 , Issue.1 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3
  • 28
    • 0037621983 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells
    • Chiba H., Gotoh T., Kojima T., et al. Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells. Exp. Cell Res. 2003 Jun 10, 286(2):288-297.
    • (2003) Exp. Cell Res. , vol.286 , Issue.2 , pp. 288-297
    • Chiba, H.1    Gotoh, T.2    Kojima, T.3
  • 29
    • 1842480044 scopus 로고    scopus 로고
    • Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors
    • Lazarevich N.L., Cheremnova O.A., Varga E.V., et al. Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. Hepatology 2004 Apr, 39(4):1038-1047.
    • (2004) Hepatology , vol.39 , Issue.4 , pp. 1038-1047
    • Lazarevich, N.L.1    Cheremnova, O.A.2    Varga, E.V.3
  • 30
    • 0032559647 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells
    • Spath G.F., Weiss M.C. Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells. J. Cell Biol. 1998 Feb 23, 140(4):935-946.
    • (1998) J. Cell Biol. , vol.140 , Issue.4 , pp. 935-946
    • Spath, G.F.1    Weiss, M.C.2
  • 31
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya S., Suzuki A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 2011 Jul 21, 475(7356):390-393.
    • (2011) Nature , vol.475 , Issue.7356 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 32
    • 84887278742 scopus 로고    scopus 로고
    • MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination
    • Lu M., Jolly M.K., Levine H., et al. MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination. Proc. Natl. Acad. Sci. U. S. A. 2013 Nov 5, 110(45):18144-18149.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.45 , pp. 18144-18149
    • Lu, M.1    Jolly, M.K.2    Levine, H.3
  • 33
    • 84860773704 scopus 로고    scopus 로고
    • An epistatic mini-circuitry between the transcription factors Snail and HNF4alpha controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs
    • Garibaldi F., Cicchini C., Conigliaro A., et al. An epistatic mini-circuitry between the transcription factors Snail and HNF4alpha controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs. Cell Death Differ. 2012 Jun, 19(6):937-946.
    • (2012) Cell Death Differ. , vol.19 , Issue.6 , pp. 937-946
    • Garibaldi, F.1    Cicchini, C.2    Conigliaro, A.3
  • 34
    • 84906794809 scopus 로고    scopus 로고
    • Modulation of miR-29 expression by alpha-fetoprotein is linked to the hepatocellular carcinoma epigenome
    • Parpart S., Roessler S., Dong F., et al. Modulation of miR-29 expression by alpha-fetoprotein is linked to the hepatocellular carcinoma epigenome. Hepatology 2014 Sep, 60(3):872-883.
    • (2014) Hepatology , vol.60 , Issue.3 , pp. 872-883
    • Parpart, S.1    Roessler, S.2    Dong, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.