Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

BMC Research Notes

Volumn 3, Issue , 2010, Pages

  Neves, Rui ^a   Scheel, Christina ^b   Weinhold, Sandra ^a   Honisch, Ellen ^a   Iwaniuk, Katharina M ^a   Trompeter, Hans Ingo ^a   Niederacher, Dieter ^a   Wernet, Peter ^a   Santourlidis, Simeon ^a   Uhrberg, Markus ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956243561     PISSN: None     EISSN: 17560500     Source Type: Journal    
DOI: 10.1186/1756-0500-3-219     Document Type: Article

References (32)

1. Epithelial-mesenchymal transitions in tumour progression. JP Thiery, Nat Rev Cancer 2002 2 442 454 10.1038/nrc822 12189386
2. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. SM Park AB Gaur E Lengyel ME Peter, Genes Dev 2008 22 894 907 10.1101/gad.1640608 18381893
3. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. M Korpal ES Lee G Hu Y Kang, J Biol Chem 2008 283 14910 14914 10.1074/jbc.C800074200 18411277
4. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. PA Gregory AG Bert EL Paterson SC Barry A Tsykin G Farshid MA Vadas Y Khew-Goodall GJ Goodall, Nat Cell Biol 2008 10 593 601 10.1038/ncb1722 18376396
5. MicroRNAs: target recognition and regulatory functions. DP Bartel, Cell 2009 136 215 233 10.1016/j.cell.2009.01.002 19167326
6. Oncomirs - microRNAs with a role in cancer. A Esquela-Kerscher FJ Slack, Nat Rev Cancer 2006 6 259 269 10.1038/nrc1840 16557279
7. MicroRNA Expression Profiles in Serous Ovarian Carcinoma. EJ Nam H Yoon SW Kim H Kim YT Kim JH Kim JW Kim S Kim, Clin Cancer Res 2008 14 2690 2695 10.1158/1078-0432.CCR-07-1731 18451233
8. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. DD Taylor C Gercel-Taylor, Gynecol Oncol 2008 110 13 21 10.1016/j.ygyno.2008.04.033 18589210
9. MicroRNA signatures in human ovarian cancer. MV Iorio R Visone G Di Leva V Donati F Petrocca P Casalini C Taccioli S Volinia CG Liu H Alder, et al. Cancer Res 2007 67 8699 8707 10.1158/0008-5472.CAN-07-1936 17875710
10. Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. GJ Hurteau JA Carlson SD Spivack GJ Brock, Cancer Res 2007 67 7972 7976 10.1158/0008-5472.CAN- 07-1058 17804704
11. Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c. C Nakada K Matsuura Y Tsukamoto M Tanigawa T Yoshimoto T Narimatsu LT Nguyen N Hijiya T Uchida F Sato, et al. J Pathol 2008 216 418 427 10.1002/path.2437 18925646
12. E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. M Lombaerts T van Wezel K Philippo JW Dierssen RM Zimmerman J Oosting R van Eijk PH Eilers WB van de CJ Cornelisse, et al. Br J Cancer 2006 94 661 671 16495925
13. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. M Esteller JG Herman, J Pathol 2002 196 1 7 10.1002/path.1024 11748635
14. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. U Wellner J Schubert UC Burk O Schmalhofer F Zhu A Sonntag B Waldvogel C Vannier D Darling HA zur, et al. Nat Cell Biol 2009 11 1487 1495 10.1038/ncb1998 19935649
15. Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. O Saydam Y Shen T Wurdinger O Senol E Boke MF James BA Tannous AO Stemmer-Rachamimov M Yi RM Stephens, et al. Mol Cell Biol 2009 29 5923 5940 10.1128/MCB.00332-09 19703993
16. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. DM Dykxhoorn Y Wu H Xie F Yu A Lal F Petrocca D Martinvalet E Song B Lim J Lieberman, PLoS One 2009 4 7181 10.1371/journal.pone.0007181 19787069
17. MicroRNA-141 Regulates Smad Interacting Protein 1 (SIP1) and Inhibits Migration and Invasion of Colorectal Cancer Cells. M Hu M Xia X Chen Z Lin Y Xu Y Ma L Su, Dig Dis Sci 2009 19830559
18. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. CP Bracken PA Gregory N Kolesnikoff AG Bert J Wang MF Shannon GJ Goodall, Cancer Res 2008 68 7846 7854 10.1158/0008-5472.CAN-08-1942 18829540
19. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. U Burk J Schubert U Wellner O Schmalhofer E Vincan S Spaderna T Brabletz, EMBO Rep 2008 9 582 589 10.1038/embor.2008.74 18483486
20. The role of DNA methylation in mammalian epigenetics. PA Jones D Takai, Science 2001 293 1068 1070 10.1126/science.1063852 11498573
21. Relevance of breast cancer cell lines as models for breast tumours: an update. M Lacroix G Leclercq, Breast Cancer Res Treat 2004 83 249 289 10.1023/B:BREA.0000014042.54925.cc 14758095
22. Genomic analysis of human microRNA transcripts. HK Saini S Griffiths-Jones AJ Enright, Proc Natl Acad Sci USA 2007 104 17719 17724 10.1073/pnas.0703890104 17965236
23. A mammalian microRNA expression atlas based on small RNA library sequencing. P Landgraf M Rusu R Sheridan A Sewer N Iovino A Aravin S Pfeffer A Rice AO Kamphorst M Landthaler, et al. Cell 2007 129 1401 1414 10.1016/j.cell.2007.04.040 17604727
24. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Y Shimono M Zabala RW Cho N Lobo P Dalerba D Qian M Diehn H Liu SP Panula E Chiao, et al. Cell 2009 138 592 603 10.1016/j.cell.2009.07.011 19665978
25. Cellular differentiation, cytidine analogs and DNA methylation. PA Jones SM Taylor, Cell 1980 20 85 93 10.1016/0092-8674(80)90237-8 6156004
26. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. K Yoshiura Y Kanai A Ochiai Y Shimoyama T Sugimura S Hirohashi, Proc Natl Acad Sci USA 1995 92 7416 7419 10.1073/pnas.92.16.7416 7543680
27. Characterization of epithelial phenotypes in mortal and immortal human breast cells. TM Paine HD Soule RJ Pauley PJ Dawson, Int J Cancer 1992 50 463 473 10.1002/ijc.2910500323 1370949
28. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. J Yang SA Mani JL Donaher S Ramaswamy RA Itzykson C Come P Savagner I Gitelman A Richardson RA Weinberg, Cell 2004 117 927 939 10.1016/j.cell.2004.06.006 15210113
29. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells. L Vrba TJ Jensen JC Garbe RL Heimark AE Cress S Dickinson MR Stampfer BW Futscher, PLoS One 2010 5 8697 10.1371/journal.pone.0008697 20084174
30. ZEB represses transcription through interaction with the corepressor CtBP. AA Postigo DC Dean, Proc Natl Acad Sci USA 1999 96 6683 6688 10.1073/pnas.96.12.6683 10359772
31. Transcriptional regulation by C-terminal binding proteins. G Chinnadurai, Int J Biochem Cell Biol 2007 39 1593 1607 10.1016/j.biocel.2007.01.025 17336131
32. The Polycomb group protein EZH2 directly controls DNA methylation. E Vire C Brenner R Deplus L Blanchon M Fraga C Didelot L Morey A Van Eynde D Bernard JM Vanderwinden, et al. Nature 2006 439 871 874 10.1038/nature04431 16357870