메뉴 건너뛰기




Volumn 32, Issue 5, 2008, Pages 187-235

DNA Methylation: Its Role in Cancer Development and Therapy

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZA 001; AZACITIDINE; BIOLOGICAL MARKER; BUSULFAN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; FAZARABINE; FLUCYTOSINE DEOXYRIBOSIDE; IMATINIB; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; ZEBULARINE;

EID: 52949144622     PISSN: 01470272     EISSN: 15356345     Source Type: Journal    
DOI: 10.1016/j.currproblcancer.2008.08.002     Document Type: Article
Times cited : (66)

References (256)
  • 1
    • 0035328527 scopus 로고    scopus 로고
    • Accelerated age-related CpG island methylation in ulcerative colitis
    • Issa J.P., Ahuja N., Toyota M., Bronner M.P., and Brentnall T.A. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res 61 (2001) 3573-3577
    • (2001) Cancer Res , vol.61 , pp. 3573-3577
    • Issa, J.P.1    Ahuja, N.2    Toyota, M.3    Bronner, M.P.4    Brentnall, T.A.5
  • 2
    • 0035852729 scopus 로고    scopus 로고
    • Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors
    • Henderson J.P., Byun J., Williams M.V., McCormick M.L., Parks W.C., Ridnour L.A., et al. Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors. Proc Natl Acad Sci U S A 98 (2001) 1631-1636
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1631-1636
    • Henderson, J.P.1    Byun, J.2    Williams, M.V.3    McCormick, M.L.4    Parks, W.C.5    Ridnour, L.A.6
  • 3
    • 0030777056 scopus 로고    scopus 로고
    • Hypochlorous acid-induced base modifications in isolated calf thymus DNA
    • Whiteman M., Jenner A., and Halliwell B. Hypochlorous acid-induced base modifications in isolated calf thymus DNA. Chem Res Toxicol 10 (1997) 1240-1246
    • (1997) Chem Res Toxicol , vol.10 , pp. 1240-1246
    • Whiteman, M.1    Jenner, A.2    Halliwell, B.3
  • 4
    • 34250860821 scopus 로고    scopus 로고
    • Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers
    • Valinluck V., and Sowers L.C. Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers. Cancer Res 67 (2007) 5583-5586
    • (2007) Cancer Res , vol.67 , pp. 5583-5586
    • Valinluck, V.1    Sowers, L.C.2
  • 5
    • 0025871037 scopus 로고
    • Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation
    • Forman D., Newell D.G., Fullerton F., Yarnell J.W., Stacey A.R., Wald N., et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Br Med J 302 (1991) 1302-1305
    • (1991) Br Med J , vol.302 , pp. 1302-1305
    • Forman, D.1    Newell, D.G.2    Fullerton, F.3    Yarnell, J.W.4    Stacey, A.R.5    Wald, N.6
  • 6
    • 0032957424 scopus 로고    scopus 로고
    • Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study
    • Hansen S., Melby K.K., Aase S., Jellum E., and Vollset S.E. Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. Scand J Gastroenterol 34 (1999) 353-360
    • (1999) Scand J Gastroenterol , vol.34 , pp. 353-360
    • Hansen, S.1    Melby, K.K.2    Aase, S.3    Jellum, E.4    Vollset, S.E.5
  • 9
    • 32944459562 scopus 로고    scopus 로고
    • High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk
    • Maekita T., Nakazawa K., Mihara M., Nakajima T., Yanaoka K., Iguchi M., et al. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 12 (2006) 989-995
    • (2006) Clin Cancer Res , vol.12 , pp. 989-995
    • Maekita, T.1    Nakazawa, K.2    Mihara, M.3    Nakajima, T.4    Yanaoka, K.5    Iguchi, M.6
  • 10
    • 33845999566 scopus 로고    scopus 로고
    • Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer
    • Fuccio L., Zagari R.M., Minardi M.E., and Bazzoli F. Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer. Aliment Pharmacol Ther 25 (2007) 133-141
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 133-141
    • Fuccio, L.1    Zagari, R.M.2    Minardi, M.E.3    Bazzoli, F.4
  • 11
    • 0034583855 scopus 로고    scopus 로고
    • Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression
    • Moayyedi P., Wason C., Peacock R., Walan A., Bardhan K., Axon A.T., et al. Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. Helicobacter 5 (2000) 206-214
    • (2000) Helicobacter , vol.5 , pp. 206-214
    • Moayyedi, P.1    Wason, C.2    Peacock, R.3    Walan, A.4    Bardhan, K.5    Axon, A.T.6
  • 12
    • 0033915780 scopus 로고    scopus 로고
    • Long-term effects of Helicobacter pylori eradication on gastric antral mucosa in duodenal ulcer patients
    • Zerbib F., Lenk C., Sawan B., Cayla R., Broutet N., Carles B., et al. Long-term effects of Helicobacter pylori eradication on gastric antral mucosa in duodenal ulcer patients. Eur J Gastroenterol Hepatol 12 (2000) 719-725
    • (2000) Eur J Gastroenterol Hepatol , vol.12 , pp. 719-725
    • Zerbib, F.1    Lenk, C.2    Sawan, B.3    Cayla, R.4    Broutet, N.5    Carles, B.6
  • 13
    • 34547118090 scopus 로고    scopus 로고
    • Molecular mechanisms of alcohol-mediated carcinogenesis
    • Seitz H.K., and Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7 (2007) 599-612
    • (2007) Nat Rev Cancer , vol.7 , pp. 599-612
    • Seitz, H.K.1    Stickel, F.2
  • 17
    • 0035477897 scopus 로고    scopus 로고
    • Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development
    • Nakagawa H., Nuovo G.J., Zervos E.E., Martin Jr. E.W., Salovaara R., Aaltonen L.A., et al. Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 61 (2001) 6991-6995
    • (2001) Cancer Res , vol.61 , pp. 6991-6995
    • Nakagawa, H.1    Nuovo, G.J.2    Zervos, E.E.3    Martin Jr., E.W.4    Salovaara, R.5    Aaltonen, L.A.6
  • 19
    • 34247172535 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: incidence and survival in the United States
    • Ma X., Does M., Raza A., and Mayne S.T. Myelodysplastic syndromes: incidence and survival in the United States. Cancer 109 (2007) 1536-1542
    • (2007) Cancer , vol.109 , pp. 1536-1542
    • Ma, X.1    Does, M.2    Raza, A.3    Mayne, S.T.4
  • 20
    • 0035862552 scopus 로고    scopus 로고
    • Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)
    • Lai F., Godley L.A., Joslin J., Fernald A.A., Liu J., Espinosa R., et al. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). Genomics 71 (2001) 235-245
    • (2001) Genomics , vol.71 , pp. 235-245
    • Lai, F.1    Godley, L.A.2    Joslin, J.3    Fernald, A.A.4    Liu, J.5    Espinosa, R.6
  • 21
    • 0022617302 scopus 로고
    • Clinical and cytogenetic correlations in 63 patients with therapy- related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7
    • Le Beau M.M., Albain K.S., Larson R.A., Vardiman J.W., Davis E.M., Blough R.R., et al. Clinical and cytogenetic correlations in 63 patients with therapy- related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol 4 (1986) 325-345
    • (1986) J Clin Oncol , vol.4 , pp. 325-345
    • Le Beau, M.M.1    Albain, K.S.2    Larson, R.A.3    Vardiman, J.W.4    Davis, E.M.5    Blough, R.R.6
  • 22
    • 33947218451 scopus 로고    scopus 로고
    • RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis
    • Boumber Y.A., Kondo Y., Chen X., Shen L., Gharibyan V., Konishi K., et al. RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis. Cancer Res. 67 (2007) 1997-2005
    • (2007) Cancer Res. , vol.67 , pp. 1997-2005
    • Boumber, Y.A.1    Kondo, Y.2    Chen, X.3    Shen, L.4    Gharibyan, V.5    Konishi, K.6
  • 23
    • 0032523011 scopus 로고    scopus 로고
    • Methylation of the p15INK4b gene in myelodysplastic syndromes is frequent and acquired during disease progression
    • Quesnel B., Guillerm G., Vereecque R., Wattel E., Preudhomme C., Bauters F., et al. Methylation of the p15INK4b gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood 91 (1998) 2985-2990
    • (1998) Blood , vol.91 , pp. 2985-2990
    • Quesnel, B.1    Guillerm, G.2    Vereecque, R.3    Wattel, E.4    Preudhomme, C.5    Bauters, F.6
  • 24
    • 0035134705 scopus 로고    scopus 로고
    • Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation
    • Tien H.-F., Tang J.-L., Tsay W., Liu M.-C., Lee F.-Y., Wang C.-H., et al. Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation. Br J Haematol 112 (2001) 148-154
    • (2001) Br J Haematol , vol.112 , pp. 148-154
    • Tien, H.-F.1    Tang, J.-L.2    Tsay, W.3    Liu, M.-C.4    Lee, F.-Y.5    Wang, C.-H.6
  • 26
    • 0031025368 scopus 로고    scopus 로고
    • Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
    • Herman J.G., Civin C.I., Issa J.-P.J., Collector M.I., Sharkis S.J., and Baylin S.B. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 57 (1997) 837-841
    • (1997) Cancer Res , vol.57 , pp. 837-841
    • Herman, J.G.1    Civin, C.I.2    Issa, J.-P.J.3    Collector, M.I.4    Sharkis, S.J.5    Baylin, S.B.6
  • 27
    • 0033179375 scopus 로고    scopus 로고
    • Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
    • Melki J.R., Vincent P.C., and Clark S.J. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res 59 (1999) 3730-3740
    • (1999) Cancer Res , vol.59 , pp. 3730-3740
    • Melki, J.R.1    Vincent, P.C.2    Clark, S.J.3
  • 29
    • 2942566395 scopus 로고    scopus 로고
    • Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells
    • Liu Z.-J., Zhang X.-B., Zhang Y., and Yang X. Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells. FEBS Lett 567 (2004) 327-332
    • (2004) FEBS Lett , vol.567 , pp. 327-332
    • Liu, Z.-J.1    Zhang, X.-B.2    Zhang, Y.3    Yang, X.4
  • 30
    • 33750214824 scopus 로고    scopus 로고
    • Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia
    • Scardocci A., Guidi F., D'Alo F., Gumiero D., Fabiani E., Diruscio A., et al. Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia. Br J Cancer 95 (2006) 1108-1113
    • (2006) Br J Cancer , vol.95 , pp. 1108-1113
    • Scardocci, A.1    Guidi, F.2    D'Alo, F.3    Gumiero, D.4    Fabiani, E.5    Diruscio, A.6
  • 32
    • 0035902166 scopus 로고    scopus 로고
    • Cancer genetics
    • Ponder B.A.J. Cancer genetics. Nature 411 (2001) 336-341
    • (2001) Nature , vol.411 , pp. 336-341
    • Ponder, B.A.J.1
  • 35
    • 34447546704 scopus 로고    scopus 로고
    • Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes
    • Roman-Gomez J., Jimenez-Velasco A., Barrios M., Prosper F., Heiniger A., Torres A., et al. Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes. Leuk Lymphoma 48 (2007) 1269-1282
    • (2007) Leuk Lymphoma , vol.48 , pp. 1269-1282
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Barrios, M.3    Prosper, F.4    Heiniger, A.5    Torres, A.6
  • 36
    • 4944236206 scopus 로고    scopus 로고
    • Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia
    • Roman-Gomez J., Jimenez-Velasco A., Castillejo J.A., Agirre X., Barrios M., Navarro S., et al. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood 104 (2004) 2492-2498
    • (2004) Blood , vol.104 , pp. 2492-2498
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Castillejo, J.A.3    Agirre, X.4    Barrios, M.5    Navarro, S.6
  • 37
    • 34047274820 scopus 로고    scopus 로고
    • Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia
    • Taylor K.H., Pena-Hernandez K.E., Davis J.W., Arthur G.L., Duff D.J., Shi H., et al. Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia. Cancer Res 67 (2007) 2617-2625
    • (2007) Cancer Res , vol.67 , pp. 2617-2625
    • Taylor, K.H.1    Pena-Hernandez, K.E.2    Davis, J.W.3    Arthur, G.L.4    Duff, D.J.5    Shi, H.6
  • 38
    • 0037207526 scopus 로고    scopus 로고
    • p14ARF, p15INK4b, and p16INK4a methylation status in chronic myelogenous leukemia
    • Kusy S., Cividin M., Sorel N., Brizard F., Guilhot F., Brizard A., et al. p14ARF, p15INK4b, and p16INK4a methylation status in chronic myelogenous leukemia. Blood 101 (2003) 374-375
    • (2003) Blood , vol.101 , pp. 374-375
    • Kusy, S.1    Cividin, M.2    Sorel, N.3    Brizard, F.4    Guilhot, F.5    Brizard, A.6
  • 39
    • 0028035056 scopus 로고
    • Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia
    • Zion M., Ben-Yehuda D., Avraham A., Cohen O., Wetzler M., Melloul D., et al. Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. Proc Natl Acad Sci U S A 91 (1994) 10722-10726
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10722-10726
    • Zion, M.1    Ben-Yehuda, D.2    Avraham, A.3    Cohen, O.4    Wetzler, M.5    Melloul, D.6
  • 40
    • 0033214222 scopus 로고    scopus 로고
    • ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia
    • Asimakopoulos F.A., Shteper P.J., Krichevsky S., Fibach E., Polliack A., Rachmilewitz E., et al. ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia. Blood 94 (1999) 2452-2460
    • (1999) Blood , vol.94 , pp. 2452-2460
    • Asimakopoulos, F.A.1    Shteper, P.J.2    Krichevsky, S.3    Fibach, E.4    Polliack, A.5    Rachmilewitz, E.6
  • 41
    • 0033559955 scopus 로고    scopus 로고
    • Methylation of the ABL1 promoter in chronic myelogenous leukemia: lack of prognostic significance
    • Issa J.P., Kantarjian H., Mohan A., O'Brien S., Cortes J., Pierce S., et al. Methylation of the ABL1 promoter in chronic myelogenous leukemia: lack of prognostic significance. Blood 93 (1999) 2075-2080
    • (1999) Blood , vol.93 , pp. 2075-2080
    • Issa, J.P.1    Kantarjian, H.2    Mohan, A.3    O'Brien, S.4    Cortes, J.5    Pierce, S.6
  • 42
    • 0034192151 scopus 로고    scopus 로고
    • Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications
    • Nguyen T.T., Mohrbacher A.F., Tsai Y.C., Groffen J., Heisterkamp N., Nichols P.W., et al. Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications. Blood 95 (2000) 2990-2992
    • (2000) Blood , vol.95 , pp. 2990-2992
    • Nguyen, T.T.1    Mohrbacher, A.F.2    Tsai, Y.C.3    Groffen, J.4    Heisterkamp, N.5    Nichols, P.W.6
  • 43
    • 0034657952 scopus 로고    scopus 로고
    • Hypermethylation of E-cadherin in leukemia
    • Melki J.R., Vincent P.C., Brown R.D., and Clark S.J. Hypermethylation of E-cadherin in leukemia. Blood 95 (2000) 3208-3213
    • (2000) Blood , vol.95 , pp. 3208-3213
    • Melki, J.R.1    Vincent, P.C.2    Brown, R.D.3    Clark, S.J.4
  • 44
    • 0031594270 scopus 로고    scopus 로고
    • Hypermethylation of the M27beta (DXS255) locus in chronic B-cell leukaemia
    • Crossen P.E., and Morrison M.J. Hypermethylation of the M27beta (DXS255) locus in chronic B-cell leukaemia. Br J Haematol 100 (1998) 191-193
    • (1998) Br J Haematol , vol.100 , pp. 191-193
    • Crossen, P.E.1    Morrison, M.J.2
  • 45
    • 0037102325 scopus 로고    scopus 로고
    • Restriction landmark genomic scanning for DNA methylation in cancer: past, present, and future applications
    • Rush L.J., and Plass C. Restriction landmark genomic scanning for DNA methylation in cancer: past, present, and future applications. Anal Biochem 307 (2002) 191-201
    • (2002) Anal Biochem , vol.307 , pp. 191-201
    • Rush, L.J.1    Plass, C.2
  • 46
    • 11144356462 scopus 로고    scopus 로고
    • Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets
    • Rush L.J., Raval A., Funchain P., Johnson A.J., Smith L., Lucas D.M., et al. Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets. Cancer Res 64 (2004) 2424-2433
    • (2004) Cancer Res , vol.64 , pp. 2424-2433
    • Rush, L.J.1    Raval, A.2    Funchain, P.3    Johnson, A.J.4    Smith, L.5    Lucas, D.M.6
  • 47
    • 31544469759 scopus 로고    scopus 로고
    • CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia
    • Liu T.-H., Raval A., Chen S.-S., Matkovic J.J., Byrd J.C., and Plass C. CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia. Cancer Res 66 (2006) 653-658
    • (2006) Cancer Res , vol.66 , pp. 653-658
    • Liu, T.-H.1    Raval, A.2    Chen, S.-S.3    Matkovic, J.J.4    Byrd, J.C.5    Plass, C.6
  • 49
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau S.N., Bren G., and Schaid D. Microsatellite instability in cancer of the proximal colon. Science 260 (1993) 816-819
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 50
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman J.G., Umar A., Polyak K., Graff J.R., Ahuja N., Issa J.-P.J., et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 95 (1998) 6870-6875
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3    Graff, J.R.4    Ahuja, N.5    Issa, J.-P.J.6
  • 51
    • 34250639863 scopus 로고    scopus 로고
    • Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR
    • Bettstetter M., Dechant S., Ruemmele P., Grabowski M., Keller G., Holinski-Feder E., et al. Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. Clin Cancer Res 13 (2007) 3221-3228
    • (2007) Clin Cancer Res , vol.13 , pp. 3221-3228
    • Bettstetter, M.1    Dechant, S.2    Ruemmele, P.3    Grabowski, M.4    Keller, G.5    Holinski-Feder, E.6
  • 52
    • 33750536877 scopus 로고    scopus 로고
    • Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers
    • Watanabe T., Kobunai T., Toda E., Yamamoto Y., Kanazawa T., Kazama Y., et al. Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers. Cancer Res 66 (2006) 9804-9808
    • (2006) Cancer Res , vol.66 , pp. 9804-9808
    • Watanabe, T.1    Kobunai, T.2    Toda, E.3    Yamamoto, Y.4    Kanazawa, T.5    Kazama, Y.6
  • 53
    • 85047688675 scopus 로고    scopus 로고
    • Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples
    • Wang Y.C., Lu Y.P., Tseng R.C., Lin R.K., Chang J.W., Chen J.T., et al. Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples. J Clin Invest 111 (2003) 887-895
    • (2003) J Clin Invest , vol.111 , pp. 887-895
    • Wang, Y.C.1    Lu, Y.P.2    Tseng, R.C.3    Lin, R.K.4    Chang, J.W.5    Chen, J.T.6
  • 54
    • 0033871166 scopus 로고    scopus 로고
    • hMLH1 and hMSH2 expression correlates with allelic imbalance on chromosome 3p in non-small cell lung carcinomas
    • Xinarianos G., Liloglou T., Prime W., Maloney P., Callaghan J., Fielding P., et al. hMLH1 and hMSH2 expression correlates with allelic imbalance on chromosome 3p in non-small cell lung carcinomas. Cancer Res 60 (2000) 4216-4221
    • (2000) Cancer Res , vol.60 , pp. 4216-4221
    • Xinarianos, G.1    Liloglou, T.2    Prime, W.3    Maloney, P.4    Callaghan, J.5    Fielding, P.6
  • 55
    • 23044491195 scopus 로고    scopus 로고
    • Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer
    • Hsu H.-S., Wen C.-K., Tang Y.-A., Lin R.-K., Li W.-Y., Hsa W.-H., et al. Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer. Clin Cancer Res 11 (2005) 5410-5416
    • (2005) Clin Cancer Res , vol.11 , pp. 5410-5416
    • Hsu, H.-S.1    Wen, C.-K.2    Tang, Y.-A.3    Lin, R.-K.4    Li, W.-Y.5    Hsa, W.-H.6
  • 56
    • 0033535612 scopus 로고    scopus 로고
    • A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
    • Strathdee G., MacKean M.J., Illand M., and Brown R. A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene 18 (1999) 2335-2341
    • (1999) Oncogene , vol.18 , pp. 2335-2341
    • Strathdee, G.1    MacKean, M.J.2    Illand, M.3    Brown, R.4
  • 57
    • 3042774430 scopus 로고    scopus 로고
    • The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients
    • Gifford G., Paul J., Vasey P.A., Kaye S.B., and Brown R. The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res 10 (2004) 4420-4426
    • (2004) Clin Cancer Res , vol.10 , pp. 4420-4426
    • Gifford, G.1    Paul, J.2    Vasey, P.A.3    Kaye, S.B.4    Brown, R.5
  • 58
    • 28244460828 scopus 로고    scopus 로고
    • BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy
    • Wei M., Grushko T.A., Dignam J., Hagos F., Nanda R., Sveen L., et al. BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. Cancer Res 65 (2005) 10692-10699
    • (2005) Cancer Res , vol.65 , pp. 10692-10699
    • Wei, M.1    Grushko, T.A.2    Dignam, J.3    Hagos, F.4    Nanda, R.5    Sveen, L.6
  • 59
    • 0034307160 scopus 로고    scopus 로고
    • BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study
    • Baldwin R.L., Nemeth E., Tran H., Shvartsman H., Cass I., Narod S., et al. BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res 60 (2000) 5329-5333
    • (2000) Cancer Res , vol.60 , pp. 5329-5333
    • Baldwin, R.L.1    Nemeth, E.2    Tran, H.3    Shvartsman, H.4    Cass, I.5    Narod, S.6
  • 61
    • 1142311552 scopus 로고    scopus 로고
    • Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene
    • Wang C., Horiuchi A., Imai T., Ohira S., Itoh K., Nikaido T., et al. Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene. J Pathol 202 (2004) 215-223
    • (2004) J Pathol , vol.202 , pp. 215-223
    • Wang, C.1    Horiuchi, A.2    Imai, T.3    Ohira, S.4    Itoh, K.5    Nikaido, T.6
  • 62
    • 48249117114 scopus 로고    scopus 로고
    • DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma
    • Seng T.J., Currey N., Cooper W.A., Lee C.S., Chan C., Horvath L., et al. DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Br J Cancer 99 (2008) 375-382
    • (2008) Br J Cancer , vol.99 , pp. 375-382
    • Seng, T.J.1    Currey, N.2    Cooper, W.A.3    Lee, C.S.4    Chan, C.5    Horvath, L.6
  • 63
    • 40849124009 scopus 로고    scopus 로고
    • DNA methylation markers and early recurrence in stage I lung cancer
    • Brock M.V., Hooker C.M., Ota-Machida E., Han Y., Guo M., Ames S., et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 358 (2008) 1118-1128
    • (2008) N Engl J Med , vol.358 , pp. 1118-1128
    • Brock, M.V.1    Hooker, C.M.2    Ota-Machida, E.3    Han, Y.4    Guo, M.5    Ames, S.6
  • 64
    • 33846187641 scopus 로고    scopus 로고
    • Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer
    • Gu J., Berman D., Lu C., et al. Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clin Cancer Res 12 (2006) 7329-7338
    • (2006) Clin Cancer Res , vol.12 , pp. 7329-7338
    • Gu, J.1    Berman, D.2    Lu, C.3
  • 65
    • 0035870282 scopus 로고    scopus 로고
    • p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • Kim D.-H., Nelson H.H., Wiencke J.K., Zheng S., Christiani D.C., Wain J.C., et al. p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res 61 (2001) 3419-3424
    • (2001) Cancer Res , vol.61 , pp. 3419-3424
    • Kim, D.-H.1    Nelson, H.H.2    Wiencke, J.K.3    Zheng, S.4    Christiani, D.C.5    Wain, J.C.6
  • 66
    • 17644414480 scopus 로고    scopus 로고
    • Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer
    • Russo A.L., Thiagalingam A., Pan H., Califano J., Cheng K.-H., Ponte J.F., et al. Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res 11 (2005) 2466-2470
    • (2005) Clin Cancer Res , vol.11 , pp. 2466-2470
    • Russo, A.L.1    Thiagalingam, A.2    Pan, H.3    Califano, J.4    Cheng, K.-H.5    Ponte, J.F.6
  • 67
    • 19744380352 scopus 로고    scopus 로고
    • Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS)
    • Leach M.O., Boggis C.R., Dixon A.K., Easton D.F., Eeles R.A., Evans D.G., et al. Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS). Lancet 365 (2005) 1769-1778
    • (2005) Lancet , vol.365 , pp. 1769-1778
    • Leach, M.O.1    Boggis, C.R.2    Dixon, A.K.3    Easton, D.F.4    Eeles, R.A.5    Evans, D.G.6
  • 70
    • 33645521023 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort
    • Belinsky S.A., Liechty K.C., Gentry F.D., Wolf H.J., Rogers J., Vu K., et al. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res 66 (2006) 3338-3344
    • (2006) Cancer Res , vol.66 , pp. 3338-3344
    • Belinsky, S.A.1    Liechty, K.C.2    Gentry, F.D.3    Wolf, H.J.4    Rogers, J.5    Vu, K.6
  • 72
    • 34247895661 scopus 로고    scopus 로고
    • Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
    • Zhang Y.-J., Wu H.-C., Shen J., Ahsan H., Tsai W.Y., Yang H.-I., et al. Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin Cancer Res 13 (2007) 2378-2384
    • (2007) Clin Cancer Res , vol.13 , pp. 2378-2384
    • Zhang, Y.-J.1    Wu, H.-C.2    Shen, J.3    Ahsan, H.4    Tsai, W.Y.5    Yang, H.-I.6
  • 75
    • 43749094544 scopus 로고    scopus 로고
    • MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients
    • Brandes A.A., Franceschi E., Tosoni A., Blatt V., Pession A., Tallini G., et al. MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients. J Clin Oncol 26 (2008) 2192-2197
    • (2008) J Clin Oncol , vol.26 , pp. 2192-2197
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3    Blatt, V.4    Pession, A.5    Tallini, G.6
  • 76
    • 42949177399 scopus 로고    scopus 로고
    • Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    • Levin B., Lieberman D.A., McFarland B., Smith R.A., Brooks D., Andrews K.S., et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin 58 (2008) 130-160
    • (2008) CA Cancer J Clin , vol.58 , pp. 130-160
    • Levin, B.1    Lieberman, D.A.2    McFarland, B.3    Smith, R.A.4    Brooks, D.5    Andrews, K.S.6
  • 77
    • 33947498117 scopus 로고    scopus 로고
    • Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions
    • Huang Z.H., Li L.H., Yang F., and Wang J.F. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. World J Gastroenterol 13 (2007) 950-954
    • (2007) World J Gastroenterol , vol.13 , pp. 950-954
    • Huang, Z.H.1    Li, L.H.2    Yang, F.3    Wang, J.F.4
  • 78
    • 0037055554 scopus 로고    scopus 로고
    • Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis
    • Lecomte T., Berger A., Zinzindohoue F., Micard S., Landi B., Blons H., et al. Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis. Int J Cancer 100 (2002) 542-548
    • (2002) Int J Cancer , vol.100 , pp. 542-548
    • Lecomte, T.1    Berger, A.2    Zinzindohoue, F.3    Micard, S.4    Landi, B.5    Blons, H.6
  • 80
    • 0036152815 scopus 로고    scopus 로고
    • Detection of aberrant p16 methylation in the serum of colorectal cancer patients
    • Zou H.-Z., Yu B.-M., Wang Z.-W., Sun J.-Y., Cang H., Gao F., et al. Detection of aberrant p16 methylation in the serum of colorectal cancer patients. Clin Cancer Res 8 (2002) 188-191
    • (2002) Clin Cancer Res , vol.8 , pp. 188-191
    • Zou, H.-Z.1    Yu, B.-M.2    Wang, Z.-W.3    Sun, J.-Y.4    Cang, H.5    Gao, F.6
  • 81
    • 0038662810 scopus 로고    scopus 로고
    • Molecular detection of p16 promoter methylation in the serum of recurrent colorectal cancer patients
    • Nakayama H., Hibi K., Takase T., Yamazaki T., Kasai Y., Ito K., et al. Molecular detection of p16 promoter methylation in the serum of recurrent colorectal cancer patients. Int J Cancer 105 (2003) 491-493
    • (2003) Int J Cancer , vol.105 , pp. 491-493
    • Nakayama, H.1    Hibi, K.2    Takase, T.3    Yamazaki, T.4    Kasai, Y.5    Ito, K.6
  • 82
    • 33644878393 scopus 로고    scopus 로고
    • Promoter hypermethylation of p15INK4B. HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients
    • Aggerholm A., Holm M.S., Guldberg P., Olesen L.H., and Hokland P. Promoter hypermethylation of p15INK4B. HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 76 (2006) 23-32
    • (2006) Eur J Haematol , vol.76 , pp. 23-32
    • Aggerholm, A.1    Holm, M.S.2    Guldberg, P.3    Olesen, L.H.4    Hokland, P.5
  • 83
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    • Kantarjian H., Issa J.P., Rosenfeld C.S., Bennett J.M., Albitar M., DiPersio J., et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 106 (2006) 1794-1803
    • (2006) Cancer , vol.106 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3    Bennett, J.M.4    Albitar, M.5    DiPersio, J.6
  • 84
    • 0034016884 scopus 로고    scopus 로고
    • Intensive chemotherapy with idarubicin, ara-C, etoposide, and m-AMSA followed by immunotherapy with interleukin-2 for myelodysplastic syndromes and high-risk acute myeloid leukemia (AML)
    • Ganser A.H.G., Heil G., Seipelt G., Hofmann W., Fischer J.T., Langer W., et al. Intensive chemotherapy with idarubicin, ara-C, etoposide, and m-AMSA followed by immunotherapy with interleukin-2 for myelodysplastic syndromes and high-risk acute myeloid leukemia (AML). Ann Hematol 79 (2000) 30-35
    • (2000) Ann Hematol , vol.79 , pp. 30-35
    • Ganser, A.H.G.1    Heil, G.2    Seipelt, G.3    Hofmann, W.4    Fischer, J.T.5    Langer, W.6
  • 85
    • 0028861053 scopus 로고
    • Intensive chemotherapy for poor prognosis myelodysplasia (MDS) and secondary acute myeloid leukemia (sAML) following MDS of more than 6 months duration. A pilot study by the Leukemia Cooperative Group of the European Organisationi for Research and Treatment in Cancer (EORTC-LCG)
    • de Witte T.M., Suciu S., Peetermans M., Fenaux P., Strijckmans P., Hayat M., et al. Intensive chemotherapy for poor prognosis myelodysplasia (MDS) and secondary acute myeloid leukemia (sAML) following MDS of more than 6 months duration. A pilot study by the Leukemia Cooperative Group of the European Organisationi for Research and Treatment in Cancer (EORTC-LCG). Leukemia 9 (1995) 1805-1811
    • (1995) Leukemia , vol.9 , pp. 1805-1811
    • de Witte, T.M.1    Suciu, S.2    Peetermans, M.3    Fenaux, P.4    Strijckmans, P.5    Hayat, M.6
  • 86
    • 33847082188 scopus 로고    scopus 로고
    • DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia
    • Agrawal S., Unterberg M., Koschmieder S., zur Stadt U., Brunnberg U., Verbeek W., et al. DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia. Cancer Res 67 (2007) 1370-1377
    • (2007) Cancer Res , vol.67 , pp. 1370-1377
    • Agrawal, S.1    Unterberg, M.2    Koschmieder, S.3    zur Stadt, U.4    Brunnberg, U.5    Verbeek, W.6
  • 87
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones P.A., and Taylor S.M. Cellular differentiation, cytidine analogs and DNA methylation. Cell 20 (1980) 85-93
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 88
    • 31344466008 scopus 로고    scopus 로고
    • DNA methylation and gene silencing in cancer
    • (suppl 1).
    • Baylin S.B. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2 (2005) S4-S11 (suppl 1).
    • (2005) Nat Clin Pract Oncol , vol.2
    • Baylin, S.B.1
  • 90
    • 0027154222 scopus 로고
    • Effects of treatment with 5-azacytidine on the in vivo and in vitor hematopoiesis in patienst with myelodysplastic syndromes
    • Silverman L.R., Holland J.F., Weinberg R.S., Alter B.P., Davis R.B., Ellison R.R., et al. Effects of treatment with 5-azacytidine on the in vivo and in vitor hematopoiesis in patienst with myelodysplastic syndromes. Leukemia 7 (1993) 21-29
    • (1993) Leukemia , vol.7 , pp. 21-29
    • Silverman, L.R.1    Holland, J.F.2    Weinberg, R.S.3    Alter, B.P.4    Davis, R.B.5    Ellison, R.R.6
  • 91
    • 0002858015 scopus 로고
    • Azacitidine in myelodysplastic syndromes: CALGB studies 8421 and 8921
    • Silverman L.H.J., Demakos E., et al. Azacitidine in myelodysplastic syndromes: CALGB studies 8421 and 8921. Ann Hematol 68 (1994) A12
    • (1994) Ann Hematol , vol.68
    • Silverman, L.H.J.1    Demakos, E.2
  • 92
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
    • Silverman L.R., Demakos E.P., Peterson B.L., Kornblith A.B., Holland J.C., Odchimar-Reissiq R., et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 20 (2002) 2429-2440
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3    Kornblith, A.B.4    Holland, J.C.5    Odchimar-Reissiq, R.6
  • 93
    • 0037092962 scopus 로고    scopus 로고
    • Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study
    • Kornblith A.B., Herndon II J.E., Silverman L.R., Demakos E.P., Odchimar-Reissig R., Holland J.F., et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol 20 (2002) 2441-2452
    • (2002) J Clin Oncol , vol.20 , pp. 2441-2452
    • Kornblith, A.B.1    Herndon II, J.E.2    Silverman, L.R.3    Demakos, E.P.4    Odchimar-Reissig, R.5    Holland, J.F.6
  • 94
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman L.R., McKenzie D.R., Peterson B.L., Holland J.F., Backstrom J.T., Beach C.L., et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 24 (2006) 3895-3903
    • (2006) J Clin Oncol , vol.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3    Holland, J.F.4    Backstrom, J.T.5    Beach, C.L.6
  • 95
    • 17644404081 scopus 로고    scopus 로고
    • Bioavailability of azacitidine subcutaneous versus intravenous in patients with the myelodysplastic syndromes
    • Marcucci G., Silverman L., Eller M., Lintz L., and Beach C.L. Bioavailability of azacitidine subcutaneous versus intravenous in patients with the myelodysplastic syndromes. J Clin Pharmacol 45 (2005) 597-602
    • (2005) J Clin Pharmacol , vol.45 , pp. 597-602
    • Marcucci, G.1    Silverman, L.2    Eller, M.3    Lintz, L.4    Beach, C.L.5
  • 96
    • 45749095568 scopus 로고    scopus 로고
    • Results of the initial treatment phase of a study of three alternative dosing schedules of azacitidine (Vidaza(R)) in patients with myelodysplastic syndromes (MDS)
    • Lyons R.M., Cosgriff T., Modi S., McIntyre H., Fernando I., Backstrom J., et al. Results of the initial treatment phase of a study of three alternative dosing schedules of azacitidine (Vidaza(R)) in patients with myelodysplastic syndromes (MDS). ASH Annual Meeting Abstr 110 (2007) 819
    • (2007) ASH Annual Meeting Abstr , vol.110 , pp. 819
    • Lyons, R.M.1    Cosgriff, T.2    Modi, S.3    McIntyre, H.4    Fernando, I.5    Backstrom, J.6
  • 97
    • 42049096709 scopus 로고    scopus 로고
    • Azacitidine (AZA) treatment prolongs overall survival (OS) in higher-risk MDS patients compared with conventional care regimens (CCR): results of the AZA-001 Phase III study
    • Fenaux P., Mufti G.J., Santini V., Finelli C., Giagounidis A., et al. Azacitidine (AZA) treatment prolongs overall survival (OS) in higher-risk MDS patients compared with conventional care regimens (CCR): results of the AZA-001 Phase III study. ASH Annual Meeting Abstr 110 (2007) 817
    • (2007) ASH Annual Meeting Abstr , vol.110 , pp. 817
    • Fenaux, P.1    Mufti, G.J.2    Santini, V.3    Finelli, C.4    Giagounidis, A.5
  • 98
    • 33745968917 scopus 로고    scopus 로고
    • Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
    • Cheson B.D., Greenberg P.L., Bennett J.M., Lowenberg B., Wijermans P.W., Nimer S.D., et al. Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 108 (2006) 419-425
    • (2006) Blood , vol.108 , pp. 419-425
    • Cheson, B.D.1    Greenberg, P.L.2    Bennett, J.M.3    Lowenberg, B.4    Wijermans, P.W.5    Nimer, S.D.6
  • 99
    • 54949128600 scopus 로고    scopus 로고
    • Effect of azacitidine on overall survival in higher-risk myelodysplastic syndromes without complete remission
    • List A.F., Fenaux P., Mufti G.J., Hellström-Lindberg E., Gore S., Bennett J.M., et al. Effect of azacitidine on overall survival in higher-risk myelodysplastic syndromes without complete remission. J Clin Oncol 26 (2008) 7006
    • (2008) J Clin Oncol , vol.26 , pp. 7006
    • List, A.F.1    Fenaux, P.2    Mufti, G.J.3    Hellström-Lindberg, E.4    Gore, S.5    Bennett, J.M.6
  • 101
    • 0023009744 scopus 로고
    • Induction failures in childhood acute nonlymphocytic leukemia: etoposide/5-azacytidine for cases refractory to daunorubicin/cytarabine
    • Kalwinsky D.K., Dahl G.V., Mirro J., Jackson C.W., and Look A.T. Induction failures in childhood acute nonlymphocytic leukemia: etoposide/5-azacytidine for cases refractory to daunorubicin/cytarabine. Med Pediatr Oncol 14 (1986) 245-250
    • (1986) Med Pediatr Oncol , vol.14 , pp. 245-250
    • Kalwinsky, D.K.1    Dahl, G.V.2    Mirro, J.3    Jackson, C.W.4    Look, A.T.5
  • 102
    • 0029963320 scopus 로고    scopus 로고
    • Therapy of refractory or recurrent childhood acute myeloid leukemia using amsacrine and etoposide with or without azacitidine: a Pediatric Oncology Group randomized phase II study
    • Steuber C.P., Krischer J., Holbrook T., Camitta B., Land V., Sexauer C., et al. Therapy of refractory or recurrent childhood acute myeloid leukemia using amsacrine and etoposide with or without azacitidine: a Pediatric Oncology Group randomized phase II study. J Clin Oncol 14 (1996) 1521-1525
    • (1996) J Clin Oncol , vol.14 , pp. 1521-1525
    • Steuber, C.P.1    Krischer, J.2    Holbrook, T.3    Camitta, B.4    Land, V.5    Sexauer, C.6
  • 103
  • 104
    • 65549151070 scopus 로고    scopus 로고
    • 5-Azacitidine induces hematologic responses in a high proportion of patients with acute myeloid leukaemia refractory to or not eligible for intensive chemotherapy
    • Al-Ali H.K., Schwind S., Becker C., Mueller C., and Niederwieser D. 5-Azacitidine induces hematologic responses in a high proportion of patients with acute myeloid leukaemia refractory to or not eligible for intensive chemotherapy. ASH Annual Meeting Abstr 108 (2006) 1953
    • (2006) ASH Annual Meeting Abstr , vol.108 , pp. 1953
    • Al-Ali, H.K.1    Schwind, S.2    Becker, C.3    Mueller, C.4    Niederwieser, D.5
  • 105
    • 52949095590 scopus 로고    scopus 로고
    • 5-Azacitidine therapy in elderly patients with acute myelogenous leukemia yields similar survival compared to 3+7 induction chemotherapy with less transfusional support, bacteremias, and hospital days
    • Goldberg S.L., Hsu J.W., Orr A.R., Rowley S.D., Donato M.L., McKiernan P., et al. 5-Azacitidine therapy in elderly patients with acute myelogenous leukemia yields similar survival compared to 3+7 induction chemotherapy with less transfusional support, bacteremias, and hospital days. ASH Annual Meeting Abstr 108 (2006) 4569
    • (2006) ASH Annual Meeting Abstr , vol.108 , pp. 4569
    • Goldberg, S.L.1    Hsu, J.W.2    Orr, A.R.3    Rowley, S.D.4    Donato, M.L.5    McKiernan, P.6
  • 106
    • 52949154499 scopus 로고    scopus 로고
    • Azacitidine plus gemtuzumab ozogamicin (GO): a novel combination in the treatment of acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS) in the elderly
    • Nand S., Godwin J., Smith S., Barton K., Germano E., and Stiff P. Azacitidine plus gemtuzumab ozogamicin (GO): a novel combination in the treatment of acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS) in the elderly. ASH Annual Meeting Abstr 108 (2006) 1981
    • (2006) ASH Annual Meeting Abstr , vol.108 , pp. 1981
    • Nand, S.1    Godwin, J.2    Smith, S.3    Barton, K.4    Germano, E.5    Stiff, P.6
  • 109
    • 52949106305 scopus 로고    scopus 로고
    • A phase IIa study of a sequential regimen using azacitidine to reverse platinum resistance to carboplatin in patients with platinum resistant or refractory epithelial ovarian cancer
    • Bast R.C.L.R., and Hu W. A phase IIa study of a sequential regimen using azacitidine to reverse platinum resistance to carboplatin in patients with platinum resistant or refractory epithelial ovarian cancer. J Clin Oncol 26 (2008) 3500
    • (2008) J Clin Oncol , vol.26 , pp. 3500
    • Bast, R.C.L.R.1    Hu, W.2
  • 110
    • 0032403081 scopus 로고    scopus 로고
    • Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells
    • Jarrard D.F., Kinoshita H., Shi Y., Sandefur C., Hoff D., Meisner L.F., et al. Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells. Cancer Res 58 (1998) 5310-5314
    • (1998) Cancer Res , vol.58 , pp. 5310-5314
    • Jarrard, D.F.1    Kinoshita, H.2    Shi, Y.3    Sandefur, C.4    Hoff, D.5    Meisner, L.F.6
  • 111
    • 52949136114 scopus 로고    scopus 로고
    • Azacitidine for castration-resistant prostate cancer progressing on combined androgen blockade
    • Sonpavde G.A.A., Delaune R., Garbo L.E., Rousey R.E., Weinstein R.E., et al. Azacitidine for castration-resistant prostate cancer progressing on combined androgen blockade. J Clin Oncol 26 (2008) 5172
    • (2008) J Clin Oncol , vol.26 , pp. 5172
    • Sonpavde, G.A.A.1    Delaune, R.2    Garbo, L.E.3    Rousey, R.E.4    Weinstein, R.E.5
  • 112
    • 29144517352 scopus 로고    scopus 로고
    • Decitabine: a historical review of the development of an epigenetic drug
    • de Vos D., and van Overveld W. Decitabine: a historical review of the development of an epigenetic drug. Ann Hematol 84 suppl 1 (2005) 3-8
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 1 , pp. 3-8
    • de Vos, D.1    van Overveld, W.2
  • 113
    • 0000929806 scopus 로고
    • Synthesis of 2′-deoxy-D-ribofuranosyl-5-azacytosine
    • Pliml J.S.F. Synthesis of 2′-deoxy-D-ribofuranosyl-5-azacytosine. Coll Czeck Chem Commun 29 (1964) 2576-2577
    • (1964) Coll Czeck Chem Commun , vol.29 , pp. 2576-2577
    • Pliml, J.S.F.1
  • 114
    • 0030985018 scopus 로고    scopus 로고
    • Continuous infusion of low-dose 5-Aza-2′-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome
    • Wijermans P.W., Krulder J.W., Huijgens P.C., and Neve P. Continuous infusion of low-dose 5-Aza-2′-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome. Leukemia 11 (1997) 1-5
    • (1997) Leukemia , vol.11 , pp. 1-5
    • Wijermans, P.W.1    Krulder, J.W.2    Huijgens, P.C.3    Neve, P.4
  • 115
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients
    • Wijermans P., Lubbert M., Verhoef G., Bosly A., Ravoet C., Andre M., et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 18 (2000) 956-962
    • (2000) J Clin Oncol , vol.18 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3    Bosly, A.4    Ravoet, C.5    Andre, M.6
  • 116
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa J.P., Garcia-Manero G., Giles F.J., Mannari R., Thomas D., Faderl S., et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 103 (2004) 1635-1640
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3    Mannari, R.4    Thomas, D.5    Faderl, S.6
  • 117
    • 33846011361 scopus 로고    scopus 로고
    • Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    • Kantarjian H., Oki Y., Garcia-Manero G., et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 109 (2007) 52-57
    • (2007) Blood , vol.109 , pp. 52-57
    • Kantarjian, H.1    Oki, Y.2    Garcia-Manero, G.3
  • 118
    • 33646051586 scopus 로고    scopus 로고
    • Superiority of prolonged low-dose azanucleoside administration?. Results of 5-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients
    • Ruter B., Wijermans P.W., and Lubbert M. Superiority of prolonged low-dose azanucleoside administration?. Results of 5-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients. Cancer 106 (2006) 1744-1750
    • (2006) Cancer , vol.106 , pp. 1744-1750
    • Ruter, B.1    Wijermans, P.W.2    Lubbert, M.3
  • 119
    • 42049097308 scopus 로고    scopus 로고
    • Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine
    • Borthakur G., Ahdab S.E., Ravandi F., Faderl S., Ferrajoli A., Newman B., et al. Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. Leuk Lymphoma 49 (2008) 690-695
    • (2008) Leuk Lymphoma , vol.49 , pp. 690-695
    • Borthakur, G.1    Ahdab, S.E.2    Ravandi, F.3    Faderl, S.4    Ferrajoli, A.5    Newman, B.6
  • 120
    • 0022303520 scopus 로고
    • Clinical trial on 5-AZA-2′-deoxycytidine in patients with acute leukemia
    • Momparler R.L., Rivard G.E., and Gyger M. Clinical trial on 5-AZA-2′-deoxycytidine in patients with acute leukemia. Pharmacol Ther 30 (1985) 277-286
    • (1985) Pharmacol Ther , vol.30 , pp. 277-286
    • Momparler, R.L.1    Rivard, G.E.2    Gyger, M.3
  • 121
    • 0034940793 scopus 로고    scopus 로고
    • Decitabine with allogeneic peripheral blood stem cell transplantation in the therapy of leukemia relapse following a prior transplant: results of a phase I study
    • Ravandi F., Kantarjian H., Cohen A., Davis M., O'Brien S., Anderlini P., et al. Decitabine with allogeneic peripheral blood stem cell transplantation in the therapy of leukemia relapse following a prior transplant: results of a phase I study. Bone Marrow Transplant 27 (2001) 1221-1225
    • (2001) Bone Marrow Transplant , vol.27 , pp. 1221-1225
    • Ravandi, F.1    Kantarjian, H.2    Cohen, A.3    Davis, M.4    O'Brien, S.5    Anderlini, P.6
  • 122
    • 0344211845 scopus 로고    scopus 로고
    • Long-term follow-up of a phase I study of high-dose decitabine, busulfan, and cyclophosphamide plus allogeneic transplantation for the treatment of patients with leukemias
    • de Lima M., Ravandi F., Shahjahan M., Andersson B., Couriel D., Donato M., et al. Long-term follow-up of a phase I study of high-dose decitabine, busulfan, and cyclophosphamide plus allogeneic transplantation for the treatment of patients with leukemias. Cancer 97 (2003) 1242-1247
    • (2003) Cancer , vol.97 , pp. 1242-1247
    • de Lima, M.1    Ravandi, F.2    Shahjahan, M.3    Andersson, B.4    Couriel, D.5    Donato, M.6
  • 123
    • 16944363756 scopus 로고    scopus 로고
    • Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia
    • Kantarjian H.M., O'Brien S.M., Keating M., Bennett J.M., Albitar M., DiPersio J., et al. Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia. Leukemia 11 (1997) 1617-1620
    • (1997) Leukemia , vol.11 , pp. 1617-1620
    • Kantarjian, H.M.1    O'Brien, S.M.2    Keating, M.3    Bennett, J.M.4    Albitar, M.5    DiPersio, J.6
  • 124
    • 0037962005 scopus 로고    scopus 로고
    • Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia
    • Kantarjian H.M., O'Brien S., Cortes J., Giles F.J., Faderl S., Issa J.P., et al. Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia. Cancer 98 (2003) 522-528
    • (2003) Cancer , vol.98 , pp. 522-528
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.3    Giles, F.J.4    Faderl, S.5    Issa, J.P.6
  • 125
    • 21244431605 scopus 로고    scopus 로고
    • Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
    • Issa J.-P.J., Gharibyan V., Cortes J., Jelinek J., Morris G., Verstovsek S., et al. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 23 (2005) 3948-3956
    • (2005) J Clin Oncol , vol.23 , pp. 3948-3956
    • Issa, J.-P.J.1    Gharibyan, V.2    Cortes, J.3    Jelinek, J.4    Morris, G.5    Verstovsek, S.6
  • 126
    • 9144271748 scopus 로고    scopus 로고
    • In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines
    • La Rosee P., Johnson K., Corbin A.S., Stoffregen E.P., Moseson E.M., Willis S., et al. In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines. Blood 103 (2004) 208-215
    • (2004) Blood , vol.103 , pp. 208-215
    • La Rosee, P.1    Johnson, K.2    Corbin, A.S.3    Stoffregen, E.P.4    Moseson, E.M.5    Willis, S.6
  • 127
    • 33847395041 scopus 로고    scopus 로고
    • Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia
    • Oki Y., Kantarjian H.M., Gharibyan V., Jones D., O'Brien S., Verstovsek S., et al. Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia. Cancer 109 (2007) 899-906
    • (2007) Cancer , vol.109 , pp. 899-906
    • Oki, Y.1    Kantarjian, H.M.2    Gharibyan, V.3    Jones, D.4    O'Brien, S.5    Verstovsek, S.6
  • 128
    • 0022501789 scopus 로고
    • Phase I and pharmacokinetic study of 5-Aza-2′-deoxycytidine (NSC 127716) in cancer patients
    • van Groeningen C.J., Leyva A., O'Brien A.M.P., Gall H.E., and Pinedo H.M. Phase I and pharmacokinetic study of 5-Aza-2′-deoxycytidine (NSC 127716) in cancer patients. Cancer Res 46 (1986) 4831-4836
    • (1986) Cancer Res , vol.46 , pp. 4831-4836
    • van Groeningen, C.J.1    Leyva, A.2    O'Brien, A.M.P.3    Gall, H.E.4    Pinedo, H.M.5
  • 129
    • 0023573963 scopus 로고
    • The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas
    • Abele R., Clavel M., Dodion P., Bruntsch U., Gundersen S., Smyth J., et al. The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas. Eur J Cancer Clin Oncol 23 (1987) 1921-1924
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1921-1924
    • Abele, R.1    Clavel, M.2    Dodion, P.3    Bruntsch, U.4    Gundersen, S.5    Smyth, J.6
  • 130
    • 0026572102 scopus 로고
    • 5-Aza-2′-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer. Phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group
    • Clavel M., Monfardini S., Fossa S., Smyth J., Renard J., and Kaye S.B. 5-Aza-2′-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer. Phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group. Ann Oncol 3 (1992) 399-400
    • (1992) Ann Oncol , vol.3 , pp. 399-400
    • Clavel, M.1    Monfardini, S.2    Fossa, S.3    Smyth, J.4    Renard, J.5    Kaye, S.B.6
  • 131
    • 0025355878 scopus 로고
    • Phase II study of 5-aza-2′-deoxycytidine in advanced ovarian carcinoma. The EORTC Early Clinical Trials Group
    • Sessa C., ten Bokkel Huinink W., Stoter G., Renard J., and Cavalli F. Phase II study of 5-aza-2′-deoxycytidine in advanced ovarian carcinoma. The EORTC Early Clinical Trials Group. Eur J Cancer 26 (1990) 137-138
    • (1990) Eur J Cancer , vol.26 , pp. 137-138
    • Sessa, C.1    ten Bokkel Huinink, W.2    Stoter, G.3    Renard, J.4    Cavalli, F.5
  • 132
    • 0031945210 scopus 로고    scopus 로고
    • A phase II study of 5-aza-2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
    • Thibault A., Figg W.D., Bergan R.C., Lush R.M., Myers C.E., Tompkins A., et al. A phase II study of 5-aza-2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori 84 (1998) 87-89
    • (1998) Tumori , vol.84 , pp. 87-89
    • Thibault, A.1    Figg, W.D.2    Bergan, R.C.3    Lush, R.M.4    Myers, C.E.5    Tompkins, A.6
  • 133
    • 0030974771 scopus 로고    scopus 로고
    • Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer
    • Momparler R.L., Bouffard D.Y., Momparler L.F., Dionne J., Belanger K., and Ayoub J. Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anticancer Drugs 8 (1997) 358-368
    • (1997) Anticancer Drugs , vol.8 , pp. 358-368
    • Momparler, R.L.1    Bouffard, D.Y.2    Momparler, L.F.3    Dionne, J.4    Belanger, K.5    Ayoub, J.6
  • 134
    • 0026598056 scopus 로고
    • Studies on the mechanism of the synergistic interaction between 2′-deoxy-5-azacytidine and cisplatin
    • Abbruzzese J.L., and Frost P. Studies on the mechanism of the synergistic interaction between 2′-deoxy-5-azacytidine and cisplatin. Cancer Chemother Pharmacol 30 (1992) 31-36
    • (1992) Cancer Chemother Pharmacol , vol.30 , pp. 31-36
    • Abbruzzese, J.L.1    Frost, P.2
  • 135
    • 0028179981 scopus 로고
    • Modulation of cisplatin resistance by 2′-deoxy-5-azacytidine in human ovarian tumor cell lines
    • Lenzi R., Frost P., and Abbruzzese J.L. Modulation of cisplatin resistance by 2′-deoxy-5-azacytidine in human ovarian tumor cell lines. Anticancer Res 14 (1994) 247-251
    • (1994) Anticancer Res , vol.14 , pp. 247-251
    • Lenzi, R.1    Frost, P.2    Abbruzzese, J.L.3
  • 136
    • 0034106513 scopus 로고    scopus 로고
    • A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer
    • Schwartsmann G., Schunemann H., Gorini C.N., Filho A.F., Garbino C., Sabini G., et al. A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer. Invest New Drugs 18 (2000) 83-91
    • (2000) Invest New Drugs , vol.18 , pp. 83-91
    • Schwartsmann, G.1    Schunemann, H.2    Gorini, C.N.3    Filho, A.F.4    Garbino, C.5    Sabini, G.6
  • 138
    • 21244449980 scopus 로고    scopus 로고
    • Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation
    • Samlowski W.E., Leachman S.A., Wade M., Cassidy P., Porter-Gill P., Busby L., et al. Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation. J Clin Oncol 23 (2005) 3897-3905
    • (2005) J Clin Oncol , vol.23 , pp. 3897-3905
    • Samlowski, W.E.1    Leachman, S.A.2    Wade, M.3    Cassidy, P.4    Porter-Gill, P.5    Busby, L.6
  • 139
    • 33750326078 scopus 로고    scopus 로고
    • Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura
    • Schrump D.S., Fischette M.R., Nguyen D.M., Zhao M., Li X., Kunst T.F., et al. Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura. Clin Cancer Res 12 (2006) 5777-5785
    • (2006) Clin Cancer Res , vol.12 , pp. 5777-5785
    • Schrump, D.S.1    Fischette, M.R.2    Nguyen, D.M.3    Zhao, M.4    Li, X.5    Kunst, T.F.6
  • 140
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A., Herman J.G., Mao L., Lee D.J., Gabrielson E., Burger P.C., et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1 (1995) 686-692
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6
  • 141
    • 2642673605 scopus 로고    scopus 로고
    • A survey of the humoral immune response of cancer patients to a panel of human tumor antigens
    • Stockert E., Jager E., Chen Y.T., Scanlan M.J., Gout I., Karbach J., et al. A survey of the humoral immune response of cancer patients to a panel of human tumor antigens. J Exp Med 187 (1998) 1349-1354
    • (1998) J Exp Med , vol.187 , pp. 1349-1354
    • Stockert, E.1    Jager, E.2    Chen, Y.T.3    Scanlan, M.J.4    Gout, I.5    Karbach, J.6
  • 142
    • 33646098665 scopus 로고    scopus 로고
    • Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1
    • Tureci O., Mack U., Luxemburger U., Heinen H., Krummenauer F., Sester M., et al. Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1. Cancer Lett 236 (2006) 64-71
    • (2006) Cancer Lett , vol.236 , pp. 64-71
    • Tureci, O.1    Mack, U.2    Luxemburger, U.3    Heinen, H.4    Krummenauer, F.5    Sester, M.6
  • 143
    • 0026323307 scopus 로고
    • Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues
    • Driscoll J.S., Marquez V.E., Plowman J., Liu P.S., Kelley J.A., and Barchi Jr. J.J. Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J Med Chem 34 (1991) 3280-3284
    • (1991) J Med Chem , vol.34 , pp. 3280-3284
    • Driscoll, J.S.1    Marquez, V.E.2    Plowman, J.3    Liu, P.S.4    Kelley, J.A.5    Barchi Jr., J.J.6
  • 144
    • 0019126392 scopus 로고
    • Sulphydryl dependence of the inhibition of mitogen-induced human lymphocyte proliferation by sodium aurothiomalate
    • McCormack P.L., and Palmer D.G. Sulphydryl dependence of the inhibition of mitogen-induced human lymphocyte proliferation by sodium aurothiomalate. Biochem Pharmacol 29 (1980) 3333-3336
    • (1980) Biochem Pharmacol , vol.29 , pp. 3333-3336
    • McCormack, P.L.1    Palmer, D.G.2
  • 146
    • 61549106628 scopus 로고    scopus 로고
    • Yoo CB, Chuang JC, Byun H-M, Egger G, Yang AS, Dubeau L, et al. Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res 2008:1940-6207.CAPR-1907-0008.
    • Yoo CB, Chuang JC, Byun H-M, Egger G, Yang AS, Dubeau L, et al. Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res 2008:1940-6207.CAPR-1907-0008.
  • 147
    • 21044457206 scopus 로고    scopus 로고
    • Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyltransferase inhibitor, zebularine
    • Holleran J.L., Parise R.A., Joseph E., Eiseman J.L., Covey J.M., Glaze E.R., et al. Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyltransferase inhibitor, zebularine. Clin Cancer Res 11 (2005) 3862-3868
    • (2005) Clin Cancer Res , vol.11 , pp. 3862-3868
    • Holleran, J.L.1    Parise, R.A.2    Joseph, E.3    Eiseman, J.L.4    Covey, J.M.5    Glaze, E.R.6
  • 148
    • 0020456158 scopus 로고
    • Metabolism and mechanism of action of 5-fluorodeoxycytidine
    • Newman E.M., and Santi D.V. Metabolism and mechanism of action of 5-fluorodeoxycytidine. Proc Natl Acad Sci U S A 79 (1982) 6419-6423
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 6419-6423
    • Newman, E.M.1    Santi, D.V.2
  • 149
    • 0022556527 scopus 로고
    • Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells
    • Kaysen J., Spriggs D., and Kufe D. Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells. Cancer Res 46 (1986) 4534-4538
    • (1986) Cancer Res , vol.46 , pp. 4534-4538
    • Kaysen, J.1    Spriggs, D.2    Kufe, D.3
  • 150
    • 43749124047 scopus 로고    scopus 로고
    • Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)
    • Beumer J.H., Parise R.A., Newman E.M., Doroshow J.H., Synold T.W., Lenz H.J., et al. Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer Chemother Pharmacol 62 (2008) 363-368
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 363-368
    • Beumer, J.H.1    Parise, R.A.2    Newman, E.M.3    Doroshow, J.H.4    Synold, T.W.5    Lenz, H.J.6
  • 151
    • 45049086493 scopus 로고    scopus 로고
    • 2′-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1
    • Byun H.M., Choi S.H., Laird P.W., Trinh B., Siddiqui M.A., Marquez V.E., et al. 2′-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1. Cancer Lett 266 (2008) 238-248
    • (2008) Cancer Lett , vol.266 , pp. 238-248
    • Byun, H.M.1    Choi, S.H.2    Laird, P.W.3    Trinh, B.4    Siddiqui, M.A.5    Marquez, V.E.6
  • 152
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • Brueckner B., Garcia Boy R., Siedlecki P., Musch T., Kliem H.C., Zielenkiewicz P., et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 65 (2005) 6305-6311
    • (2005) Cancer Res , vol.65 , pp. 6305-6311
    • Brueckner, B.1    Garcia Boy, R.2    Siedlecki, P.3    Musch, T.4    Kliem, H.C.5    Zielenkiewicz, P.6
  • 153
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann C., Brueckner B., Musch T., Stopper H., and Lyko F. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 66 (2006) 2794-2800
    • (2006) Cancer Res , vol.66 , pp. 2794-2800
    • Stresemann, C.1    Brueckner, B.2    Musch, T.3    Stopper, H.4    Lyko, F.5
  • 154
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia E., Golbus J., Maybaum J., Strahler J., Hanash S., and Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 140 (1988) 2197-2200
    • (1988) J Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 155
    • 0345275879 scopus 로고    scopus 로고
    • Tea polyphenol (-)-epigallocatechin-3-Gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    • Fang M.Z., Wang Y., Ai N., Hou Z., Sun Y., Lu H., et al. Tea polyphenol (-)-epigallocatechin-3-Gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 63 (2003) 7563-7570
    • (2003) Cancer Res , vol.63 , pp. 7563-7570
    • Fang, M.Z.1    Wang, Y.2    Ai, N.3    Hou, Z.4    Sun, Y.5    Lu, H.6
  • 156
    • 27644597195 scopus 로고    scopus 로고
    • Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine
    • Chuang J.C., Yoo C.B., Kwan J.M., Li T.W.H., Liang G., Yang A.S., et al. Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine. Mol Cancer Ther 4 (2005) 1515-1520
    • (2005) Mol Cancer Ther , vol.4 , pp. 1515-1520
    • Chuang, J.C.1    Yoo, C.B.2    Kwan, J.M.3    Li, T.W.H.4    Liang, G.5    Yang, A.S.6
  • 157
    • 0242539836 scopus 로고    scopus 로고
    • Momparler RL. Cancer epigenetics. Oncogene 22:6479-83.
    • Momparler RL. Cancer epigenetics. Oncogene 22:6479-83.
  • 158
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 16 (2002) 6-21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 159
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-induced repression- belts, braces, and chromatin
    • Bird A.P., and Wolffe A.P. Methylation-induced repression- belts, braces, and chromatin. Cell 99 (1999) 451-454
    • (1999) Cell , vol.99 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 160
    • 0037115392 scopus 로고    scopus 로고
    • Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
    • Fahrner J.A., Eguchi S., Herman J.G., and Baylin S.B. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res 62 (2002) 7213-7218
    • (2002) Cancer Res , vol.62 , pp. 7213-7218
    • Fahrner, J.A.1    Eguchi, S.2    Herman, J.G.3    Baylin, S.B.4
  • 161
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 162
    • 0031837109 scopus 로고    scopus 로고
    • Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
    • Jones P.L., Jan Veenstra G.C., Wade P.A., et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19 (1998) 187-191
    • (1998) Nat Genet , vol.19 , pp. 187-191
    • Jones, P.L.1    Jan Veenstra, G.C.2    Wade, P.A.3
  • 163
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron E.E., Bachman K.E., Myohanen S., Herman J.G., and Baylin S.B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21 (1999) 103-107
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 164
    • 0037358032 scopus 로고    scopus 로고
    • Interaction of 5-aza-2′-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells
    • Gagnon J., Shaker S., Primeau M., Hurtubise A., and Momparler R.L. Interaction of 5-aza-2′-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells. Anticancer Drugs 14 (2003) 193-202
    • (2003) Anticancer Drugs , vol.14 , pp. 193-202
    • Gagnon, J.1    Shaker, S.2    Primeau, M.3    Hurtubise, A.4    Momparler, R.L.5
  • 165
    • 0037427805 scopus 로고    scopus 로고
    • Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2prime-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells
    • Primeau M., Gagnon J., and Momparler R.L. Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2prime-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells. Int J Cancer 103 (2003) 177-184
    • (2003) Int J Cancer , vol.103 , pp. 177-184
    • Primeau, M.1    Gagnon, J.2    Momparler, R.L.3
  • 166
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore S.D., Baylin S., Sugar E., Carraway H., Miller C.B., Carducci M., et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 66 (2006) 6361-6369
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3    Carraway, H.4    Miller, C.B.5    Carducci, M.6
  • 167
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Gottlicher M., Minucci S., Zhu P., Kramer O.H., Schimpf A., Giavara S., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20 (2001) 6969-6978
    • (2001) EMBO J , vol.20 , pp. 6969-6978
    • Gottlicher, M.1    Minucci, S.2    Zhu, P.3    Kramer, O.H.4    Schimpf, A.5    Giavara, S.6
  • 168
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel C.J., Zhang F., Huang E.Y., Guenther M.G., Lazar M.A., and Klein P.S. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276 (2001) 36734-36741
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 169
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G., Kantarjian H.M., Sanchez-Gonzalez B., Yang H., Rosner G., Verstovsek S., et al. Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia. Blood 108 (2006) 3271-3279
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3    Yang, H.4    Rosner, G.5    Verstovsek, S.6
  • 170
    • 34548529948 scopus 로고    scopus 로고
    • Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
    • Blum W., Klisovic R.B., Hackanson B., Liu Z., Liu S., Devine H., et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 25 (2007) 3884-3891
    • (2007) J Clin Oncol , vol.25 , pp. 3884-3891
    • Blum, W.1    Klisovic, R.B.2    Hackanson, B.3    Liu, Z.4    Liu, S.5    Devine, H.6
  • 171
    • 38949096781 scopus 로고    scopus 로고
    • Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero G., Yang H., Bueso-Ramos C., Ferrajoli A., Cortes J., Wierda W.G., et al. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 111 (2008) 1060-1066
    • (2008) Blood , vol.111 , pp. 1060-1066
    • Garcia-Manero, G.1    Yang, H.2    Bueso-Ramos, C.3    Ferrajoli, A.4    Cortes, J.5    Wierda, W.G.6
  • 172
    • 0035126974 scopus 로고    scopus 로고
    • Sequential 5-aza-2′-deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1
    • Weiser T.S., Guo Z.S., Ohnmacht G.A., Parkhurst M.L., Tong-On P., Marincola F.M., et al. Sequential 5-aza-2′-deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1. J Immunother 24 (2001) 151-161
    • (2001) J Immunother , vol.24 , pp. 151-161
    • Weiser, T.S.1    Guo, Z.S.2    Ohnmacht, G.A.3    Parkhurst, M.L.4    Tong-On, P.5    Marincola, F.M.6
  • 173
    • 52949085309 scopus 로고    scopus 로고
    • A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: A New York Cancer Consortium
    • Silverman L.R., Verma A., Odchimar-Reissig R., Cozza A., Najfeld V., and Licht J.D. A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: A New York Cancer Consortium. J Clin Oncol 26 (2008) 7000
    • (2008) J Clin Oncol , vol.26 , pp. 7000
    • Silverman, L.R.1    Verma, A.2    Odchimar-Reissig, R.3    Cozza, A.4    Najfeld, V.5    Licht, J.D.6
  • 174
    • 52949147619 scopus 로고    scopus 로고
    • A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia (AML)
    • Yee K.W.L., Minden M.D., Brandwein J., Schimmer A., Schuh A., Gupta V., et al. A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia (AML). ASH Annual Meeting Abstr 110 (2007) 908
    • (2007) ASH Annual Meeting Abstr , vol.110 , pp. 908
    • Yee, K.W.L.1    Minden, M.D.2    Brandwein, J.3    Schimmer, A.4    Schuh, A.5    Gupta, V.6
  • 175
    • 44749094151 scopus 로고    scopus 로고
    • Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome
    • Lin J., Yao D.-m., Qian J., Wang Y.-l., Han L.-x., Jiang Y.-w., et al. Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome. Leuk Res 32 (2008) 1541-1545
    • (2008) Leuk Res , vol.32 , pp. 1541-1545
    • Lin, J.1    Yao, D.-m.2    Qian, J.3    Wang, Y.-l.4    Han, L.-x.5    Jiang, Y.-w.6
  • 176
    • 34548535326 scopus 로고    scopus 로고
    • DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets
    • Wu Q., Lothe R., Ahlquist T., Silins I., Trope C., Micci F., et al. DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Mol Cancer 6 (2007) 45
    • (2007) Mol Cancer , vol.6 , pp. 45
    • Wu, Q.1    Lothe, R.2    Ahlquist, T.3    Silins, I.4    Trope, C.5    Micci, F.6
  • 177
    • 17144366936 scopus 로고    scopus 로고
    • Aberrant methylation of the negative regulators RASSFIA, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukaemia
    • Johan M.F., Bowen D.T., Frew M.E., Goodeve A.C., and Reilly J.T. Aberrant methylation of the negative regulators RASSFIA, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol 129 (2005) 60-65
    • (2005) Br J Haematol , vol.129 , pp. 60-65
    • Johan, M.F.1    Bowen, D.T.2    Frew, M.E.3    Goodeve, A.C.4    Reilly, J.T.5
  • 178
    • 0027394949 scopus 로고
    • Hypermethylation of the calcitonin gene in the myelodysplastic syndromes
    • Ihalainen J.P.S., Savolainen E.R., Janssen S.E., and Palotie A. Hypermethylation of the calcitonin gene in the myelodysplastic syndromes. Leukemia 7 (1993) 263-267
    • (1993) Leukemia , vol.7 , pp. 263-267
    • Ihalainen, J.P.S.1    Savolainen, E.R.2    Janssen, S.E.3    Palotie, A.4
  • 179
    • 48749092367 scopus 로고    scopus 로고
    • Jost E, Schmid J, Wilop S, Schubert C, Suzuki H, Herman JG, et al. Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia. Br J Haematol 2008 [Epub ahead of print].
    • Jost E, Schmid J, Wilop S, Schubert C, Suzuki H, Herman JG, et al. Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia. Br J Haematol 2008 [Epub ahead of print].
  • 180
    • 51649122312 scopus 로고    scopus 로고
    • Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
    • Kroeger H., Jelinek J., Estecio M.R.H., He R., Kondo K., Chung W., et al. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood 112 (2008) 1366-1373
    • (2008) Blood , vol.112 , pp. 1366-1373
    • Kroeger, H.1    Jelinek, J.2    Estecio, M.R.H.3    He, R.4    Kondo, K.5    Chung, W.6
  • 181
    • 46749094288 scopus 로고    scopus 로고
    • Concurrent methylation of promoters from tumor associated genes predicts outcome in acute myeloid leukemia
    • Hess C.J., Errami A., Berkhof J., Denkers F., Ossenkoppele G.J., Nygren A.O.H., et al. Concurrent methylation of promoters from tumor associated genes predicts outcome in acute myeloid leukemia. Leuk Lymphoma 49 (2008) 1132-1141
    • (2008) Leuk Lymphoma , vol.49 , pp. 1132-1141
    • Hess, C.J.1    Errami, A.2    Berkhof, J.3    Denkers, F.4    Ossenkoppele, G.J.5    Nygren, A.O.H.6
  • 182
    • 14844313747 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
    • Schmelz K., Wagner M., Dorken B., and Tamm I. 5-Aza-2′-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int J Cancer 114 (2005) 683-695
    • (2005) Int J Cancer , vol.114 , pp. 683-695
    • Schmelz, K.1    Wagner, M.2    Dorken, B.3    Tamm, I.4
  • 183
    • 0037112439 scopus 로고    scopus 로고
    • Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas
    • Oka T., Ouchida M., Koyama M., Oka T., Ouchida M., Koyama M., et al. Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res 62 (2002) 6390-6394
    • (2002) Cancer Res , vol.62 , pp. 6390-6394
    • Oka, T.1    Ouchida, M.2    Koyama, M.3    Oka, T.4    Ouchida, M.5    Koyama, M.6
  • 184
    • 34247610968 scopus 로고    scopus 로고
    • Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia
    • Hoshino K., Quintas-Cardama A., Yang H., Sanchez-Gonzalez B., and Garcia-Manero G. Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia. Leukemia 21 (2007) 906-911
    • (2007) Leukemia , vol.21 , pp. 906-911
    • Hoshino, K.1    Quintas-Cardama, A.2    Yang, H.3    Sanchez-Gonzalez, B.4    Garcia-Manero, G.5
  • 185
    • 33645215136 scopus 로고    scopus 로고
    • Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia
    • Agirre X., Roman-Gomez J., Vazquez I., Jimenez-Velasco A., Garate L., Montiel-Duarte C., et al. Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. Int J Cancer 118 (2006) 1945-1953
    • (2006) Int J Cancer , vol.118 , pp. 1945-1953
    • Agirre, X.1    Roman-Gomez, J.2    Vazquez, I.3    Jimenez-Velasco, A.4    Garate, L.5    Montiel-Duarte, C.6
  • 186
  • 187
    • 0141483265 scopus 로고    scopus 로고
    • Frequent methylation of p16INK4A and p14ARF genes implicated in the evolution of chronic myeloid leukaemia from its chronic to accelerated phase
    • Nagy E., Beck Z., Kiss A., et al. Frequent methylation of p16INK4A and p14ARF genes implicated in the evolution of chronic myeloid leukaemia from its chronic to accelerated phase. Eur J Cancer 39 (2003) 2298-2305
    • (2003) Eur J Cancer , vol.39 , pp. 2298-2305
    • Nagy, E.1    Beck, Z.2    Kiss, A.3
  • 188
    • 0037842155 scopus 로고    scopus 로고
    • Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon
    • Roman-Gomez J., Castillejo J.A., Jimenez A., Cervantes F., Boque C., Hermosin L., et al. Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon. Alfa J Clin Oncol 21 (2003) 1472-1479
    • (2003) Alfa J Clin Oncol , vol.21 , pp. 1472-1479
    • Roman-Gomez, J.1    Castillejo, J.A.2    Jimenez, A.3    Cervantes, F.4    Boque, C.5    Hermosin, L.6
  • 189
    • 0038281349 scopus 로고    scopus 로고
    • JunB gene expression is inactivated by methylation in chronic myeloid leukemia
    • Yang M.-Y., Liu T.-C., Chang J.-G., Lin P.-M., and Lin S.-F. JunB gene expression is inactivated by methylation in chronic myeloid leukemia. Blood 101 (2003) 3205-3211
    • (2003) Blood , vol.101 , pp. 3205-3211
    • Yang, M.-Y.1    Liu, T.-C.2    Chang, J.-G.3    Lin, P.-M.4    Lin, S.-F.5
  • 190
    • 0037112439 scopus 로고    scopus 로고
    • Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas
    • Oka T., Ouchida M., Koyama M., Ogama Y., Takada S., Nakatani Y., et al. Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res 62 (2002) 6390-6394
    • (2002) Cancer Res , vol.62 , pp. 6390-6394
    • Oka, T.1    Ouchida, M.2    Koyama, M.3    Ogama, Y.4    Takada, S.5    Nakatani, Y.6
  • 192
    • 34548819044 scopus 로고    scopus 로고
    • Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis
    • Strathdee G., Holyoake T.L., Sim A., Parker A., Oscier D.G., Melo J.V., et al. Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis. Clin Cancer Res 13 (2007) 5048-5055
    • (2007) Clin Cancer Res , vol.13 , pp. 5048-5055
    • Strathdee, G.1    Holyoake, T.L.2    Sim, A.3    Parker, A.4    Oscier, D.G.5    Melo, J.V.6
  • 194
    • 34250658446 scopus 로고    scopus 로고
    • Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia
    • Motiwala T., Majumder S., Kutay H., Smith D.S., Neuberg D.S., Lucas D.M., et al. Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia. Clin Cancer Res 13 (2007) 3174-3181
    • (2007) Clin Cancer Res , vol.13 , pp. 3174-3181
    • Motiwala, T.1    Majumder, S.2    Kutay, H.3    Smith, D.S.4    Neuberg, D.S.5    Lucas, D.M.6
  • 195
    • 34249314024 scopus 로고    scopus 로고
    • Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia
    • Raval A., Tanner S.M., Byrd J.C., Perko J.D., Chen S.-S., et al. Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell 129 (2007) 879-890
    • (2007) Cell , vol.129 , pp. 879-890
    • Raval, A.1    Tanner, S.M.2    Byrd, J.C.3    Perko, J.D.4    Chen, S.-S.5
  • 197
    • 33745198269 scopus 로고    scopus 로고
    • Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL
    • Strathdee G., Sim A., Parker A., Oscier D., and Brown R. Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL. Leukemia 20 (2006) 1326-1329
    • (2006) Leukemia , vol.20 , pp. 1326-1329
    • Strathdee, G.1    Sim, A.2    Parker, A.3    Oscier, D.4    Brown, R.5
  • 198
    • 21244503530 scopus 로고    scopus 로고
    • TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia
    • Raval A., Lucas D.M., Matkovic J.J., Bennett K.L., Liyanarachchi S., Young D.C., et al. TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia. J Clin Oncol 23 (2005) 3877-3885
    • (2005) J Clin Oncol , vol.23 , pp. 3877-3885
    • Raval, A.1    Lucas, D.M.2    Matkovic, J.J.3    Bennett, K.L.4    Liyanarachchi, S.5    Young, D.C.6
  • 199
    • 0036142690 scopus 로고    scopus 로고
    • CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia
    • Bechter O.E., Eisterer W., Dlaska M., Kühr T., and Thaler J. CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia. Exp Hematol 30 (2002) 26-33
    • (2002) Exp Hematol , vol.30 , pp. 26-33
    • Bechter, O.E.1    Eisterer, W.2    Dlaska, M.3    Kühr, T.4    Thaler, J.5
  • 202
    • 34249294535 scopus 로고    scopus 로고
    • A change in promoter methylation of hMLH1 is a cause of acquired resistance to platinum-based chemotherapy in epithelial ovarian cancer
    • Watanabe Y., Ueda H., Etoh T., Koike E., Fujinami N., Mitsuhashi A., et al. A change in promoter methylation of hMLH1 is a cause of acquired resistance to platinum-based chemotherapy in epithelial ovarian cancer. Anticancer Res 27 (2007) 1449-1452
    • (2007) Anticancer Res , vol.27 , pp. 1449-1452
    • Watanabe, Y.1    Ueda, H.2    Etoh, T.3    Koike, E.4    Fujinami, N.5    Mitsuhashi, A.6
  • 203
    • 33745871210 scopus 로고    scopus 로고
    • Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential
    • Wiley A., Katsaros D., Chen H., Rigault de la Longrais I.A., Beeghly A., Puopolo M., et al. Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential. Cancer 107 (2006) 299-308
    • (2006) Cancer , vol.107 , pp. 299-308
    • Wiley, A.1    Katsaros, D.2    Chen, H.3    Rigault de la Longrais, I.A.4    Beeghly, A.5    Puopolo, M.6
  • 204
    • 33644822879 scopus 로고    scopus 로고
    • Aberrant hypermethylation of RASSF1A promoter in ovarian borderline tumors and carcinomas
    • Choi Y.L., Kang S.Y., Shin Y.K., Choi J.S., Kim S.H., Lee S.J., et al. Aberrant hypermethylation of RASSF1A promoter in ovarian borderline tumors and carcinomas. Virchows Arch 448 (2006) 331-336
    • (2006) Virchows Arch , vol.448 , pp. 331-336
    • Choi, Y.L.1    Kang, S.Y.2    Shin, Y.K.3    Choi, J.S.4    Kim, S.H.5    Lee, S.J.6
  • 206
    • 33751270220 scopus 로고    scopus 로고
    • Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer
    • Petrocca F., Iliopoulos D., Qin H.R., et al. Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer. Cancer Res 66 (2006) 10287-10291
    • (2006) Cancer Res , vol.66 , pp. 10287-10291
    • Petrocca, F.1    Iliopoulos, D.2    Qin, H.R.3
  • 207
    • 40749133034 scopus 로고    scopus 로고
    • Epigenetic regulation of the ras effector//tumour suppressor RASSF2 in breast and lung cancer
    • Cooper W.N., Dickinson R.E., Dallol A., Grigorieva E.V., Pavlova T.V., Hesson L.B., et al. Epigenetic regulation of the ras effector//tumour suppressor RASSF2 in breast and lung cancer. Oncogene 27 (2007) 1805-1811
    • (2007) Oncogene , vol.27 , pp. 1805-1811
    • Cooper, W.N.1    Dickinson, R.E.2    Dallol, A.3    Grigorieva, E.V.4    Pavlova, T.V.5    Hesson, L.B.6
  • 208
    • 0035360824 scopus 로고    scopus 로고
    • Loss of expression and aberrant methylation of the CDH13 (H-Cadherin) gene in breast and lung carcinomas
    • Toyooka K.O., Toyooka S., Virmani A.K., Sathyanarayana U.G., Euhus D.M., Gilcrease M., et al. Loss of expression and aberrant methylation of the CDH13 (H-Cadherin) gene in breast and lung carcinomas. Cancer Res 61 (2001) 4556-4560
    • (2001) Cancer Res , vol.61 , pp. 4556-4560
    • Toyooka, K.O.1    Toyooka, S.2    Virmani, A.K.3    Sathyanarayana, U.G.4    Euhus, D.M.5    Gilcrease, M.6
  • 210
    • 33745700196 scopus 로고    scopus 로고
    • Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer
    • Machida E.O., Brock M.V., Hooker C.M., Nakayama J., Ishida A., Amano J., et al. Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer Res 66 (2006) 6210-6218
    • (2006) Cancer Res , vol.66 , pp. 6210-6218
    • Machida, E.O.1    Brock, M.V.2    Hooker, C.M.3    Nakayama, J.4    Ishida, A.5    Amano, J.6
  • 211
    • 1642564204 scopus 로고    scopus 로고
    • Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience
    • Brock M.V., Kim M.P., Hooker C.M., Alberg A.J., Jordan M.M., Roig C.M., et al. Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience. Ann Thorac Surg 77 (2004) 271-277
    • (2004) Ann Thorac Surg , vol.77 , pp. 271-277
    • Brock, M.V.1    Kim, M.P.2    Hooker, C.M.3    Alberg, A.J.4    Jordan, M.M.5    Roig, C.M.6
  • 212
    • 0028845142 scopus 로고    scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman J.G., Merlo A., Mao L., Lapidus R.G., Issa J.-P.J., Davidson N.E., et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55 (1995) 4525-4530
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.-P.J.5    Davidson, N.E.6
  • 213
    • 0034703742 scopus 로고    scopus 로고
    • p53: Death Star
    • Vousden K.H. p53: Death Star. Cell 103 (2000) 691-694
    • (2000) Cell , vol.103 , pp. 691-694
    • Vousden, K.H.1
  • 215
    • 0037099602 scopus 로고    scopus 로고
    • A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor
    • Gazzoli I., Loda M., Garber J., Syngal S., and Kolodner R.D. A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor. Cancer Res 62 (2002) 3925-3928
    • (2002) Cancer Res , vol.62 , pp. 3925-3928
    • Gazzoli, I.1    Loda, M.2    Garber, J.3    Syngal, S.4    Kolodner, R.D.5
  • 216
    • 0037372967 scopus 로고    scopus 로고
    • p14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53
    • Shen L., Kondo Y., Hamilton S.R., Rashid A., and Issa J.-P.J. p14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology 124 (2003) 626-633
    • (2003) Gastroenterology , vol.124 , pp. 626-633
    • Shen, L.1    Kondo, Y.2    Hamilton, S.R.3    Rashid, A.4    Issa, J.-P.J.5
  • 217
    • 0035117307 scopus 로고    scopus 로고
    • Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability
    • Whitehall V.L.J., Walsh M.D., Young J., Leggett B.A., and Jass J.R. Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res 61 (2001) 827-830
    • (2001) Cancer Res , vol.61 , pp. 827-830
    • Whitehall, V.L.J.1    Walsh, M.D.2    Young, J.3    Leggett, B.A.4    Jass, J.R.5
  • 218
    • 46249090608 scopus 로고    scopus 로고
    • Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer
    • Noetzel E., Veeck J., Niederacher D., Galm O., Horn F., Hartmann A., et al. Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer. BMC Cancer 8 (2008) 154
    • (2008) BMC Cancer , vol.8 , pp. 154
    • Noetzel, E.1    Veeck, J.2    Niederacher, D.3    Galm, O.4    Horn, F.5    Hartmann, A.6
  • 219
    • 0028845142 scopus 로고    scopus 로고
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa J-PJ, Davidson NE, et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. 1995;55:4525-30.
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa J-PJ, Davidson NE, et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. 1995;55:4525-30.
  • 220
    • 0035342577 scopus 로고    scopus 로고
    • Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast
    • Droufakou S., Deshmane V., Roylance R., Hanby A., Tomlinson I., and Hart I.R. Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast. Int J Cancer 92 (2001) 404-408
    • (2001) Int J Cancer , vol.92 , pp. 404-408
    • Droufakou, S.1    Deshmane, V.2    Roylance, R.3    Hanby, A.4    Tomlinson, I.5    Hart, I.R.6
  • 221
    • 0037479867 scopus 로고    scopus 로고
    • Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability
    • Sarrio D., Moreno-Bueno G., Hardisson D., Sanchez-Estevez C., Guo M., Herman J.G., et al. Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer 106 (2003) 208-215
    • (2003) Int J Cancer , vol.106 , pp. 208-215
    • Sarrio, D.1    Moreno-Bueno, G.2    Hardisson, D.3    Sanchez-Estevez, C.4    Guo, M.5    Herman, J.G.6
  • 222
    • 33746033715 scopus 로고    scopus 로고
    • Pattern of expression of genes linked to epigenetic silencing in human breast cancer
    • Munot K., Bell S.M., Lane S., Horgan K., Hanby A.M., and Speirs V. Pattern of expression of genes linked to epigenetic silencing in human breast cancer. Hum Pathol 37 (2006) 989-999
    • (2006) Hum Pathol , vol.37 , pp. 989-999
    • Munot, K.1    Bell, S.M.2    Lane, S.3    Horgan, K.4    Hanby, A.M.5    Speirs, V.6
  • 223
    • 9244242523 scopus 로고    scopus 로고
    • Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis
    • Xu X.L., Yu J., Zhang H.Y., Sun M.H., Gu J., Du X., et al. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol 10 (2004) 3441-3454
    • (2004) World J Gastroenterol , vol.10 , pp. 3441-3454
    • Xu, X.L.1    Yu, J.2    Zhang, H.Y.3    Sun, M.H.4    Gu, J.5    Du, X.6
  • 224
    • 36849037857 scopus 로고    scopus 로고
    • Epigenetic regulation as a new target for breast cancer therapy
    • Stearns V., Zhou Q., and Davidson N.E. Epigenetic regulation as a new target for breast cancer therapy. Cancer Invest 25 (2007) 659-665
    • (2007) Cancer Invest , vol.25 , pp. 659-665
    • Stearns, V.1    Zhou, Q.2    Davidson, N.E.3
  • 225
    • 0028152397 scopus 로고
    • Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
    • Lee W.H., Morton R.A., Epstein J.I., Brooks J.D., Campbell P.A., Bova G.S., et al. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc Natl Acad Sci U S A 91 (1994) 11733-11737
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11733-11737
    • Lee, W.H.1    Morton, R.A.2    Epstein, J.I.3    Brooks, J.D.4    Campbell, P.A.5    Bova, G.S.6
  • 226
    • 0030734880 scopus 로고    scopus 로고
    • Modulation of Igf2 genomic imprinting in mice induced by 5-azacytidine, an inhibitor of DNA methylation
    • Hu J.-F., Nguyen P.H., Pham N.V., Vu T.H., and Hoffman A.R. Modulation of Igf2 genomic imprinting in mice induced by 5-azacytidine, an inhibitor of DNA methylation. Mol Endocrinol 11 (1997) 1891-1898
    • (1997) Mol Endocrinol , vol.11 , pp. 1891-1898
    • Hu, J.-F.1    Nguyen, P.H.2    Pham, N.V.3    Vu, T.H.4    Hoffman, A.R.5
  • 228
    • 10644270602 scopus 로고    scopus 로고
    • A loss of insulin-like growth factor-2 imprinting is modulated by CCCTC-binding factor down-regulation at senescence in human epithelial cells
    • Fu V.X., Schwarze S.R., Kenowski M.L., LeBlanc S., Svaren J., and Jarrard D.F. A loss of insulin-like growth factor-2 imprinting is modulated by CCCTC-binding factor down-regulation at senescence in human epithelial cells. J Biol Chem 279 (2004) 52218-52226
    • (2004) J Biol Chem , vol.279 , pp. 52218-52226
    • Fu, V.X.1    Schwarze, S.R.2    Kenowski, M.L.3    LeBlanc, S.4    Svaren, J.5    Jarrard, D.F.6
  • 229
    • 0028072991 scopus 로고
    • Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
    • Herman J.G., Latif F., Weng Y., Lerman M.I., Zbar B., Liu S., et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A 91 (1994) 9700-9704
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9700-9704
    • Herman, J.G.1    Latif, F.2    Weng, Y.3    Lerman, M.I.4    Zbar, B.5    Liu, S.6
  • 230
    • 44649194410 scopus 로고    scopus 로고
    • CpG hypermethylation of the UCHL1 Gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma
    • Kagara I., Enokida H., Kawakami K., Matsuda R., Toki K., Nishimura H., et al. CpG hypermethylation of the UCHL1 Gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma. J Urol 180 (2008) 343-351
    • (2008) J Urol , vol.180 , pp. 343-351
    • Kagara, I.1    Enokida, H.2    Kawakami, K.3    Matsuda, R.4    Toki, K.5    Nishimura, H.6
  • 231
    • 43949121738 scopus 로고    scopus 로고
    • Hypermethylation of the 5′CpG island of the FHIT gene in clear cell renal carcinomas
    • Kvasha S., Gordiyuk V., Kondratov A., Ugryn D., Zgonnyk Y.M., Rynditch A.V., et al. Hypermethylation of the 5′CpG island of the FHIT gene in clear cell renal carcinomas. Cancer Lett 265 (2008) 250-257
    • (2008) Cancer Lett , vol.265 , pp. 250-257
    • Kvasha, S.1    Gordiyuk, V.2    Kondratov, A.3    Ugryn, D.4    Zgonnyk, Y.M.5    Rynditch, A.V.6
  • 232
    • 33749016030 scopus 로고    scopus 로고
    • Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications
    • Christoph F., Weikert S., Kempkensteffen C., Krause H., Schostak M., Kollermann J., et al. Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications. Clin Cancer Res 12 (2006) 5040-5046
    • (2006) Clin Cancer Res , vol.12 , pp. 5040-5046
    • Christoph, F.1    Weikert, S.2    Kempkensteffen, C.3    Krause, H.4    Schostak, M.5    Kollermann, J.6
  • 233
    • 34548071005 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma
    • Gumz M.L., Zou H., Kreinest P.A., Childs A.C., Belmonte L.S., LeGrand S.N., et al. Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 13 (2007) 4740-4749
    • (2007) Clin Cancer Res , vol.13 , pp. 4740-4749
    • Gumz, M.L.1    Zou, H.2    Kreinest, P.A.3    Childs, A.C.4    Belmonte, L.S.5    LeGrand, S.N.6
  • 234
    • 34547779010 scopus 로고    scopus 로고
    • Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors
    • Costa V., Henrique R., Ribeiro F., Pinto M., Oliveira J., Lobo F., et al. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. BMC Cancer 7 (2007) 133
    • (2007) BMC Cancer , vol.7 , pp. 133
    • Costa, V.1    Henrique, R.2    Ribeiro, F.3    Pinto, M.4    Oliveira, J.5    Lobo, F.6
  • 235
    • 35748956403 scopus 로고    scopus 로고
    • mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive phenotype
    • Christoph F., Hinz S., Kempkensteffen C., Schostak M., Schrader M., and Miller K. mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive phenotype. J Urol 178 (2007) 2655-2659
    • (2007) J Urol , vol.178 , pp. 2655-2659
    • Christoph, F.1    Hinz, S.2    Kempkensteffen, C.3    Schostak, M.4    Schrader, M.5    Miller, K.6
  • 236
    • 33947426013 scopus 로고    scopus 로고
    • Aberrant methylation of the 8p22 tumor suppressor gene DLC1 in renal cell carcinoma
    • Zhang Q., Ying J., Zhang K., Li H., Ng K.M., Zhao Y., et al. Aberrant methylation of the 8p22 tumor suppressor gene DLC1 in renal cell carcinoma. Cancer Lett 249 (2007) 220-226
    • (2007) Cancer Lett , vol.249 , pp. 220-226
    • Zhang, Q.1    Ying, J.2    Zhang, K.3    Li, H.4    Ng, K.M.5    Zhao, Y.6
  • 237
    • 33645025199 scopus 로고    scopus 로고
    • Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma
    • Okuda H., Toyota M., Ishida W., Furihata M., Tsuchiya M., Kamada M., et al. Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma. Oncogene 25 (2005) 1733-1742
    • (2005) Oncogene , vol.25 , pp. 1733-1742
    • Okuda, H.1    Toyota, M.2    Ishida, W.3    Furihata, M.4    Tsuchiya, M.5    Kamada, M.6
  • 238
    • 0036097181 scopus 로고    scopus 로고
    • Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
    • Fukushima N., Sato N., Ueki T., Su G.H., Hruban R.H., and Goggins M. Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am J Pathol 160 (2002) 1573-1581
    • (2002) Am J Pathol , vol.160 , pp. 1573-1581
    • Fukushima, N.1    Sato, N.2    Ueki, T.3    Su, G.H.4    Hruban, R.H.5    Goggins, M.6
  • 239
    • 0037534075 scopus 로고    scopus 로고
    • Dammann R, Schagdarsurengin U, Liu L, Otto N, Gimm O, Dralle H, et al. Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma. Oncogene 22:3806-12.
    • Dammann R, Schagdarsurengin U, Liu L, Otto N, Gimm O, Dralle H, et al. Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma. Oncogene 22:3806-12.
  • 240
    • 0037389979 scopus 로고    scopus 로고
    • Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues
    • Matsubayashi H., Sato N., Fukushima N., Yeo C.J., Walter K.M., Brune K., et al. Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues. Clin Cancer Res 9 (2003) 1446-1452
    • (2003) Clin Cancer Res , vol.9 , pp. 1446-1452
    • Matsubayashi, H.1    Sato, N.2    Fukushima, N.3    Yeo, C.J.4    Walter, K.M.5    Brune, K.6
  • 241
    • 0042575343 scopus 로고    scopus 로고
    • Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms
    • Fukushima N., Sato N., Sahin F., Su G.H., Hruban R.H., and Goggins M. Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer 89 (2003) 338-343
    • (2003) Br J Cancer , vol.89 , pp. 338-343
    • Fukushima, N.1    Sato, N.2    Sahin, F.3    Su, G.H.4    Hruban, R.H.5    Goggins, M.6
  • 242
    • 0034075153 scopus 로고    scopus 로고
    • Hypermethylation of multiple genes in pancreatic adenocarcinoma
    • Ueki T., Toyota M., Sohn T., Yeo C.J., Issa J.-P.J., Hruban R.H., et al. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res 60 (2000) 1835-1839
    • (2000) Cancer Res , vol.60 , pp. 1835-1839
    • Ueki, T.1    Toyota, M.2    Sohn, T.3    Yeo, C.J.4    Issa, J.-P.J.5    Hruban, R.H.6
  • 243
    • 0034607234 scopus 로고    scopus 로고
    • Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. 2000;92:564-9.
    • Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. 2000;92:564-9.
  • 244
    • 38949178861 scopus 로고    scopus 로고
    • Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer
    • Winter J.M., Ting A.H., Vilardell F., Gallmeier E., Baylin S.B., Hruban R.H., et al. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res 14 (2008) 412-418
    • (2008) Clin Cancer Res , vol.14 , pp. 412-418
    • Winter, J.M.1    Ting, A.H.2    Vilardell, F.3    Gallmeier, E.4    Baylin, S.B.5    Hruban, R.H.6
  • 245
    • 33744973086 scopus 로고    scopus 로고
    • E-cadherin and DAP kinase in pancreatic adenocarcinoma and corresponding lymph node metastases
    • Dansranjavin T., Mobius C., Tannapfel A., Bartels M., Wittekind C., Hauss J., et al. E-cadherin and DAP kinase in pancreatic adenocarcinoma and corresponding lymph node metastases. Oncol Rep 15 (2006) 1125-1131
    • (2006) Oncol Rep , vol.15 , pp. 1125-1131
    • Dansranjavin, T.1    Mobius, C.2    Tannapfel, A.3    Bartels, M.4    Wittekind, C.5    Hauss, J.6
  • 246
    • 0038476350 scopus 로고    scopus 로고
    • Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis
    • Kang G.H., Lee S., Kim J.S., and Jung H.Y. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis. Lab Invest 83 (2003) 635-641
    • (2003) Lab Invest , vol.83 , pp. 635-641
    • Kang, G.H.1    Lee, S.2    Kim, J.S.3    Jung, H.Y.4
  • 247
    • 0037146740 scopus 로고    scopus 로고
    • Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer
    • To K.F., Leung W.K., Lee T.L., Yu J., Tong J.H., Chan M.W., et al. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. Int J Cancer 102 (2002) 623-628
    • (2002) Int J Cancer , vol.102 , pp. 623-628
    • To, K.F.1    Leung, W.K.2    Lee, T.L.3    Yu, J.4    Tong, J.H.5    Chan, M.W.6
  • 248
    • 14044279223 scopus 로고    scopus 로고
    • Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma
    • Seidel C., Bartel F., Rastetter M., Bluemke K., Wurl P., Taubert H., et al. Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma. Int J Cancer 114 (2005) 442-447
    • (2005) Int J Cancer , vol.114 , pp. 442-447
    • Seidel, C.1    Bartel, F.2    Rastetter, M.3    Bluemke, K.4    Wurl, P.5    Taubert, H.6
  • 251
    • 0037380925 scopus 로고    scopus 로고
    • Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma
    • Spugnardi M., Tommasi S., Dammann R., Pfeifer G.P., and Hoon D.S.B. Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. Cancer Res 63 (2003) 1639-1643
    • (2003) Cancer Res , vol.63 , pp. 1639-1643
    • Spugnardi, M.1    Tommasi, S.2    Dammann, R.3    Pfeifer, G.P.4    Hoon, D.S.B.5
  • 252
    • 2542522279 scopus 로고    scopus 로고
    • Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients
    • Hoon D.S.B., Spugnardi M., Kuo C., Huang S.K., Morton D.L., and Taback B. Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients. Oncogene 23 (2004) 4014-4022
    • (2004) Oncogene , vol.23 , pp. 4014-4022
    • Hoon, D.S.B.1    Spugnardi, M.2    Kuo, C.3    Huang, S.K.4    Morton, D.L.5    Taback, B.6
  • 253
    • 3142710392 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of the APC gene in malignant melanoma
    • Worm J., Christensen C., Gronbaek K., Tulchinsky E., and Guldberg P. Genetic and epigenetic alterations of the APC gene in malignant melanoma. Oncogene 23 (2004) 5215-5226
    • (2004) Oncogene , vol.23 , pp. 5215-5226
    • Worm, J.1    Christensen, C.2    Gronbaek, K.3    Tulchinsky, E.4    Guldberg, P.5
  • 254
    • 33846258311 scopus 로고    scopus 로고
    • Promoter methylation of RASSF1A. RAR[beta] and DAPK predict poor prognosis of patients with malignant mesothelioma
    • Fischer J.R., Ohnmacht U., Rieger N., Zemaitis M., Stoffregen C., Kostrzewa M., et al. Promoter methylation of RASSF1A. RAR[beta] and DAPK predict poor prognosis of patients with malignant mesothelioma. Lung Cancer 54 (2006) 109-116
    • (2006) Lung Cancer , vol.54 , pp. 109-116
    • Fischer, J.R.1    Ohnmacht, U.2    Rieger, N.3    Zemaitis, M.4    Stoffregen, C.5    Kostrzewa, M.6
  • 255
    • 19944429818 scopus 로고    scopus 로고
    • Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung
    • Tsou J.A., Shen L.Y.C., Siegmund K.D., Long T.I., Laird P.W., Seneviratne C.K., et al. Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung. Lung Cancer 47 (2005) 193-204
    • (2005) Lung Cancer , vol.47 , pp. 193-204
    • Tsou, J.A.1    Shen, L.Y.C.2    Siegmund, K.D.3    Long, T.I.4    Laird, P.W.5    Seneviratne, C.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.