Opposing LSD1 complexes function in developmental gene activation and repression programmes

Nature

Volumn 446, Issue 7138, 2007, Pages 882-887

  Wang, Jianxun ^a,b   Scully, Kathleen ^a   Zhu, Xiaoyan ^a   Cai, Ling ^a,b   Zhang, Jie ^a   Prefontaine, Gratien G ^a   Krones, Anna ^a   Ohgi, Kenneth A ^a   Zhu, Ping ^a   Garcia Bassets, Ivan ^a   Liu, Forrest ^a   Taylor, Havilah ^a   Lozach, Jean ^c   Jayes, Friederike L ^d   Korach, Kenneth S ^d   Glass, Christopher K ^c   Fu, Xiang Dong ^c   Rosenfeld, Michael G ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE LYSINE DEMETHYLASE; KRUPPEL LIKE FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ENZYME; GENE; GENETIC DIFFERENTIATION; METAZOAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; COREST GENE; CTBP GENE; EMBRYO; GENE ACTIVITY; GENE EXPRESSION; GENE REPRESSION; GENOTYPE; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REPRESSOR GENE; ZEB1 GENE;

MAMMALIA; METAZOA;

EID: 34247348215     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05671     Document Type: Article

References (50)

1. Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression, how the genome integrates intrinsic and environmental signals. Nature Genet. 33, (Suppl.) 245-254 (2003).
2. Fischle, W., Wang, Y. & Allis, C. D. Binary switches and modification cassettes in histone biology and beyond. Nature 425, 475-479 (2003).
3. Martin, C. & Zhang, Y. The diverse functions of histone lysine methylation. Nature Rev. Mol. Cell Biol. 6, 838-849 (2005).
4. Chong, J. A. et al. REST, a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80, 949-957 (1995).
5. Schoenherr, C. J. & Anderson, D. J. The neuron-restrictive silencer factor (NRSF), a coordinate repressor of multiple neuron-specific genes. Science 267, 1360-1363 (1995).
6. Andres, M. E. et al. CoREST, a functional corepressor required for regulation of neural-specific gene expression. Proc. Natl Acad. Sci. USA 96, 9873-9878 (1999).
7. Ballas, N. et al. Regulation of neuronal traits by a novel transcriptional complex. Neuron 31, 353-365 (2001).
8. Lunyak, V. V. et al. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298, 1747-1752 (2002).
9. Shi, Y. et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422, 735-738 (2003).
10. You, A., Tong, J. K., Grozinger, C. M. & Schreiber, S. L. CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc. Natl Acad. Sci. USA 98, 1454-1458 (2001).
11. Humphrey, G. W. et al. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J. Biol. Chem. 276, 6817-6824 (2001).
12. Nakamura, T. et al. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol. Cell 10, 1119-1128 (2002).
13. Hakimi, M. A. et al. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc. Natl Acad. Sci. USA 99, 7420-7425 (2002).
14. Hakimi, M. A. et al. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J. Biol. Chem. 278, 7234-7239 (2003).
15. Shi, Y. et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953 (2004).
16. Metzger, E. et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437, 436-439 (2005).
17. Tsukada, Y. et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 439, 811-816 (2005).
18. Yamane, K. et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 125, 483-495 (2006).
19. Whetstine, J. R. et al. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 125, 467-481 (2006).
20. Keegan, C. E. & Camper, S. A. Mouse knockout solves endocrine puzzle and promotes new pituitary lineage model. Genes Dev. 17, 677-682 (2003).
21. Scully, K. M. & Rosenfeld, M. G. Pituitary development, regulatory codes in mammalian organogenesis. Science 295, 2231-2235 (2002).
22. Olson, L. E. et al. A homeodomain-mediated mechanism for b-catenindependent switching events dictates cell lineage determination. Cell 125, 593-605 (2006).
23. Mayo, K. E. Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. Mol. Endocrinol. 6, 1734-1744 (1992).
24. Lin, C., Lin, S. C., Chang, C. P. & Rosenfeld, M. G. Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature 360, 765-768 (1992).
25. Godfrey, P. et al. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nature Genet. 4, 227-232 (1993).
26. Maier, M. M. & Gessler, M. Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. Biochem. Biophys. Res. Commun. 275, 652-660 (2000).
27. Oswald, F. et al. RBP-Jκ/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell. Biol. 25, 10379-10390 (2005).
28. Zhu, X. et al. Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev. 20, 2739-2753 (2006).
29. Sornson, M. W. et al. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 384, 327-333 (1996).
30. Ward, R. D. et al. Role of PROP1 in pituitary gland growth. Mol. Endocrinol. 19, 698-710 (2005).
31. Gage, P. J., Roller, M. L., Saunders, T. L., Scarlett, L. M. & Camper, S. A. Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion. Development 122, 151-160 (1996).
32. Botz, J. et al. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16, 3401-3409 (1996).
33. Hu, N. et al. Heterozygous Rb-1 delta 20/1mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9, 1021-1027 (1994).
34. Lasorella, A., Rothschild, G., Yokota, Y., Russell, R. G. & Iavarone, A. Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Mol. Cell. Biol. 25, 3563-3574 (2005).
35. Behringer, R. R., Mathews, L. S., Palmiter, R. D. & Brinster, R. L. Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Genes Dev. 2, 453-461 (1988).
36. Borrelli, E., Heyman, R. A., Arias, C., Sawchenko, P. E. & Evans, R. M. Transgenic mice with inducible dwarfism. Nature 339, 538-541 (1989).
37. Scully, K. M. et al. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science 290, 1127-1131 (2000).
38. Williams, T. M. et al. Identification of a zinc finger protein that inhibits IL-2 gene expression. Science 254, 1791-1794 (1991).
39. Postigo, A. A. & Dean, D. C. ZEB represses transcription through interaction with the corepressor CtBP. Proc. Natl Acad. Sci. USA 96, 6683-6688 (1999).
40. Fernandes, I. et al. Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. Mol. Cell 11, 139-150 (2003).
41. Perissi, V. & Rosenfeld, M. G. Controlling nuclear receptors, the circular logic of cofactor cycles. Nature Rev. Mol. Cell Biol. 6, 542-554 (2005).
42. Satijn, D. P. et al. Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. Mol. Cell. Biol. 17, 6076-6086 (1997).
43. Kagey, M. H., Melhuish, T. A. & Wotton, D. The polycomb protein Pc2 is a SUMO E3. Cell 113, 127-137 (2003).
44. Wysocka, J. et al. WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell 121, 859-872 (2005).
45. Ooi, G. T., Tawadros, N. & Escalona, R. M. Pituitary cell lines and their endocrine applications. Mol. Cell. Endocrinol. 228, 1-21 (2004).
46. Korach, K. S. Insights from the study of animals lacking functional estrogen receptor. Science 266, 1524-1527 (1994).
47. Chamberlain, E. M. & Sanders, M. M. Identification of the novel player δEF1 in estrogen transcriptional cascades. Mol. Cell. Biol. 19, 3600-3606 (1999).
48. Lieberman, M. E., Slabaugh, M. B., Rutledge, J. J. & Gorski, J. The role of estrogen in the differentiation of prolactin producing cells. J. Steroid Biochem. 19, 275-281 (1983).
49. Day, R. N., Koike, S., Sakai, M., Muramatsu, M. & Maurer, R. A. Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Mol. Endocrinol. 4, 1964-1971 (1990).
50. Long, J., Zuo, D. & Park, M. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J. Biol. Chem. 280, 35477-35489 (2005).