Hepatic fat content is a determinant of metabolic phenotypes and increased carotid intima-media thickness in obese adults

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Zhang, Huijie ^a,b   Ma, Zhimin ^c   Pan, Lingling ^d   Xu, Yanfang ^e   Shao, Jin ^a   Huang, Zhufeng ^a   Chen, Zheng ^a   Sun, Qian ^a   Liu, Changqin ^a   Lin, Mingzhu ^a   Yang, Shuyu ^a   Li, Xuejun ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b TULANE UNIVERSITY   (United States)

^c THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; AGED; ARTERIAL WALL THICKNESS; COMPLICATION; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; INSULIN RESISTANCE; LIVER; MALE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; RECEIVER OPERATING CHARACTERISTIC; REGRESSION ANALYSIS; RISK FACTOR; SEVERITY OF ILLNESS INDEX; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; ADULT; AGED; CAROTID INTIMA-MEDIA THICKNESS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INSULIN RESISTANCE; LIVER; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PHENOTYPE; REGRESSION ANALYSIS; RISK FACTORS; ROC CURVE; SEVERITY OF ILLNESS INDEX; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84959114791     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21894     Document Type: Article

References (37)

1. Hu, F. B. et al. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med 351, 2694-2703 (2004).
2. Juonala, M. et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 365, 1876-1885 (2011).
3. Stefan, N. et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168, 1609-1616 (2008).
4. Kramer, C. K., Zinman, B. & Retnakaran, R. Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis. Ann Intern Med 159, 758-769 (2013).
5. Marini, M. A. et al. Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women. Diabetes Care 30, 2145-2147 (2007).
6. Gomez-Ambrosi, J. et al. Increased cardiometabolic risk factors and inflammation in adipose tissue in obese subjects classified as metabolically healthy. Diabetes Care 37, 2813-2821 (2014).
7. Phillips, C. M. Metabolically healthy obesity: definitions, determinants and clinical implications. Rev Endocr Metab Disord 14, 219-227 (2013).
8. Perreault, M. et al. A distinct fatty acid profile underlies the reduced inflammatory state of metabolically healthy obese individuals. PLoS One 9, e88539,(2014).
9. Naukkarinen, J. et al. Characterising metabolically healthy obesity in weight-discordant monozygotic twins. Diabetologia 57, 167-176 (2014).
10. Mangge, H. et al. Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults. Obesity (Silver Spring) 21, E71-77 (2013).
11. Shulman, G. I. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371, 1131-1141 (2014).
12. Arsenault, B. J. et al. Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome. Arch Intern Med 167, 1518-1525 (2007).
13. Despres, J. P. & Lemieux, I. Abdominal obesity and metabolic syndrome. Nature 444, 881-887 (2006).
14. Targher, G., Day, C. P. & Bonora, E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 363, 1341-1350 (2010).
15. Cohen, G. I. et al. Relationship between carotid disease on ultrasound and coronary disease on CT angiography. JACC Cardiovasc Imaging 6, 1160-1167 (2013).
16. Nambi, V. et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol 55, 1600-1607 (2010).
17. Yeboah, J. et al. Mediation of cardiovascular risk factor effects through subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 34, 1778-1783 (2014).
18. Naqvi, T. Z. & Lee, M. S. Carotid intima-media thickness and plaque in cardiovascular risk assessment. JACC Cardiovasc Imaging 7, 1025-1038 (2014).
19. Calori, G. et al. Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study. Diabetes Care 34, 210-215 (2011).
20. Sung, K. C., Cha, S. C., Sung, J. W., So, M. S. & Byrne, C. D. Metabolically healthy obese subjects are at risk of fatty liver but not of pre-clinical atherosclerosis. Nutr Metab Cardiovasc Dis 24, 256-262 (2014).
21. Kuk, J. L. & Ardern, C. I. Are metabolically normal but obese individuals at lower risk for all-cause mortality? Diabetes Care 32, 2297-2299,(2009).
22. Fan, J., Song, Y., Chen, Y., Hui, R. & Zhang, W. Combined effect of obesity and cardio-metabolic abnormality on the risk of cardiovascular disease: a meta-analysis of prospective cohort studies. Int J Cardiol 168, 4761-4768 (2013).
23. Karelis, A. D., St-Pierre, D. H., Conus, F., Rabasa-Lhoret, R. & Poehlman, E. T. Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab 89, 2569-2575 (2004).
24. Peppa, M. et al. Body composition determinants of metabolic phenotypes of obesity in nonobese and obese postmenopausal women. Obesity (Silver Spring) 21, 1807-1814 (2013).
25. Messier, V. et al. Metabolically healthy but obese individuals: relationship with hepatic enzymes. Metabolism 59, 20-24 (2010).
26. Lin, H. et al. Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study. PLoS One 10, e0140379 (2015).
27. Chen, Z. et al. Serum alanine aminotransferase independently correlates with intrahepatic triglyceride contents in obese subjects. Dig Dis Sci 59, 2470-2476 (2014).
28. Wong, V. W. et al. Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy. J Hepatol 62, 182-189 (2015).
29. Pan, L. L. et al. Intrahepatic triglyceride content is independently associated with chronic kidney disease in obese adults: A cross-sectional study. Metabolism 64, 1077-1085 (2015).
30. Velho, S., Paccaud, F., Waeber, G., Vollenweider, P. & Marques-Vidal, P. Metabolically healthy obesity: different prevalences using different criteria. Eur J Clin Nutr 64, 1043-1051 (2010).
31. Stefan, N., Haring, H. U., Hu, F. B. & Schulze, M. B. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 1, 152-162 (2013).
32. Johnson, H. M. & Stein, J. H. Measurement of carotid intima-media thickness and carotid plaque detection for cardiovascular risk assessment. J Nucl Cardiol 18, 153-162 (2011).
33. Zhang, H. J. et al. Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol 59, 557-562 (2013).
34. Frimel, T. N., Deivanayagam, S., Bashir, A., O'Connor, R. & Klein, S. Assessment of intrahepatic triglyceride content using magnetic resonance spectroscopy. J Cardiometab Syndr 2, 136-138 (2007).
35. Alberti, K. G., Zimmet, P. & Shaw, J. The metabolic syndrome - a new worldwide definition. Lancet 366, 1059-1062 (2005).
36. Cuspidi, C. et al. Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: the Assessment of Prognostic Risk Observational Survey. J Hypertens 20, 1307-1314 (2002).
37. de Groot, E. et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation 109, III33-38 (2004).