메뉴 건너뛰기




Volumn 16, Issue 1, 2015, Pages

MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study

Author keywords

Apob containing lipoproteins; LDL C; Microsomal triglyceride transfer protein (MTP); Non alcoholic fatty liver disease (NAFLD); Non HDL C; Q297H polymorphism

Indexed keywords

APOLIPOPROTEIN B; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; CARRIER PROTEIN; CHOLESTEROL;

EID: 84944061167     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/s12881-015-0242-6     Document Type: Article
Times cited : (38)

References (39)
  • 2
    • 84857133310 scopus 로고    scopus 로고
    • Multiple functions of microsomal triglyceride transfer protein
    • Hussain MM, Rava P, Walsh M, Rana M, Iqbal J. Multiple functions of microsomal triglyceride transfer protein. Nutr Metabol. 2012;9:14.
    • (2012) Nutr Metabol , vol.9 , pp. 14
    • Hussain, M.M.1    Rava, P.2    Walsh, M.3    Rana, M.4    Iqbal, J.5
  • 4
    • 84900524103 scopus 로고    scopus 로고
    • Hypobetalipoproteinemia and abetalipoproteinemia
    • Welty FK. Hypobetalipoproteinemia and abetalipoproteinemia. Curr Opin Lipidol. 2014;25(3):161-8.
    • (2014) Curr Opin Lipidol , vol.25 , Issue.3 , pp. 161-168
    • Welty, F.K.1
  • 5
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    • Musso G, Cassader M, Rosina F, Gambino R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia. 2012;55(4):885-904.
    • (2012) Diabetologia , vol.55 , Issue.4 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 6
    • 84898439031 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
    • Koo SH. Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis. Clin Mol Hepatol. 2013;19(3):210-5.
    • (2013) Clin Mol Hepatol , vol.19 , Issue.3 , pp. 210-215
    • Koo, S.H.1
  • 7
    • 84886558949 scopus 로고    scopus 로고
    • Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
    • Kawano Y, Cohen DE. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol. 2013;48(4):434-41.
    • (2013) J Gastroenterol , vol.48 , Issue.4 , pp. 434-441
    • Kawano, Y.1    Cohen, D.E.2
  • 8
    • 0037244002 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
    • Hussain MM, Shi J, Dreizen P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res. 2003;44(1):22-32.
    • (2003) J Lipid Res , vol.44 , Issue.1 , pp. 22-32
    • Hussain, M.M.1    Shi, J.2    Dreizen, P.3
  • 9
    • 84926410232 scopus 로고    scopus 로고
    • Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia
    • Di Filippo M, Moulin P, Roy P, Samson-Bouma ME, Collardeau-Frachon S, Chebel-Dumont S, et al. Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia. J Hepatol. 2014;61(4):891-902.
    • (2014) J Hepatol , vol.61 , Issue.4 , pp. 891-902
    • Filippo, M.1    Moulin, P.2    Roy, P.3    Samson-Bouma, M.E.4    Collardeau-Frachon, S.5    Chebel-Dumont, S.6
  • 10
    • 84877898353 scopus 로고    scopus 로고
    • Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia
    • Khatun I, Walsh MT, Hussain MM. Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia. J Lipid Res. 2013;54(6):1541-9.
    • (2013) J Lipid Res , vol.54 , Issue.6 , pp. 1541-1549
    • Khatun, I.1    Walsh, M.T.2    Hussain, M.M.3
  • 11
    • 48649094349 scopus 로고    scopus 로고
    • The influence of polymorphism of -493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress
    • Zak A, Jachymova M, Tvrzicka E, Vecka M, Duffkova L, Zeman M, et al. The influence of polymorphism of -493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress. J Nutr Biochem. 2008;19(9):634-41.
    • (2008) J Nutr Biochem , vol.19 , Issue.9 , pp. 634-641
    • Zak, A.1    Jachymova, M.2    Tvrzicka, E.3    Vecka, M.4    Duffkova, L.5    Zeman, M.6
  • 12
    • 84890129642 scopus 로고    scopus 로고
    • MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population
    • Peng XE, Wu YL, Lu QQ, Hu ZJ, Lin X. MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population. Liver Int. 2014;34(1):118-28.
    • (2014) Liver Int , vol.34 , Issue.1 , pp. 118-128
    • Peng, X.E.1    Wu, Y.L.2    Lu, Q.Q.3    Hu, Z.J.4    Lin, X.5
  • 13
    • 77955845052 scopus 로고    scopus 로고
    • Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis
    • Musso G, Gambino R, Cassader M. Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis. J Nutr Biochem. 2010;21(9):834-40.
    • (2010) J Nutr Biochem , vol.21 , Issue.9 , pp. 834-840
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 14
    • 0038801313 scopus 로고    scopus 로고
    • Effect of the microsomal triglyceride transfer protein -493 G/T polymorphism and type 2 diabetes mellitus on LDL subfractions
    • Chen SP, Tan KC, Lam KS. Effect of the microsomal triglyceride transfer protein -493 G/T polymorphism and type 2 diabetes mellitus on LDL subfractions. Atherosclerosis. 2003;167(2):287-92.
    • (2003) Atherosclerosis , vol.167 , Issue.2 , pp. 287-292
    • Chen, S.P.1    Tan, K.C.2    Lam, K.S.3
  • 15
    • 73149107963 scopus 로고    scopus 로고
    • Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease
    • Aminoff A, Ledmyr H, Thulin P, Lundell K, Nunez L, Strandhagen E, et al. Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease. J Lipid Res. 2010;51(1):103-11.
    • (2010) J Lipid Res , vol.51 , Issue.1 , pp. 103-111
    • Aminoff, A.1    Ledmyr, H.2    Thulin, P.3    Lundell, K.4    Nunez, L.5    Strandhagen, E.6
  • 16
    • 0029047046 scopus 로고
    • Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression
    • Lin MC, Gordon D, Wetterau JR. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J Lipid Res. 1995;36(5):1073-81.
    • (1995) J Lipid Res , vol.36 , Issue.5 , pp. 1073-1081
    • Lin, M.C.1    Gordon, D.2    Wetterau, J.R.3
  • 17
    • 83455220717 scopus 로고    scopus 로고
    • A protocol for computer-based protein structure and function prediction
    • Roy A, Xu D, Poisson J, Zhang Y. A protocol for computer-based protein structure and function prediction. J Vis Exp. 2011;57, e3259.
    • (2011) J Vis Exp , vol.57
    • Roy, A.1    Xu, D.2    Poisson, J.3    Zhang, Y.4
  • 18
    • 79959942908 scopus 로고    scopus 로고
    • SDM-a server for predicting effects of mutations on protein stability and malfunction
    • Worth CL, Preissner R, Blundell TL. SDM-a server for predicting effects of mutations on protein stability and malfunction. Nucleic Acids Res. 2011;39(Web Server issue):W215-22.
    • (2011) Nucleic Acids Res , vol.39 , Issue.WEB SERVER ISSUE , pp. W215-W222
    • Worth, C.L.1    Preissner, R.2    Blundell, T.L.3
  • 19
    • 0031807231 scopus 로고    scopus 로고
    • A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels
    • Karpe F, Lundahl B, Ehrenborg E, Eriksson P, Hamsten A. A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels. Arterioscler Thromb Vasc Biol. 1998;18(5):756-61.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , Issue.5 , pp. 756-761
    • Karpe, F.1    Lundahl, B.2    Ehrenborg, E.3    Eriksson, P.4    Hamsten, A.5
  • 20
    • 33646092551 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles
    • Lundahl B, Skoglund-Andersson C, Caslake M, Bedford D, Stewart P, Hamsten A, et al. Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles. Am J Physiol Endocrinol Metab. 2006;290(4):E739-45.
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , Issue.4 , pp. E739-E745
    • Lundahl, B.1    Skoglund-Andersson, C.2    Caslake, M.3    Bedford, D.4    Stewart, P.5    Hamsten, A.6
  • 21
    • 0036180958 scopus 로고    scopus 로고
    • Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men
    • St-Pierre J, Lemieux I, Miller-Felix I, Prud'homme D, Bergeron J, Gaudet D, et al. Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men. Atherosclerosis. 2002;160(2):317-24.
    • (2002) Atherosclerosis , vol.160 , Issue.2 , pp. 317-324
    • St-Pierre, J.1    Lemieux, I.2    Miller-Felix, I.3    Prud'homme, D.4    Bergeron, J.5    Gaudet, D.6
  • 22
    • 55949112773 scopus 로고    scopus 로고
    • MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort
    • Bohme M, Grallert H, Fischer A, Gieger C, Nitz I, Heid I, et al. MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort. Mol Genet Metab. 2008;95(4):229-32.
    • (2008) Mol Genet Metab , vol.95 , Issue.4 , pp. 229-232
    • Bohme, M.1    Grallert, H.2    Fischer, A.3    Gieger, C.4    Nitz, I.5    Heid, I.6
  • 23
    • 0033789548 scopus 로고    scopus 로고
    • Effect of microsomal triglyceride transfer protein gene variants (-493G>T, Q95H and H297Q) on plasma lipid levels in healthy middle-aged UK men
    • Talmud PJ, Palmen J, Miller G, Humphries SE. Effect of microsomal triglyceride transfer protein gene variants (-493G>T, Q95H and H297Q) on plasma lipid levels in healthy middle-aged UK men. Ann Hum Genet. 2000;64(Pt 4):269-76.
    • (2000) Ann Hum Genet , vol.64 , pp. 269-276
    • Talmud, P.J.1    Palmen, J.2    Miller, G.3    Humphries, S.E.4
  • 24
    • 0036161597 scopus 로고    scopus 로고
    • Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index
    • Ledmyr H, Karpe F, Lundahl B, McKinnon M, Skoglund-Andersson C, Ehrenborg E. Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index. J Lipid Res. 2002;43(1):51-8.
    • (2002) J Lipid Res , vol.43 , Issue.1 , pp. 51-58
    • Ledmyr, H.1    Karpe, F.2    Lundahl, B.3    McKinnon, M.4    Skoglund-Andersson, C.5    Ehrenborg, E.6
  • 25
    • 84901714613 scopus 로고    scopus 로고
    • MTP -493G>T polymorphism and susceptibility to nonalcoholic fatty liver disease: a meta-analysis
    • Zheng W, Wang L, Su X, Hu XF. MTP -493G>T polymorphism and susceptibility to nonalcoholic fatty liver disease: a meta-analysis. DNA Cell Biol. 2014;33(6):361-9.
    • (2014) DNA Cell Biol , vol.33 , Issue.6 , pp. 361-369
    • Zheng, W.1    Wang, L.2    Su, X.3    Hu, X.F.4
  • 26
    • 12644303527 scopus 로고    scopus 로고
    • Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step
    • Gordon DA, Jamil H, Gregg RE, Olofsson SO, Boren J. Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J Biol Chem. 1996;271(51):33047-53.
    • (1996) J Biol Chem , vol.271 , Issue.51 , pp. 33047-33053
    • Gordon, D.A.1    Jamil, H.2    Gregg, R.E.3    Olofsson, S.O.4    Boren, J.5
  • 27
    • 84860138796 scopus 로고    scopus 로고
    • Lumenal lipid metabolism: implications for lipoprotein assembly
    • Lehner R, Lian J, Quiroga AD. Lumenal lipid metabolism: implications for lipoprotein assembly. Arterioscler Thromb Vasc Biol. 2012;32(5):1087-93.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , Issue.5 , pp. 1087-1093
    • Lehner, R.1    Lian, J.2    Quiroga, A.D.3
  • 28
    • 33746066022 scopus 로고    scopus 로고
    • The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein
    • Ledmyr H, Ottosson L, Sunnerhagen M, Ehrenborg E. The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein. J Lipid Res. 2006;47(7):1378-85.
    • (2006) J Lipid Res , vol.47 , Issue.7 , pp. 1378-1385
    • Ledmyr, H.1    Ottosson, L.2    Sunnerhagen, M.3    Ehrenborg, E.4
  • 29
    • 0032797263 scopus 로고    scopus 로고
    • N-terminal domain of apolipoprotein B has structural homology to lipovitellin and microsomal triglyceride transfer protein: a "lipid pocket" model for self-assembly of apob-containing lipoprotein particles
    • Segrest JP, Jones MK, Dashti N. N-terminal domain of apolipoprotein B has structural homology to lipovitellin and microsomal triglyceride transfer protein: a "lipid pocket" model for self-assembly of apob-containing lipoprotein particles. J Lipid Res. 1999;40(8):1401-16.
    • (1999) J Lipid Res , vol.40 , Issue.8 , pp. 1401-1416
    • Segrest, J.P.1    Jones, M.K.2    Dashti, N.3
  • 30
    • 0037018919 scopus 로고    scopus 로고
    • The N-terminal 1000 residues of apolipoprotein B associate with microsomal triglyceride transfer protein to create a lipid transfer pocket required for lipoprotein assembly
    • Dashti N, Gandhi M, Liu X, Lin X, Segrest JP. The N-terminal 1000 residues of apolipoprotein B associate with microsomal triglyceride transfer protein to create a lipid transfer pocket required for lipoprotein assembly. Biochemistry. 2002;41(22):6978-87.
    • (2002) Biochemistry , vol.41 , Issue.22 , pp. 6978-6987
    • Dashti, N.1    Gandhi, M.2    Liu, X.3    Lin, X.4    Segrest, J.P.5
  • 31
    • 0344349000 scopus 로고    scopus 로고
    • Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
    • Raabe M, Veniant MM, Sullivan MA, Zlot CH, Bjorkegren J, Nielsen LB, et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest. 1999;103(9):1287-98.
    • (1999) J Clin Invest , vol.103 , Issue.9 , pp. 1287-1298
    • Raabe, M.1    Veniant, M.M.2    Sullivan, M.A.3    Zlot, C.H.4    Bjorkegren, J.5    Nielsen, L.B.6
  • 32
    • 84862789317 scopus 로고    scopus 로고
    • Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice
    • Khatun I, Zeissig S, Iqbal J, Wang M, Curiel D, Shelness GS, et al. Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice. Hepatology. 2012;55(5):1356-68.
    • (2012) Hepatology , vol.55 , Issue.5 , pp. 1356-1368
    • Khatun, I.1    Zeissig, S.2    Iqbal, J.3    Wang, M.4    Curiel, D.5    Shelness, G.S.6
  • 33
    • 84899520245 scopus 로고    scopus 로고
    • Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice
    • Dikkers A, Annema W, de Boer JF, Iqbal J, Hussain MM, Tietge UJ. Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice. J Lipid Res. 2014;55(5):816-25.
    • (2014) J Lipid Res , vol.55 , Issue.5 , pp. 816-825
    • Dikkers, A.1    Annema, W.2    Boer, J.F.3    Iqbal, J.4    Hussain, M.M.5    Tietge, U.J.6
  • 34
    • 84882927131 scopus 로고    scopus 로고
    • New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes
    • Sahebkar A, Watts GF. New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes. Clin Ther. 2013;35(8):1082-98.
    • (2013) Clin Ther , vol.35 , Issue.8 , pp. 1082-1098
    • Sahebkar, A.1    Watts, G.F.2
  • 35
    • 84895548648 scopus 로고    scopus 로고
    • Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia
    • Rader DJ, Kastelein JJ. Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia. Circulation. 2014;129(9):1022-32.
    • (2014) Circulation , vol.129 , Issue.9 , pp. 1022-1032
    • Rader, D.J.1    Kastelein, J.J.2
  • 36
    • 84888090979 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial
    • Thomas GS, Cromwell WC, Ali S, Chin W, Flaim JD, Davidson M. Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol. 2013;62(23):2178-84.
    • (2013) J Am Coll Cardiol , vol.62 , Issue.23 , pp. 2178-2184
    • Thomas, G.S.1    Cromwell, W.C.2    Ali, S.3    Chin, W.4    Flaim, J.D.5    Davidson, M.6
  • 37
    • 84907224063 scopus 로고    scopus 로고
    • Lomitapide: a novel agent for the treatment of homozygous familial hypercholesterolemia
    • Davis KA, Miyares MA. Lomitapide: a novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014;71(12):1001-8.
    • (2014) Am J Health Syst Pharm , vol.71 , Issue.12 , pp. 1001-1008
    • Davis, K.A.1    Miyares, M.A.2
  • 38
    • 84898829262 scopus 로고    scopus 로고
    • Potential approaches to ameliorate hepatic fat accumulation seen with MTP inhibition
    • Lin M, Zhao S, Shen L, Xu D. Potential approaches to ameliorate hepatic fat accumulation seen with MTP inhibition. Drug Saf. 2014;37(4):213-24.
    • (2014) Drug Saf , vol.37 , Issue.4 , pp. 213-224
    • Lin, M.1    Zhao, S.2    Shen, L.3    Xu, D.4
  • 39
    • 36348948428 scopus 로고    scopus 로고
    • Significant correlations between severe fatty liver and risk factors for metabolic syndrome
    • Hsiao PJ, Kuo KK, Shin SJ, Yang YH, Lin WY, Yang JF, et al. Significant correlations between severe fatty liver and risk factors for metabolic syndrome. J Gastroenterol Hepatol. 2007;22(12):2118-23.
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.12 , pp. 2118-2123
    • Hsiao, P.J.1    Kuo, K.K.2    Shin, S.J.3    Yang, Y.H.4    Lin, W.Y.5    Yang, J.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.