Quantum coherence spectroscopy to measure dietary fat retention in the liver

JCI Insight

Volumn 1, Issue 13, 2016, Pages

  Lindeboom, Lucas ^a,b   de Graaf, Robin A ^c   Nabuurs, Christine I ^a,b   van Ewijk, Petronella A ^a   Hesselink, Matthijs K C ^a   Wildberger, Joachim E ^a   Schrauwen, Patrick ^a,b   Schrauwen Hinderling, Vera B ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85055597575     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.84671     Document Type: Article

References (24)

1. Szczepaniak LS, et al. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol. 1999;276(5 Pt 1):E977–E989.
2. Boesch C, Slotboom J, Hoppeler H, Kreis R. In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn Reson Med. 1997;37(4):484–493.
3. Hwang JH, et al. Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab. 2007;293(6):E1663–E1669.
4. Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology. 2008;134(5):1369–1375.
5. Seppälä-Lindroos A, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab. 2002;87(7):3023–3028.
6. Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010;363(14):1341–1350.
7. Reddy JK, Rao MS. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol. 2006;290(5):G852–G858.
8. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest. 2005;115(5):1343–1351.
9. Labbé SM, et al. Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography. Am J Physiol Endocrinol Metab. 2011;300(3):E445–E453.
10. Ravikumar B, et al. Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes. Am J Physiol Endocrinol Metab. 2005;288(4):E789–E797.
11. de Graaf RA, Rothman DL, Behar KL. State of the art direct 13C and indirect 1H-[13C] NMR spectroscopy in vivo. A practical guide. NMR Biomed. 2011;24(8):958–972.
12. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Ann N Y Acad Sci. 1987;508:333–348.
13. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hänicke W, Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo. Magn Reson Med. 1989;9(1):79–93.
14. Ruiz-Cabello J, Vuister GW, Moonen CT, van Gelderen P, Cohen JS, van Zijl PC. Gradient-enhanced heteronuclear correlation spectroscopy: theory and experimental aspects. 1992. J Magn Reson. 2011;213(2):446–466.
15. de Graaf RA, Brown PB, Mason GF, Rothman DL, Behar KL. Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy. Magn Reson Med. 2003;49(1):37–46.
16. Rothman DL, et al. 1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo. Proc Natl Acad Sci U S A. 1985;82(6):1633–1637.
17. Jonkers RA, Geraedts TR, van Loon LJ, Nicolay K, Prompers JJ. Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized 1H-[13C] magnetic resonance spectroscopy. Magn Reson Med. 2012;68(4):997–1006.
18. Yahya A, Allen PS. Single-shot 3D localized indirect 13C detection. Presented at: 13th Annual ISMRM Scientific Meeting and Exhibition; May 20, 2004; Kyoto, Japan. Abstract 680.
19. Knuttel A, Kimmich R, Spohn KH. Indirect 13C tomography and volume-selective spectroscopy via proton NMR. I. Spectrocopic techniques. J Magn Reson. 1990;86(3):526–541.
20. de Graaf RA, De Feyter HM, Rothman DL. High-sensitivity, broadband-decoupled (13) C MR spectroscopy in humans at 7T using two-dimensional heteronuclear single-quantum coherence. Magn Reson Med. 2015;74(4):903–914.
21. Gruetter R. Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn Reson Med. 1993;29(6):804–811.
22. Vanhamme L, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson. 1997;129(1):35–43.
23. Guiu B, et al. Quantification of liver fat content: comparison of triple-echo chemical shift gradient-echo imaging and in vivo proton MR spectroscopy. Radiology. 2009;250(1):95–102.
24. Molina DK, DiMaio VJ. Normal organ weights in men: part II-the brain, lungs, liver, spleen, and kidneys. Am J Forensic Med Pathol. 2012;33(4):368–372.