-
1
-
-
64749100501
-
Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
-
Nathan DM, Buse JB, Davidson MB et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203.
-
(2009)
Diabetes Care
, vol.32
, pp. 193-203
-
-
Nathan, D.M.1
Buse, J.B.2
Davidson, M.B.3
-
3
-
-
39749147110
-
Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
-
DOI 10.1038/nrm2327, PII NRM2327
-
Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008;9:193-205. (Pubitemid 351301824)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.3
, pp. 193-205
-
-
Muoio, D.M.1
Newgard, C.B.2
-
4
-
-
53649083550
-
Is mitochondrial dysfunction a cause of insulin resistance?
-
Turner N, Heilbronn LK. Is mitochondrial dysfunction a cause of insulin resistance? Trends Endocrinol Metab 2008;19:324-330.
-
(2008)
Trends Endocrinol Metab
, vol.19
, pp. 324-330
-
-
Turner, N.1
Heilbronn, L.K.2
-
5
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
Koves TR, Ussher JR, Noland RC et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008;7:45-56.
-
(2008)
Cell Metab
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
-
6
-
-
35548999739
-
Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes
-
DOI 10.1016/j.cell.2007.08.047, PII S009286740701197X
-
Pospisilik JA, Knauf C, Joza N et al. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 2007;131:476-491. (Pubitemid 350017761)
-
(2007)
Cell
, vol.131
, Issue.3
, pp. 476-491
-
-
Pospisilik, J.A.1
Knauf, C.2
Joza, N.3
Benit, P.4
Orthofer, M.5
Cani, P.D.6
Ebersberger, I.7
Nakashima, T.8
Sarao, R.9
Neely, G.10
Esterbauer, H.11
Kozlov, A.12
Kahn, C.R.13
Kroemer, G.14
Rustin, P.15
Burcelin, R.16
Penninger, J.M.17
-
7
-
-
71849094328
-
Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients
-
Liu J, Shen W, Zhao B et al. Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients. Adv Drug Deliv Rev 2009;61: 1343-1352.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 1343-1352
-
-
Liu, J.1
Shen, W.2
Zhao, B.3
-
8
-
-
37549032661
-
Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets?
-
Buechler C, Schäffler A. Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets? Endocr Metab Immune Disord Drug Targets 2007;7:250-258.
-
(2007)
Endocr Metab Immune Disord Drug Targets
, vol.7
, pp. 250-258
-
-
Buechler, C.1
Schäffler, A.2
-
9
-
-
56149097362
-
Resistance to diet-induced obesity in mice with a single substituted chromosome
-
Buchner DA, Burrage LC, Hill AE et al. Resistance to diet-induced obesity in mice with a single substituted chromosome. Physiol Genomics 2008;35:116-122.
-
(2008)
Physiol Genomics
, vol.35
, pp. 116-122
-
-
Buchner, D.A.1
Burrage, L.C.2
Hill, A.E.3
-
10
-
-
23144442351
-
VAMPIRE microarray suite: A web-based platform for the interpretation of gene expression data
-
DOI 10.1093/nar/gki443
-
Hsiao A, Ideker T, Olefsky JM, Subramaniam S. VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data. Nucleic Acids Res 2005;33:W627-W632. (Pubitemid 44529998)
-
(2005)
Nucleic Acids Research
, vol.33
, Issue.WEB. SERV. ISS.
-
-
Hsiao, A.1
Ideker, T.2
Olefsky, J.M.3
Subramaniam, S.4
-
11
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
DOI 10.1073/pnas.0506580102
-
Subramanian A, Tamayo P, Mootha VK et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005;102:15545-15550. (Pubitemid 41528093)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.43
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
12
-
-
0018399518
-
Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states
-
Hoppel C, DiMarco J P, Tandler B. Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states. J Biol Chem 1979;254:4164-4170. (Pubitemid 9178641)
-
(1979)
Journal of Biological Chemistry
, vol.254
, Issue.10
, pp. 4164-4170
-
-
Hoppel, C.1
DiMarco, J.P.2
Tandler, B.3
-
13
-
-
73049107663
-
Antidiabetic effects of IGFBP2, a leptin-regulated gene
-
Hedbacker K, Birsoy K, Wysocki RW et al. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab 2010;11:11-22.
-
(2010)
Cell Metab
, vol.11
, pp. 11-22
-
-
Hedbacker, K.1
Birsoy, K.2
Wysocki, R.W.3
-
14
-
-
33847045938
-
IGF-binding protein-2 protects against the development of obesity and insulin resistance
-
Wheatcroft SB, Kearney M T, Shah AM et al. IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes 2007;56:285-294.
-
(2007)
Diabetes
, vol.56
, pp. 285-294
-
-
Wheatcroft, S.B.1
Kearney, M.T.2
Shah, A.M.3
-
15
-
-
33847768085
-
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
-
DOI 10.1073/pnas.0610416104
-
Almind K, Manieri M, Sivitz WI, Cinti S, Kahn CR. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci USA 2007;104: 2366-2371. (Pubitemid 46391403)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.7
, pp. 2366-2371
-
-
Almind, K.1
Manieri, M.2
Sivitz, W.I.3
Cinti, S.4
Kahn, C.R.5
-
16
-
-
34250740323
-
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
-
DOI 10.1038/nature05861, PII NATURE05861
-
Li X, Monks B, Ge Q, Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription co-activator. Nature 2007;447:1012-1016. (Pubitemid 46975750)
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 1012-1016
-
-
Li, X.1
Monks, B.2
Ge, Q.3
Birnbaum, M.J.4
-
17
-
-
0032167516
-
Transcription occurs in pulses in muscle fibers
-
Newlands S, Levitt LK, Robinson CS et al. Transcription occurs in pulses in muscle fibers. Genes Dev 1998;12:2748-2758. (Pubitemid 28420654)
-
(1998)
Genes and Development
, vol.12
, Issue.17
, pp. 2748-2758
-
-
Newlands, S.1
Levitt, L.K.2
Robinson, C.S.3
Karpf, A.B.C.4
Hodgson, V.R.M.5
Wade, R.P.6
Hardeman, E.C.7
-
18
-
-
38549126643
-
KEGG for linking genomes to life and the environment
-
DOI 10.1093/nar/gkm882
-
Kanehisa M, Araki M, Goto S et al. KEGG for linking genomes to life and the environment. Nucleic Acids Res 2008;36:D480-D484. (Pubitemid 351149770)
-
(2008)
Nucleic Acids Research
, vol.36
, Issue.SUPPL. 1
-
-
Kanehisa, M.1
Araki, M.2
Goto, S.3
Hattori, M.4
Hirakawa, M.5
Itoh, M.6
Katayama, T.7
Kawashima, S.8
Okuda, S.9
Tokimatsu, T.10
Yamanishi, Y.11
-
19
-
-
0031806620
-
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways
-
Ceresa B P, Kao AW, Santeler SR, Pessin JE. Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways. Mol Cell Biol 1998;18:3862-3870. (Pubitemid 28287909)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.7
, pp. 3862-3870
-
-
Ceresa, B.P.1
Kao, A.W.2
Santeler, S.R.3
Pessin, J.E.4
-
20
-
-
0038054341
-
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
DOI 10.1038/ng1180
-
Mootha VK, Lindgren CM, Eriksson KF et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003;34:267-273. (Pubitemid 36792858)
-
(2003)
Nature Genetics
, vol.34
, Issue.3
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.-F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstrale, M.9
Laurila, E.10
Houstis, N.11
Daly, M.J.12
Patterson, N.13
Mesirov, J.P.14
Golub, T.R.15
Tamayo, P.16
Spiegelman, B.17
Lander, E.S.18
Hirschhorn, J.N.19
Altshuler, D.20
Groop, L.C.21
more..
-
21
-
-
52649149879
-
Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus
-
Abdul-Ghani MA, DeFronzo RA. Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus. Curr Diab Rep 2008;8:173-178.
-
(2008)
Curr Diab Rep
, vol.8
, pp. 173-178
-
-
Abdul-Ghani, M.A.1
Defronzo, R.A.2
-
22
-
-
34247637323
-
Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes
-
Misu H, Takamura T, Matsuzawa N et al. Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Diabetologia 2007;50:268-277.
-
(2007)
Diabetologia
, vol.50
, pp. 268-277
-
-
Misu, H.1
Takamura, T.2
Matsuzawa, N.3
-
23
-
-
58149316376
-
Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients
-
Takamura T, Misu H, Matsuzawa-Nagata N et al. Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. Obesity (Silver Spring) 2008;16:2601-2609.
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 2601-2609
-
-
Takamura, T.1
Misu, H.2
Matsuzawa-Nagata, N.3
-
24
-
-
33644660537
-
PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
-
DOI 10.1172/JCI27794
-
Finck BN, Kelly D P. PGC-1 co-activators: Inducible regulators of energy metabolism in health and disease. J Clin Invest 2006;116:615-622. (Pubitemid 43326866)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 615-622
-
-
Finck, B.N.1
Kelly, D.P.2
-
25
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coaotivator PGC-1
-
DOI 10.1038/35093050
-
Yoon JC, Puigserver P, Chen G et al. Control of hepatic gluconeogenesis through the transcriptional co-activator PGC-1. Nature 2001;413:131-138. (Pubitemid 32867868)
-
(2001)
Nature
, vol.413
, Issue.6852
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
26
-
-
67749142348
-
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes
-
Samuel VT, Beddow SA, Iwasaki T et al. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes. Proc Natl Acad Sci USA 2009;106:12121-12126.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12121-12126
-
-
Samuel, V.T.1
Beddow, S.A.2
Iwasaki, T.3
-
27
-
-
33747853190
-
Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
-
DOI 10.1016/j.cmet.2006.08.005, PII S1550413106002750
-
Finck BN, Gropler MC, Chen Z et al. Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway. Cell Metab 2006;4:199-210. (Pubitemid 44283957)
-
(2006)
Cell Metabolism
, vol.4
, Issue.3
, pp. 199-210
-
-
Finck, B.N.1
Gropler, M.C.2
Chen, Z.3
Leone, T.C.4
Croce, M.A.5
Harris, T.E.6
Lawrence Jr., J.C.7
Kelly, D.P.8
-
29
-
-
0035036343
-
Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling
-
DOI 10.1016/S0896-6273(01)00273-2
-
Krishnan KS, Rikhy R, Rao S et al. Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling. Neuron 2001;30:197-210. (Pubitemid 32441687)
-
(2001)
Neuron
, vol.30
, Issue.1
, pp. 197-210
-
-
Krishnan, K.S.1
Rikhy, R.2
Rao, S.3
Shivalkar, M.4
Mosko, M.5
Narayanan, R.6
Etter, P.7
Estes, P.S.8
Ramaswami, M.9
-
30
-
-
46349086273
-
Clathrin-Dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: Regulation by mitochondrial uncoupling
-
DOI 10.1111/j.1600-0854.2008.00755.x
-
Antonescu CN, Díaz M, Femia G, Planas J V, Klip A. Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling. Traffic 2008;9:1173-1190. (Pubitemid 351916891)
-
(2008)
Traffic
, vol.9
, Issue.7
, pp. 1173-1190
-
-
Antonescu, C.N.1
Diaz, M.2
Femia, G.3
Planas, J.V.4
Klip, A.5
-
31
-
-
0032566652
-
Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling
-
DOI 10.1074/jbc.273.39.25450
-
Kao AW, Ceresa B P, Santeler SR, Pessin JE. Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling. J Biol Chem 1998;273:25450-25457. (Pubitemid 28443314)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.39
, pp. 25450-25457
-
-
Kao, A.W.1
Ceresa, B.P.2
Santeler, S.R.3
Pessin, J.E.4
-
32
-
-
0037387146
-
Regulation of melanocortin-4 receptor signaling: Agonist-mediated desensitization and internalization
-
DOI 10.1210/en.2002-220931
-
Shinyama H, Masuzaki H, Fang H, Flier JS. Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology 2003;144:1301-1314. (Pubitemid 36428472)
-
(2003)
Endocrinology
, vol.144
, Issue.4
, pp. 1301-1314
-
-
Shinyama, H.1
Masuzaki, H.2
Fang, H.3
Flier, J.S.4
-
33
-
-
70449591270
-
A new paradigm for MAPK: Structural interactions of hERK1 with mitochondria in HeLa cells
-
Galli S, Jahn O, Hitt R et al. A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells. PLoS ONE 2009;4:e7541.
-
(2009)
PLoS ONE
, vol.4
-
-
Galli, S.1
Jahn, O.2
Hitt, R.3
|