Relationships of body composition and liver fat content with insulin resistance in obesity-matched adolescents and adults

Obesity

Volumn 22, Issue 5, 2014, Pages 1325-1331

  Linder, Katarzyna ^a,b,c   Springer, Fabian ^a   MacHann, Jürgen ^a,b,c   Schick, Fritz ^a   Fritsche, Andreas ^a,b,c   Häring, Hans Ulrich ^a,b,c   Blumenstock, Gunnar ^c   Ranke, Michael B ^a   Stefan, Norbert ^a,b,c   Binder, Gerhard ^a   Ehehalt, Stefan ^a,d  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d Department of Pediatrics Dental Health Care and Social Services   (Germany)

Author keywords

body composition; insulin resistance; liver fat

Indexed keywords

GLUCOSE; INSULIN;

ADOLESCENT; ADULT; AGE; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BODY FAT; BODY FAT DISTRIBUTION; BODY HEIGHT; BODY MASS; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; FAT CONTENT; FAT MASS; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE; HUMAN; INDEPENDENT VARIABLE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULINEMIA; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LIPID STORAGE; LIVER FAT CONTENT; MALE; OBESITY; PHENOTYPE; PROTON NUCLEAR MAGNETIC RESONANCE; SEX; WHOLE BODY MRI; CHEMISTRY; COMPARATIVE STUDY; LIVER; LONGITUDINAL STUDY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; STATISTICAL MODEL;

ADIPOSITY; ADOLESCENT; ADULT; AGE FACTORS; BODY MASS INDEX; FEMALE; HUMANS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LINEAR MODELS; LIVER; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBESITY;

EID: 84899974579     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20685     Document Type: Article

References (40)

1. Després JP, Lemieux I,. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881-887
2. Stefan N, Kantartzis K, Machann J, et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 2008; 168: 1609-1616
3. Amati F, Pennant M, Azuma K, et al. Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance. Obesity (Silver Spring) 2012; 20: 1115-1117.
4. Fabbrini E, Magkos F, Mohammed BS, et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA 2009; 106: 15430-15435.
5. Kantartzis K, Machann J, Schick F, et al. Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia 2011; 54: 864-868.
6. Cohen JC, Horton JD, Hobbs HH,. Human fatty liver disease: old questions and new insights. Science 2011; 332: 1519-1523.
7. Gastaldelli A, Cusi K, Pettiti M, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 2007; 133: 496-506.
8. Roden M,. Mechanisms of disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance. Nat Clin Pract Endocrinol Metab 2006; 2: 335-348.
9. Kotronen A, Yki-Järvinen H,. Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 2008; 28: 27-38.
10. Ogden CL, Carroll MD, Kit BK, Flegal KM,. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 2012; 307: 483-490.
11. Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002; 346: 802-810.
12. Taksali SE, Caprio S, Dziura J, et al. High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes 2008; 57: 367-371.
13. Kim JS, Lê KA, Mahurkar S, Davis JN, Goran MI,. Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese Hispanic adolescents. Pediatr Obes 2012; 7: 158-164.
14. D'Adamo E, Cali AM, Weiss R, et al. Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents. Diabetes Care 2012; 33: 1817-1822.
15. Perseghin G, Bonfanti R, Magni S, et al. Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease. Am J Physiol Endocrinol Metab 2006; 291: 697-703.
16. Bennett B, Larson-Meyer DE, Ravussin E, et al. Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children. Obesity (Silver Spring) 2012; 20: 371-375.
17. Kim G, Giannini C, Pierpont B, et al. Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth. Diabetes Care 2013; 36: 130-136.
18. Cali AM, De Oliveira AM, Kim H, et al. Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link? Hepatology 2009; 49: 1896-1903.
19. Springer F, Ehehalt S, Sommer J, et al. Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings. Eur Radiol 2011; 21: 816-822.
20. Kromeyer-Hauschild K, Wabitsch M, Kunze D, et al. Perzentile für den Body-Mass-Index für das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilk 2011; 149: 807-818.
21. Marshall WA, Tanner JM,. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291-303.
22. Marshall WA, Tanner JM,. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13-23.
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC,. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
24. Genuth S, Alberti KG, Bennett P, et al. Follow up report on the diagnosis of diabetes mellitus. Diabetes Care 2003; 26: 3160-3167.
25. Machann J, Thamer C, Schnoedt B, et al. Standardized assessment of whole body adipose tissue topography by MRI. J Magn Reson Imaging 2005; 21: 455-462.
26. Szczepaniak LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005; 288: E462-E468.
27. Odegaard JI, Chawla A,. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 2013; 339: 172-177.
28. Amiel SA, Sherwin RS, Simonson DC, Lauritano AA, Tamborlane WV,. Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes. N Engl J Med 1986; 315: 215-219.
29. Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA,. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002; 87: 4652-4656.
30. Levy-Marchal C, Arslanian S, Cutfield W, et al. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab 2010; 95: 5189-5198.
31. Kurtoǧlu S, Hatipoǧlu N, Mazicioǧlu M, Kendirici M, Keskin M, Kondolot M,. Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010; 2: 100-106.
32. Goran MI, Gower BA,. Longitudinal study on pubertal insulin resistance. Diabetes 2001; 50: 2444-2450.
33. Adam TC, Hasson RE, Lane CJ, et al. Fasting indicators of insulin sensitivity: effects of ethnicity and pubertal status. Diabetes Care 2011; 34: 994-999.
34. Roemmich JN, Clark PA, Lusk M, et al. Pubertal alterations in growth and body composition. VI. Pubertal insulin resistance: relation to adiposity, body fat distribution and hormone release. Int J Obes Relat Metab Disord 2002; 26: 701-709.
35. Trujillo ME, Scherer PE,. Adipose tissue-derived factors: impact on health and disease. Endocr Rev 2005; 27: 762-778.
36. Pedersen BK, Febbraio MA,. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 2012; 8: 457-465.
37. Stefan N, Häring HU,. The role of hepatokines in metabolism. Nat Rev Endocrinol 2013; 9: 144-152.
38. Stefan N, Häring HU,. The metabolically benign and malignant fatty liver. Diabetes 2011; 60: 2011-2017.
39. Brufani C, Tozzi A, Fintini D, et al. Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects. Eur J Endocrinol 2009; 160: 769-775.
40. Siervogel RM, Demerath EW, Schubert C, et al. Puberty and body composition. Horm Res 2003; 60 (Suppl 1): 36-45.