메뉴 건너뛰기




Volumn 16, Issue , 2017, Pages 137-167

Glial GABA transporters as modulators of inhibitory signalling in epilepsy and stroke

Author keywords

BGT1; Epilepsy; GABAA receptors; GAT; GAT1; GAT3; Ischemic stroke; Tonic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID CARRIER; BICUCULLINE; DIAZEPAM; GABA TRANSPORTER 1; GABA TRANSPORTER 3; GABOXADOL; HYPERTONIC SOLUTION; ISATIN; PICROTOXIN; TIAGABINE;

EID: 85028063755     PISSN: 21905215     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-319-55769-4_7     Document Type: Chapter
Times cited : (26)

References (189)
  • 1
    • 17644446163 scopus 로고    scopus 로고
    • Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat
    • Akbar MT, Rattray M, Williams RJ, Chong NWS, Meldrum BS. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. Neuroscience. 1998;85(4):1235–51.
    • (1998) Neuroscience , vol.85 , Issue.4 , pp. 1235-1251
    • Akbar, M.T.1    Rattray, M.2    Williams, R.J.3    Chong, N.W.S.4    Meldrum, B.S.5
  • 2
    • 84918775764 scopus 로고    scopus 로고
    • Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1
    • Al-Khawaja A, Petersen JG, Damgaard M, Jensen MH, Vogensen SB, Lie MEK, et al. Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1). Neurochem Res. 2014;39(10):1988–96.
    • (2014) Neurochem Res , vol.39 , Issue.10 , pp. 1988-1996
    • Al-Khawaja, A.1    Petersen, J.G.2    Damgaard, M.3    Jensen, M.H.4    Vogensen, S.B.5    Lie, M.E.K.6
  • 3
    • 84964324589 scopus 로고    scopus 로고
    • Astrocyte scar formation aids central nervous system axon regeneration
    • Anderson M, Burda J, Ren Y, Ao Y, O’Shea T, Kawaguchi R, et al. Astrocyte scar formation aids central nervous system axon regeneration. Nature. 2016;532(7598):195–200.
    • (2016) Nature , vol.532 , Issue.7598 , pp. 195-200
    • Anderson, M.1    Burda, J.2    Ren, Y.3    Ao, Y.4    O’Shea, T.5    Kawaguchi, R.6
  • 4
    • 0034865559 scopus 로고    scopus 로고
    • Alterations of hippocampal GABAergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy
    • André V, Marescaux C, Nehlig A, Fritschy JM. Alterations of hippocampal GABAergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy. Hippocampus. 2001;11(4):452–68.
    • (2001) Hippocampus , vol.11 , Issue.4 , pp. 452-468
    • André, V.1    Marescaux, C.2    Nehlig, A.3    Fritschy, J.M.4
  • 5
    • 0346097885 scopus 로고    scopus 로고
    • Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus
    • Arellano JI, Muñoz A, Ballesteros-Yáñez I, Sola RG, DeFelipe J. Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain. 2004;127(1):45–64.
    • (2004) Brain , vol.127 , Issue.1 , pp. 45-64
    • Arellano, J.I.1    Muñoz, A.2    Ballesteros-Yáñez, I.3    Sola, R.G.4    Defelipe, J.5
  • 6
    • 33947143011 scopus 로고    scopus 로고
    • Inhibitory networks in epilepsy-associated gangliogliomas and in the perilesional epileptic cortex
    • Aronica E, Redeker S, Boer K, Spliet WGM, van Rijen PC, Gorter JA, et al. Inhibitory networks in epilepsy-associated gangliogliomas and in the perilesional epileptic cortex. Epilepsy Res. 2007;74(1):33–44.
    • (2007) Epilepsy Res , vol.74 , Issue.1 , pp. 33-44
    • Aronica, E.1    Redeker, S.2    Boer, K.3    Spliet, W.G.M.4    Van Rijen, P.C.5    Gorter, J.A.6
  • 8
    • 0028275367 scopus 로고
    • Attenuation by chlorme-thiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat
    • May
    • Baldwin HA, Williams JL, Snares M, Ferreira T, Cross AJ, Green AR. Attenuation by chlorme-thiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat. Br J Pharmacol. 1994 May;112(1):188–94.
    • (1994) Br J Pharmacol , vol.112 , Issue.1 , pp. 188-194
    • Baldwin, H.A.1    Williams, J.L.2    Snares, M.3    Ferreira, T.4    Cross, A.J.5    Green, A.R.6
  • 10
    • 33746302765 scopus 로고    scopus 로고
    • Human epilepsies: Interaction of genetic and acquired factors
    • Berkovic SF, Mulley JC, Scheffer IE, Petrou S. Human epilepsies: interaction of genetic and acquired factors. Trends Neurosci. 2006;29(7):391–7.
    • (2006) Trends Neurosci , vol.29 , Issue.7 , pp. 391-397
    • Berkovic, S.F.1    Mulley, J.C.2    Scheffer, I.E.3    Petrou, S.4
  • 12
    • 84912034203 scopus 로고    scopus 로고
    • Alleviation of glutamate mediated neuronal insult by piroxicam in rodent model of focal cerebral ischemia: A possible mechanism of GABA agonism
    • Bhattacharya P, Pandey AK, Paul S, Patnaik R. Alleviation of glutamate mediated neuronal insult by piroxicam in rodent model of focal cerebral ischemia: a possible mechanism of GABA agonism. J Physiol Biochem. 2014;70(4):901–13.
    • (2014) J Physiol Biochem , vol.70 , Issue.4 , pp. 901-913
    • Bhattacharya, P.1    Pandey, A.K.2    Paul, S.3    Patnaik, R.4
  • 14
    • 0032980011 scopus 로고    scopus 로고
    • Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity
    • Bolvig T, Larsson OM, Pickering DS, Nelson N, Falch E, Krogsgaard-Larsen P, et al. Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity. Eur J Pharmacol. 1999;375(1–3):367–74.
    • (1999) Eur J Pharmacol , vol.375 , Issue.1-3 , pp. 367-374
    • Bolvig, T.1    Larsson, O.M.2    Pickering, D.S.3    Nelson, N.4    Falch, E.5    Krogsgaard-Larsen, P.6
  • 15
    • 0030272426 scopus 로고    scopus 로고
    • GABA transporter heterogeneity: Pharmacology and cellular localization
    • Borden LA, Caplan MJ. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int. 1996;29(4):335–56.
    • (1996) Neurochem Int , vol.29 , Issue.4 , pp. 335-356
    • Borden, L.A.1    Caplan, M.J.2
  • 18
    • 84855729789 scopus 로고    scopus 로고
    • Receptors: Their function in the CNS and implications for disease
    • A receptors: their function in the CNS and implications for disease. Neuron. 2012;73(1):23–34.
    • (2012) Neuron , vol.73 , Issue.1 , pp. 23-34
    • Brickley, S.G.1    Mody, I.2    Extrasynaptic, G.A.B.A.A.3
  • 19
    • 60849126407 scopus 로고    scopus 로고
    • In vivo voltage-sensitive dye imaging in adult mice reveals that somatosensory maps lost to stroke are replaced over weeks by new structural and functional circuits with prolonged modes of activation within both the peri-infarct zone and distant sites
    • Brown CE, Aminoltejari K, Erb H, Winship IR, Murphy TH. In vivo voltage-sensitive dye imaging in adult mice reveals that somatosensory maps lost to stroke are replaced over weeks by new structural and functional circuits with prolonged modes of activation within both the peri-infarct zone and distant sites. J Neurosci. 2009;29(6):1719–34.
    • (2009) J Neurosci , vol.29 , Issue.6 , pp. 1719-1734
    • Brown, C.E.1    Aminoltejari, K.2    Erb, H.3    Winship, I.R.4    Murphy, T.H.5
  • 20
    • 84892741034 scopus 로고    scopus 로고
    • Reactive gliosis and the multicellular response to CNS damage and disease
    • Burda JE, Sofroniew MV. Reactive gliosis and the multicellular response to CNS damage and disease. Neuron. 2014;81(2):229–48.
    • (2014) Neuron , vol.81 , Issue.2 , pp. 229-248
    • Burda, J.E.1    Sofroniew, M.V.2
  • 21
    • 0036758641 scopus 로고    scopus 로고
    • Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy
    • Calcagnotto ME, Paredes MF, Baraban SC. Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy. J Neurosci. 2002;22(17): 7596–605.
    • (2002) J Neurosci , vol.22 , Issue.17 , pp. 7596-7605
    • Calcagnotto, M.E.1    Paredes, M.F.2    Baraban, S.C.3
  • 22
    • 27144467085 scopus 로고    scopus 로고
    • Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia
    • Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC. Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia. J Neurosci. 2005;25(42):9649–57.
    • (2005) J Neurosci , vol.25 , Issue.42 , pp. 9649-9657
    • Calcagnotto, M.E.1    Paredes, M.F.2    Tihan, T.3    Barbaro, N.M.4    Baraban, S.C.5
  • 23
    • 0021713542 scopus 로고
    • Bicuculline epileptogenesis in the rat
    • Campbell AM, Holmes O. Bicuculline epileptogenesis in the rat. Brain Res. 1984;323(2):239–46.
    • (1984) Brain Res , vol.323 , Issue.2 , pp. 239-246
    • Campbell, A.M.1    Holmes, O.2
  • 24
    • 84856851275 scopus 로고    scopus 로고
    • Brain excitability in stroke: The yin and yang of stroke progression
    • Carmichael ST. Brain excitability in stroke: the yin and yang of stroke progression. Arch Neurol. 2012;69(2):161–7.
    • (2012) Arch Neurol , vol.69 , Issue.2 , pp. 161-167
    • Carmichael, S.T.1
  • 25
    • 34250167199 scopus 로고    scopus 로고
    • Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: Evolution monitored with MR imaging and histopathology
    • Chen F, Suzuki Y, Nagai N, Jin L, Yu J, Wang H, et al. Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: evolution monitored with MR imaging and histopathology. Eur J Radiol. 2007;63(1):68–75.
    • (2007) Eur J Radiol , vol.63 , Issue.1 , pp. 68-75
    • Chen, F.1    Suzuki, Y.2    Nagai, N.3    Jin, L.4    Yu, J.5    Wang, H.6
  • 26
    • 0034683189 scopus 로고    scopus 로고
    • Neuroprotective activity of tiagabine in a focal embolic model of cerebral ischemia
    • Chen Xu W, Yi Y, Qiu L, Shuaib A. Neuroprotective activity of tiagabine in a focal embolic model of cerebral ischemia. Brain Res. 2000;874(1):75–7.
    • (2000) Brain Res , vol.874 , Issue.1 , pp. 75-77
    • Chen Xu, W.1    Yi, Y.2    Qiu, L.3    Shuaib, A.4
  • 27
    • 16244405559 scopus 로고    scopus 로고
    • GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum
    • Chiu C-S, Brickley S, Jensen K, Southwell A, Mckinney S, Cull-Candy S, et al. GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. J Neurosci. 2005;25(12):3234–45.
    • (2005) J Neurosci , vol.25 , Issue.12 , pp. 3234-3245
    • Chiu, C.-S.1    Brickley, S.2    Jensen, K.3    Southwell, A.4    McKinney, S.5    Cull-Candy, S.6
  • 29
    • 78149431325 scopus 로고    scopus 로고
    • Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke
    • Clarkson AN, Huang BS, Macisaac SE, Mody I, Carmichael ST. Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature. 2010;468(7321): 305–9.
    • (2010) Nature , vol.468 , Issue.7321 , pp. 305-309
    • Clarkson, A.N.1    Huang, B.S.2    Macisaac, S.E.3    Mody, I.4    Carmichael, S.T.5
  • 30
    • 19944428485 scopus 로고    scopus 로고
    • Selective inhibitors of GABA uptake: Synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues
    • Clausen RP, Moltzen EK, Perregaard J, Lenz SM, Sanchez C, Falch E, et al. Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues. Bioorg Med Chem. 2005;13(3):895–908.
    • (2005) Bioorg Med Chem , vol.13 , Issue.3 , pp. 895-908
    • Clausen, R.P.1    Moltzen, E.K.2    Perregaard, J.3    Lenz, S.M.4    Sanchez, C.5    Falch, E.6
  • 32
    • 0032557811 scopus 로고    scopus 로고
    • Neuronal and glial localization of GAT-1, a high-affinity γ-aminobutyric acid plasma membrane transporter, in human cerebral cortex: With a note on its distribution in monkey cortex
    • Conti F, Melone M, De Biasi S, Minelli A, Brecha NC, Ducati A. Neuronal and glial localization of GAT-1, a high-affinity γ-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex. J Comp Neurol. 1998;396(1):51–63.
    • (1998) J Comp Neurol , vol.396 , Issue.1 , pp. 51-63
    • Conti, F.1    Melone, M.2    De Biasi, S.3    Minelli, A.4    Brecha, N.C.5    Ducati, A.6
  • 33
    • 3042649213 scopus 로고    scopus 로고
    • GABA transporters in the mammalian cerebral cortex: Localization, development and pathological implications
    • Conti F, Minelli A, Melone M. GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications. Brain Res Rev. 2004;45(3):196–212.
    • (2004) Brain Res Rev , vol.45 , Issue.3 , pp. 196-212
    • Conti, F.1    Minelli, A.2    Melone, M.3
  • 34
    • 0033526902 scopus 로고    scopus 로고
    • Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures
    • Conti F, Zuccarello LV, Barbaresi P, Minelli A, Brecha NC, Melone M. Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures. J Comp Neurol. 1999;409(3):482–94.
    • (1999) J Comp Neurol , vol.409 , Issue.3 , pp. 482-494
    • Conti, F.1    Zuccarello, L.V.2    Barbaresi, P.3    Minelli, A.4    Brecha, N.C.5    Melone, M.6
  • 37
    • 0014964638 scopus 로고
    • GABA, bicuculline and central inhibition
    • Curtis DR, Duggan AW, Felix D, Johnston G. GABA, bicuculline and central inhibition. Nature. 1970;226(5252):1222–4.
    • (1970) Nature , vol.226 , Issue.5252 , pp. 1222-1224
    • Curtis, D.R.1    Duggan, A.W.2    Felix, D.3    Johnston, G.4
  • 38
    • 0033884270 scopus 로고    scopus 로고
    • GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors
    • Dalby NO. GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000;39(12):2399–407.
    • (2000) Neuropharmacology , vol.39 , Issue.12 , pp. 2399-2407
    • Dalby, N.O.1
  • 39
    • 0242660375 scopus 로고    scopus 로고
    • Inhibition of γ-aminobutyric acid uptake: Anatomy, physiology and effects against epileptic seizures
    • Dalby NO. Inhibition of γ-aminobutyric acid uptake: anatomy, physiology and effects against epileptic seizures. Eur J Pharmacol. 2003;479(1–3):127–37.
    • (2003) Eur J Pharmacol , vol.479 , Issue.1-3 , pp. 127-137
    • Dalby, N.O.1
  • 40
    • 0030849231 scopus 로고    scopus 로고
    • Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1
    • Dalby NO, Thomsen C, Fink-Jensen A, Lundbeck J, Søkilde B, Man CM, et al. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 1997;28(1):51–61.
    • (1997) Epilepsy Res , vol.28 , Issue.1 , pp. 51-61
    • Dalby, N.O.1    Thomsen, C.2    Fink-Jensen, A.3    Lundbeck, J.4    Søkilde, B.5    Man, C.M.6
  • 42
    • 84941930838 scopus 로고    scopus 로고
    • Identification of the first highly subtype-selective inhibitor of human GABA transporter GAT3
    • Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie MEK, et al. Identification of the first highly subtype-selective inhibitor of human GABA transporter GAT3. ACS Chem Neurosci. 2015;6(9):1591–9.
    • (2015) ACS Chem Neurosci , vol.6 , Issue.9 , pp. 1591-1599
    • Damgaard, M.1    Al-Khawaja, A.2    Vogensen, S.B.3    Jurik, A.4    Sijm, M.5    Lie, M.E.K.6
  • 44
    • 0028064577 scopus 로고
    • Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: Identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT- 3
    • Dhar TGM, Borden LA, Tyagarajan S, Smith KE, Branchek TA, Weinshank RL, et al. Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT- 3. J Med Chem. 1994;37(15):2334–42.
    • (1994) J Med Chem , vol.37 , Issue.15 , pp. 2334-2342
    • Dhar, T.G.M.1    Borden, L.A.2    Tyagarajan, S.3    Smith, K.E.4    Branchek, T.A.5    Weinshank, R.L.6
  • 45
    • 39049106121 scopus 로고    scopus 로고
    • Training and exercise to drive poststroke recovery
    • Dobkin BH. Training and exercise to drive poststroke recovery. Nat Clin Pract Neurol. 2008;4(2):76–85.
    • (2008) Nat Clin Pract Neurol , vol.4 , Issue.2 , pp. 76-85
    • Dobkin, B.H.1
  • 46
    • 84996484006 scopus 로고    scopus 로고
    • New evidence for therapies in stroke rehabilitation
    • Dobkin BH, Dorsch A. New evidence for therapies in stroke rehabilitation. Curr Atheroscler Rep. 2013;15(6):331.
    • (2013) Curr Atheroscler Rep , vol.15 , Issue.6 , pp. 331
    • Dobkin, B.H.1    Dorsch, A.2
  • 47
    • 65949088370 scopus 로고    scopus 로고
    • Role of glutamate and GABA transporters in development of pentylenetetrazol-kindling
    • Doi T, Ueda Y, Nagatomo K, Willmore LJ. Role of glutamate and GABA transporters in development of pentylenetetrazol-kindling. Neurochem Res. 2009;34(7):1324–31.
    • (2009) Neurochem Res , vol.34 , Issue.7 , pp. 1324-1331
    • Doi, T.1    Ueda, Y.2    Nagatomo, K.3    Willmore, L.J.4
  • 50
    • 0029011707 scopus 로고
    • Hippocampal GABA transporter function in temporal-lobe epilepsy
    • During MJ, Ryder KM, Spencer DD. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature. 1995;376(6536):174–7.
    • (1995) Nature , vol.376 , Issue.6536 , pp. 174-177
    • During, M.J.1    Ryder, K.M.2    Spencer, D.D.3
  • 51
    • 84919432580 scopus 로고    scopus 로고
    • Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials
    • Emberson J, Lees K, Lyden P, Blackwell L, Albers G, Bluhmki E, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet. 2014;385(9958):1929–35.
    • (2014) Lancet , vol.385 , Issue.9958 , pp. 1929-1935
    • Emberson, J.1    Lees, K.2    Lyden, P.3    Blackwell, L.4    Albers, G.5    Bluhmki, E.6
  • 54
    • 0033610230 scopus 로고    scopus 로고
    • Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy
    • Esclapez M, Houser CR. Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy. J Comp Neurol. 1999;412(3):488–505.
    • (1999) J Comp Neurol , vol.412 , Issue.3 , pp. 488-505
    • Esclapez, M.1    Houser, C.R.2
  • 56
    • 0026709603 scopus 로고
    • The γ-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats
    • Fink-Jensen A, Suzdak PD, Swedberg MDB, Judge ME, Hansen L, Nielsen PG. The γ-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. Eur J Pharmacol. 1992;220(2–3):197–201.
    • (1992) Eur J Pharmacol , vol.220 , Issue.2-3 , pp. 197-201
    • Fink-Jensen, A.1    Suzdak, P.D.2    Swedberg, M.D.B.3    Judge, M.E.4    Hansen, L.5    Nielsen, P.G.6
  • 57
    • 4444229575 scopus 로고    scopus 로고
    • Regulation of GABA transporter mRNA and protein after photothrombotic infarct in rat brain
    • Frahm C, Haupt C, Weinandy F, Siegel G, Bruehl C, Witte OW. Regulation of GABA transporter mRNA and protein after photothrombotic infarct in rat brain. J Comp Neurol. 2004;478(2):176–88.
    • (2004) J Comp Neurol , vol.478 , Issue.2 , pp. 176-188
    • Frahm, C.1    Haupt, C.2    Weinandy, F.3    Siegel, G.4    Bruehl, C.5    Witte, O.W.6
  • 58
    • 33747165254 scopus 로고    scopus 로고
    • Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus
    • Freichel C, Potschka H, Ebert U, Brandt C, Löscher W. Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus. Neuroscience. 2006;141(4):2177–94.
    • (2006) Neuroscience , vol.141 , Issue.4 , pp. 2177-2194
    • Freichel, C.1    Potschka, H.2    Ebert, U.3    Brandt, C.4    Löscher, W.5
  • 59
    • 84948166471 scopus 로고    scopus 로고
    • Nefiracetam attenuates pro-inflammatory cytokines and GABA transporter in specific brain regions of rats with post-ischemic seizures
    • Fu CY, He XY, Li XF, Zhang X, Huang ZW, Li J, et al. Nefiracetam attenuates pro-inflammatory cytokines and GABA transporter in specific brain regions of rats with post-ischemic seizures. Cell Physiol Biochem. 2015;37(5):2023–31.
    • (2015) Cell Physiol Biochem , vol.37 , Issue.5 , pp. 2023-2031
    • Cy, F.1    He, X.Y.2    Li, X.F.3    Zhang, X.4    Huang, Z.W.5    Li, J.6
  • 60
    • 0000401319 scopus 로고
    • Treatment of status epilepticus with diazepam (Valium)
    • Gastaut H, Naquet R, Poire R, Tassinari C. Treatment of status epilepticus with diazepam (Valium). Epilepsia. 1965;6:167–82.
    • (1965) Epilepsia , vol.6 , pp. 167-182
    • Gastaut, H.1    Naquet, R.2    Poire, R.3    Tassinari, C.4
  • 61
    • 48849089052 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: Past, present and future
    • Ginsberg MD. Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology. 2008;55(3):363–89.
    • (2008) Neuropharmacology , vol.55 , Issue.3 , pp. 363-389
    • Ginsberg, M.D.1
  • 63
    • 0034078117 scopus 로고    scopus 로고
    • GABA potentiation: A logical pharmacological approach for the treatment of acute ischaemic stroke
    • Green AR, Hainsworth AH, Jackson DM. GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke. Neuropharmacology. 2000;39(9):1483–94.
    • (2000) Neuropharmacology , vol.39 , Issue.9 , pp. 1483-1494
    • Green, A.R.1    Hainsworth, A.H.2    Jackson, D.M.3
  • 65
    • 84860426170 scopus 로고    scopus 로고
    • Astrocytes convert network excitation to tonic inhibition of neurons
    • Héja L, Nyitrai G, Kékesi O, Dobolyi Á, Szabó P, Fiáth R, et al. Astrocytes convert network excitation to tonic inhibition of neurons. BMC Biol. 2012;10(26):1–22.
    • (2012) BMC Biol , vol.10 , Issue.26 , pp. 1-22
    • Héja, L.1    Nyitrai, G.2    Kékesi, O.3    Dobolyi, Á.4    Szabó, P.5    Fiáth, R.6
  • 66
    • 0024260896 scopus 로고
    • Seizures and recovery from experimental brain damage
    • Hernandez TD, Schallert T. Seizures and recovery from experimental brain damage. Exp Neurol. 1988;102(3):318–24.
    • (1988) Exp Neurol , vol.102 , Issue.3 , pp. 318-324
    • Hernandez, T.D.1    Schallert, T.2
  • 67
    • 85007489674 scopus 로고    scopus 로고
    • Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulfora-phane by promoting M2 polarization of microglia
    • Hernandez-Rabaza V, Cabrera-Pastor A, Taoro-Gonzalez L, Gonzalez-Usano A, Agusti A, Balzano T, et al. Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulfora-phane by promoting M2 polarization of microglia. J Neuroinflammation. 2016;13(1):83.
    • (2016) J Neuroinflammation , vol.13 , Issue.1 , pp. 83
    • Hernandez-Rabaza, V.1    Cabrera-Pastor, A.2    Taoro-Gonzalez, L.3    Gonzalez-Usano, A.4    Agusti, A.5    Balzano, T.6
  • 68
    • 0015707760 scopus 로고
    • A comparative study of some convulsant substances as γ-aminobutyric acid antagonists in the feline cerebral cortex
    • Hill RG, Simmonds MA, Straughan DW. A comparative study of some convulsant substances as γ-aminobutyric acid antagonists in the feline cerebral cortex. Br J Pharmacol. 1973;49(1):37–51.
    • (1973) Br J Pharmacol , vol.49 , Issue.1 , pp. 37-51
    • Hill, R.G.1    Simmonds, M.A.2    Straughan, D.W.3
  • 70
    • 0031884324 scopus 로고    scopus 로고
    • Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats
    • Hirao T, Morimoto K, Yamamoto Y, Watanabe T, Sato H, Sato K, et al. Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats. Mol Brain Res. 1998;54(1):49–55.
    • (1998) Mol Brain Res , vol.54 , Issue.1 , pp. 49-55
    • Hirao, T.1    Morimoto, K.2    Yamamoto, Y.3    Watanabe, T.4    Sato, H.5    Sato, K.6
  • 74
    • 0029556193 scopus 로고
    • Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus
    • Inglefield JR, Perry JM, Schwartz RD. Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus. Hippocampus. 1995;5(5):460–8.
    • (1995) Hippocampus , vol.5 , Issue.5 , pp. 460-468
    • Inglefield, J.R.1    Perry, J.M.2    Schwartz, R.D.3
  • 75
    • 0037118934 scopus 로고    scopus 로고
    • Neuroprotective effect of tiagabine in transient forebrain global ischemia: An in vivo microdialysis, behavioral, and histological study
    • Iqbal S, Baziany A, Gordon S, Wright S, Hussain M, Miyashita H, et al. Neuroprotective effect of tiagabine in transient forebrain global ischemia: an in vivo microdialysis, behavioral, and histological study. Brain Res. 2002;946(2):162–70.
    • (2002) Brain Res , vol.946 , Issue.2 , pp. 162-170
    • Iqbal, S.1    Baziany, A.2    Gordon, S.3    Wright, S.4    Hussain, M.5    Miyashita, H.6
  • 77
    • 0014029736 scopus 로고
    • Simple allosteric model for membrane pumps
    • Jardetzky O. Simple allosteric model for membrane pumps. Nature. 1966;211(5052):969–70.
    • (1966) Nature , vol.211 , Issue.5052 , pp. 969-970
    • Jardetzky, O.1
  • 79
    • 0025913968 scopus 로고
    • Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells
    • Johansen FF, Diemer NH. Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells. Acta Neurol Scand. 1991;84(1):1–6.
    • (1991) Acta Neurol Scand , vol.84 , Issue.1 , pp. 1-6
    • Johansen, F.F.1    Diemer, N.H.2
  • 80
    • 0342813030 scopus 로고    scopus 로고
    • Differential effects of nipecotic acid and 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol on extracellular α-aminobutyrate levels in rat thalamus
    • Juhász G, Kékesi KA, Nyitrai G, Dobolyi A, Krogsgaard-Larsen P, Schousboe A. Differential effects of nipecotic acid and 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol on extracellular α-aminobutyrate levels in rat thalamus. Eur J Pharmacol. 1997;331(2–3):139–44.
    • (1997) Eur J Pharmacol , vol.331 , Issue.2-3 , pp. 139-144
    • Juhász, G.1    Kékesi, K.A.2    Nyitrai, G.3    Dobolyi, A.4    Krogsgaard-Larsen, P.5    Schousboe, A.6
  • 81
    • 72949149579 scopus 로고
    • Anticonvulsant properties of a new psychotherapeutic drug
    • Kaim S, Rosenstein I. Anticonvulsant properties of a new psychotherapeutic drug. Dis Nerv Syst. 1960;21(3):46–8.
    • (1960) Dis Nerv Syst , vol.21 , Issue.3 , pp. 46-48
    • Kaim, S.1    Rosenstein, I.2
  • 82
    • 0035823420 scopus 로고    scopus 로고
    • The changes in the expressions of γ-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure
    • Kang TC, Kim HS, Seo MO, Park SK, Kwon HY, Kang JH, et al. The changes in the expressions of γ-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure. Neurosci Lett. 2001;310(1):29–32.
    • (2001) Neurosci Lett , vol.310 , Issue.1 , pp. 29-32
    • Kang, T.C.1    Kim, H.S.2    Seo, M.O.3    Park, S.K.4    Kwon, H.Y.5    Kang, J.H.6
  • 83
    • 0028968680 scopus 로고
    • Intracerebral human microdialysis. In vivo study of an acute focal ischemic model of the human brain
    • Kanthan R, Shuaib A, Griebel R, Miyashita H. Intracerebral human microdialysis. In vivo study of an acute focal ischemic model of the human brain. Stroke. 1995;26(5):870–3.
    • (1995) Stroke , vol.26 , Issue.5 , pp. 870-873
    • Kanthan, R.1    Shuaib, A.2    Griebel, R.3    Miyashita, H.4
  • 84
    • 23944493552 scopus 로고    scopus 로고
    • A conductances in rat neocortex
    • A conductances in rat neocortex. J Neurophysiol. 2005;94(3):2073–85.
    • (2005) J Neurophysiol , vol.94 , Issue.3 , pp. 2073-2085
    • Keros, S.1    Hablitz, J.J.2
  • 85
    • 84877800385 scopus 로고    scopus 로고
    • A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus
    • Kersanté F, Rowley SCS, Pavlov I, Gutièrrez-Mecinas M, Semyanov A, Reul JMHM, et al. A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Physiol. 2013;591(10):2429–41.
    • (2013) J Physiol , vol.591 , Issue.10 , pp. 2429-2441
    • Kersanté, F.1    Rowley, S.C.S.2    Pavlov, I.3    Gutièrrez-Mecinas, M.4    Semyanov, A.5    Reul, J.M.H.M.6
  • 87
    • 84903614782 scopus 로고    scopus 로고
    • Functional recovery after ischemic stroke is associated with reduced GABAergic inhibition in the cerebral cortex: A GABA PET study
    • Kim YK, Yang EJ, Cho K, Lim JY, Paik N-J. Functional recovery after ischemic stroke is associated with reduced GABAergic inhibition in the cerebral cortex: a GABA PET study. Neurorehabil Neural Repair. 2014;28(6):576–83.
    • (2014) Neurorehabil Neural Repair , vol.28 , Issue.6 , pp. 576-583
    • Kim, Y.K.1    Yang, E.J.2    Cho, K.3    Lim, J.Y.4    Paik, N.-J.5
  • 88
    • 0033180239 scopus 로고    scopus 로고
    • Tiagabine-induced absence status in idiopathic generalized epilepsy
    • Knake S, Hamer H, Schomburg U, Oertel W, Rosenow F. Tiagabine-induced absence status in idiopathic generalized epilepsy. Seizure. 1999;8:314–7.
    • (1999) Seizure , vol.8 , pp. 314-317
    • Knake, S.1    Hamer, H.2    Schomburg, U.3    Oertel, W.4    Rosenow, F.5
  • 89
    • 84906282999 scopus 로고    scopus 로고
    • Conformationally restricted GABA with bicyclo[3.1.0]hexane backbone as the first highly selective BGT-1 inhibitor
    • Kobayashi T, Suemasa A, Igawa A, Ide S, Fukuda H, Abe H, et al. Conformationally restricted GABA with bicyclo[3.1.0]hexane backbone as the first highly selective BGT-1 inhibitor. ACS Med Chem Lett. 2014;5(8):889–93.
    • (2014) ACS Med Chem Lett , vol.5 , Issue.8 , pp. 889-893
    • Kobayashi, T.1    Suemasa, A.2    Igawa, A.3    Ide, S.4    Fukuda, H.5    Abe, H.6
  • 90
    • 84897503151 scopus 로고    scopus 로고
    • Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model
    • Kong S, Cheng Z, Liu J, Wang Y. Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model. Neural Plast. 2014;2014:9–11.
    • (2014) Neural Plast , vol.2014 , pp. 9-11
    • Kong, S.1    Cheng, Z.2    Liu, J.3    Wang, Y.4
  • 91
    • 84863981333 scopus 로고    scopus 로고
    • The role of glutamate in neuronal ischemic injury: The role of spark in fire
    • Kostandy BB. The role of glutamate in neuronal ischemic injury: the role of spark in fire. Neurol Sci. 2012;33(2):223–37.
    • (2012) Neurol Sci , vol.33 , Issue.2 , pp. 223-237
    • Kostandy, B.B.1
  • 92
    • 84884908850 scopus 로고    scopus 로고
    • Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a noncompetitive pharmacological profile
    • Kragholm B, Kvist T, Madsen KK, Jørgensen L, Vogensen SB, Schousboe A, et al. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a noncompetitive pharmacological profile. Biochem Pharmacol. 2013;86(4):521–8.
    • (2013) Biochem Pharmacol , vol.86 , Issue.4 , pp. 521-528
    • Kragholm, B.1    Kvist, T.2    Madsen, K.K.3    Jørgensen, L.4    Vogensen, S.B.5    Schousboe, A.6
  • 94
    • 0037989817 scopus 로고    scopus 로고
    • A receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures
    • A receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures. Brain Res. 2003;973(2):303–6.
    • (2003) Brain Res , vol.973 , Issue.2 , pp. 303-306
    • Kristensen, B.W.1    Noraberg, J.2    Zimmer, J.3
  • 95
    • 0034865950 scopus 로고    scopus 로고
    • Long-term safety of tiagabine
    • Kälviäinen R. Long-term safety of tiagabine. Epilepsia. 2001;42(Suppl 1):46–9.
    • (2001) Epilepsia , vol.42 , pp. 46-49
    • Kälviäinen, R.1
  • 96
    • 4644231691 scopus 로고    scopus 로고
    • Tiagabine. Clinical efficacy and use in epilepsy
    • ed. New York: Raven Press
    • Kälviäinen R. Tiagabine. Clinical efficacy and use in epilepsy. In: Antiepileptic drugs. 5th ed. New York: Raven Press; 2002. p. 698–704.
    • (2002) Antiepileptic Drugs , pp. 698-704
    • Kälviäinen, R.1
  • 97
    • 84942990575 scopus 로고    scopus 로고
    • The effects of delayed reduction of tonic inhibition on ischemic lesion and sensorimotor function
    • Lake EMR, Chaudhuri J, Thomason L, Janik R, Ganguly M, Brown M, et al. The effects of delayed reduction of tonic inhibition on ischemic lesion and sensorimotor function. J Cereb Blood Flow Metab. 2015;35(10):1601–9.
    • (2015) J Cereb Blood Flow Metab , vol.35 , Issue.10 , pp. 1601-1609
    • Lake, E.M.R.1    Chaudhuri, J.2    Thomason, L.3    Janik, R.4    Ganguly, M.5    Brown, M.6
  • 98
    • 84901466965 scopus 로고    scopus 로고
    • Post-traumatic epilepsy: Review of risks, pathophysiology, and potential biomarkers
    • Lamar CD, Hurley RA, Rowland JA, Taber KH. Post-traumatic epilepsy: review of risks, pathophysiology, and potential biomarkers. J Neuropsychiatr Clin Neurosci. 2014;26(2):108–13.
    • (2014) J Neuropsychiatr Clin Neurosci , vol.26 , Issue.2 , pp. 108-113
    • Lamar, C.D.1    Hurley, R.A.2    Rowland, J.A.3    Taber, K.H.4
  • 100
    • 80052787159 scopus 로고    scopus 로고
    • Mechanisms of GABA release from human astrocytes
    • Lee M, McGeer E, McGeer P. Mechanisms of GABA release from human astrocytes. Glia. 2011;59(11):1600–11.
    • (2011) Glia , vol.59 , Issue.11 , pp. 1600-1611
    • Lee, M.1    McGeer, E.2    McGeer, P.3
  • 101
    • 33645760509 scopus 로고    scopus 로고
    • GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus
    • Lee TS, Bjørnsen LP, Paz C, Kim JH, Spencer SS, Spencer DD, et al. GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus. Acta Neuropathol. 2006;111(4):351–63.
    • (2006) Acta Neuropathol , vol.111 , Issue.4 , pp. 351-363
    • Lee, T.S.1    Bjørnsen, L.P.2    Paz, C.3    Kim, J.H.4    Spencer, S.S.5    Spencer, D.D.6
  • 102
    • 84893218966 scopus 로고    scopus 로고
    • A receptor-mediated inhibition on neuronal excitability varies across brain region and cell type
    • A receptor-mediated inhibition on neuronal excitability varies across brain region and cell type. Front Neural Circuits. 2014;8(3):1–27.
    • (2014) Front Neural Circuits , vol.8 , Issue.3 , pp. 1-27
    • Lee, V.1    Maguire, J.2
  • 103
    • 79957936782 scopus 로고    scopus 로고
    • Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice
    • Lehre AC, Rowley NM, Zhou Y, Holmseth S, Guo C, Holen T, et al. Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res. 2011;95(1–2):70–81.
    • (2011) Epilepsy Res , vol.95 , Issue.1-2 , pp. 70-81
    • Lehre, A.C.1    Rowley, N.M.2    Zhou, Y.3    Holmseth, S.4    Guo, C.5    Holen, T.6
  • 104
    • 0021260259 scopus 로고
    • In vivo effects of nipecotic acid on levels of extracellular gaba and taurine, and hippocampal excitability
    • Lerma J, Herreras O, Herranz AS, Munoz D, del Rio RM. In vivo effects of nipecotic acid on levels of extracellular gaba and taurine, and hippocampal excitability. Neuropharmacology. 1984;23(5):595–8.
    • (1984) Neuropharmacology , vol.23 , Issue.5 , pp. 595-598
    • Lerma, J.1    Herreras, O.2    Herranz, A.S.3    Munoz, D.4    Del Rio, R.M.5
  • 105
    • 77049102824 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats
    • Li C, Yan Z, Yang J, Chen H, Li H, Jiang Y, et al. Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats. Neurochem Int. 2010a;56(3):495–500.
    • (2010) Neurochem Int , vol.56 , Issue.3 , pp. 495-500
    • Li, C.1    Yan, Z.2    Yang, J.3    Chen, H.4    Li, H.5    Jiang, Y.6
  • 106
    • 77953134574 scopus 로고    scopus 로고
    • Simultaneous monitoring multiple neurotransmitters and neuromodulators during cerebral ischemia/reperfusion in rats by microdialysis and capillary electrophoresis
    • Li H, Li C, Yan Z-Y, Yang J, Chen H. Simultaneous monitoring multiple neurotransmitters and neuromodulators during cerebral ischemia/reperfusion in rats by microdialysis and capillary electrophoresis. J Neurosci Methods. 2010b;189(2):162–8.
    • (2010) J Neurosci Methods , vol.189 , Issue.2 , pp. 162-168
    • Li, H.1    Li, C.2    Yan, Z.-Y.3    Yang, J.4    Chen, H.5
  • 107
    • 84901695723 scopus 로고    scopus 로고
    • Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice
    • Li H, Zhang N, Lin HY, Yu Y, Cai QY, Ma L, et al. Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice. BMC Neurosci. 2014;15(58):1–13.
    • (2014) BMC Neurosci , vol.15 , Issue.58 , pp. 1-13
    • Li, H.1    Zhang, N.2    Lin, H.Y.3    Yu, Y.4    Cai, Q.Y.5    Ma, L.6
  • 108
    • 84914674471 scopus 로고    scopus 로고
    • Optogenetic mapping after stroke reveals network-wide scaling of functional connections and heterogeneous recovery of the peri-infarct
    • Lim DH, LeDue JM, Mohajerani MH, Murphy TH. Optogenetic mapping after stroke reveals network-wide scaling of functional connections and heterogeneous recovery of the peri-infarct. J Neurosci. 2014;34(49):16455–66.
    • (2014) J Neurosci , vol.34 , Issue.49 , pp. 16455-16466
    • Lim, D.H.1    Ledue, J.M.2    Mohajerani, M.H.3    Murphy, T.H.4
  • 109
    • 84928311014 scopus 로고    scopus 로고
    • The canonical Notch pathway effector RBP-J regulates neuronal plasticity and expression of GABA transporters in hippocampal networks
    • Liu S, Wang Y, Worley PF, Mattson MP, Gaiano N. The canonical Notch pathway effector RBP-J regulates neuronal plasticity and expression of GABA transporters in hippocampal networks. Hippocampus. 2015;25(5):670–8.
    • (2015) Hippocampus , vol.25 , Issue.5 , pp. 670-678
    • Liu, S.1    Wang, Y.2    Worley, P.F.3    Mattson, M.P.4    Gaiano, N.5
  • 110
    • 43249116466 scopus 로고    scopus 로고
    • New penumbra: Transitioning from injury into repair after stroke
    • Lo EH. A new penumbra: transitioning from injury into repair after stroke. Nat Med. 2008;14(5): 497–500.
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 497-500
    • Lo, E.H.A.1
  • 111
    • 0017804721 scopus 로고
    • Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neurones
    • Macdonald R, Barker JL. Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neurones. Nature. 1978;271(5645):563–4.
    • (1978) Nature , vol.271 , Issue.5645 , pp. 563-564
    • Macdonald, R.1    Barker, J.L.2
  • 114
    • 76749145072 scopus 로고    scopus 로고
    • Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs
    • Madsen KK, White HS, Schousboe A. Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs. Pharmacol Ther. 2010;125(3):394–401.
    • (2010) Pharmacol Ther , vol.125 , Issue.3 , pp. 394-401
    • Madsen, K.K.1    White, H.S.2    Schousboe, A.3
  • 116
    • 0033015919 scopus 로고    scopus 로고
    • Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy
    • Mathern GW, Mendoza D, Lozada A, Pretorius JK, Dehnes Y, Danbolt NC, et al. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology. 1999;52(3):453–72.
    • (1999) Neurology , vol.52 , Issue.3 , pp. 453-472
    • Mathern, G.W.1    Mendoza, D.2    Lozada, A.3    Pretorius, J.K.4    Dehnes, Y.5    Danbolt, N.C.6
  • 117
    • 84865440798 scopus 로고    scopus 로고
    • Rapid compensatory changes in the expression of EAAT-3 and GAT-1 transporters during seizures in cells of the CA1 and dentate gyrus
    • Medina-Ceja L, Sandoval-García F, Morales-Villagrán A, López-Pérez SJ. Rapid compensatory changes in the expression of EAAT-3 and GAT-1 transporters during seizures in cells of the CA1 and dentate gyrus. J Biomed Sci. 2012;19(78):1–11.
    • (2012) J Biomed Sci , vol.19 , Issue.78 , pp. 1-11
    • Medina-Ceja, L.1    Sandoval-García, F.2    Morales-Villagrán, A.3    López-Pérez, S.J.4
  • 118
    • 0015238873 scopus 로고
    • Convulsive effects of 4-deoxypyridoxine and of bicuculline in photosensitive baboons (Papio papio) and in rhesus monkeys (Macaca mulatta
    • Meldrum BS, Horton RW. Convulsive effects of 4-deoxypyridoxine and of bicuculline in photosensitive baboons (Papio papio) and in rhesus monkeys (Macaca mulatta). Brain Res. 1971;35(2):419–36.
    • (1971) Brain Res , vol.35 , Issue.2 , pp. 419-436
    • Meldrum, B.S.1    Horton, R.W.2
  • 119
    • 21744432838 scopus 로고    scopus 로고
    • Neuronal localization of the GABA transporter GAT-3 in human cerebral cortex: A procedural artifact?
    • Melone M, Barbaresi P, Fattorini G, Conti F. Neuronal localization of the GABA transporter GAT-3 in human cerebral cortex: a procedural artifact? J Chem Neuroanat. 2005;30(1):45–54.
    • (2005) J Chem Neuroanat , vol.30 , Issue.1 , pp. 45-54
    • Melone, M.1    Barbaresi, P.2    Fattorini, G.3    Conti, F.4
  • 120
    • 0042334538 scopus 로고    scopus 로고
    • Transient focal ischemia triggers neuronal expression of GAT-3 in the rat perilesional cortex
    • Melone M, Cozzi A, Pellegrini-Giampietro DE, Conti F. Transient focal ischemia triggers neuronal expression of GAT-3 in the rat perilesional cortex. Neurobiol Dis. 2003;14(1):120–32.
    • (2003) Neurobiol Dis , vol.14 , Issue.1 , pp. 120-132
    • Melone, M.1    Cozzi, A.2    Pellegrini-Giampietro, D.E.3    Conti, F.4
  • 121
    • 70450267518 scopus 로고    scopus 로고
    • Plasticity during stroke recovery: From synapse to behaviour
    • Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009;10(12):861–72.
    • (2009) Nat Rev Neurosci , vol.10 , Issue.12 , pp. 861-872
    • Murphy, T.H.1    Corbett, D.2
  • 122
    • 33846638729 scopus 로고    scopus 로고
    • Functional role of GABA transporters for kindling development in GLAST KO mice
    • Nagatomo K, Ueda Y, Doi T, Takaki M, Tsuru N. Functional role of GABA transporters for kindling development in GLAST KO mice. Neurosci Res. 2007;57(2):319–21.
    • (2007) Neurosci Res , vol.57 , Issue.2 , pp. 319-321
    • Nagatomo, K.1    Ueda, Y.2    Doi, T.3    Takaki, M.4    Tsuru, N.5
  • 123
    • 0004916337 scopus 로고
    • First attempt at treatment of experimental status epilepticus in animals and spontaneous status epilepticus in man with diazepam
    • Naquet R, Soulayrol R, Dolce G, Tassinari C, Broughton R, Loeb H. First attempt at treatment of experimental status epilepticus in animals and spontaneous status epilepticus in man with diazepam. Electroencephalogr Clin Neurophysiol. 1965;18:424–7.
    • (1965) Electroencephalogr Clin Neurophysiol , vol.18 , pp. 424-427
    • Naquet, R.1    Soulayrol, R.2    Dolce, G.3    Tassinari, C.4    Broughton, R.5    Loeb, H.6
  • 124
    • 0033939414 scopus 로고    scopus 로고
    • On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone
    • Nelson RM, Green AR, Lambert DG, Hainsworth AH. On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone. Br J Pharmacol. 2000;130(5):1124–30.
    • (2000) Br J Pharmacol , vol.130 , Issue.5 , pp. 1124-1130
    • Nelson, R.M.1    Green, A.R.2    Lambert, D.G.3    Hainsworth, A.H.4
  • 126
    • 0035854553 scopus 로고    scopus 로고
    • Anti-ischemic and cognition-enhancing properties of NNC-711, γ-aminobutyric acid reuptake inhibitor
    • O’Connell AW, Fox GB, Kjøller C, Gallagher HC, Murphy KJ, Kelly J, et al. Anti-ischemic and cognition-enhancing properties of NNC-711, γ-aminobutyric acid reuptake inhibitor. Eur J Pharmacol. 2001;424(1):37–44.
    • (2001) Eur J Pharmacol , vol.424 , Issue.1 , pp. 37-44
    • O’Connell, A.W.1    Fox, G.B.2    Kjøller, C.3    Gallagher, H.C.4    Murphy, K.J.5    Kelly, J.6
  • 127
    • 26244461268 scopus 로고    scopus 로고
    • Effect of hyperosmotic conditions on the expression of the betaine-GABA-transporter (BGT-1) in cultured mouse astrocytes
    • Olsen M, Sarup A, Larsson OMOM, Schousboe A. Effect of hyperosmotic conditions on the expression of the betaine-GABA-transporter (BGT-1) in cultured mouse astrocytes. Neurochem Res. 2005;30(6–7):855–65.
    • (2005) Neurochem Res , vol.30 , Issue.6-7 , pp. 855-865
    • Olsen, M.1    Sarup, A.2    Larsson, O.M.O.M.3    Schousboe, A.4
  • 128
    • 0031116041 scopus 로고    scopus 로고
    • GABA and epileptogenesis
    • Olsen RW, Avoli M. GABA and epileptogenesis. Epilepsia. 1997;38(4):399–407.
    • (1997) Epilepsia , vol.38 , Issue.4 , pp. 399-407
    • Olsen, R.W.1    Avoli, M.2
  • 129
    • 0033768652 scopus 로고    scopus 로고
    • Increased expression of γ-aminobutyric acid transporter-1 in the forebrain of infant rats with corticotropin-releasing hormone-induced seizures but not in those with hyperthermia-induced seizures
    • Orozco-Suarez S, Brunson KL, Feria-Velasco A, Ribak CE. Increased expression of γ-aminobutyric acid transporter-1 in the forebrain of infant rats with corticotropin-releasing hormone-induced seizures but not in those with hyperthermia-induced seizures. Epilepsy Res. 2000;42(2–3):141–57.
    • (2000) Epilepsy Res , vol.42 , Issue.2-3 , pp. 141-157
    • Orozco-Suarez, S.1    Brunson, K.L.2    Feria-Velasco, A.3    Ribak, C.E.4
  • 130
    • 33745174192 scopus 로고    scopus 로고
    • A receptors are critical targets for sedative-hypnotic drugs
    • A receptors are critical targets for sedative-hypnotic drugs. J Clin Sleep Med. 2006;2(2):S12–8.
    • (2006) J Clin Sleep Med , vol.2 , Issue.2 , pp. S12-S18
    • Orser, B.A.1
  • 131
    • 34249302805 scopus 로고    scopus 로고
    • Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum
    • Ouyang C, Guo L, Lu Q, Xu X, Wang H. Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum. Neurosci Lett. 2007;420(2):174–8.
    • (2007) Neurosci Lett , vol.420 , Issue.2 , pp. 174-178
    • Ouyang, C.1    Guo, L.2    Lu, Q.3    Xu, X.4    Wang, H.5
  • 132
    • 84862849214 scopus 로고    scopus 로고
    • Development of an (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4
    • Pabel J, Faust M, Prehn C, Wörlein B, Allmendinger L, Höfner G, et al. Development of an (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4. ChemMedChem. 2012;7(7):1245–55.
    • (2012) Chemmedchem , vol.7 , Issue.7 , pp. 1245-1255
    • Pabel, J.1    Faust, M.2    Prehn, C.3    Wörlein, B.4    Allmendinger, L.5    Höfner, G.6
  • 133
    • 0035065938 scopus 로고    scopus 로고
    • GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis
    • Patrylo PR, Spencer DD, Williamson A. GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. J Neurophysiol. 2001;85(4):1533–42.
    • (2001) J Neurophysiol , vol.85 , Issue.4 , pp. 1533-1542
    • Patrylo, P.R.1    Spencer, D.D.2    Williamson, A.3
  • 136
    • 0029024396 scopus 로고
    • CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil
    • Phillis JW. CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil. Gen Pharmacol. 1995;26(5):1061–4.
    • (1995) Gen Pharmacol , vol.26 , Issue.5 , pp. 1061-1064
    • Phillis, J.W.1
  • 137
    • 84873709774 scopus 로고    scopus 로고
    • Transporter GAT-1 dysfunction in experimental absence seizures
    • Pirttimaki T, Parri HR, Crunelli V. Astrocytic GABA transporter GAT-1 dysfunction in experimental absence seizures. J Physiol. 2013;591(4):823–33.
    • (2013) J Physiol , vol.591 , Issue.4 , pp. 823-833
    • Pirttimaki, T.1    Parri, H.R.2    Crunelli, V.3    Astrocytic, G.A.B.A.4
  • 139
    • 0344441291 scopus 로고    scopus 로고
    • B2 mRNA variants expression in hippocampus resected from patients with temporal lobe epilepsy
    • B2 mRNA variants expression in hippocampus resected from patients with temporal lobe epilepsy. Neuroscience. 2003a;122(4):975–84.
    • (2003) Neuroscience , vol.122 , Issue.4 , pp. 975-984
    • Princivalle, A.P.1    Duncan, J.S.2    Thom, M.3    Bowery, N.G.4
  • 141
    • 84959508925 scopus 로고    scopus 로고
    • Van Velthoven-Wurster V, Feuerstein TJ. Neocortical GABA release at high intracellular sodium and low extracellular calcium: An anti-seizure mechanism
    • Rassner MP, Moser A, Follo M, Joseph K, van Velthoven-Wurster V, Feuerstein TJ. Neocortical GABA release at high intracellular sodium and low extracellular calcium: an anti-seizure mechanism. J Neurochem. 2016;137(2):177–89.
    • (2016) J Neurochem , vol.137 , Issue.2 , pp. 177-189
    • Rassner, M.P.1    Moser, A.2    Follo, M.3    Joseph, K.4
  • 142
    • 0036897551 scopus 로고    scopus 로고
    • A-receptor subtypes after focal cortical infarcts in rats: Mediation by NMDA-dependent processes
    • A-receptor subtypes after focal cortical infarcts in rats: mediation by NMDA-dependent processes. J Cereb Blood Flow Metab. 2002;22(12):1463–75.
    • (2002) J Cereb Blood Flow Metab , vol.22 , Issue.12 , pp. 1463-1475
    • Redecker, C.1    Wang, W.2    Fritschy, J.-M.3    Witte, O.W.4
  • 143
    • 0141676728 scopus 로고    scopus 로고
    • Dynamic equilibrium of neurotransmitter transporters: Not just for reuptake anymore
    • Richerson GB, Wu Y. Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore. J Neurophysiol. 2003;90(3):1363–74.
    • (2003) J Neurophysiol , vol.90 , Issue.3 , pp. 1363-1374
    • Richerson, G.B.1    Wu, Y.2
  • 144
    • 79952570817 scopus 로고    scopus 로고
    • Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus
    • Rowley NM, Smith MD, Lamb JG, Schousboe A, White HS. Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus. J Neurochem. 2011;117(1):82–90.
    • (2011) J Neurochem , vol.117 , Issue.1 , pp. 82-90
    • Rowley, N.M.1    Smith, M.D.2    Lamb, J.G.3    Schousboe, A.4    White, H.S.5
  • 146
    • 0022504946 scopus 로고
    • Recovery of function after brain damage: Severe and chronic disruption by diazepam
    • Schallert T, Hernandez TD, Barth TM. Recovery of function after brain damage: severe and chronic disruption by diazepam. Brain Res. 1986;379(1):104–11.
    • (1986) Brain Res , vol.379 , Issue.1 , pp. 104-111
    • Schallert, T.1    Hernandez, T.D.2    Barth, T.M.3
  • 148
    • 34547123577 scopus 로고    scopus 로고
    • The neurobiology of epilepsy
    • Scharfman HE. The neurobiology of epilepsy. Curr Neuro Neurosci Rep. 2007;7(4):348–54.
    • (2007) Curr Neuro Neurosci Rep. , vol.7 , Issue.4 , pp. 348-354
    • Scharfman, H.E.1
  • 149
    • 84941557429 scopus 로고    scopus 로고
    • Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis
    • Schijns O, Karaca Ü, Andrade P, de Nijs L, Küsters B, Peeters A, et al. Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis. J Chem Neuroanat. 2015;68:39–44.
    • (2015) J Chem Neuroanat , vol.68 , pp. 39-44
    • Schijns, O.1    Karaca, Ü.2    Andrade, P.3    De Nijs, L.4    Küsters, B.5    Peeters, A.6
  • 151
    • 0037320032 scopus 로고    scopus 로고
    • Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission
    • Schousboe A. Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission. Neurochem Res. 2003;28(2):347–52.
    • (2003) Neurochem Res , vol.28 , Issue.2 , pp. 347-352
    • Schousboe, A.1
  • 152
    • 0021064679 scopus 로고
    • Transport and metabolism of γ-aminobutyric acid in neurons and glia: Implications for epilepsy
    • Schousboe A, Larsson OM, Wood JD, Krogsgaard-Larsen P. Transport and metabolism of γ-aminobutyric acid in neurons and glia: implications for epilepsy. Epilepsia. 1983;24(5):531–8.
    • (1983) Epilepsia , vol.24 , Issue.5 , pp. 531-538
    • Schousboe, A.1    Larsson, O.M.2    Wood, J.D.3    Krogsgaard-Larsen, P.4
  • 153
    • 79951659203 scopus 로고    scopus 로고
    • GABA transport inhibitors and seizure protection: The past and future
    • Schousboe A, Madsen KK, White HS. GABA transport inhibitors and seizure protection: the past and future. Future Med Chem. 2011;3(2):183–7.
    • (2011) Future Med Chem , vol.3 , Issue.2 , pp. 183-187
    • Schousboe, A.1    Madsen, K.K.2    White, H.S.3
  • 154
    • 85028072835 scopus 로고    scopus 로고
    • Astrocytic GABA-transporters: Pharmacological properties and targets for antiepileptic drugs
    • Ortega A, Schousboe A, editors, Cham: Springer, in press
    • Schousboe A, Wellendorph P, Frølund B, Clausen RP, Krogsgaard-Larsen P. Astrocytic GABA-transporters: pharmacological properties and targets for antiepileptic drugs. In: Ortega A, Schousboe A, editors. Glial amino acid transporters. Cham: Springer; in press.
    • Glial Amino Acid Transporters
    • Schousboe, A.1    Wellendorph, P.2    Frølund, B.3    Clausen, R.P.4    Krogsgaard-Larsen, P.5
  • 155
    • 0035044262 scopus 로고    scopus 로고
    • A neurotransmission and cerebral ischemia
    • A neurotransmission and cerebral ischemia. J Neurochem. 2001;77(2):353–71.
    • (2001) J Neurochem , vol.77 , Issue.2 , pp. 353-371
    • Schwartz-Bloom, R.D.1    Sah, R.2
  • 156
    • 84884753607 scopus 로고    scopus 로고
    • Innovations in epilepsy management - An overview
    • Shaju M, Abraham S. Innovations in epilepsy management - an overview. J Pharm Pharm Sci. 2013;16(4):564–76.
    • (2013) J Pharm Pharm Sci , vol.16 , Issue.4 , pp. 564-576
    • Shaju, M.1    Abraham, S.2
  • 157
    • 40149084008 scopus 로고    scopus 로고
    • Inhibition of the betaine-GABA transporter (MGAT2/BGT-1) modulates spontaneous electro-graphic bursting in the medial entorhinal cortex (mEC)
    • Smith MD, Saunders GW, Clausen RP, Frølund B, Krogsgaard-Larsen P, Larsson OM, et al. Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electro-graphic bursting in the medial entorhinal cortex (mEC). Epilepsy Res. 2008;79(1):6–13.
    • (2008) Epilepsy Res , vol.79 , Issue.1 , pp. 6-13
    • Smith, M.D.1    Saunders, G.W.2    Clausen, R.P.3    Frølund, B.4    Krogsgaard-Larsen, P.5    Larsson, O.M.6
  • 158
    • 84928122606 scopus 로고    scopus 로고
    • Astrocyte barriers to neurotoxic inflammation
    • Sofroniew MV. Astrocyte barriers to neurotoxic inflammation. Nat Rev Neurosci. 2015;16(5): 249–63.
    • (2015) Nat Rev Neurosci , vol.16 , Issue.5 , pp. 249-263
    • Sofroniew, M.V.1
  • 159
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: Biology and pathology
    • Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2010;119(1): 7–35.
    • (2010) Acta Neuropathol , vol.119 , Issue.1 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 160
    • 84874541649 scopus 로고    scopus 로고
    • Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources
    • Song I, Volynski K, Brenner T, Ushkaryov Y, Walker M, Semyanov A. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources. Front Cell Neurosci. 2013;7(23):1–7.
    • (2013) Front Cell Neurosci , vol.7 , Issue.23 , pp. 1-7
    • Song, I.1    Volynski, K.2    Brenner, T.3    Ushkaryov, Y.4    Walker, M.5    Semyanov, A.6
  • 161
    • 84976865494 scopus 로고    scopus 로고
    • The IUPHAR/ BPS Guide to Pharmacology in 2016: Towards curated quantitative interactions between 1300 protein targets and 6000 ligands
    • Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH, et al. The IUPHAR/ BPS Guide to Pharmacology in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res. 2016;44(D1):D1054–68.
    • (2016) Nucleic Acids Res , vol.44 , Issue.D1 , pp. D1054-D1068
    • Southan, C.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Pawson, A.J.5    Alexander, S.P.H.6
  • 162
    • 0242624593 scopus 로고    scopus 로고
    • Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures
    • Sperk G, Schwarzer C, Heilman J, Furtinger S, Reimer RJ, Edwards RH, et al. Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures. Hippocampus. 2003;13(7):806–15.
    • (2003) Hippocampus , vol.13 , Issue.7 , pp. 806-815
    • Sperk, G.1    Schwarzer, C.2    Heilman, J.3    Furtinger, S.4    Reimer, R.J.5    Edwards, R.H.6
  • 164
    • 84923697997 scopus 로고    scopus 로고
    • Molecular mechanisms of epilepsy
    • Staley K. Molecular mechanisms of epilepsy. Nat Neurosci. 2015;18(3):367–72.
    • (2015) Nat Neurosci , vol.18 , Issue.3 , pp. 367-372
    • Staley, K.1
  • 165
    • 84925522108 scopus 로고    scopus 로고
    • Role for pro-inflammatory cytokines in regulating expression of GABA transporter type 1 and 3 in specific brain regions of kainic acid-induced status epilepticus
    • Su J, Yin J, Qin W, Sha S, Xu J, Jiang C. Role for pro-inflammatory cytokines in regulating expression of GABA transporter type 1 and 3 in specific brain regions of kainic acid-induced status epilepticus. Neurochem Res. 2015;40(3):621–7.
    • (2015) Neurochem Res , vol.40 , Issue.3 , pp. 621-627
    • Su, J.1    Yin, J.2    Qin, W.3    Sha, S.4    Xu, J.5    Jiang, C.6
  • 166
    • 0033047641 scopus 로고    scopus 로고
    • GABA release and uptake measured in crude synaptosomes from Genetic Absence Epilepsy Rats from Strasbourg (GAERS)
    • Sutch RJ, Davies CC, Bowery NG. GABA release and uptake measured in crude synaptosomes from Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Neurochem Int. 1999;34(5):415–25.
    • (1999) Neurochem Int , vol.34 , Issue.5 , pp. 415-425
    • Sutch, R.J.1    Davies, C.C.2    Bowery, N.G.3
  • 167
    • 0030955132 scopus 로고    scopus 로고
    • 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter
    • Thomsen C, Sørensen PO, Egebjerg J. 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br J Pharmacol. 1997;120(6):983–5.
    • (1997) Br J Pharmacol , vol.120 , Issue.6 , pp. 983-985
    • Thomsen, C.1    Sørensen, P.O.2    Egebjerg, J.3
  • 168
    • 0034865645 scopus 로고    scopus 로고
    • GABAergic mechanisms in epilepsy
    • Treiman DM. GABAergic mechanisms in epilepsy. Epilepsia. 2001;42(Suppl. 3):8–12.
    • (2001) Epilepsia , vol.42 , pp. 8-12
    • Treiman, D.M.1
  • 170
    • 0034662017 scopus 로고    scopus 로고
    • Hippocampal γ-aminobutyric acid transporter alterations following focal epileptogenesis induced in rat amygdala
    • Ueda Y, Willmore LJ. Hippocampal γ-aminobutyric acid transporter alterations following focal epileptogenesis induced in rat amygdala. Brain Res Bull. 2000;52(5):357–61.
    • (2000) Brain Res Bull , vol.52 , Issue.5 , pp. 357-361
    • Ueda, Y.1    Willmore, L.J.2
  • 171
    • 0014589399 scopus 로고
    • On the mechanisms of picrotoxin epileptic seizure (Macro-and micro-electrode investigations
    • Usunoff G, Atsev E, Tchavdarov D. On the mechanisms of picrotoxin epileptic seizure (macro-and micro-electrode investigations). Electroencephalogr Clin Neurophysiol. 1969;27(4):444.
    • (1969) Electroencephalogr Clin Neurophysiol , vol.27 , Issue.4 , pp. 444
    • Usunoff, G.1    Atsev, E.2    Tchavdarov, D.3
  • 172
    • 14744276023 scopus 로고    scopus 로고
    • Tiagabine-induced gener-alised non convulsive status epilepticus in patients with lesional focal epilepsy
    • Vinton A, Kornberg A, Cowley M, Matkovic Z, Kilpatrick C, O’Brien T. Tiagabine-induced gener-alised non convulsive status epilepticus in patients with lesional focal epilepsy. J Clin Neurosci. 2005;12(2):128–33.
    • (2005) J Clin Neurosci , vol.12 , Issue.2 , pp. 128-133
    • Vinton, A.1    Kornberg, A.2    Cowley, M.3    Matkovic, Z.4    Kilpatrick, C.5    O’Brien, T.6
  • 173
    • 84875137124 scopus 로고    scopus 로고
    • Selective mGAT2 (BGT-1) GABA uptake inhibitors: Design, synthesis, and pharmacological characterization
    • Vogensen SB, Jørgensen L, Madsen KK, Borkar N, Wellendorph P, Skovgaard-Petersen J, et al. Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization. J Med Chem. 2013;56(5):2160–4.
    • (2013) J Med Chem , vol.56 , Issue.5 , pp. 2160-2164
    • Vogensen, S.B.1    Jørgensen, L.2    Madsen, K.K.3    Borkar, N.4    Wellendorph, P.5    Skovgaard-Petersen, J.6
  • 174
    • 84970021169 scopus 로고    scopus 로고
    • Epigenetic suppression of GADs expression is involved in temporal lobe epilepsy and pilocarpine-induced mice epilepsy
    • Wang J-G, Cai Q, Zheng J, Dong Y-S, Li J-J, Li J-C, et al. Epigenetic suppression of GADs expression is involved in temporal lobe epilepsy and pilocarpine-induced mice epilepsy. Neurochem Res. 2016;41(7):1751–60.
    • (2016) Neurochem Res , vol.41 , Issue.7 , pp. 1751-1760
    • Wang, J.-G.1    Cai, Q.2    Zheng, J.3    Dong, Y.-S.4    Li, J.-J.5    Li, J.-C.6
  • 176
    • 0027172935 scopus 로고
    • Anticonvulsant activity of the γ-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol
    • White HS, Hunt J, Wolf HH, Swinyard EA, Falch E, Krogsgaard-Larsen P, et al. Anticonvulsant activity of the γ-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol. Eur J Pharmacol. 1993;236(1):147–9.
    • (1993) Eur J Pharmacol , vol.236 , Issue.1 , pp. 147-149
    • White, H.S.1    Hunt, J.2    Wolf, H.H.3    Swinyard, E.A.4    Falch, E.5    Krogsgaard-Larsen, P.6
  • 177
    • 0036077331 scopus 로고    scopus 로고
    • Correlation between anticonvulsant activity and inhibitory action on glial γ-aminobutyric acid uptake of the highly selective mouse γ-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated anal
    • White HS, Sarup A, Bolvig T, Kristensen AS, Petersen G, Nelson N, et al. Correlation between anticonvulsant activity and inhibitory action on glial γ-aminobutyric acid uptake of the highly selective mouse γ-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated anal. J Pharmacol Exp Ther. 2002;302(2):636–44.
    • (2002) J Pharmacol Exp Ther , vol.302 , Issue.2 , pp. 636-644
    • White, H.S.1    Sarup, A.2    Bolvig, T.3    Kristensen, A.S.4    Petersen, G.5    Nelson, N.6
  • 178
    • 19944433063 scopus 로고    scopus 로고
    • First demonstration of a functional role for central nervous system betaine/γ-aminobutyric acid transporter (MGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2
    • White HS, Watson WP, Hansen SL, Slough S, Perregaard J, Sarup A, et al. First demonstration of a functional role for central nervous system betaine/γ-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther. 2005;312(2):866–74.
    • (2005) J Pharmacol Exp Ther , vol.312 , Issue.2 , pp. 866-874
    • White, H.S.1    Watson, W.P.2    Hansen, S.L.3    Slough, S.4    Perregaard, J.5    Sarup, A.6
  • 179
    • 85028069357 scopus 로고    scopus 로고
    • [cited 2016 Sept 1]. Available from
    • World Health Federation. Stroke [Internet]. 2016 [cited 2016 Sept 1]. Available from: www.world-heart-federation.org/cardiovascular-health/stroke/
    • (2016) Stroke [Internet]
  • 180
    • 84876776195 scopus 로고    scopus 로고
    • [cited 2016 Jun 30]. Available from
    • WHO. Epilepsy Fact Sheet [Internet]. 2016a [cited 2016 Jun 30]. Available from: www.who.int/ mediacentre/factsheets/fs999/en/
    • (2016) Epilepsy Fact Sheet [Internet]
  • 181
    • 49349107361 scopus 로고    scopus 로고
    • [cited 2016 Jun 30]. Available from
    • WHO. The top 10 causes of death Fact Sheet [Internet]. 2016b [cited 2016 Jun 30]. Available from: www.who.int/mediacentre/factsheets/fs310/en/
    • (2016) The Top 10 Causes of Death Fact Sheet [Internet]
  • 182
    • 0020702638 scopus 로고
    • Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO
    • Wood JD, Johnson DD, Krogsgaard-Larsen P, Schousboe A. Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO. Neuropharmacology. 1983;22(1):139–42.
    • (1983) Neuropharmacology , vol.22 , Issue.1 , pp. 139-142
    • Wood, J.D.1    Johnson, D.D.2    Krogsgaard-Larsen, P.3    Schousboe, A.4
  • 183
    • 84902438828 scopus 로고    scopus 로고
    • Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzhiemer’s disease model
    • Wu Z, Guo Z, Gearing M, Chen G. Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzhiemer’s disease model. Nat Commun. 2014;5(4159):1–13.
    • (2014) Nat Commun , vol.5 , Issue.4159 , pp. 1-13
    • Wu, Z.1    Guo, Z.2    Gearing, M.3    Chen, G.4
  • 184
    • 0034647809 scopus 로고    scopus 로고
    • Dose-dependent neuroprotection with tiagabine in a focal cerebral ischemia model in rat
    • Yang Y, Li Q, Wang CX, Jeerakathil T, Shuaib A. Dose-dependent neuroprotection with tiagabine in a focal cerebral ischemia model in rat. Neuroreport. 2000;11(10):2307–11.
    • (2000) Neuroreport , vol.11 , Issue.10 , pp. 2307-2311
    • Yang, Y.1    Li, Q.2    Wang, C.X.3    Jeerakathil, T.4    Shuaib, A.5
  • 185
    • 84873168142 scopus 로고    scopus 로고
    • How phenobarbital revolutionized epilepsy therapy: The story of phenobarbital therapy in epilepsy in the last 100 years
    • Yasiry Z, Shorvon SD. How phenobarbital revolutionized epilepsy therapy: the story of phenobarbital therapy in epilepsy in the last 100 years. Epilepsia. 2012;53(Suppl 8):26–39.
    • (2012) Epilepsia , vol.53 , pp. 26-39
    • Yasiry, Z.1    Shorvon, S.D.2
  • 186
    • 0021336316 scopus 로고
    • Novel inhibitors of γ-aminobutyric acid (GABA) uptake: Anticonvulsant actions in rats and mice
    • Yunger LM, Fowler PJ, Zarevics P, Setler PE. Novel inhibitors of γ-aminobutyric acid (GABA) uptake: anticonvulsant actions in rats and mice. J Pharmacol Exp Ther. 1984;228(1):109–15.
    • (1984) J Pharmacol Exp Ther , vol.228 , Issue.1 , pp. 109-115
    • Yunger, L.M.1    Fowler, P.J.2    Zarevics, P.3    Setler, P.E.4
  • 187
    • 84862908959 scopus 로고    scopus 로고
    • The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface
    • Zhou Y, Holmseth S, Hua R, Lehre AC, Olofsson AM, Poblete-Naredo I, et al. The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface. AJP Ren Physiol. 2012;302(3):316–28.
    • (2012) AJP Ren Physiol , vol.302 , Issue.3 , pp. 316-328
    • Zhou, Y.1    Holmseth, S.2    Hua, R.3    Lehre, A.C.4    Olofsson, A.M.5    Poblete-Naredo, I.6
  • 188
    • 3242765241 scopus 로고    scopus 로고
    • Changes in GABA transporters in the rat hippocampus after kainate-induced neuronal injury: Decrease in GAT-1 and GAT-3 but upregulation of betaine/GABA transporter BGT-1
    • Zhu XM, Ong WY. Changes in GABA transporters in the rat hippocampus after kainate-induced neuronal injury: decrease in GAT-1 and GAT-3 but upregulation of betaine/GABA transporter BGT-1. J Neurosci Res. 2004a;77(3):402–9.
    • (2004) J Neurosci Res , vol.77 , Issue.3 , pp. 402-409
    • Zhu, X.M.1    Ong, W.Y.2
  • 189
    • 3042737002 scopus 로고    scopus 로고
    • A light and electron microscopic study of betaine/GABA transporter distribution in the monkey cerebral neocortex and hippocampus
    • Zhu XM, Ong WY. A light and electron microscopic study of betaine/GABA transporter distribution in the monkey cerebral neocortex and hippocampus. J Neurocytol. 2004b;33(2):233–40.
    • (2004) J Neurocytol , vol.33 , Issue.2 , pp. 233-240
    • Zhu, X.M.1    Ong, W.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.