-
1
-
-
0141722273
-
Classification of seizures and epilepsy
-
Riviello JJ. Classification of seizures and epilepsy. Curr Neurol Neurosci Rep. 2003; 3:325-331.
-
(2003)
Curr Neurol Neurosci Rep.
, vol.3
, pp. 325-331
-
-
Riviello, J.J.1
-
2
-
-
0035915637
-
Neuropsychological effects of epilepsy and antiepileptic drugs
-
Kwan P, Brodie MJ. Neuropsychological effects of epilepsy and antiepileptic drugs. Lancet. 2001; 357:216-222.
-
(2001)
Lancet.
, vol.357
, pp. 216-222
-
-
Kwan, P.1
Brodie, M.J.2
-
3
-
-
0031467881
-
Prevalence, classification, and severity of epilepsy and epileptic syndromes in children
-
Eriksson KJ, Koivikko MJ. Prevalence, classification, and severity of epilepsy and epileptic syndromes in children. Epilepsia. 1997; 38:1275-1282.
-
(1997)
Epilepsia.
, vol.38
, pp. 1275-1282
-
-
Eriksson, K.J.1
Koivikko, M.J.2
-
4
-
-
27744569880
-
Systemic prenatal insults disrupt telencephalon development:Implications for potential interventions
-
Robinson S. Systemic prenatal insults disrupt telencephalon development: Implications for potential interventions. Epilepsy Behav. 2005; 7:345-363.
-
(2005)
Epilepsy Behav.
, vol.7
, pp. 345-363
-
-
Robinson, S.1
-
8
-
-
79958836018
-
New concepts in classification of the epilepsies:entering the 21st century
-
Berg AT, Scheffer IE. New concepts in classification of the epilepsies: entering the 21st century. Epilepsia. 2011; 52:1058-1062.
-
(2011)
Epilepsia.
, vol.52
, pp. 1058-1062
-
-
Berg, A.T.1
Scheffer, I.E.2
-
9
-
-
84865302785
-
World Health Organization.
-
Epilepsy. http://www.who.int/ mediacentre/factsheets/fs999/en/ (accessed July 29).
-
World Health Organization. Epilepsy. http://www.who.int/ mediacentre/factsheets/fs999/en/ (accessed July 29, 2012).
-
(2012)
-
-
-
11
-
-
79954622504
-
The pharmacological treatment of epilepsy in adults
-
Perucca E, Tomson T. The pharmacological treatment of epilepsy in adults. Lancet Neurol. 2011; 10:446-456.
-
(2011)
Lancet Neurol.
, vol.10
, pp. 446-456
-
-
Perucca, E.1
Tomson, T.2
-
13
-
-
61849097126
-
The major advances in epilepsy in the 20th century and what we can expect (hope for) in the future
-
Cereghino JJ. The major advances in epilepsy in the 20th century and what we can expect (hope for) in the future. Epilepsia. 2009; 50:351-357.
-
(2009)
Epilepsia.
, vol.50
, pp. 351-357
-
-
Cereghino, J.J.1
-
14
-
-
0036259012
-
The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors
-
Jensen AA, Mosbacher J, Elg S, Lingenhoehl K, Lohmann T, Johansen TN, Abrahamsen B, Mattsson JP, Lehmann A, Bettler B, Bräuner-Osborne H. The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. Mol Pharmacol. 2002; 61:1377-1384.
-
(2002)
Mol Pharmacol.
, vol.61
, pp. 1377-1384
-
-
Jensen, A.A.1
Mosbacher, J.2
Elg, S.3
Lingenhoehl, K.4
Lohmann, T.5
Johansen, T.N.6
Abrahamsen, B.7
Mattsson, J.P.8
Lehmann, A.9
Bettler, B.10
Bräuner-Osborne, H.11
-
15
-
-
3042841014
-
Gabapentin activates presynaptic GABA B heteroreceptors in rat cortical slices
-
Parker DA, Ong J, Marino V, Kerr DI. Gabapentin activates presynaptic GABA B heteroreceptors in rat cortical slices. Eur J Pharmacol. 2004; 495:137-143.
-
(2004)
Eur J Pharmacol.
, vol.495
, pp. 137-143
-
-
Parker, D.A.1
Ong, J.2
Marino, V.3
Kerr, D.I.4
-
16
-
-
30844440069
-
The mechanisms of action of gabapentin and pregabalin
-
Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol. 2006; 6:108-113.
-
(2006)
Curr Opin Pharmacol.
, vol.6
, pp. 108-113
-
-
Sills, G.J.1
-
18
-
-
0030946333
-
Overview of the safety of newer antiepileptic drugs
-
Shorvon S, Stefan H. Overview of the safety of newer antiepileptic drugs. Epilepsia. 1997; 38:S45-S51.
-
(1997)
Epilepsia.
, vol.38
, pp. S45-S51
-
-
Shorvon, S.1
Stefan, H.2
-
19
-
-
58849085924
-
Vigabatrin:2008 update
-
Willmore LJ, Abelson MB, Ben-Menachem E, Pellock JM, Shields WD. Vigabatrin: 2008 update. Epilepsia. 2009; 50:163-173.
-
(2009)
Epilepsia.
, vol.50
, pp. 163-173
-
-
Willmore, L.J.1
Abelson, M.B.2
Ben-Menachem, E.3
Pellock, J.M.4
Shields, W.D.5
-
20
-
-
49849105442
-
New antiepileptic drugs in pediatric epilepsy
-
Hwang H, Kim KJ. New antiepileptic drugs in pediatric epilepsy. Brain Dev. 2008; 30:549-555.
-
(2008)
Brain Dev.
, vol.30
, pp. 549-555
-
-
Hwang, H.1
Kim, K.J.2
-
21
-
-
0347364667
-
Peripheral retinal dysfunction in patients taking vigabatrin
-
McDonagh J, Stephen LJ, Dolan FM, et al. Peripheral retinal dysfunction in patients taking vigabatrin. Neurology. 2003; 61:1690-1694.
-
(2003)
Neurology.
, vol.61
, pp. 1690-1694
-
-
McDonagh, J.1
Stephen, L.J.2
Dolan, F.M.3
-
23
-
-
33846030193
-
Targets for antiepileptic drugs in the synapse
-
Landmark CJ. Targets for antiepileptic drugs in the synapse. Med Sci Monit. 2007; 13:RA1-RA7.
-
(2007)
Med Sci Monit.
, vol.13
, pp. RA1-RA7
-
-
Landmark, C.J.1
-
24
-
-
44749094527
-
Interactions between tiagabine and conventional antiepileptic drugs in the rat model of complex partial seizures
-
Borowicz KK, Zadrozniak M, Luszczki JJ, Czuczwar SJ. Interactions between tiagabine and conventional antiepileptic drugs in the rat model of complex partial seizures. J Neural Transm. 2008; 115:661-667.
-
(2008)
J Neural Transm.
, vol.115
, pp. 661-667
-
-
Borowicz, K.K.1
Zadrozniak, M.2
Luszczki, J.J.3
Czuczwar, S.J.4
-
25
-
-
52649141658
-
Tiagabine:Efficacy and safety in partial seizures-current status
-
Bauer J, Cooper-Mahkorn D. Tiagabine: Efficacy and safety in partial seizures-current status. Neuropsychiatr Dis Treat. 2008; 4:731-736.
-
(2008)
Neuropsychiatr Dis Treat.
, vol.4
, pp. 731-736
-
-
Bauer, J.1
Cooper-Mahkorn, D.2
-
26
-
-
0029011113
-
Messenheimer JA. Lamotrigine. Epilepsia
-
Messenheimer JA. Lamotrigine. Epilepsia. 1995; 36: S87-S95.
-
(1995)
36
, pp. S87-S95
-
-
-
27
-
-
78149248492
-
The anticonvulsive drug lamotrigine blocks neuronal a4p2 nicotinic acetylcholine receptors
-
Zheng C, Yang K, Liu Q, Wang MY, Shen J, Valles AS, Lukas RJ, Barrantes FJ, Wu J. The anticonvulsive drug lamotrigine blocks neuronal a4p2 nicotinic acetylcholine receptors. Pharmacol Exp Ther. 2010; 335:401-408.
-
(2010)
Pharmacol Exp Ther.
, vol.335
, pp. 401-408
-
-
Zheng, C.1
Yang, K.2
Liu, Q.3
Wang, M.Y.4
Shen, J.5
Valles, A.S.6
Lukas, R.J.7
Barrantes, F.J.8
Wu, J.9
-
28
-
-
0030863344
-
Safety of long-term lamotrigine in epilepsy
-
Mackay FJ, Wilton LV, Peace GL, Freemantle SN, Mann RD. Safety of long-term lamotrigine in epilepsy. Epilepsia. 1997; 38:881-886.
-
(1997)
Epilepsia.
, vol.38
, pp. 881-886
-
-
Mackay, F.J.1
Wilton, L.V.2
Peace, G.L.3
Freemantle, S.N.4
Mann, R.D.5
-
29
-
-
80052024668
-
Lamotrigine-dextran conjugates-synthesis, characterization, and biological evaluation
-
Pugazhendhy S, Shrivastava PK, Sinha SK, Shrivastava SK. Lamotrigine-dextran conjugates-synthesis, characterization, and biological evaluation. Med Chem Res. 2001; 20:595-600.
-
(2001)
Med Chem Res.
, vol.20
, pp. 595-600
-
-
Pugazhendhy, S.1
Shrivastava, P.K.2
Sinha, S.K.3
Shrivastava, S.K.4
-
30
-
-
77958508858
-
Efficacy, safety, and potential of extended-release lamotrigine in the treatment of epileptic patients
-
Blaszczyk B, Czuczwar SJ. Efficacy, safety, and potential of extended-release lamotrigine in the treatment of epileptic patients. Neuropsychiatr Dis Treat. 2010; 6:145-150.
-
(2010)
Neuropsychiatr Dis Treat.
, vol.6
, pp. 145-150
-
-
Blaszczyk, B.1
Czuczwar, S.J.2
-
31
-
-
78649904882
-
Adjunctive lamotrigine XR for primary generalized tonic-clonic seizures in a randomized, placebo-controlled study
-
Biton V, Di Memmo J, Shukla R, Lee YY, Poverennova I, Demchenko V, Saiers J, Adams B, Hammer A, Vuong A, Messenheimer J. Adjunctive lamotrigine XR for primary generalized tonic-clonic seizures in a randomized, placebo-controlled study. Epilepsy Behav. 2010; 19:352-358.
-
(2010)
Epilepsy Behav.
, vol.19
, pp. 352-358
-
-
Biton, V.1
Di Memmo, J.2
Shukla, R.3
Lee, Y.Y.4
Poverennova, I.5
Demchenko, V.6
Saiers, J.7
Adams, B.8
Hammer, A.9
Vuong, A.10
Messenheimer, J.11
-
32
-
-
22844451397
-
Effectiveness of lamotrigine in clinical practice:Results of a retrospective population-based study
-
Knoester PD, Keyser A, Renier WO, Egberts ACG, Hekster YA, Deckers CLP. Effectiveness of lamotrigine in clinical practice: Results of a retrospective population-based study. Epilepsy Res. 2005; 65:93-100.
-
(2005)
Epilepsy Res.
, vol.65
, pp. 93-100
-
-
Knoester, P.D.1
Keyser, A.2
Renier, W.O.3
Egberts, A.C.G.4
Hekster, Y.A.5
Deckers, C.L.P.6
-
33
-
-
33947241772
-
The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy:An unblinded randomised controlled trial
-
Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: An unblinded randomised controlled trial. Lancet. 2007; 369:1000-1015.
-
(2007)
Lancet.
, vol.369
, pp. 1000-1015
-
-
Marson, A.G.1
Al-Kharusi, A.M.2
Alwaidh, M.3
-
34
-
-
0034162314
-
Oxcarbazepine:A review
-
Shorvon S. Oxcarbazepine: A review. Seizure. 2000; 9:75-79.
-
(2000)
Seizure.
, vol.9
, pp. 75-79
-
-
Shorvon, S.1
-
35
-
-
0027141297
-
Felbamate:Successful development of a new compound for the treatment of epilepsy
-
Schmidt D. Felbamate: Successful development of a new compound for the treatment of epilepsy. Epilepsia. 1993; 34:S30-S33.
-
(1993)
Epilepsia.
, vol.34
, pp. S30-S33
-
-
Schmidt, D.1
-
36
-
-
0036799687
-
Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus
-
Mazarati AM, Sofia RD, Wasterlain CG. Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. Seizure. 2002; 11:423-430.
-
(2002)
Seizure.
, vol.11
, pp. 423-430
-
-
Mazarati, A.M.1
Sofia, R.D.2
Wasterlain, C.G.3
-
38
-
-
45749095470
-
Modifications of antiepileptic drugs for improved tolerability and efficacy
-
Landmark CJ, Johannessen SI. Modifications of antiepileptic drugs for improved tolerability and efficacy. Perspect Medicin Chem. 2008; 2:21-39.
-
(2008)
Perspect Medicin Chem.
, vol.2
, pp. 21-39
-
-
Landmark, C.J.1
Johannessen, S.I.2
-
40
-
-
42749097966
-
The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons
-
Deshpande LS, Nagarkatti N, Sombati S, DeLorenzo RJ. The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Res. 2008; 79:158-165.
-
(2008)
Epilepsy Res.
, vol.79
, pp. 158-165
-
-
Deshpande, L.S.1
Nagarkatti, N.2
Sombati, S.3
DeLorenzo, R.J.4
-
41
-
-
33747047760
-
A new drug, RWJ-333369, displays potent antiepileptic properties in genetic models of absence and audiogenic epilepsy
-
Nehlig A, Rigoulot MA, Boehrer A. A new drug, RWJ-333369, displays potent antiepileptic properties in genetic models of absence and audiogenic epilepsy. Epilepsia. 2005; 46:215.
-
(2005)
Epilepsia.
, vol.46
, pp. 215
-
-
Nehlig, A.1
Rigoulot, M.A.2
Boehrer, A.3
-
42
-
-
33646271996
-
The use of chronic models in antiepileptic drug discovery:The effect of RWJ-333369 on spontaneous motor seizures in rats with kainate-induced epilepsy
-
Grabenstatter HL, Dudek FE. The use of chronic models in antiepileptic drug discovery: The effect of RWJ-333369 on spontaneous motor seizures in rats with kainate-induced epilepsy. Epilepsia. 2004; 45:197.
-
(2004)
Epilepsia.
, vol.45
, pp. 197
-
-
Grabenstatter, H.L.1
Dudek, F.E.2
-
43
-
-
33646230334
-
A new drug RWJ 333369 protects limbic areas in the lithium-pilocarpine model (lipilo) of epilepsy and delays or prevents the occurrence of spontaneous seizures (abstract)
-
Francois J, Ferrandon A, Koning E, Nehlig A. A new drug RWJ 333369 protects limbic areas in the lithium-pilocarpine model (lipilo) of epilepsy and delays or prevents the occurrence of spontaneous seizures (abstract). Epilepsia. 2005; 46:269.
-
(2005)
Epilepsia.
, vol.46
, pp. 269
-
-
Francois, J.1
Ferrandon, A.2
Koning, E.3
Nehlig, A.4
-
44
-
-
33750900787
-
Pharmacokinetics of the new antiepileptic and CNS drug RWJ-333369 following single and multiple dosing to humans
-
Yao C, Doose DR, Novak G, Bialer M. Pharmacokinetics of the new antiepileptic and CNS drug RWJ-333369 following single and multiple dosing to humans. Epilepsia. 2006; 47:1822-1829.
-
(2006)
Epilepsia.
, vol.47
, pp. 1822-1829
-
-
Yao, C.1
Doose, D.R.2
Novak, G.3
Bialer, M.4
-
45
-
-
0029857877
-
Topiramate:A new antiepileptic drug for refractory epilepsy
-
Walker MC, Sander JW. Topiramate: A new antiepileptic drug for refractory epilepsy. Seizure. 1996; 5:199-203.
-
(1996)
Seizure.
, vol.5
, pp. 199-203
-
-
Walker, M.C.1
Sander, J.W.2
-
46
-
-
0043127452
-
Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons
-
Gryder DS, Rogawski MA. Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. J Neurosci. 2003; 23:7069-7074.
-
(2003)
J Neurosci.
, vol.23
, pp. 7069-7074
-
-
Gryder, D.S.1
Rogawski, M.A.2
-
47
-
-
0031418448
-
Topiramate:A review of preclinical, pharmacokinetic, and clinical data
-
Rosenfeld WE. Topiramate: A review of preclinical, pharmacokinetic, and clinical data. Clin Ther. 1997; 19:1294-1308.
-
(1997)
Clin Ther.
, vol.19
, pp. 1294-1308
-
-
Rosenfeld, W.E.1
-
48
-
-
70350220710
-
The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins
-
Luna-Tortos C, Rambeck B, Jurgens UH, Loscher W. The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins. Pharm Res. 2009; 26:2464-2470.
-
(2009)
Pharm Res.
, vol.26
, pp. 2464-2470
-
-
Luna-Tortos, C.1
Rambeck, B.2
Jurgens, U.H.3
Loscher, W.4
-
49
-
-
70449642650
-
Pharmacokinetics of topiramate during pregnancy
-
Ohman I, Sabers A, de Flon P, Luef G, Tomson T. Pharmacokinetics of topiramate during pregnancy. Epilepsy Res. 2009; 87:124-129.
-
(2009)
Epilepsy Res.
, vol.87
, pp. 124-129
-
-
Ohman, I.1
Sabers, A.2
de Flon, P.3
Luef, G.4
Tomson, T.5
-
50
-
-
20144366554
-
Efficacy and safety of topiramate in infants according to epilepsy syndromes
-
Grosso S, Galimberti D, Farnetani MA, Cioni M, Mostardini R, Vivarelli R, Di Bartolo RM, Bernardoni E, Berardi R, Morgese G, Balestri P. Efficacy and safety of topiramate in infants according to epilepsy syndromes. Seizure. 2005; 14:183-189.
-
(2005)
Seizure.
, vol.14
, pp. 183-189
-
-
Grosso, S.1
Galimberti, D.2
Farnetani, M.A.3
Cioni, M.4
Mostardini, R.5
Vivarelli, R.6
Di Bartolo, R.M.7
Bernardoni, E.8
Berardi, R.9
Morgese, G.10
Balestri, P.11
-
51
-
-
78649265245
-
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy:A randomized double-blind clinical trial
-
Ramsay E, Faught E, Krumholz A, Naritoku D, Privitera M, Schwarzman L, Mao L, Wiegand F, Hulihan J. Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: A randomized double-blind clinical trial. Epilepsia. 2010; 51:1970-1977.
-
(2010)
Epilepsia.
, vol.51
, pp. 1970-1977
-
-
Ramsay, E.1
Faught, E.2
Krumholz, A.3
Naritoku, D.4
Privitera, M.5
Schwarzman, L.6
Mao, L.7
Wiegand, F.8
Hulihan, J.9
-
52
-
-
56949101467
-
Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster
-
Hamann M, Sander SE, Richter A. Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster. Eur J Pharmacol. 2008; 601:99-102.
-
(2008)
Eur J Pharmacol.
, vol.601
, pp. 99-102
-
-
Hamann, M.1
Sander, S.E.2
Richter, A.3
-
53
-
-
0028825031
-
The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes
-
Noyer M, Gillard M, Matagne A, Henichart JP, Wulfert E. The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. Eur J Pharmacol. 1995; 286:137-146.
-
(1995)
Eur J Pharmacol.
, vol.286
, pp. 137-146
-
-
Noyer, M.1
Gillard, M.2
Matagne, A.3
Henichart, J.P.4
Wulfert, E.5
-
54
-
-
70449727382
-
Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures
-
Ulloa CM, Towfigh A, Safdieh J. Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures. Neuropsychiatr Dis Treat. 2009 5:467-476.
-
(2009)
Neuropsychiatr Dis Treat.
, pp. 467-476
-
-
Ulloa, C.M.1
Towfigh, A.2
Safdieh, J.3
-
55
-
-
3042748137
-
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
-
Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A. 2004; 101:9861-9866.
-
(2004)
Proc Natl Acad Sci U S A.
, vol.101
, pp. 9861-9866
-
-
Lynch, B.A.1
Lambeng, N.2
Nocka, K.3
Kensel-Hammes, P.4
Bajjalieh, S.M.5
Matagne, A.6
Fuks, B.7
-
56
-
-
0033592991
-
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
-
Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM. Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc Nat Acad Sci U S A. 1999; 96:15268-15273.
-
(1999)
Proc Nat Acad Sci U S A.
, vol.96
, pp. 15268-15273
-
-
Crowder, K.M.1
Gunther, J.M.2
Jones, T.A.3
Hale, B.D.4
Zhang, H.Z.5
Peterson, M.R.6
Scheller, R.H.7
Chavkin, C.8
Bajjalieh, S.M.9
-
57
-
-
33745236710
-
Margineanu DG. Seletracetam (ucb 44212), a new pyrrolidone derivative, lacks effect on Na+ currents in rat brain neurons in vitro. Epilepsia
-
Zona C, Niespodziany I, Pieri M, Klitgaard H, Margineanu DG. Seletracetam (ucb 44212), a new pyrrolidone derivative, lacks effect on Na+ currents in rat brain neurons in vitro. Epilepsia. 2005; 46:116.
-
(2005)
46
, pp. 116
-
-
Zona, C.1
Niespodziany, I.2
Pieri, M.3
Klitgaard, H.4
-
58
-
-
33745276696
-
Seletracetam (ucb 44212):Effect on inhibitory and excitatory neurotransmission
-
Rigo JM, Nguyen L, Hans G, Belachew S, Moonen G, Matagne A, Klitgaard H. Seletracetam (ucb 44212): Effect on inhibitory and excitatory neurotransmission. Epilepsia. 2005; 46:110-111.
-
(2005)
Epilepsia.
, vol.46
, pp. 110-111
-
-
Rigo, J.M.1
Nguyen, L.2
Hans, G.3
Belachew, S.4
Moonen, G.5
Matagne, A.6
Klitgaard, H.7
-
59
-
-
67349156665
-
Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy
-
Matagne A, Margineanu DG, Potschka H, Loscher W, Michel P, Kenda B, Klitgaard H. Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy. Eur J Pharmacol. 2009; 614:30-37.
-
(2009)
Eur J Pharmacol.
, vol.614
, pp. 30-37
-
-
Matagne, A.1
Margineanu, D.G.2
Potschka, H.3
Loscher, W.4
Michel, P.5
Kenda, B.6
Klitgaard, H.7
-
60
-
-
33846336489
-
(UCB 44212)
-
Bennett B, Matagne A, Michel P, Leonard M, Cornet M, Meeus MA, Toublanc N. Seletracetam (UCB 44212). Neurotherapeutics. 2007; 4:117-122.
-
(2007)
Neurotherapeutics.
, vol.4
, pp. 117-122
-
-
Bennett, B.1
Matagne, A.2
Michel, P.3
Leonard, M.4
Cornet, M.5
Meeus, M.A.6
Toublanc, N.7
-
61
-
-
9144238050
-
Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity
-
Kenda BM, Matagne AC, Talaga PE, Pasau PM, Differding E, Lallemand BI, Frycia AM, Moureau FG, Klitgaard HV, Gillard MR, Fuks B, Michel P. Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. J Med Chem. 2004; 47:530-549.
-
(2004)
J Med Chem.
, vol.47
, pp. 530-549
-
-
Kenda, B.M.1
Matagne, A.C.2
Talaga, P.E.3
Pasau, P.M.4
Differding, E.5
Lallemand, B.I.6
Frycia, A.M.7
Moureau, F.G.8
Klitgaard, H.V.9
Gillard, M.R.10
Fuks, B.11
Michel, P.12
-
62
-
-
36749053371
-
Brivaracetam is superior to levetiracetam in a rat model of post-hypoxic myoclonus
-
Tai KK, Truong DD. Brivaracetam is superior to levetiracetam in a rat model of post-hypoxic myoclonus. J Neural Transm. 2007; 114:1547-1551.
-
(2007)
J Neural Transm.
, vol.114
, pp. 1547-1551
-
-
Tai, K.K.1
Truong, D.D.2
-
63
-
-
49449094989
-
Anti-convulsive and antiepileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A
-
Matagne A, Margineanu DG, Kenda B, Michel P, Klitgaard H. Anti-convulsive and antiepileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A. Br J Pharmacol. 2008; 154:1662-1671.
-
(2008)
Br J Pharmacol.
, vol.154
, pp. 1662-1671
-
-
Matagne, A.1
Margineanu, D.G.2
Kenda, B.3
Michel, P.4
Klitgaard, H.5
-
64
-
-
49549119738
-
A rational drug discovery success story
-
Rogawski M. Brivaracetam: A rational drug discovery success story. Br J Pharmacol. 2008; 154:1555-1557.
-
(2008)
Br J Pharmacol.
, vol.154
, pp. 1555-1557
-
-
Brivaracetam, R.M.1
-
66
-
-
32644473010
-
Introduction to zonisamide
-
Baulac M. Introduction to zonisamide. Epilepsy Res. 2006; 68:S3-S9.
-
(2006)
Epilepsy Res.
, vol.68
, pp. S3-S9
-
-
Baulac, M.1
-
67
-
-
7044271164
-
Zonisamide:Chemistry, mechanism of action, and pharmacokinetics
-
Leppik IE. Zonisamide: Chemistry, mechanism of action, and pharmacokinetics. Seizure. 2004; 13:S5-S9.
-
(2004)
Seizure.
, vol.13
, pp. S5-S9
-
-
Leppik, I.E.1
-
68
-
-
32644476871
-
Zonisamide in the management of epilepsy-Japanese experience
-
Ohtahara S. Zonisamide in the management of epilepsy-Japanese experience. Epilepsy Res. 2006; 68:S25-S33.
-
(2006)
Epilepsy Res.
, vol.68
, pp. S25-S33
-
-
Ohtahara, S.1
-
69
-
-
79958853369
-
Drug safety evaluation of zonisamide for the treatment of epilepsy
-
Zaccara G, Tramacere L, Cincotta M. Drug safety evaluation of zonisamide for the treatment of epilepsy. Expert Opin Drug Saf. 2011; 10:623-631.
-
(2011)
Expert Opin Drug Saf.
, vol.10
, pp. 623-631
-
-
Zaccara, G.1
Tramacere, L.2
Cincotta, M.3
-
70
-
-
84855542993
-
Our clinical experience with zonisamide in resistant generalized epilepsy syndromes
-
Kelemen A, Rasonyl G, Neuwirth M, Barcs G, Szucs A, Jakus R, Fabo D, Juhos V, Palfy B, Halasz P. Our clinical experience with zonisamide in resistant generalized epilepsy syndromes. Ideggyogy Sz. 2011; 64:187-192.
-
(2011)
Ideggyogy Sz.
, vol.64
, pp. 187-192
-
-
Kelemen, A.1
Rasonyl, G.2
Neuwirth, M.3
Barcs, G.4
Szucs, A.5
Jakus, R.6
Fabo, D.7
Juhos, V.8
Palfy, B.9
Halasz, P.10
-
72
-
-
67650215631
-
Third-generation antiepileptic drugs:Mechanisms of action, pharmacokinetics and interactions
-
Luszczki JJ. Third-generation antiepileptic drugs: Mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep. 2009; 61:197-216.
-
(2009)
Pharmacol Rep.
, vol.61
, pp. 197-216
-
-
Luszczki, J.J.1
-
73
-
-
54249137787
-
A new antiepileptic drug as adjunctive therapy in patients with partial-onset seizures
-
Saussele T. Lacosamide. A new antiepileptic drug as adjunctive therapy in patients with partial-onset seizures. Med Monatsschr Pharm. 2008; 31:374-377.
-
(2008)
Med Monatsschr Pharm.
, vol.31
, pp. 374-377
-
-
Saussele, T.1
-
74
-
-
67649388104
-
Lacosamide:A new approach to target voltage-gated sodium currents in epileptic disorders
-
Curia G, Biagini G, Perucca E, Avoli M. Lacosamide: A new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009; 23:555-568.
-
(2009)
CNS Drugs.
, vol.23
, pp. 555-568
-
-
Curia, G.1
Biagini, G.2
Perucca, E.3
Avoli, M.4
-
76
-
-
47249119666
-
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models
-
White HS, Franklin MR, Kupferberg HJ, Schmutz M, Stables JP, Wolf HH. The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008; 49:1213-1220.
-
(2008)
Epilepsia.
, vol.49
, pp. 1213-1220
-
-
White, H.S.1
Franklin, M.R.2
Kupferberg, H.J.3
Schmutz, M.4
Stables, J.P.5
Wolf, H.H.6
-
77
-
-
45749116975
-
Rufinamide:Clinical pharmacokinetics and concentration-response relationships in patients with epilepsy
-
Perucca E, Cloyd J, Critchley D, Fuseau E. Rufinamide: Clinical pharmacokinetics and concentration-response relationships in patients with epilepsy. Epilepsia. 2008; 49:1123-1141.
-
(2008)
Epilepsia.
, vol.49
, pp. 1123-1141
-
-
Perucca, E.1
Cloyd, J.2
Critchley, D.3
Fuseau, E.4
-
78
-
-
79952139953
-
Adopting an Orphan Drug:Rufinamide for Lennox-Gastaut Syndrome
-
Herman ST. Adopting an Orphan Drug: Rufinamide for Lennox-Gastaut Syndrome. Epilepsy Curr. 2009; 9:72-74.
-
(2009)
Epilepsy Curr.
, vol.9
, pp. 72-74
-
-
Herman, S.T.1
-
79
-
-
78751503816
-
Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome
-
Coppola G, Grosso S, Franzoni E, Veggiotti P, Zamponi N, Parisi P, Spalice A, Habetswallner F, Fels A, Verrotti A, D'Aniello A, Mangano S, Balestri A, Curatolo P, Pascotto A. Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome. Eur J Neurol. 2011; 18:246-251.
-
(2011)
Eur J Neurol.
, vol.18
, pp. 246-251
-
-
Coppola, G.1
Grosso, S.2
Franzoni, E.3
Veggiotti, P.4
Zamponi, N.5
Parisi, P.6
Spalice, A.7
Habetswallner, F.8
Fels, A.9
Verrotti, A.10
D'Aniello, A.11
Mangano, S.12
Balestri, A.13
Curatolo, P.14
Pascotto, A.15
-
80
-
-
77955534377
-
Kothare SV Experience with rufinamide in a pediatric population:a single center's experience
-
Vendrame M, Loddenkemper T, Gooty VD, Takeoka M, Rotenberg A, Bergin AM, Eksioglu YZ, Poduri A, Duffy FH, Libenson M, Bourgeois BF, Kothare SV Experience with rufinamide in a pediatric population: a single center's experience. Pediatr Neuro. 2010; 43:155-158.
-
(2010)
Pediatr Neuro.
, vol.43
, pp. 155-158
-
-
Vendrame, M.1
Loddenkemper, T.2
Gooty, V.D.3
Takeoka, M.4
Rotenberg, A.5
Bergin, A.M.6
Eksioglu, Y.Z.7
Poduri, A.8
Duffy, F.H.9
Libenson, M.10
Bourgeois, B.F.11
-
81
-
-
77950626042
-
Rufinamide:A new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome
-
Wisniewski CS. Rufinamide: A new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome. Ann Pharmacother. 2010; 44:658-667.
-
(2010)
Ann Pharmacother.
, vol.44
, pp. 658-667
-
-
Wisniewski, C.S.1
-
82
-
-
0036628434
-
Labiner DM. DP-VPA D-Pharm. Curr Opin Investig Drugs
-
Labiner DM. DP-VPA D-Pharm. Curr Opin Investig Drugs. 2002; 3:921-923.
-
(2002)
3
, pp. 921-923
-
-
-
83
-
-
3543031633
-
New generation of valproic acid
-
Trojnar MK, Wierzchowska-Cioch E, Krzyzanowski M, Jargiello M, Czuczwar SJ. New generation of valproic acid. Pol J Pharmacol. 2004; 56:283-288.
-
(2004)
Pol J Pharmacol.
, vol.56
, pp. 283-288
-
-
Trojnar, M.K.1
Wierzchowska-Cioch, E.2
Krzyzanowski, M.3
Jargiello, M.4
Czuczwar, S.J.5
-
84
-
-
38549101558
-
The oral absorption of phospholipid prodrugs:In vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproic acid conjugate following oral administration
-
Dahan A, Duvdevani R, Shapiro I, Elmann A, Finkelstein E, Hoffman A. The oral absorption of phospholipid prodrugs: In vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproic acid conjugate following oral administration. J Control Release. 2008; 126:1-9.
-
(2008)
J Control Release.
, vol.126
, pp. 1-9
-
-
Dahan, A.1
Duvdevani, R.2
Shapiro, I.3
Elmann, A.4
Finkelstein, E.5
Hoffman, A.6
-
85
-
-
57849141134
-
Progress report on new antiepileptic drugs:A summary of the Ninth Eilat Conference (EILAT IX)
-
Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009; 83:1-43.
-
(2009)
Epilepsy Res.
, vol.83
, pp. 1-43
-
-
Bialer, M.1
Johannessen, S.I.2
Levy, R.H.3
Perucca, E.4
Tomson, T.5
White, H.S.6
-
86
-
-
0036127241
-
Mechanisms of action of carbamazepine and its derivatives
-
Ambrosio AF, Soares-Da-Silva P, Carvalho CM, Carvalho AP. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem Res. 2002; 27:121-130.
-
(2002)
and BIA 2-024.
, vol.27
, pp. 2-093
-
-
Ambrosio, A.F.1
Soares-Da-Silva, P.2
Carvalho, C.M.3
Carvalho, A.P.4
-
87
-
-
61849168486
-
Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures:A randomized, double-blind, placebo-controlled, parallel-group phase III study
-
Elger C, Halasz P, Maia J, Almeida L, Soares-da-Silva P. Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: A randomized, double-blind, placebo-controlled, parallel-group phase III study. Epilepsia. 2009; 50:454-463.
-
(2009)
Epilepsia.
, vol.50
, pp. 454-463
-
-
Elger, C.1
Halasz, P.2
Maia, J.3
Almeida, L.4
Soares-da-Silva, P.5
-
88
-
-
0034023578
-
Modification of behavioral effects of drugs in mice by neuroactive steroids
-
Ungard JT, Beekman M, Gasior M, Carter RB, Dijkstra D, Witkin JM. Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology. 2000; 148:336-343.
-
(2000)
Psychopharmacology.
, vol.148
, pp. 336-343
-
-
Ungard, J.T.1
Beekman, M.2
Gasior, M.3
Carter, R.B.4
Dijkstra, D.5
Witkin, J.M.6
-
89
-
-
0032846421
-
Ganaxolone:A novel positive allosteric modulator of the GABAA receptor complex for the treatment of epilepsy
-
Monaghan EP, McAculey JW, Data JL. Ganaxolone: A novel positive allosteric modulator of the GABAA receptor complex for the treatment of epilepsy. Exp Opin Invest Drugs. 1999; 8:1663-1671.
-
(1999)
Exp Opin Invest Drugs.
, vol.8
, pp. 1663-1671
-
-
Monaghan, E.P.1
McAculey, J.W.2
Data, J.L.3
-
90
-
-
34447523470
-
Use of the newer antiepileptic drugs in pediatric epilepsies
-
Malphrus AD, Wilfong AA. Use of the newer antiepileptic drugs in pediatric epilepsies. Curr Treat Options Neurol. 2007; 9:256-267.
-
(2007)
Curr Treat Options Neurol.
, vol.9
, pp. 256-267
-
-
Malphrus, A.D.1
Wilfong, A.A.2
-
91
-
-
35148899318
-
Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy
-
Pieribone VA, Tsai J, Soufflet C, Rey E, Shaw K, Giller E, Dulac O. Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy. Epilepsia. 2007; 48:1870-1874.
-
(2007)
Epilepsia.
, vol.48
, pp. 1870-1874
-
-
Pieribone, V.A.1
Tsai, J.2
Soufflet, C.3
Rey, E.4
Shaw, K.5
Giller, E.6
Dulac, O.7
-
92
-
-
63149166858
-
Neurosteroid replacement therapy for catamenial epilepsy
-
Reddy DS, Rogawski MA. Neurosteroid replacement therapy for catamenial epilepsy. Neurotherapeutics. 2009; 6:392-401.
-
(2009)
Neurotherapeutics.
, vol.6
, pp. 392-401
-
-
Reddy, D.S.1
Rogawski, M.A.2
-
93
-
-
0031420891
-
Losigamone:From plant extract to antiepileptic drug
-
Chatterjee SS, Noldner M. Losigamone: From plant extract to antiepileptic drug. CNS Drug Rev. 1997; 3:225-244.
-
(1997)
CNS Drug Rev.
, vol.3
, pp. 225-244
-
-
Chatterjee, S.S.1
Noldner, M.2
-
94
-
-
0029149763
-
Effects of the anticonvulsant losigamone and its isomers on the GABAa receptor system
-
Dimpfel W, Chatterjee SS, Noldner M, Ticku MK. Effects of the anticonvulsant losigamone and its isomers on the GABAa receptor system. Epilepsia. 1995; 36:983-989.
-
(1995)
Epilepsia.
, vol.36
, pp. 983-989
-
-
Dimpfel, W.1
Chatterjee, S.S.2
Noldner, M.3
Ticku, M.K.4
-
95
-
-
0030833897
-
The effect of losigamone (AO-33) on electrical activity and excitatory amino acid release in mouse cortical slices
-
Srinivasan J, Richens A, Davies JA. The effect of losigamone (AO-33) on electrical activity and excitatory amino acid release in mouse cortical slices. Br J Pharmacol. 1997; 122:1490-1494.
-
(1997)
Br J Pharmacol.
, vol.122
, pp. 1490-1494
-
-
Srinivasan, J.1
Richens, A.2
Davies, J.A.3
-
96
-
-
0032754438
-
The anticonvulsant effects of the enantiomers of losigamone
-
Jones FA, Davies JA. The anticonvulsant effects of the enantiomers of losigamone. Br J Pharmacol. 1999; 128:1223-1228.
-
(1999)
Br J Pharmacol.
, vol.128
, pp. 1223-1228
-
-
Jones, F.A.1
Davies, J.A.2
-
97
-
-
0035976512
-
The antiepileptic drug losigamone decreases the persistent Na+ current in rat hippocampal neurons
-
Gebhardt C, Breustedt JM, Noldner M, Chatterjee SS, Heinemann U. The antiepileptic drug losigamone decreases the persistent Na+ current in rat hippocampal neurons. Brain Res. 2001; 920:27-31.
-
(2001)
Brain Res.
, vol.920
, pp. 27-31
-
-
Gebhardt, C.1
Breustedt, J.M.2
Noldner, M.3
Chatterjee, S.S.4
Heinemann, U.5
-
98
-
-
0042827363
-
Efficacy and safety of losigamone in partial seizures:A randomized double-blind study
-
Baulac M, Klement S. Efficacy and safety of losigamone in partial seizures: A randomized double-blind study. Epilepsy Res. 2003; 55:177-189.
-
(2003)
Epilepsy Res.
, vol.55
, pp. 177-189
-
-
Baulac, M.1
Klement, S.2
-
99
-
-
0037087039
-
Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice
-
Santangeli S, Sills GJ, Stone TW, Brodie MJ. Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice. Neurosci Lett. 2002; 321:33-36.
-
(2002)
Neurosci Lett.
, vol.321
, pp. 33-36
-
-
Santangeli, S.1
Sills, G.J.2
Stone, T.W.3
Brodie, M.J.4
-
100
-
-
18344407004
-
Remacemide-a novel potential antiepileptic drug
-
Malek R, Borowicz KK, Kimber-Trojnar Z, Sobieszek G, Piskorska B, Czuczwar SJ. Remacemide-a novel potential antiepileptic drug. Pol J Pharmacol. 2003; 55:691-698.
-
(2003)
Pol J Pharmacol.
, vol.55
, pp. 691-698
-
-
Malek, R.1
Borowicz, K.K.2
Kimber-Trojnar, Z.3
Sobieszek, G.4
Piskorska, B.5
Czuczwar, S.J.6
-
101
-
-
0035990514
-
Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride
-
Sills GJ, Santangeli S, Forrest G, Brodie MJ. Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. Epilepsy Res. 2002; 49:247-254.
-
(2002)
Epilepsy Res.
, vol.49
, pp. 247-254
-
-
Sills, G.J.1
Santangeli, S.2
Forrest, G.3
Brodie, M.J.4
-
102
-
-
63049112725
-
The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy
-
Wesnes KA, Edgar C, Dean AD, Wroe SJ. The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy. Epilepsy Behav. 2009; 14:522-528.
-
(2009)
Epilepsy Behav.
, vol.14
, pp. 522-528
-
-
Wesnes, K.A.1
Edgar, C.2
Dean, A.D.3
Wroe, S.J.4
-
103
-
-
34447643554
-
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock
-
Borowicz KK, Malek R, Luszczki JJ, Ratnaraj N, Patsalos PN, Czuczwar SJ. Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. Epilepsy Behav. 2007; 11:6-12.
-
(2007)
Epilepsy Behav.
, vol.11
, pp. 6-12
-
-
Borowicz, K.K.1
Malek, R.2
Luszczki, J.J.3
Ratnaraj, N.4
Patsalos, P.N.5
Czuczwar, S.J.6
-
105
-
-
0030668611
-
The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells
-
Rundfeldt C. The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells. Eur J Pharmacol. 1997; 336:243-249.
-
(1997)
Eur J Pharmacol.
, vol.336
, pp. 243-249
-
-
Rundfeldt, C.1
-
106
-
-
15744400656
-
The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate
-
Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol. 2005; 67:1009-1017.
-
(2005)
Mol Pharmacol.
, vol.67
, pp. 1009-1017
-
-
Wuttke, T.V.1
Seebohm, G.2
Bail, S.3
Maljevic, S.4
Lerche, H.5
-
107
-
-
50549100189
-
Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres
-
Roza C, Lopez-Garcia JA. Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres. Pain. 2008; 138:537-545.
-
(2008)
Pain.
, vol.138
, pp. 537-545
-
-
Roza, C.1
Lopez-Garcia, J.A.2
-
108
-
-
77953317302
-
Retigabine:The newer potential antiepileptic drug
-
Czuczwar P, Wojtak A, Cioczek-Czuczwar A, Parada-Turska J, Maciejewski R, Czuczwar SJ, Retigabine: The newer potential antiepileptic drug. Pharmacol Rep. 2010; 62:211-219.
-
(2010)
Pharmacol Rep.
, vol.62
, pp. 211-219
-
-
Czuczwar, P.1
Wojtak, A.2
Cioczek-Czuczwar, A.3
Parada-Turska, J.4
Maciejewski, R.5
Czuczwar, S.J.6
-
109
-
-
15144352587
-
Synthesis and anticonvulsant activity of a new class of 2-[(arylalkyl)amino]alkanamide derivatives
-
Pevarello P, Bonsignori A, Dostert P, Heidempergher F, Pinciroli V, Colombo M, McArthur RA, Salvati P, Post C, Fariello RG, Varasi M. Synthesis and anticonvulsant activity of a new class of 2-[(arylalkyl)amino]alkanamide derivatives. J Med Chem. 1998; 41:579-590.
-
(1998)
J Med Chem.
, vol.41
, pp. 579-590
-
-
Pevarello, P.1
Bonsignori, A.2
Dostert, P.3
Heidempergher, F.4
Pinciroli, V.5
Colombo, M.6
McArthur, R.A.7
Salvati, P.8
Post, C.9
Fariello, R.G.10
Varasi, M.11
-
110
-
-
33846358524
-
Fariello RG. Safinamide. Neurotherapeutics
-
Fariello RG. Safinamide. Neurotherapeutics. 2007; 4:110-116.
-
(2007)
4
, pp. 110-116
-
-
-
111
-
-
0031033190
-
-
Maurizis JC, Madelmont JC, Rapp M, Marijnen C, Cerf MC, Gillardin JM, Lepage F, Veyre A. Disposition and metabolism of 2,6-dimethylbenzamide jV-(5-methyl-3-isoxazolyl) (D2916) in male and female rats. Drug Metab Dispos. 1997; 25:33-39.
-
(1997)
Disposition and metabolism of
, vol.25
, pp. 33-39
-
-
Maurizis, J.C.1
Madelmont, J.C.2
Rapp, M.3
Marijnen, C.4
Cerf, M.C.5
Gillardin, J.M.6
Lepage, F.7
Veyre, A.8
-
112
-
-
85008736339
-
Drugs in early clinical development.
-
In: Antiepileptic drugs (Levy RH, Mattson RH, Meldrum BS, Perucca E, eds.). Lippincott Williams & Wilkins, Philadelphia, USA
-
Perucca E, Kupferberg HJ. Drugs in early clinical development. In: Antiepileptic drugs (Levy RH, Mattson RH, Meldrum BS, Perucca E, eds.). Lippincott Williams & Wilkins, Philadelphia, USA, 2002; pp. 913-992.
-
(2002)
, pp. 913-992
-
-
Perucca, E.1
Kupferberg, H.J.2
-
113
-
-
0034638786
-
Stiripentol in severe myoclonic epilepsy in infancy:A randomised placebo-controlled syndrome-dedicated trial
-
Chiron C, Marchand MC, Tran A, Rey E, d'Athis P, Vincent J, Dulac O, Pons G. Stiripentol in severe myoclonic epilepsy in infancy: A randomised placebo-controlled syndrome-dedicated trial. Lancet. 2000; 356:1638-1642.
-
(2000)
Lancet.
, vol.356
, pp. 1638-1642
-
-
Chiron, C.1
Marchand, M.C.2
Tran, A.3
Rey, E.4
d'Athis, P.5
Vincent, J.6
Dulac, O.7
Pons, G.8
-
114
-
-
33645106149
-
In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism
-
Giraud C, Treluyer JM, Rey E, Chiron C, Vincent J, Pons G, Tran A. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. Drug Metab Dispos. 2006; 34:608-611.
-
(2006)
Drug Metab Dispos.
, vol.34
, pp. 608-611
-
-
Giraud, C.1
Treluyer, J.M.2
Rey, E.3
Chiron, C.4
Vincent, J.5
Pons, G.6
Tran, A.7
-
115
-
-
58049084097
-
The anticonvulsant stiripentol acts directly on the GABA (A) receptor as a positive allosteric modulator
-
Fisher JL. The anticonvulsant stiripentol acts directly on the GABA (A) receptor as a positive allosteric modulator. Neuropharmacology. 2009; 56:190-197.
-
(2009)
Neuropharmacology.
, vol.56
, pp. 190-197
-
-
Fisher, J.L.1
-
116
-
-
0034059343
-
Pharmacology of AMPA/Kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders
-
Lees GJ. Pharmacology of AMPA/Kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders. Drugs. 2000; 59:33-78.
-
(2000)
Drugs.
, vol.59
, pp. 33-78
-
-
Lees, G.J.1
-
117
-
-
13444267833
-
AMPA receptor antagonists as potential anticonvulsant drugs
-
De Sarro G, Gitto R, Russo E, Ibbadu GF, Barreca ML, De Luca L, Chimirri A. AMPA receptor antagonists as potential anticonvulsant drugs. Curr Top Med Chem. 2005; 5:31-42.
-
(2005)
Curr Top Med Chem.
, vol.5
, pp. 31-42
-
-
De Sarro, G.1
Gitto, R.2
Russo, E.3
Ibbadu, G.F.4
Barreca, M.L.5
De Luca, L.6
Chimirri, A.7
-
119
-
-
0027404879
-
Rogawski MA
-
Donevan SD, Rogawski MA. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron. 1993; 10:51-59.
-
(1993)
GYKI 52466, a
, vol.10
, pp. 51-59
-
-
Donevan, S.D.1
-
120
-
-
0037413584
-
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist
-
Gitto R, Barreca ML, De Luca L, De Sarro G, Ferreri G, Quartarone S, Russo E, Constanti A, Chimirri A. Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist. J Med Chem. 2003; 46:197-200.
-
(2003)
J Med Chem.
, vol.46
, pp. 197-200
-
-
Gitto, R.1
Barreca, M.L.2
De Luca, L.3
De Sarro, G.4
Ferreri, G.5
Quartarone, S.6
Russo, E.7
Constanti, A.8
Chimirri, A.9
-
121
-
-
34547828792
-
Development of new antiepileptic drugs:Challenges, incentives, and recent advances
-
Perucca E, French J, Bialer M. Development of new antiepileptic drugs: Challenges, incentives, and recent advances. Lancet Neurol. 2007; 6:793-804.
-
(2007)
Lancet Neurol.
, vol.6
, pp. 793-804
-
-
Perucca, E.1
French, J.2
Bialer, M.3
-
122
-
-
33846251309
-
Neurotherapeutics
-
Howes JF, Bell C. Talampanel. Neurotherapeutics. 2007; 4:126-129.
-
(2007)
4
, pp. 126-129
-
-
Howes, J.F.1
Bell, C.2
-
123
-
-
84856685605
-
Revisiting AMPA receptors as an antiepileptic drug target
-
Rogawski MA. Revisiting AMPA receptors as an antiepileptic drug target. Epilepsy Curr. 2011; 11:56-63.
-
(2011)
Epilepsy Curr.
, vol.11
, pp. 56-63
-
-
Rogawski, M.A.1
-
124
-
-
85008724999
-
Valrocemide licensed for worldwide development, production and marketing.
-
http://www.epilepsy.org.uk/ node/1133 (accessed July 29).
-
Valrocemide licensed for worldwide development, production and marketing. http://www.epilepsy.org.uk/ node/1133 (accessed July 29, 2012).
-
(2012)
-
-
-
125
-
-
0034844676
-
Anticonvulsant profile of valrocemide (TV1901):A new antiepileptic drug
-
Isoherranen N, Woodhead JH, White HS, Bialer M. Anticonvulsant profile of valrocemide (TV1901): A new antiepileptic drug. Epilepsia. 2001; 42:831-836.
-
(2001)
Epilepsia.
, vol.42
, pp. 831-836
-
-
Isoherranen, N.1
Woodhead, J.H.2
White, H.S.3
Bialer, M.4
-
126
-
-
2342426213
-
Hovinga CA. Valrocemide (Teva/Acorda). Curr Opin Investig Drugs
-
Hovinga CA. Valrocemide (Teva/Acorda). Curr Opin Investig Drugs. 2004; 5:101-106.
-
(2004)
5
, pp. 101-106
-
-
-
127
-
-
32044466013
-
Pregabalin:A new antiepileptic drug for refractory epilepsy
-
Hamandi K, Sander JW. Pregabalin: A new antiepileptic drug for refractory epilepsy. Seizure. 2006; 15:73-78.
-
(2006)
Seizure.
, vol.15
, pp. 73-78
-
-
Hamandi, K.1
Sander, J.W.2
-
128
-
-
33745399645
-
Pregabalin:From molecule to medicine
-
Kavoussi R. Pregabalin: From molecule to medicine. Eur Neuropsychopharmacol. 2006; 2:S128-S133.
-
(2006)
Eur Neuropsychopharmacol.
, vol.2
, pp. S128-S133
-
-
Kavoussi, R.1
-
130
-
-
64149132484
-
Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin
-
Briggs DE, Lee CM, Spiegel K, French JA. Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. Epilepsy Res. 2008; 82:86-92.
-
(2008)
Epilepsy Res.
, vol.82
, pp. 86-92
-
-
Briggs, D.E.1
Lee, C.M.2
Spiegel, K.3
French, J.A.4
-
131
-
-
23844482080
-
Genetics of drug resistance in epilepsy
-
Sisodiya SM. Genetics of drug resistance in epilepsy. Curr Neurol Neurosci Rep. 2005; 5:307-311.
-
(2005)
Curr Neurol Neurosci Rep.
, vol.5
, pp. 307-311
-
-
Sisodiya, S.M.1
-
132
-
-
77954668304
-
Alexopoulos AV Pharmacoresistant epilepsy:From pathogenesis to current and emerging therapies
-
Pati S, Alexopoulos AV Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies. Cleve Clin J Med. 2010; 77:457-467.
-
(2010)
Cleve Clin J Med.
, vol.77
, pp. 457-467
-
-
Pati, S.1
-
133
-
-
0032918385
-
Clinical aspects and biological bases of drug-resistant epilepsies
-
Regesta G, Tanganelli P. Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res. 1999; 34:109-122.
-
(1999)
Epilepsy Res.
, vol.34
, pp. 109-122
-
-
Regesta, G.1
Tanganelli, P.2
-
134
-
-
0345382778
-
A novel mechanism underlying drug resistance in chronic epilepsy
-
Remy S, Gabriel S, Urban BW, Dietrich D, Lehmann TN, Elger CE, Heinemann U, Beck H. A novel mechanism underlying drug resistance in chronic epilepsy. Ann Neurol. 2003; 53:469-479.
-
(2003)
Ann Neurol.
, vol.53
, pp. 469-479
-
-
Remy, S.1
Gabriel, S.2
Urban, B.W.3
Dietrich, D.4
Lehmann, T.N.5
Elger, C.E.6
Heinemann, U.7
Beck, H.8
-
135
-
-
20444439127
-
Multidrug resistance in epilepsy: Rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.
-
Volk HA, Loscher W. Multidrug resistance in epilepsy: Rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures. Brain. 2005; 128:1358-1368.
-
(2005)
Brain.
, vol.128
, pp. 1358-1368
-
-
Volk, H.A.1
Loscher, W.2
-
136
-
-
0037431040
-
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
-
Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med. 2003; 348:1442-1448.
-
(2003)
N Engl J Med.
, vol.348
, pp. 1442-1448
-
-
Siddiqui, A.1
Kerb, R.2
Weale, M.E.3
Brinkmann, U.4
Smith, A.5
Goldstein, D.B.6
Wood, N.W.7
Sisodiya, S.M.8
-
137
-
-
76349096470
-
Genetic factors associated with drug-resistance of epilepsy:Relevance of stratification by patient age and aetiology of epilepsy
-
Sanchez MB, Herranz JL, Leno C, Arteaga R, Oterino A, Valdizan EM, Nicolas JM, Adin J, Armijo JA, Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy. Seizure. 2010; 19:93-101.
-
(2010)
Seizure.
, vol.19
, pp. 93-101
-
-
Sanchez, M.B.1
Herranz, J.L.2
Leno, C.3
Arteaga, R.4
Oterino, A.5
Valdizan, E.M.6
Nicolas, J.M.7
Adin, J.8
Armijo, J.A.9
-
138
-
-
32544437036
-
Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95):A trial of the Eastern Cooperative Oncology Group
-
Friedenberg WR, Rue M, Blood EA, Dalton WS, Shustik C, Larson RA, Sonneveld P, Greipp PR. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): A trial of the Eastern Cooperative Oncology Group. Cancer. 2006; 106:830-838.
-
(2006)
Cancer.
, vol.106
, pp. 830-838
-
-
Friedenberg, W.R.1
Rue, M.2
Blood, E.A.3
Dalton, W.S.4
Shustik, C.5
Larson, R.A.6
Sonneveld, P.7
Greipp, P.R.8
-
139
-
-
40049097199
-
Seizure-freedom with combination therapy in localization-related epilepsy
-
Peltola J, Peltola M, Raitanen J, Keranen T, Kharazmi E, Auvinen A. Seizure-freedom with combination therapy in localization-related epilepsy. Seizure. 2008; 17:276-280.
-
(2008)
Seizure.
, vol.17
, pp. 276-280
-
-
Peltola, J.1
Peltola, M.2
Raitanen, J.3
Keranen, T.4
Kharazmi, E.5
Auvinen, A.6
-
143
-
-
61849098715
-
Benefit of combination therapy in epilepsy:A review of the preclinical evidence with levetiracetam
-
Kaminski RM, Matagne A, Patsalos PN, Klitgaard H. Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam. Epilepsia. 2009; 50:387-397.
-
(2009)
Epilepsia.
, vol.50
, pp. 387-397
-
-
Kaminski, R.M.1
Matagne, A.2
Patsalos, P.N.3
Klitgaard, H.4
|