L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors

Neuropharmacology

Volumn 51, Issue 6, 2006, Pages 1023-1029

  Atack, John R ^a   Bayley, Peter J ^a   Seabrook, Guy R ^a   Wafford, Keith A ^a   McKernan, Ruth M ^a   Dawson, Gerard R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

5 Subunit; Benzodiazepine; Cognition; GABAA receptor; Inverse agonist; L 655,708; Morris water maze; Proconvulsant

Indexed keywords

2 PHENYL 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; BRETAZENIL; CONVULSANT AGENT; FLUMAZENIL; L 655 708; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; PENTETRAZOLE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOLOGICAL MODEL; BRAIN DEPTH STIMULATION; BRAIN SLICE; CLONIC SEIZURE; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG TARGETING; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; LEARNING; LONG TERM POTENTIATION; MALE; MAZE TEST; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; THETA RHYTHM; TONIC SEIZURE;

ANIMALS; COGNITION; CONVULSANTS; ELECTROPHYSIOLOGY; GABA AGONISTS; HIPPOCAMPUS; HUMANS; IMIDAZOLES; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; PATCH-CLAMP TECHNIQUES; PENTYLENETETRAZOLE; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; SEIZURES;

EID: 33750608691     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.04.018     Document Type: Article

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