Nefiracetam Attenuates Pro-Inflammatory Cytokines and GABA Transporter in Specific Brain Regions of Rats with Post-Ischemic Seizures

Cellular Physiology and Biochemistry

Volumn 37, Issue 5, 2015, Pages 2023-2031

  Fu, Chuan Yi ^a   He, Xu Ying ^a   Li, Xi Feng ^a   Zhang, Xin ^a   Huang, Zhi Wei ^a   Li, Jun ^a   Chen, Min ^a   Duan, Chuan Zhi ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral Ischemia; Cytokines; GABA; Nefiracetam; Seizure

Indexed keywords

CYTOKINE; GABA TRANSPORTER 1; GABA TRANSPORTER 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEFIRACETAM; TUMOR NECROSIS FACTOR ALPHA; 2 PYRROLIDONE DERIVATIVE; 4 AMINOBUTYRIC ACID CARRIER;

AMYGDALOID NUCLEUS; ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG MECHANISM; ELECTROENCEPHALOGRAM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PARIETAL CORTEX; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; AMYGDALA; ANIMAL; BRAIN; BRAIN ISCHEMIA; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PARIETAL LOBE; SEIZURES; SPRAGUE DAWLEY RAT;

AMYGDALA; ANIMALS; BRAIN; BRAIN ISCHEMIA; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; HIPPOCAMPUS; MALE; PARIETAL LOBE; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 84948166471     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000438562     Document Type: Article

References (34)

1. Borden LA: GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int 1996;29:335-356.
2. Overstreet LS, Westbrook GL: Synapse density regulates independence at unitary inhibitory synapses. J Neurosci 2003;23:2618-2626.
3. Richerson GB, Wu Y: Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore. J Neurophysiol 2003;90:1363-1374.
4. Semyanov A, Walker MC, Kullmann DM, Silver RA: Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci 2004;27:262-269.
5. Conti F, Minelli A, Melone M: GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications. Brain Res Rev 2004;45:196-212.
6. Jin XT, Galvan A, Wichmann T, Smith Y: Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia. Front Syst Neurosci 2011;5:63.
7. da Cruz GM, Felipe CF, Scorza FA, da Costa MA, Tavares AF, Menezes ML, de Andrade GM, Leal LK, Brito GA, da Graca Naffah-Mazzacoratti M, Cavalheiro EA, de Barros Viana GS: Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms. Pharmacol Biochem Behav 2013;104:144-153.
8. Hattingen E, Luckerath C, Pellikan S, Vronski D, Roth C, Knake S, Kieslich M, Pilatus U: Frontal and thalamic changes of GABA concentration indicate dysfunction of thalamofrontal networks in juvenile myoclonic epilepsy. Epilepsia 2014;55:1030-1037.
9. Li G, Bauer S, Nowak M, Norwood B, Tackenberg B, Rosenow F, Knake S, Oertel WH, Hamer HM: Cytokines and epilepsy. Seizure 2011;20:249-256.
10. Vezzani A, Balosso S, Ravizza T: Inflammation and epilepsy. Handb Clin Neurol 2012;107:163-175.
11. Su J, Yin J, Qin W, Sha S, Xu J, Jiang C: Role for Pro-inflammatory Cytokines in Regulating Expression of GABA Transporter Type 1 and 3 in Specific Brain Regions of Kainic Acid-Induced Status Epilepticus. Neurochem Res 2015;40:621-627.
12. Kitano Y, Komiyama C, Makino M, Kasai Y, Takasuna K, Kinoshita M, Yamazaki O, Takazawa A, Yamauchi T, Sakurada S: Effects of Nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 2005;46:1561-1568.
13. Kitano Y, Komiyama C, Makino M, Takasuna K, Satoh H, Aoki T, Kinoshita M, Takazawa A, Yamauchi T, Sakurada S: Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats. Brain Res 2005;1057:168-176.
14. Williams AJ, Tortella FC, Lu XM, Moreton JE, Hartings JA: Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. J Pharmacol Exp Ther 2004;311:220-227.
15. Xie C, Sun J, Qiao W, Lu D, Wei L, Na M, Song Y, Hou X, Lin Z: Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy. PLoS ONE 2011;6:e24966.
16. Balosso S, Maroso M, Sanchez-Alavez M, Ravizza T, Frasca A, Bartfai T, Vezzani A: A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1β. Brain 2008;131:3256-3265.
17. Vezzani A, Granata T: Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005;46:1724-1743.
18. Voutsinos-Porche B, Koning E, Kaplan H, Ferrandon A, Guenounou M, Nehlig A, Motte J: Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy. Neurobiol Dis 2004;17:385-402.
19. Vezzani A, Conti M, de Luigi A, Ravizza T, Moneta D, Marchesi F, de Simoni MG: Interleukin-1b immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J. Neurosci 1999;19:5054-5065.
20. Dube C, Vezzani A, Behrens M, Bartfai T, Baram TZ: Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol 2005;57:152-155.
21. Ravizza T, Rizzi M, Perego C, Richichi C, Veliskova J, Moshe SL, De Simoni MG, Vezzani A: Inflammatory response and glia activation in developing rat hippocampus after status epilepticus. Epilepsia 2005;46:113-117.
22. Galic MA, Riazi K, Henderson AK, Tsutsui S, Pittman QJ: Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats. Neurobiol Dis 2009;36:343-351.
23. Ravizza T, Noe F, Zardoni D, Vaghi V, Sifringer M, Vezzani A: Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production. Neurobiol Dis 2008;31:327-333.
24. Rao RS, Medhi B, Saikia UN, Arora SK, Toor JS, Khanduja KL, Pandhi P: Experimentally induced various inflammatory models and seizure: understanding the role of cytokine in rat. Eur Neuropsychopharmacol 2008;18:760-767.
25. Marchi N, Fan Q, Ghosh C, Fazio V, Bertolini F, Betto G, Batra A, Carlton E, Najm I, Granata T, Janigro D: Antagonism of peripheral inflammation reduces the severity of status epilepticus. Neurobiol Dis 2009;33:171-181.
26. Naitoh Y, Fukata J, Tominaga T, Nakai Y, Tamai S, Mori K, Imura H: Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem Biophys Res Commun 1988;155:1459-1463.
27. Kerschensteiner M, Meinl E, Hohlfeld R: Neuro-immune crosstalk in CNS diseases. Neuroscience 2009;158:1122-1132.
28. Miller RJ, Jung H, Bhangoo S, White FA: Cytokine and chemokine regulation of sensory neuron function. Handb Exp Pharmacol 2009;194:417-449.
29. Wolf J, Rose-John S, Garbers C: Interleukin-6 and its receptors: A highly regulated and dynamic system. Cytokine 2014;70:11-20.
30. Li X, Huo X, Zhang C, Ma X, Han F, Wang G: Role of continuous high thoracic epidural anesthesia in hippocampal apoptosis after global cerebral ischemia in rats. Cell Physiol Biochem 2014;34:1227-1240.
31. Wang R, Liu YY, Liu XY, Jia SW, Zhao J, Cui D, Wang L: Resveratrol protects neurons and the myocardium by reducing oxidative stress and ameliorating mitochondria damage in a cerebral ischemia rat model. Cell Physiol Biochem 2014;34:854-864.
32. Zhang W, Qian C, Li SQ: Protective effect of SGK1 in rat hippocampal neurons subjected to ischemia reperfusion. Cell Physiol Biochem 2014;34:299-312.
33. Allen NJ, Karadottir R, Attwell D: Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy. Pflugers Arch 2004;449:132-142.
34. Wu Y, Wang W, Diez-Sampedro A, Richerson GB: Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1. Neuron 2007;56:851-865.