Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis

Journal of Chemical Neuroanatomy

Volumn 68, Issue , 2015, Pages 39-44

  Schijns, Olaf ^a   Karaca, Ümit ^a   Andrade, Pablo ^a   de Nijs, Laurence ^a   Küsters, Benno ^a   Peeters, Andrea ^a   Dings, Jim ^a   Pannek, Heinz ^b   Ebner, Alois ^b   Rijkers, Kim ^a   Hoogland, Govert ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b EPILEPSY CENTER BETHEL   (Germany)

Author keywords

GABA transporter; Hilus; Hippocampal sclerosis; Temporal lobe epilepsy

Indexed keywords

GABA TRANSPORTER 1; GABA TRANSPORTER 3; 4 AMINOBUTYRIC ACID CARRIER; SLC6A1 PROTEIN, HUMAN; SLC6A11 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL COUNT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG RESISTANT EPILEPSY; FEMALE; HIPPOCAMPAL SCLEROSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TEMPORAL LOBE EPILEPSY; TEMPORAL LOBECTOMY; ADOLESCENT; AUTOPSY; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; METABOLISM; MIDDLE AGED; PATHOLOGY; PRESCHOOL CHILD; SCLEROSIS; SYNAPTIC TRANSMISSION; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AUTOPSY; CHILD; CHILD, PRESCHOOL; EPILEPSY, TEMPORAL LOBE; FEMALE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; SCLEROSIS; SYNAPTIC TRANSMISSION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84941557429     PISSN: 08910618     EISSN: 18736300     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2015.07.004     Document Type: Article

References (21)

1. Blümcke I., Pauli E., Clusmann H., Schramm J., Becker A., Elger C., Merschhemke M., Meencke J.H.J., Lehmann T., Von Deimling A., Scheiwe C., Zentner J., Volk B., Romstock J., Stefan H., Hildebrandt M. A new clinic-pathological classification system for mesial temporal sclerosis. Acta Neuropathol. 2007, 113:234-244.
2. Cammack J.N., Rakhilin S.V., Schwartz E.A. A GABA transporter operates asymmetrically and with variable stoichiometry. Neuron 1994, 13:949-960.
3. Davies K.G., Hermann B.P., Dohan F.C., Foley K.T., Bush A.J., Wyler A.R. Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients. Epilepsy Res. 1996, 24(2):119-126.
4. Doi T., Ueda Y., Tokumaru J., Willmore L.J. Molecular regulation of glumatate and GABA transporter proteins by clobazam during epileptogenesis in Fe(+++)-induced epileptic rats. Mol. Brain Res. 2005, 142(2):91-96.
5. Doi T., Ueda Y., Nagatomo K., Willmore L.J. Role of glutamate and GABA transporters in development of pentylenetetrazol-kindling. Neurochem. Res. 2009, 34:1324-1331.
6. During M.J., Spencer D.D. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 1993, 341:1607-1610.
7. During M.J., Ryder K.M., Spencer D.D. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature 1995, 376:174-177.
8. Hoogland G., Spierenburg H.A., Van Veelen C.W., Van Rijen P.C., Van Huffelen A.C., De Graan P.N. Synaptosomal glutamate and GABA transport in patients with temporal lobe epilepsy. J. Neurosci. Res. 2004, 76:881-890.
9. Jay V., Becker L.E., Ostubo H., Hwang P.A., Hoffman H.J., Harwood-Nash D. Pathology of temporal lobectomy for refractory seizures in children. Review of 20 cases including some unique malformative lesions. J. Neurosurg. 1993, 79:53-61.
10. Kaila K., Rydqvist B., Pasternack M., Voipio J. Inward current caused by sodium dependent uptake of GABA in the crayfish stretch receptor neurone. J. Physiol. 1992, 453:627-645.
11. Kang T.C., Kim D.C., Kwak S.E., Kim J.E., Won M.H., Kim D.W., Choi W.Y., Kwon O.S. Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy. Glia 2006, 54:258-271.
12. Kwan P., Arzimanoglou A., Berg A.T., Brodie M.J., Hauser W.A., Mathern G., Moshe S.L., Perucca E., Wiebe S., French J. Definition of drug resistant epilepsy. Consensus proposal by the ad hoc task force of the ILAE Commission on therapeutic strategies. Epilepsia 2009, 10.1111/j.1528-1167.2009.02397.x.
13. Lee T.S., Bjornsen L.P., Paz C., Kim J.H., Spencer S.S., Spencer D.D., Eid T., De Lanerolle N.C. GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus. Acta Neuropathol. 2006, 111:351-363.
14. Mathern G.W., Mendoza D., Lozada A., Pretorius J.K., Dehnes Y., Danbolt N.C., Nelson N., Leite J.P., Chimelli L., Born D.E., Sakamoto A.D., Assirati J.A., Fried I., Peacock W.J., Ojemann G.A., Adelson P.D. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology 1999, 52:453-472.
15. Patrylo P.R., Spencer D.D., Williamson A. GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. J. Neurophysiol. 2001, 85:1533-1542.
16. Petroff O.A. GABA and glutamate in the human brain. Neuroscientist 2002, 8:562-573.
17. Swanson R.A., Liu J., Miller J.W., Rothstein J.D., Farrell K., Stein B.A., Longuemare M.C. Neuronal regulation of glutamate transporter subtype expression in astrocytes. J. Neurosci. 1997, 17:932-940.
18. Treiman D.M. GABAergic mechanisms in epilepsy. Epilepsia 2001, 42(S3):8-12.
19. Van der Hel W.S., Notenboom R.G., Bos I.W., Van Rijen P.C., Van Veelen C.W., De Graan P.N. Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy. Neurology 2005, 64(2):326-333.
20. Williamson A., Telfeian A.E., Spencer D.D. Prolonged GABA responses in dentate granule cells in slices isolated from patients with temporal lobe sclerosis. J. Neurophysiol. 1995, 74:378-387.
21. Wyler A.R., Curtis Dohan F., Schweitzer J.B., Berry A.D. A grading system for mesial temporal pathology (hippocampal sclerosis) from anterior temporal lobectomy. J. Epilepsy 1992, 5:220-225.