Effect of hyperosmotic conditions on the expression of the betaine-GABA-transporter (BGT-1) in cultured mouse astrocytes

Neurochemical Research

Volumn 30, Issue 6-7, 2005, Pages 855-865

  Olsen, Mads ^a   Sarup, Alan ^a   Larsson, Orla M ^a   Schousboe, Arne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Betaine GABA transporter; GABA; Hyperosmolarity; Osmoregulation

Indexed keywords

4 AMINOBUTYRIC ACID; BETAINE DERIVATIVE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN; CELL GROWTH; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL; NONHUMAN; OSMOREGULATION; OSMOSIS; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CARRIER PROTEINS; CELLS, CULTURED; CULTURE MEDIA; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; MICE; OSMOLAR CONCENTRATION;

EID: 26244461268     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-005-6879-3     Document Type: Article

References (52)

1. L. L. Iversen J. S. Kelly 1975 Uptake and metabolism of γ-aminobutyric acid by neurones and glial cells Biochem. Pharmacol. 24 933 938
2. A. Schousboe O. M. Larsson J. D. Wood P. Krogsgaard-Larsen 1983 Transport and metabolism of γ-aminobutyric acid in neurons and glia: implications for epilepsy Epilepsia 24 531 538
3. P. Krogsgaard-Larsen E. Falch O. M. Larsson A. Schousboe 1987 GABA uptake inhibitors: relevance to antiepileptic drug research Epilepsy Res. 1 77 93
4. A. Schousboe A. Sarup L. K. Bak H. S. Waagepetersen O. M. Larsson 2004 Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission Neurochem. Int. 45 512 527
5. L. A. Borden 1996 GABA transporter heterogeneity: pharmacology and cellular localization Neurochem. Int. 29 335 356
6. N. O. Dalby 2003 Inhibition of γ-aminobutyric acid uptake: anatomy, physiology and effects against epileptic seizures Eur. J. Pharmacol. 479 127 137
7. A. Minelli N. C. Brecha C. Karschin S. DeBiasi F. Conti 1995 GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex J. Neurosci. 15 7734 7746
8. A. Schousboe B. I. Kanner 2002 GABA transporters: functional and pharmacological properties J. Egebjerg A. Schousboe P. Krogsgaard-Larsen Glutamate and GABA Receptors and Transporters; Structure, Function and Pharmacology Taylor and Francis London 337 350
9. C. Thomsen B. Ebert 2002 Modulators of the GABA-A receptor: novel therapeutic prospects J. Egebjerg A. Schousboe P. Krogsgaard-Larsen Glutamate and GABA Receptors and Transporters; Structure, Function and Pharmacology Taylor and Francis London 407 427
10. M. M. Durkin K. E. Smith L. A. Borden R. L. Weinshank T. A. Branchek E. L. Gustafson 1995 Localization of messenger RNAs encoding three GABA transporters in rat brain: an in situ hybridization study Brain Res. Mol. Brain Res. 33 7 21
11. A. Yamauchi S. Uchida H. M. Kwon A. S. Preston R. B. Robey A. Garcia-Perez M. B. Burg J. S. Handler 1992 Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity J. Biol. Chem. 267 649 652
12. B. Lopez-Corcuera Q. R. Liu S. Mandiyan H. Nelson N. Nelson 1992 Expression of a mouse brain cDNA encoding novel γ-aminobutyric acid transporter J. Biol. Chem. 267 17,491 17,493
13. L. A. Borden K. E. Smith E. L. Gustafson T. A. Branchek R. L. Weinshank 1995 Cloning and expression of a betaine/GABA transporter from human brain J. Neurochem. 64 977 984
14. A. Rasola L. J. Galietta V. Barone G. Romeo S. Bagnasco 1995 Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney FEBS Lett. 373 229 233
15. T. Nakanishi R. S. Balaban M. B. Burg 1988 Survey of osmolytes in renal cell lines Am. J. Physiol. 255 C181 C191
16. C. W. Heilig M. E. Stromski J. D. Blumenfeld J. P. Lee S. R. Gullans 1989 Characterization of the major brain osmolytes that accumulate in salt-loaded rats Am. J. Physiol. 257 F1108 F1116
17. M. Bitoun M. Tappaz 2000 Gene expression of the transporters and biosynthetic enzymes of the osmolytes in astrocyte primary cultures exposed to hyperosmotic conditions Glia 32 165 176
18. X. M. Zhu W. Y. Ong 2004 A light and electron microscopic study of betaine/GABA transporter distribution in the monkey cerebral neocortex and hippocampus J. Neurocytol. 33 233 240
19. A. Gadea A. M. Lopez-Colome 2001 Glial transporters for glutamate, glycine, and GABA: II. GABA transporters J. Neurosci. Res. 63 461 468
20. S. A. Kempson 1998 Differential activation of system A and betaine/GABA transport in MDCK cell membranes by hypertonic stress Biochim. Biophys. Acta 1372 117 123
21. T. Nakanishi R. J. Turner M. B. Burg 1990 Osmoregulation of betaine transport in mammalian renal medullary cells Am. J. Physiol. 258 F1061 F1067
22. S. Uchida A. Yamauchi A. S. Preston H. M. Kwon J. S. Handler 1993 Medium tonicity regulates expression of the Na(+)- and Cl(-)-dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene J. Clin. Invest. 91 1604 1607
23. A. Miyai A. Yamauchi T. Moriyama T. Kaneko M. Takenaka T. Sugiura H. Kitamura A. Ando M. Tohyama S. Shimada E. Imai T. Kamada 1996 Expression of betaine transporter mRNA: its unique localization and rapid regulation in rat kidney Kidney Int. 50 819 827
24. M. Bitoun M. Tappaz 2000 Gene expression of taurine transporter and taurine biosynthetic enzymes in brain of rats with acute or chronic hyperosmotic plasma. A comparative study with gene expression of myo-inositol transporter, betaine transporter and sorbitol biosynthetic enzyme Brain Res. Mol. Brain Res. 77 10 18
25. P. G. Petronini R. R. Alfieri M. N. Losio A. E. Caccamo A. Cavazzoni M. A. Bonelli A. F. Borghetti K. P. Wheeler 2000 Induction of BGT-1 and amino acid system A transport activities in endothelial cells exposed to hyperosmolarity Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 R1580 R1589
26. E. de Angelis P. G. Petronini P. Borghetti A. F. Borghetti K. P. Wheeler 1999 Induction of betaine-γ-aminobutyric acid transport activity in porcine chondrocytes exposed to hypertonicity J. Physiol. 518 Pt 1 187 194
27. H. Miyakawa J. S. Rim J. S. Handler H. M. Kwon 1999 Identification of the second tonicity-responsive enhancer for the betaine transporter (BGT1) gene Biochim. Biophys. Acta 1446 359 364
28. M. Takenaka A. S. Preston H. M. Kwon J. S. Handler 1994 The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress J. Biol. Chem. 269 29,379 29,381
29. H. Miyakawa S. K. Woo S. C. Dahl J. S. Handler H. M. Kwon 1999 Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity Proc. Natl. Acad. Sci. U.S.A. 96 2538 2542
30. C. Denkert U. Warskulat F. Hensel D. Haussinger 1998 Osmolyte strategy in human monocytes and macrophages: involvement of p38MAPK in hyperosmotic induction of betaine and myoinositol transporters Arch. Biochem. Biophys. 354 172 180
31. D. Sheikh-Hamad J. Di Mari W. N. Suki R. Safirstein III B. Watts D. Rouse 1998 p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells J. Biol. Chem. 273 1832 1837
32. D. Xu L. Wang J. E. Olson L. Lu 2001 Asymmetrical response of p38 kinase activation to volume changes in primary rat astrocytes Exp. Biol. Med. (Maywood) 226 927 933
33. R. P. Clausen E. K. Moltzen J. Perregaard S. M. Lenz C. Sanchez E. Falch B. Frolund T. Bolvig A. Sarup O. M. Larsson A. Schousboe P. Krogsgaard-Larsen 2005 Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues Bioorg. Med. Chem. 13 895 908
34. A. Schousboe A. Sarup O. M. Larsson H. S. White 2004 GABA transporters as drug targets for modulation of GABAergic activity Biochem. Pharmacol. 68 1557 1563
35. L. Hertz B. H. J. Juurlink E. Hertz H. Fosmark A. Schousboe 1989 Preparation of primary cultures of mouse (Rat) astrocytes A. Shahar J. De Vellis A. Vernadakis B. Haber A Dissection and Tissue Culture Manual of the Nervous System Alan R. Liss. Inc New York 105 108
36. L. Hertz B. H. J. Juurlink H. Fosmark A. Schousboe 1982 Astrocytes in primary cultures S. E. Pfeiffer Neuroscience Approached through cell Culture CRC Press Boca Raton, FL 175 186
37. H. S. White A. Sarup T. Bolvig A. S. Kristensen G. Petersen N. Nelson D. S. Pickering O. M. Larsson B. Frølund P. Krogsgaard-Larsen A. Schousboe 2002 Correlation between anticonvulsant activity and inhibitory action on glial γ-aminobutyric acid uptake of the highly selective mouse γ-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7- tetrahydro-1,2-benzisoxazole and its N-alkylated analogs J. Pharmacol. Exp. Ther. 302 636 644
38. B. Jensen A. Schousboe D. S. Pickering 1999 Role of desensitization and subunit expression for kainate receptor-mediated neurotoxicity in murine neocortical cultures J. Neurosci. Res. 55 208 217
39. O. M. Larsson R. Griffiths I. C. Allen A. Schousboe 1986 Mutual inhibition kinetic analysis of γ-aminobutyric acid, taurine, and β-alanine high-affinity transport into neurons and astrocytes: evidence for similarity between the taurine and β-alanine carriers in both cell types J. Neurochem. 47 426 432
40. A. Schousboe G. Svenneby L. Hertz 1977 Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres J. Neurochem. 29 999 1005
41. A. Sarup O. M. Larsson A. Schousboe 2003 GABA transporters and GABA-transaminase as drug targets Curr. Drug Targets. CNS. Neurol. Disord. 2 269 277
42. A. Schousboe O. M. Larsson A. Sarup H. S. White 2004 Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy Eur. J. Pharmacol. 500 281 287
43. A. D. Macknight L. G. Gordon R. D. Purves 1994 Problems in the understanding of cell volume regulation J. Exp. Zool. 268 80 89
44. H. Trachtman 1991 Cell volume regulation: a review of cerebral adaptive mechanisms and implications for clinical treatment of osmolal disturbances. I Pediatr. Nephrol. 5 743 750
45. Y. H. Lien J. I. Shapiro L. Chan 1990 Effects of hypernatremia on organic brain osmoles J. Clin. Invest. 85 1427 1435
46. X. M. Zhu W. Y. Ong 2004 Changes in GABA transporters in the rat hippocampus after kainate-induced neuronal injury: decrease in GAT-1 and GAT-3 but upregulation of betaine/GABA transporter BGT-1 J. Neurosci. Res. 77 402 409
47. J. A. Schmid P. Scholze O. Kudlacek M. Freissmuth E. A. Singer H. H. Sitte 2001 Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells J. Biol. Chem. 276 3805 3810
48. P. Scholze M. Freissmuth H. H. Sitte 2002 Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1 J. Biol. Chem. 277 43,682 43,690
49. H. H. Sitte H. Farhan J. A. Javitch 2004 Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking Mol. Intervent. 4 38 47
50. R. Radian A. Bendahan B. I. Kanner 1986 Purification and identification of the functional sodium- and chloride-coupled γ-aminobutyric acid transport glycoprotein from rat brain J. Biol. Chem. 261 15,437 15,441
51. H. S. White W. P. Watson S. L. Hansen S. Slough J. Perregaard A. Sarup T. Bolvig G. Petersen O. M. Larsson R. P. Clausen B. Frolund E. Falch P. Krogsgaard-Larsen A. Schousboe 2005 First demonstration of a functional role for central nervous system betaine/{γ}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2 J. Pharmacol. Exp. Ther. 312 866 874
52. S. L. Deken D. Wang M. W. Quick 2003 Plasma membrane GABA transporters reside on distinct vesicles and undergo rapid regulated recycling J. Neurosci. 23 1563 1568