Correlation between anticonvulsant activity and inhibitory action on glial γ-aminobutyric acid uptake of the highly selective mouse γ-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 636-644

  Steve White, H ^a,b,c   Sarup, Alan ^a,b,c   Bolvig, Tina ^a,b,c   Kristensen, Anders S ^a,b,c   Petersen, Gitte ^a,b,c   Nelson, Nathan ^a,b,c   Pickering, Darryl S ^a,b,c   Larsson, Orla M ^a,b,c   Frølund, Bente ^a,b,c   Krogsgaard Larsen, Povl ^a,b,c   Schousboe, Arne ^a,b,c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 AMINO 4,5,6,7 TETRAHYDRO 1,2 BENZISOXAZOLE; 4 AMINOBUTYRIC ACID; 4,5,6,7 TETRAHYDROISOXAZOLO[4,5 C]PYRIDIN 3 OL; CARRIER PROTEIN; N ETHYL 3 HYDROXY 4 AMINO 4,5,6,7 TETRAHYDRO 1,2 BENZISOXAZOLE; N METHYL 3 HYDROXY 4 AMINO 4,5,6,7 TETRAHYDRO 1,2 BENZISOXAZOLE; O PIVALOYLOXYMETHYL 3 HYDROXY 4 AMINO 4,5,6,7 TETRAHYDRO 1,2 BENZISOXAZOLE; OXAZOLE DERIVATIVE; PRODRUG; PROTEIN GAT1; PROTEIN GAT2; PROTEIN GAT3; PROTEIN GAT4; TIAGABINE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; ASTROCYTE; AUDIOGENIC SEIZURE; BRAIN CELL; CELL CLONE; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; EMBRYO; EMBRYO CELL; FEMALE; GABAERGIC SYSTEM; GLIA CELL; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE;

ALKYLATION; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; ASTROCYTES; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; FEMALE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; ISOXAZOLES; KINETICS; MALE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED STRAINS; NEUROGLIA; NEURONS; ORGANIC ANION TRANSPORTERS; PREFRONTAL CORTEX; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036077331     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.034819     Document Type: Article

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