Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3

ACS Chemical Neuroscience

Volumn 6, Issue 9, 2015, Pages 1591-1599

  Damgaard, Maria ^a   Al Khawaja, Anas ^a   Vogensen, Stine B ^a   Jurik, Andreas ^b   Sijm, Maarten ^a   Lie, Maria E K ^a   Bæk, Mathias I ^a   Rosenthal, Emil ^a   Jensen, Anders A ^a   Ecker, Gerhard F ^b   Frølund, Bente ^a   Wellendorph, Petrine ^a   Clausen, Rasmus P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

GABA uptake; hGAT3 selective; inhibitor; isatin; kinetics; noncompetitive

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID UPTAKE INHIBITOR; 5 (THIOPHEN 2 YL) INDOLINE 2,3 DIONE; BGT1 PROTEIN; GABA TRANSPORTER 1; GABA TRANSPORTER 2; GABA TRANSPORTER 3; GABA TRANSPORTER 3 INHIBITOR; ISATIN DERIVATIVE; SNAP 5114; UNCLASSIFIED DRUG; 1-(2-(TRIS(4-METHOXYPHENYL)METHOXY)ETHYL)-3-PIPERIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID CARRIER; ANISOLE DERIVATIVE; ISATIN; NIPECOTIC ACID DERIVATIVE; SLC6A11 PROTEIN, HUMAN; TRITIUM;

ANIMAL CELL; ARTICLE; DRUG BINDING SITE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; IC50; INHIBITION KINETICS; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETIC TRANSFECTION; GENETICS; HUMAN; KINETICS; METABOLISM; SYNTHESIS;

ANIMALS; ANISOLES; BINDING SITES; CHO CELLS; CRICETULUS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GABA UPTAKE INHIBITORS; GAMMA-AMINOBUTYRIC ACID; HUMANS; ISATIN; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; NIPECOTIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TRITIUM;

EID: 84941930838     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00150     Document Type: Article

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