Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1

Epilepsy Research

Volumn 28, Issue 1, 1997, Pages 51-61

  Dalby, Nils Ole ^a   Thomsen, Christian ^a   Fink Jensen, Anders ^a   Lundbeck, Jane ^a   Søkilde, Birgitte ^a   Man, Chiu Ming ^b   Sørensen, Per Olaf ^a   Meldrum, Brian ^b  

^a NOVO NORDISK A S   (Denmark)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Epilepsy; GABA transporter; GAT 1; GAT 3; Tiagabine

Indexed keywords

1 (3 (9H CARBAZOL 9 YL) 4 (2 METHOXYPHENYL) 4 PIPERIDINOL; 1 [3 (9H CARBAZOL 9 YL)PROPYL] 4 (2 METHOXYPHENYL) 4 PIPERIDINOL; 4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; NIPECOTIC ACID DERIVATIVE; NNC 05 2045; TIAGABINE; TRITIUM; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; AMYGDALOID NUCLEUS; ANIMAL MODEL; ANTICONVULSANT THERAPY; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; EPILEPSY; EXPERIMENTAL MODEL; GABAERGIC TRANSMISSION; INTRAPERITONEAL DRUG ADMINISTRATION; KINDLING; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TONIC CLONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; CARBAZOLES; CARRIER PROTEINS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; MALE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; NEUROTRANSMITTER UPTAKE INHIBITORS; ORGANIC ANION TRANSPORTERS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030849231     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(97)00033-8     Document Type: Article

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