-
1
-
-
0027494760
-
Structure of isocitrate dehydrogenase with isocitrate, nicotinamide adenine dinucleotide phosphate, and calcium at 2.5-a resolution: a pseudo-Michaelis ternary complex
-
Stoddard BL, Dean A, Koshland DE. Structure of isocitrate dehydrogenase with isocitrate, nicotinamide adenine dinucleotide phosphate, and calcium at 2.5-a resolution: a pseudo-Michaelis ternary complex. Biochemistry. 1993;32:9310-6.
-
(1993)
Biochemistry
, vol.32
, pp. 9310-9316
-
-
Stoddard, B.L.1
Dean, A.2
Koshland, D.E.3
-
2
-
-
0022214781
-
Probable assignment of soluble isocitrate dehydrogenase (IDH1) to 2q33.3
-
Narahara K, Kimura S, Kikkawa K, Takahashi Y, Wakita Y, Kasai R, et al. Probable assignment of soluble isocitrate dehydrogenase (IDH1) to 2q33.3. Hum Genet. 1985;71:37-40.
-
(1985)
Hum Genet
, vol.71
, pp. 37-40
-
-
Narahara, K.1
Kimura, S.2
Kikkawa, K.3
Takahashi, Y.4
Wakita, Y.5
Kasai, R.6
-
3
-
-
0032741434
-
The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase
-
Geisbrecht BV, Gould SJ. The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. J Biol Chem. 1999;274:30527-33.
-
(1999)
J Biol Chem
, vol.274
, pp. 30527-30533
-
-
Geisbrecht, B.V.1
Gould, S.J.2
-
4
-
-
52949086786
-
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
-
Hartong DT, Dange M, McGee TL, Berson EL, Dryja TP, Colman RF. Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle. Nat Genet. 2008. doi: 10.1038/ng.223.
-
(2008)
Nat Genet
-
-
Hartong, D.T.1
Dange, M.2
McGee, T.L.3
Berson, E.L.4
Dryja, T.P.5
Colman, R.F.6
-
5
-
-
0345529867
-
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells
-
Shechter I, Dai P, Huo L, Guan G. IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells. J Lipid Res. 2003. doi: 10.1194/jlr.M300285-JLR200.
-
(2003)
J Lipid Res
-
-
Shechter, I.1
Dai, P.2
Huo, L.3
Guan, G.4
-
6
-
-
4043105583
-
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
-
Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, et al. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004;32:33946-57.
-
(2004)
J Biol Chem
, vol.32
, pp. 33946-33957
-
-
Xu, X.1
Zhao, J.2
Xu, Z.3
Peng, B.4
Huang, Q.5
Arnold, E.6
-
7
-
-
0036298412
-
Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase
-
Jo SH, Lee SH, Chun HS, Lee SM, Koh HJ, Lee SE, et al. Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase. Biochem Biophys Res Commun. 2002. doi: 10.1006/bbrc.2002.6667.
-
(2002)
Biochem Biophys Res Commun
-
-
Jo, S.H.1
Lee, S.H.2
Chun, H.S.3
Lee, S.M.4
Koh, H.J.5
Lee, S.E.6
-
8
-
-
0036614971
-
Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells
-
Lee SM, Koh HJ, Park DC, Song BJ, Huh TL, Park JW. Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. Free Radic Biol Med. 2002;32:1185-96.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 1185-1196
-
-
Lee, S.M.1
Koh, H.J.2
Park, D.C.3
Song, B.J.4
Huh, T.L.5
Park, J.W.6
-
9
-
-
7944237790
-
Role of NADP+-dependent isocitrate dehydrogenase (NADP+-ICDH) on cellular defence against oxidative injury by gamma-rays
-
Lee SH, Jo SH, Lee SM, Koh HJ, Song H, Park JW, et al. Role of NADP+-dependent isocitrate dehydrogenase (NADP+-ICDH) on cellular defence against oxidative injury by gamma-rays. Int J Radiat Biol. 2004;80:635-42.
-
(2004)
Int J Radiat Biol
, vol.80
, pp. 635-642
-
-
Lee, S.H.1
Jo, S.H.2
Lee, S.M.3
Koh, H.J.4
Song, H.5
Park, J.W.6
-
10
-
-
2442628211
-
FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes
-
Hausinger RP. FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes. Crit Rev Biochem Mol Biol. 2004. doi: 10.1080/10409230490440541.
-
(2004)
Crit Rev Biochem Mol Biol
-
-
Hausinger, R.P.1
-
11
-
-
4544312373
-
Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism
-
Koh HJ, Lee SM, Son BG, Lee SH, Ryoo ZY, Chang KT, et al. Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism. J Biol Chem. 2004. doi: 10.1074/jbc.M402260200.
-
(2004)
J Biol Chem
-
-
Koh, H.J.1
Lee, S.M.2
Son, B.G.3
Lee, S.H.4
Ryoo, Z.Y.5
Chang, K.T.6
-
12
-
-
84865313576
-
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
-
Filipp FV, Scott DA, Ronai ZA, Osterman AL, Smith JW. Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res. 2012. doi: 10.1111/j.1755-148X.2012.00989.x.
-
(2012)
Pigment Cell Melanoma Res
-
-
Filipp, F.V.1
Scott, D.A.2
Ronai, Z.A.3
Osterman, A.L.4
Smith, J.W.5
-
13
-
-
0019332922
-
Chemical characterization of distinct subunits of pig heart DPN-specific isocitrate dehydrogenase
-
Ramachandran N, Colman RF. Chemical characterization of distinct subunits of pig heart DPN-specific isocitrate dehydrogenase. J Biol Chem. 1980;18:8859-64.
-
(1980)
J Biol Chem
, vol.18
, pp. 8859-8864
-
-
Ramachandran, N.1
Colman, R.F.2
-
14
-
-
0022458227
-
Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria
-
Gabriel JL, Zervos PR, Plaut GW. Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria. Metabolism. 1986;35:661-7.
-
(1986)
Metabolism
, vol.35
, pp. 661-667
-
-
Gabriel, J.L.1
Zervos, P.R.2
Plaut, G.W.3
-
15
-
-
0015221183
-
Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase. Purification and some properties
-
Barnes LD, Kuehn GD, Atkinson DE. Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase. Purification and some properties. Biochemistry. 1971;10:3939-44.
-
(1971)
Biochemistry
, vol.10
, pp. 3939-3944
-
-
Barnes, L.D.1
Kuehn, G.D.2
Atkinson, D.E.3
-
16
-
-
0034700988
-
Bovine NAD+-dependent isocitrate dehydrogenase: alternative splicing and tissue-dependent expression of subunit 1
-
Weiss C, Zeng Y, Huang J, Sobocka MB, Rushbrook JI. Bovine NAD+-dependent isocitrate dehydrogenase: alternative splicing and tissue-dependent expression of subunit 1. Biochemistry. 2000;39:1807-16.
-
(2000)
Biochemistry
, vol.39
, pp. 1807-1816
-
-
Weiss, C.1
Zeng, Y.2
Huang, J.3
Sobocka, M.B.4
Rushbrook, J.I.5
-
17
-
-
0017111386
-
Assignment of a gene for human mitochondrial isocitrate dehydrogenase (ICD-M, EC 1.1.1.41) to chromosome 15
-
Grzeschik KH. Assignment of a gene for human mitochondrial isocitrate dehydrogenase (ICD-M, EC 1.1.1.41) to chromosome 15. Hum Genet. 1976;34:23-8.
-
(1976)
Hum Genet
, vol.34
, pp. 23-28
-
-
Grzeschik, K.H.1
-
18
-
-
0033601292
-
Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform
-
Kim YO, Koh HJ, Kim SH, Jo SH, Huh JW, Jeong KS, et al. Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform. J Biol Chem. 1999;274:36866-75.
-
(1999)
J Biol Chem
, vol.274
, pp. 36866-36875
-
-
Kim, Y.O.1
Koh, H.J.2
Kim, S.H.3
Jo, S.H.4
Huh, J.W.5
Jeong, K.S.6
-
19
-
-
0036960604
-
Glutathione in defense and signaling: lessons from a small thiol
-
Dickinson DA, Forman HJ. Glutathione in defense and signaling: lessons from a small thiol. Ann N Y Acad Sci. 2002;973:488-504.
-
(2002)
Ann N Y Acad Sci
, vol.973
, pp. 488-504
-
-
Dickinson, D.A.1
Forman, H.J.2
-
20
-
-
8744228201
-
Genetic dissection of the phospholipid hydroperoxidase activity of yeast gpx3 reveals its functional importance
-
Avery AM, Willetts SA, Avery SV. Genetic dissection of the phospholipid hydroperoxidase activity of yeast gpx3 reveals its functional importance. J Biol Chem. 2004. doi: 10.1074/jbc.M408340200.
-
(2004)
J Biol Chem
-
-
Avery, A.M.1
Willetts, S.A.2
Avery, S.V.3
-
21
-
-
0000203136
-
The citrate cleavage enzyme. I. Distribution and purification
-
Srere PA. The citrate cleavage enzyme. I. Distribution and purification. J Biol Chem. 1959;10:2544-7.
-
(1959)
J Biol Chem
, vol.10
, pp. 2544-2547
-
-
Srere, P.A.1
-
22
-
-
0027441813
-
The mitochondrial tricarboxylate transport protein. cDNA cloning, primary structure, and comparison with other mitochondrial transport proteins
-
Kaplan RS, Mayor JA, Wood DO. The mitochondrial tricarboxylate transport protein. cDNA cloning, primary structure, and comparison with other mitochondrial transport proteins. J Biol Chem. 1993;18:13682-90.
-
(1993)
J Biol Chem
, vol.18
, pp. 13682-13690
-
-
Kaplan, R.S.1
Mayor, J.A.2
Wood, D.O.3
-
23
-
-
59849124365
-
Citrate transport and metabolism in mammalian cells: prostate epithelial cells and prostate cancer
-
Mycielska ME, Patel A, Rizaner N, Mazurek MP, Keun H, Patel A, et al. Citrate transport and metabolism in mammalian cells: prostate epithelial cells and prostate cancer. Bioessays. 2009. doi: 10.1002/bies.080137.
-
(2009)
Bioessays
-
-
Mycielska, M.E.1
Patel, A.2
Rizaner, N.3
Mazurek, M.P.4
Keun, H.5
Patel, A.6
-
24
-
-
0011108754
-
Studies on the mechanism of fatty acid synthesis. I. Preparation and purification of an enzymes system for reconstruction of fatty acid synthesis
-
Wakil SJ, Porter JW, Gibson DM. Studies on the mechanism of fatty acid synthesis. I. Preparation and purification of an enzymes system for reconstruction of fatty acid synthesis. Biochim Biophys Acta. 1957;24:453-61.
-
(1957)
Biochim Biophys Acta
, vol.24
, pp. 453-461
-
-
Wakil, S.J.1
Porter, J.W.2
Gibson, D.M.3
-
25
-
-
0343062302
-
Biosynthesis of tricarboxylic acids by carbon dioxide fixation; enzymatic mechanisms
-
Ochoa S. Biosynthesis of tricarboxylic acids by carbon dioxide fixation; enzymatic mechanisms. J Biol Chem. 1948;1:133-57.
-
(1948)
J Biol Chem
, vol.1
, pp. 133-157
-
-
Ochoa, S.1
-
26
-
-
0007642430
-
An alternate pathway of alpha-ketoglutarate catabolism in the isolated, perfused rat liver. I. Studies with dl-glutamate-2- and -5-14c
-
D'Adamo AF, Haft DE. An alternate pathway of alpha-ketoglutarate catabolism in the isolated, perfused rat liver. I. Studies with dl-glutamate-2- and -5-14c. J Biol Chem. 1965;2:613-7.
-
(1965)
J Biol Chem
, vol.2
, pp. 613-617
-
-
D'Adamo, A.F.1
Haft, D.E.2
-
27
-
-
78149378853
-
Quiescent fibroblasts exhibit high metabolic activity
-
Lemons JM, Feng XJ, Bennett BD, Legesse-Miller A, Johnson EL, Raitman I, et al. Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol. 2010. doi: 10.1371/journal.pbio.1000514.
-
(2010)
PLoS Biol
-
-
Lemons, J.M.1
Feng, X.J.2
Bennett, B.D.3
Legesse-Miller, A.4
Johnson, E.L.5
Raitman, I.6
-
28
-
-
84863837081
-
Lipid metabolism in cancer
-
Santos CR, Schulze A. Lipid metabolism in cancer. FEBS J. 2012. doi: 10.1111/j.1742-4658.2012.08644.x.
-
(2012)
FEBS J
-
-
Santos, C.R.1
Schulze, A.2
-
29
-
-
34748912615
-
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
-
Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 2007. doi: 10.1038/nrc2222.
-
(2007)
Nat Rev Cancer
-
-
Menendez, J.A.1
Lupu, R.2
-
30
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability
-
Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, et al. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci USA. 2011. doi: 10.1073/pnas.1117773108.
-
(2011)
Proc Natl Acad Sci USA
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.3
Cross, J.R.4
Gruber, J.J.5
Sachdeva, U.M.6
-
31
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2012;7381:385-8.
-
(2012)
Nature
, vol.7381
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
-
32
-
-
37449034854
-
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrl S, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA. 2007. doi: 10.1073/pnas.0709747104.
-
(2007)
Proc Natl Acad Sci USA
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrl, S.6
-
33
-
-
77951233410
-
Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition
-
Fan Y, Dickman KG, Zong WX. Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem. 2010. doi: 10.1074/jbc.M109.035584.
-
(2010)
J Biol Chem
-
-
Fan, Y.1
Dickman, K.G.2
Zong, W.X.3
-
34
-
-
64749116346
-
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009. doi: 10.1038/nature07823.
-
(2009)
Nature
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
-
35
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA. 2008. doi: 10.1073/pnas.0810199105.
-
(2008)
Proc Natl Acad Sci USA
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
-
36
-
-
34347402459
-
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
-
Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol. 2007. doi: 10.1083/jcb.200703099.
-
(2007)
J Cell Biol
-
-
Yuneva, M.1
Zamboni, N.2
Oefner, P.3
Sachidanandam, R.4
Lazebnik, Y.5
-
37
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2012;7381:380-4.
-
(2012)
Nature
, vol.7381
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
-
38
-
-
84855453655
-
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
-
Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012;1:110-21.
-
(2012)
Cell Metab
, vol.1
, pp. 110-121
-
-
Le, A.1
Lane, A.N.2
Hamaker, M.3
Bose, S.4
Gouw, A.5
Barbi, J.6
-
39
-
-
77956497712
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010. doi: 10.1016/j.ccr.2010.08.009.
-
(2010)
Cancer Cell
-
-
Wang, J.B.1
Erickson, J.W.2
Fuji, R.3
Ramachandran, S.4
Gao, P.5
Dinavahi, R.6
-
40
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009. doi: 10.1038/nature08617.
-
(2009)
Nature
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
-
41
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008. doi: 10.1126/science.1164382.
-
(2008)
Science
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
42
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009. doi: 10.1056/NEJMoa0808710.
-
(2009)
N Engl J Med
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
-
43
-
-
67449099808
-
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
-
Kang MR, Kim MS, Oh JE, Kim YR, Song SY, Seo SI, et al. Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers. Int J Cancer. 2009. doi: 10.1002/ijc.24379.
-
(2009)
Int J Cancer
-
-
Kang, M.R.1
Kim, M.S.2
Oh, J.E.3
Kim, Y.R.4
Song, S.Y.5
Seo, S.I.6
-
44
-
-
79956372800
-
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma
-
Krell D, Assoku M, Galloway M, Mulholland P, Tomlinson I, Bardella C, et al. Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma. PLoS ONE. 2011. doi: 10.1371/journal.pone.0019868.
-
(2011)
PLoS ONE
-
-
Krell, D.1
Assoku, M.2
Galloway, M.3
Mulholland, P.4
Tomlinson, I.5
Bardella, C.6
-
45
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
-
Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell. 2005. doi: 10.1016/j.ccr.2004.11.022.
-
(2005)
Cancer Cell
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
-
46
-
-
0033983147
-
Progress in understanding structure-function relationships in respiratory chain complex II
-
Ackrell BA. Progress in understanding structure-function relationships in respiratory chain complex II. FEBS Lett. 2000;466:1-5.
-
(2000)
FEBS Lett
, vol.466
, pp. 1-5
-
-
Ackrell, B.A.1
-
47
-
-
0034602950
-
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
-
Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science. 2000;287:848-51.
-
(2000)
Science
, vol.287
, pp. 848-851
-
-
Baysal, B.E.1
Ferrell, R.E.2
Willett-Brozick, J.E.3
Lawrence, E.C.4
Myssiorek, D.5
Bosch, A.6
-
48
-
-
0035213138
-
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
-
Gimenez-Roqueplo AP, Favier J, Rustin P, Mourad JJ, Plouin PF, Corvol P, et al. The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am J Hum Genet. 2001. doi: 10.1086/324413.
-
(2001)
Am J Hum Genet
-
-
Gimenez-Roqueplo, A.P.1
Favier, J.2
Rustin, P.3
Mourad, J.J.4
Plouin, P.F.5
Corvol, P.6
-
49
-
-
0242391866
-
SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology
-
Douwes Dekker PB, Hogendoorn PC, Kuipers-Dijkshoorn N, Prins FA, van Duinen SG, Taschner PE, et al. SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology. J Pathol. 2003. doi: 10.1002/path.1461.
-
(2003)
J Pathol
-
-
Douwes Dekker, P.B.1
Hogendoorn, P.C.2
Kuipers-Dijkshoorn, N.3
Prins, F.A.4
Duinen, S.G.5
Taschner, P.E.6
-
50
-
-
37849022071
-
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
-
Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT. Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol. 2008. doi: 10.1128/MCB.01338-07.
-
(2008)
Mol Cell Biol
-
-
Guzy, R.D.1
Sharma, B.2
Bell, E.3
Chandel, N.S.4
Schumacker, P.T.5
-
51
-
-
84880514208
-
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling
-
Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, et al. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Mol Cell. 2013. doi: 10.1016/j.molcel.2013.05.003.
-
(2013)
Mol Cell
-
-
Sullivan, L.B.1
Martinez-Garcia, E.2
Nguyen, H.3
Mullen, A.R.4
Dufour, E.5
Sudarshan, S.6
-
52
-
-
84908213474
-
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
-
Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nat Rev Cancer. 2014. doi: 10.1038/nrc3803.
-
(2014)
Nat Rev Cancer
-
-
Sabharwal, S.S.1
Schumacker, P.T.2
-
53
-
-
18544365990
-
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002. doi: 10.1038/ng849.
-
(2002)
Nat Genet
-
-
Tomlinson, I.P.1
Alam, N.A.2
Rowan, A.J.3
Barclay, E.4
Jaeger, E.E.5
Kelsell, D.6
-
54
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations
-
Pollard PJ, Briere JJ, Alam NA, Barwell J, Barclay E, Wortham NC, et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations. Hum Mol Genet. 2005. doi: 10.1093/hmg/ddi227.
-
(2005)
Hum Mol Genet
-
-
Pollard, P.J.1
Briere, J.J.2
Alam, N.A.3
Barwell, J.4
Barclay, E.5
Wortham, N.C.6
-
55
-
-
67651204610
-
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
-
Sudarshan S, Sourbier C, Kong HS, Block K, Romero VAV, Yang Y, et al. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol. 2009. doi: 10.1128/MCB.00483-09.
-
(2009)
Mol Cell Biol
-
-
Sudarshan, S.1
Sourbier, C.2
Kong, H.S.3
Block, K.4
Romero, V.A.V.5
Yang, Y.6
-
56
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009. doi: 10.1126/science.1170944.
-
(2009)
Science
-
-
Zhao, S.1
Lin, Y.2
Xu, W.3
Jiang, W.4
Zha, Z.5
Wang, P.6
-
57
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 2012. doi: 10.1038/nature10898.
-
(2012)
Nature
-
-
Koivunen, P.1
Lee, S.2
Duncan, C.G.3
Lopez, G.4
Lu, G.5
Ramkissoon, S.6
-
58
-
-
84875496294
-
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
-
Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013. doi: 10.1126/science.1231677.
-
(2013)
Science
-
-
Losman, J.A.1
Looper, R.E.2
Koivunen, P.3
Lee, S.4
Schneider, R.K.5
McMahon, C.6
-
59
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010. doi: 10.1016/j.ccr.2010.11.015.
-
(2010)
Cancer Cell
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
60
-
-
84860378609
-
Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation
-
Leonardi R, Subramanian C, Jackowski S, Rock CO. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. J Biol Chem. 2012. doi: 10.1074/jbc.C112.353946.
-
(2012)
J Biol Chem
-
-
Leonardi, R.1
Subramanian, C.2
Jackowski, S.3
Rock, C.O.4
-
62
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med. 2010. doi: 10.1084/jem.20092506.
-
(2010)
J Exp Med
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
Driggers, E.M.4
Bittinger, M.A.5
Jang, H.G.6
-
63
-
-
80054035931
-
IDH1 and IDH2 mutations in pediatric acute leukemia
-
Andersson AK, Miller DW, Lynch JA, Lemoff AS, Cai Z, Pounds SB, et al. IDH1 and IDH2 mutations in pediatric acute leukemia. Leukemia. 2011. doi: 10.1038/leu.2011.133.
-
(2011)
Leukemia
-
-
Andersson, A.K.1
Miller, D.W.2
Lynch, J.A.3
Lemoff, A.S.4
Cai, Z.5
Pounds, S.B.6
-
64
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010. doi: 10.1016/j.ccr.2010.01.020.
-
(2010)
Cancer Cell
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
-
65
-
-
84883529430
-
Isocitrate dehydrogenase mutations in leukemia
-
McKenney AS, Levine RL. Isocitrate dehydrogenase mutations in leukemia. J Clin Investig. 2013. doi: 10.1172/JCI67266.
-
(2013)
J Clin Investig
-
-
McKenney, A.S.1
Levine, R.L.2
-
66
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012. doi: 10.1038/nature10860.
-
(2012)
Nature
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
Rohle, D.4
Turcan, S.5
Abdel-Wahab, O.6
-
67
-
-
84867355390
-
Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo
-
Popovici-Muller J, Saunders JO, Salituro FG, Travins JM, Yan S, Zhao F, et al. Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo. ACS Med Chem Lett. 2012. doi: 10.1021/ml300225h.
-
(2012)
ACS Med Chem Lett
-
-
Popovici-Muller, J.1
Saunders, J.O.2
Salituro, F.G.3
Travins, J.M.4
Yan, S.5
Zhao, F.6
-
68
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013. doi: 10.1126/science.1234769.
-
(2013)
Science
-
-
Wang, F.1
Travins, J.2
DeLaBarre, B.3
Penard-Lacronique, V.4
Schalm, S.5
Hansen, E.6
-
69
-
-
66749152204
-
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids
-
Iyer LM, Tahiliani M, Rao A, Aravind L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle. 2009;8:1698-710.
-
(2009)
Cell Cycle
, vol.8
, pp. 1698-1710
-
-
Iyer, L.M.1
Tahiliani, M.2
Rao, A.3
Aravind, L.4
-
70
-
-
39349105090
-
Expanding chemical biology of 2-oxoglutarate oxygenases
-
Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol. 2008. doi: 10.1038/nchembio0308-152.
-
(2008)
Nat Chem Biol
-
-
Loenarz, C.1
Schofield, C.J.2
-
71
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 2011. doi: 10.1038/embor.2011.43.
-
(2011)
EMBO Rep
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
Hillringhaus, L.4
Bagg, E.A.5
Rose, N.R.6
-
72
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009. doi: 10.1126/science.1170116.
-
(2009)
Science
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
-
73
-
-
79955538247
-
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
-
Guo JU, Su Y, Zhong C, Ming GL, Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011. doi: 10.1016/j.cell.2011.03.022.
-
(2011)
Cell
-
-
Guo, J.U.1
Su, Y.2
Zhong, C.3
Ming, G.L.4
Song, H.5
-
74
-
-
79956302047
-
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
-
Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PA, Rappsilber J, et al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011. doi: 10.1038/nature10066.
-
(2011)
Nature
-
-
Williams, K.1
Christensen, J.2
Pedersen, M.T.3
Johansen, J.V.4
Cloos, P.A.5
Rappsilber, J.6
-
75
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010. doi: 10.1016/j.ccr.2010.03.017.
-
(2010)
Cancer Cell
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
Phillips, H.S.4
Pujara, K.5
Berman, B.P.6
-
76
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012. doi: 10.1038/nature10866.
-
(2012)
Nature
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
Walsh, L.A.4
Fang, F.5
Yilmaz, E.6
-
77
-
-
84885049499
-
The CpG island methylator phenotype: what's in a name?
-
Hughes LA, Melotte V, de Schrijver J, de Maat M, Smit VT, Bovee JV, et al. The CpG island methylator phenotype: what's in a name? Cancer Res. 2013. doi: 10.1158/0008-5472.CAN-12-4306.
-
(2013)
Cancer Res
-
-
Hughes, L.A.1
Melotte, V.2
Schrijver, J.3
Maat, M.4
Smit, V.T.5
Bovee, J.V.6
-
78
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011. doi: 10.1016/j.ccr.2010.12.014.
-
(2011)
Cancer Cell
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
-
79
-
-
84923350269
-
Human phosphoglycerate dehydrogenase produces the oncometabolite d-2-hydroxyglutarate
-
Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD, et al. Human phosphoglycerate dehydrogenase produces the oncometabolite d-2-hydroxyglutarate. ACS Chem Biol. 2015. doi: 10.1021/cb500683c.
-
(2015)
ACS Chem Biol
-
-
Fan, J.1
Teng, X.2
Liu, L.3
Mattaini, K.R.4
Looper, R.E.5
Vander Heiden, M.G.6
Rabinowitz, J.D.7
-
80
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011. doi: 10.1038/ng.890.
-
(2011)
Nat Genet
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lyssiotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
-
82
-
-
77955079630
-
An overview of l-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype study
-
Steenweg ME, Jakobs C, Errami A, van Dooren SJ, Adeva Bartolome MT, Aerssens P, et al. An overview of l-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype study. Hum Mutat. 2010. doi: 10.1002/humu.21197.
-
(2010)
Hum Mutat
-
-
Steenweg, M.E.1
Jakobs, C.2
Errami, A.3
Dooren, S.J.4
Adeva Bartolome, M.T.5
Aerssens, P.6
-
83
-
-
31644447813
-
Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to d-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
-
Struys EA, Verhoeven NM, Ten Brink HJ, Wickenhagen WV, Gibson KM, Jakobs C, et al. Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to d-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. J Inherit Metab Dis. 2005. doi: 10.1007/s10545-005-0114-x.
-
(2005)
J Inherit Metab Dis
-
-
Struys, E.A.1
Verhoeven, N.M.2
Brink, H.J.3
Wickenhagen, W.V.4
Gibson, K.M.5
Jakobs, C.6
-
85
-
-
84862776826
-
2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
-
Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, et al. 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med. 2012. doi: 10.1038/nm.2682.
-
(2012)
Nat Med
-
-
Choi, C.1
Ganji, S.K.2
DeBerardinis, R.J.3
Hatanpaa, K.J.4
Rakheja, D.5
Kovacs, Z.6
-
86
-
-
84876889621
-
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
-
Losman JA, Kaelin WG. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev. 2013. doi: 10.1101/gad.217406.113.
-
(2013)
Genes Dev
-
-
Losman, J.A.1
Kaelin, W.G.2
-
87
-
-
57349166553
-
Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review
-
Aghili M, Zahedi F, Rafiee E. Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review. J Neurooncol. 2009. doi: 10.1007/s11060-008-9706-2.
-
(2009)
J Neurooncol
-
-
Aghili, M.1
Zahedi, F.2
Rafiee, E.3
-
88
-
-
0030994414
-
l-2-Hydroxyglutaric aciduria: clinical, biochemical and magnetic resonance imaging in six Portuguese pediatric patients
-
Barbot C, Fineza I, Diogo L, Maia M, Melo J, Guimaraes A, et al. l-2-Hydroxyglutaric aciduria: clinical, biochemical and magnetic resonance imaging in six Portuguese pediatric patients. Brain Dev. 1997;19:268-73.
-
(1997)
Brain Dev
, vol.19
, pp. 268-273
-
-
Barbot, C.1
Fineza, I.2
Diogo, L.3
Maia, M.4
Melo, J.5
Guimaraes, A.6
-
89
-
-
50649109180
-
l-2-Hydroxyglutaric aciduria and brain tumors in children with mutations in the L2HGDH gene: neuroimaging findings
-
Haliloglu G, Jobard F, Oguz KK, Anlar B, Akalan N, Coskun T, et al. l-2-Hydroxyglutaric aciduria and brain tumors in children with mutations in the L2HGDH gene: neuroimaging findings. Neuropediatrics. 2008. doi: 10.1055/s-2008-1081217.
-
(2008)
Neuropediatrics
-
-
Haliloglu, G.1
Jobard, F.2
Oguz, K.K.3
Anlar, B.4
Akalan, N.5
Coskun, T.6
-
90
-
-
2442692808
-
l-2-Hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition?
-
Moroni I, Bugiani M, D'Incerti L, Maccagnano C, Rimoldi M, Bissola L, et al. l-2-Hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition? Neurology. 2004;62:1882-4.
-
(2004)
Neurology
, vol.62
, pp. 1882-1884
-
-
Moroni, I.1
Bugiani, M.2
D'Incerti, L.3
Maccagnano, C.4
Rimoldi, M.5
Bissola, L.6
-
91
-
-
0036058194
-
Medulloblastoma in a child with the metabolic disease l-2-hydroxyglutaric aciduria
-
Ozisik PA, Akalan N, Palaoglu S, Topcu M. Medulloblastoma in a child with the metabolic disease l-2-hydroxyglutaric aciduria. Pediatr Neurosurg. 2002;1:22-6.
-
(2002)
Pediatr Neurosurg
, vol.1
, pp. 22-26
-
-
Ozisik, P.A.1
Akalan, N.2
Palaoglu, S.3
Topcu, M.4
-
92
-
-
84908402760
-
l-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer
-
Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, et al. l-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014. doi: 10.1158/2159-8290.CD-13-0696.
-
(2014)
Cancer Discov
-
-
Shim, E.H.1
Livi, C.B.2
Rakheja, D.3
Tan, J.4
Benson, D.5
Parekh, V.6
-
93
-
-
84876015310
-
Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma
-
Kroger N, Klatte T, Chamie K, Rao PN, Birkhauser FD, Sinn GA, et al. Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma. Cancer. 2013. doi: 10.1002/cncr.27947.
-
(2013)
Cancer
-
-
Kroger, N.1
Klatte, T.2
Chamie, K.3
Rao, P.N.4
Birkhauser, F.D.5
Sinn, G.A.6
-
94
-
-
80455174760
-
Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis
-
Monzon FA, Alvarez K, Peterson L, Truong L, Amato RJ, Hernandez-McClain J, et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol. 2011;11:1470-9.
-
(2011)
Mod Pathol
, vol.11
, pp. 1470-1479
-
-
Monzon, F.A.1
Alvarez, K.2
Peterson, L.3
Truong, L.4
Amato, R.J.5
Hernandez-McClain, J.6
-
95
-
-
84958526383
-
Another small molecule in the oncometabolite mix: l-2-hydroxyglutarate in kidney cancer
-
Shim EH, Sudarshan S. Another small molecule in the oncometabolite mix: l-2-hydroxyglutarate in kidney cancer. Oncoscience. 2015;2:483-6.
-
(2015)
Oncoscience
, vol.2
, pp. 483-486
-
-
Shim, E.H.1
Sudarshan, S.2
-
97
-
-
77956265489
-
IDH mutations in glioma and acute myeloid leukemia
-
Dang L, Jin S, Su SM. IDH mutations in glioma and acute myeloid leukemia. Trends Mol Med. 2010. doi: 10.1016/j.molmed.2010.07.002.
-
(2010)
Trends Mol Med
-
-
Dang, L.1
Jin, S.2
Su, S.M.3
-
98
-
-
58349111311
-
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors
-
Bleeker FE, Lamba S, Leenstra S, Troost D, Hulsebos T, Vandertop WP, et al. IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum Mutat. 2009;1:7-11.
-
(2009)
Hum Mutat
, vol.1
, pp. 7-11
-
-
Bleeker, F.E.1
Lamba, S.2
Leenstra, S.3
Troost, D.4
Hulsebos, T.5
Vandertop, W.P.6
-
99
-
-
0034050890
-
Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase
-
Soundar S, Dane BL, Colman RF. Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase. J Biol Chem. 2000;275:5606-12.
-
(2000)
J Biol Chem
, vol.275
, pp. 5606-5612
-
-
Soundar, S.1
Dane, B.L.2
Colman, R.F.3
-
100
-
-
77954697566
-
Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism
-
Reitman ZJ, Yan H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst. 2010;13:932-41.
-
(2010)
J Natl Cancer Inst
, vol.13
, pp. 932-941
-
-
Reitman, Z.J.1
Yan, H.2
-
101
-
-
84867420094
-
Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
-
Kaolin WG. Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol. 2011. doi: 10.1101/sqb.2011.76.010975.
-
(2011)
Cold Spring Harb Symp Quant Biol
-
-
Kaolin, W.G.1
-
102
-
-
69949114447
-
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
-
Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A, et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 2009. doi: 10.1007/s00401-009-0561-9.
-
(2009)
Acta Neuropathol
-
-
Hartmann, C.1
Meyer, J.2
Balss, J.3
Capper, D.4
Mueller, W.5
Christians, A.6
-
103
-
-
70349594347
-
Analysis of IDH1 and IDH2 mutations in Japanese glioma patients
-
Sonoda Y, Kumabe T, Nakamura T, Saito R, Kanamori M, Yamashita Y, et al. Analysis of IDH1 and IDH2 mutations in Japanese glioma patients. Cancer Sci. 2009;10:1996-8.
-
(2009)
Cancer Sci
, vol.10
, pp. 1996-1998
-
-
Sonoda, Y.1
Kumabe, T.2
Nakamura, T.3
Saito, R.4
Kanamori, M.5
Yamashita, Y.6
-
104
-
-
77955907891
-
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
-
Paschka P, Schenk RF, Gaidzik VI, Habdank M, Kronke J, Bullinger L, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol. 2010. doi: 10.1200/JCO.2010.28.3762.
-
(2010)
J Clin Oncol
-
-
Paschka, P.1
Schenk, R.F.2
Gaidzik, V.I.3
Habdank, M.4
Kronke, J.5
Bullinger, L.6
-
105
-
-
56749156414
-
Analysis of the IDH1 codon 132 mutation in brain tumors
-
Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A, et al. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 2008. doi: 10.1007/s00401-008-0455-2.
-
(2008)
Acta Neuropathol
-
-
Balss, J.1
Meyer, J.2
Mueller, W.3
Korshunov, A.4
Hartmann, C.5
Deimling, A.6
-
106
-
-
77953019788
-
The prognostic IDH1(R132) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma
-
Bleaker FE, Atari NA, Lamba S, Junker A, Rijkeboer D, Bosch KS, et al. The prognostic IDH1(R132) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma. Acta Neuropathol. 2010. doi: 10.1007/s00401-010-0645-6.
-
(2010)
Acta Neuropathol
-
-
Bleaker, F.E.1
Atari, N.A.2
Lamba, S.3
Junker, A.4
Rijkeboer, D.5
Bosch, K.S.6
-
107
-
-
77952426827
-
Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
-
Kosmider O, Gelsi-Boyer V, Slama L, Dreyfus F, Beyne-Rauzy O, Quesnel B, et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia. 2010. doi: 10.1038/leu.2010.52.
-
(2010)
Leukemia
-
-
Kosmider, O.1
Gelsi-Boyer, V.2
Slama, L.3
Dreyfus, F.4
Beyne-Rauzy, O.5
Quesnel, B.6
-
108
-
-
77954573304
-
IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
-
Pardanani A, Lasho TL, Finke CM, Mai M, McClure RF, Tefferi A, et al. IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms. Leukemia. 2010;6:1146-51.
-
(2010)
Leukemia
, vol.6
, pp. 1146-1151
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.M.3
Mai, M.4
McClure, R.F.5
Tefferi, A.6
-
109
-
-
77954658823
-
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
-
Tefferi A, Lasho TL, Abdel-Wahab O, Guglielmelli P, Patel J, Caramazza D, et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia. 2010. doi: 10.1038/leu.2010.113.
-
(2010)
Leukemia
-
-
Tefferi, A.1
Lasho, T.L.2
Abdel-Wahab, O.3
Guglielmelli, P.4
Patel, J.5
Caramazza, D.6
-
110
-
-
84856725273
-
Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients
-
Patnaik MM, Hanson CA, Hodnefield JM, Lasho TL, Finke CM, Knudson RA, et al. Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients. Leukemia. 2012. doi: 10.1038/leu.2011.298.
-
(2012)
Leukemia
-
-
Patnaik, M.M.1
Hanson, C.A.2
Hodnefield, J.M.3
Lasho, T.L.4
Finke, C.M.5
Knudson, R.A.6
-
112
-
-
84868342138
-
Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis
-
Zhou KG, Jiang LJ, Shang Z, Wang J, Huang L, Zhou JF, et al. Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis. Leuk Lymphoma. 2012. doi: 10.3109/10428194.2012.695359.
-
(2012)
Leuk Lymphoma
-
-
Zhou, K.G.1
Jiang, L.J.2
Shang, Z.3
Wang, J.4
Huang, L.5
Zhou, J.F.6
-
113
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009. doi: 10.1056/NEJMoa0903840.
-
(2009)
N Engl J Med
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
Larson, D.E.4
McLellan, M.D.5
Chen, K.6
-
114
-
-
77957192661
-
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
-
Abbas S, Lugthart S, Kavelaars FG, Schelen A, Koenders JE, Zeilemaker A, et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood. 2010. doi: 10.1182/blood-2009-11-250878.
-
(2010)
Blood
-
-
Abbas, S.1
Lugthart, S.2
Kavelaars, F.G.3
Schelen, A.4
Koenders, J.E.5
Zeilemaker, A.6
-
115
-
-
84857575341
-
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
-
Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, et al. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood. 2012. doi: 10.1182/blood-2011-11-391748.
-
(2012)
Blood
-
-
Cairns, R.A.1
Iqbal, J.2
Lemonnier, F.3
Kucuk, C.4
Leval, L.5
Jais, J.P.6
-
116
-
-
84865683059
-
Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia
-
Zhang Y, Wei H, Tang K, Lin D, Zhang C, Mi Y, et al. Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia. Genet Test Mol Biomark. 2012. doi: 10.1089/gtmb.2011.0323.
-
(2012)
Genet Test Mol Biomark
-
-
Zhang, Y.1
Wei, H.2
Tang, K.3
Lin, D.4
Zhang, C.5
Mi, Y.6
-
117
-
-
79958226901
-
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
-
Amary MF, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011. doi: 10.1002/path.2913.
-
(2011)
J Pathol
-
-
Amary, M.F.1
Bacsi, K.2
Maggiani, F.3
Damato, S.4
Halai, D.5
Berisha, F.6
-
118
-
-
84876434644
-
Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma
-
Arai M, Nobusawa S, Ikota H, Takemura S, Nakazato Y, Nobusawa S, et al. Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma. Brain Tumor Pathol. 2012. doi: 10.1007/s10014-012-0085-1.
-
(2012)
Brain Tumor Pathol
-
-
Arai, M.1
Nobusawa, S.2
Ikota, H.3
Takemura, S.4
Nakazato, Y.5
Nobusawa, S.6
-
119
-
-
84864755321
-
Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcoma
-
Meijer D, de Jong D, Pansuriya TC, van den Akker BE, Picci P, Szuhai K, et al. Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcoma. Genes Chromosomes Cancer. 2012. doi: 10.1002/gcc.21974.
-
(2012)
Genes Chromosomes Cancer
-
-
Meijer, D.1
Jong, D.2
Pansuriya, T.C.3
Akker, B.E.4
Picci, P.5
Szuhai, K.6
-
121
-
-
82255183048
-
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
-
Pansuriya TC, van Eijk R, d'Adamo P, van Ruler MA, Kuijjer ML, Oosting J, et al. Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nat Genet. 2011. doi: 10.1038/ng.1004.
-
(2011)
Nat Genet
-
-
Pansuriya, T.C.1
Eijk, R.2
d'Adamo, P.3
Ruler, M.A.4
Kuijjer, M.L.5
Oosting, J.6
-
122
-
-
82255183051
-
Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2
-
Amary MF, Damato S, Halai D, Eskandarpour M, Berisha F, Bonar F, et al. Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2. Nat Genet. 2011. doi: 10.1038/ng.994.
-
(2011)
Nat Genet
-
-
Amary, M.F.1
Damato, S.2
Halai, D.3
Eskandarpour, M.4
Berisha, F.5
Bonar, F.6
-
123
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, et al. The consensus coding sequences of human breast and colorectal cancers. Science. 2006. doi: 10.1126/science.1133427.
-
(2006)
Science
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
-
124
-
-
77749246329
-
Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas
-
Gaal J, Burnichon N, Korpershoek E, Roncelin I, Bertherat J, Plouin PF, et al. Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas. J Clin Endocrinol Metab. 2010. doi: 10.1210/jc.2009-2170.
-
(2010)
J Clin Endocrinol Metab
-
-
Gaal, J.1
Burnichon, N.2
Korpershoek, E.3
Roncelin, I.4
Bertherat, J.5
Plouin, P.F.6
-
125
-
-
82355191818
-
Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
-
Sequist LV, Heist RS, Shaw AT, Fidias P, Rosovsky R, Temel JS, et al. Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol. 2011. doi: 10.1093/annonc/mdr489.
-
(2011)
Ann Oncol
-
-
Sequist, L.V.1
Heist, R.S.2
Shaw, A.T.3
Fidias, P.4
Rosovsky, R.5
Temel, J.S.6
-
126
-
-
84856298658
-
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
-
Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist. 2012. doi: 10.1634/theoncologist.2011-0386.
-
(2012)
Oncologist
-
-
Borger, D.R.1
Tanabe, K.K.2
Fan, K.C.3
Lopez, H.U.4
Fantin, V.R.5
Straley, K.S.6
-
127
-
-
0028167909
-
Release of alpha-ketoglutarate, malate and succinate from cultured astrocytes: possible role in amino acid neurotransmitter homeostasis
-
Westergaard N, Sonnewald U, Schousboe A. Release of alpha-ketoglutarate, malate and succinate from cultured astrocytes: possible role in amino acid neurotransmitter homeostasis. Neurosci Lett. 1994;176:105-9.
-
(1994)
Neurosci Lett
, vol.176
, pp. 105-109
-
-
Westergaard, N.1
Sonnewald, U.2
Schousboe, A.3
-
128
-
-
71549122009
-
Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors
-
Capper D, Weissert S, Balss J, Habel A, Meyer J, Jager D, et al. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol. 2010. doi: 10.1111/j.1750-3639.2009.00352.x.
-
(2010)
Brain Pathol
-
-
Capper, D.1
Weissert, S.2
Balss, J.3
Habel, A.4
Meyer, J.5
Jager, D.6
-
129
-
-
0028302955
-
Isocitric and citric acid in human prostatic and seminal fluid: implications for prostatic metabolism and secretion
-
Kavanagh JP. Isocitric and citric acid in human prostatic and seminal fluid: implications for prostatic metabolism and secretion. Prostate. 1994;24:139-42.
-
(1994)
Prostate
, vol.24
, pp. 139-142
-
-
Kavanagh, J.P.1
-
130
-
-
33748671166
-
Update on the biology of the chondrocyte and new approaches to treating cartilage diseases
-
Goldring MB. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol. 2006. doi: 10.1016/j.berh.2006.06.003.
-
(2006)
Best Pract Res Clin Rheumatol
-
-
Goldring, M.B.1
-
131
-
-
84901025674
-
Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism
-
Salazar J, Bello L, Chavez M, Anez R, Rojas J, Bermudez V, et al. Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism. Arthritis. 2014. doi: 10.1155/2014/432463.
-
(2014)
Arthritis
-
-
Salazar, J.1
Bello, L.2
Chavez, M.3
Anez, R.4
Rojas, J.5
Bermudez, V.6
-
132
-
-
27144483873
-
Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes
-
Mobasheri A, Richardson S, Mobasheri R, Shakibaei M, Hoyland JA. Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes. Histol Histopathol. 2005;4:1327-38.
-
(2005)
Histol Histopathol
, vol.4
, pp. 1327-1338
-
-
Mobasheri, A.1
Richardson, S.2
Mobasheri, R.3
Shakibaei, M.4
Hoyland, J.A.5
-
133
-
-
65349150503
-
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
-
Watanabe T, Nobusawa S, Kleihues P, Ohgaki H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol. 2009. doi: 10.2353/ajpath.2009.080958.
-
(2009)
Am J Pathol
-
-
Watanabe, T.1
Nobusawa, S.2
Kleihues, P.3
Ohgaki, H.4
-
134
-
-
84864192438
-
Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event
-
Lass U, Numann A, von Eckardstein K, Kiwit J, Stockhammer F, Horaczek JA, et al. Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event. PLoS ONE. 2012. doi: 10.1371/journal.pone.0041298.
-
(2012)
PLoS ONE
-
-
Lass, U.1
Numann, A.2
Eckardstein, K.3
Kiwit, J.4
Stockhammer, F.5
Horaczek, J.A.6
-
135
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013. doi: 10.1126/science.1236062.
-
(2013)
Science
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
Turcan, S.4
Grommes, C.5
Campos, C.6
-
136
-
-
0014218895
-
l-Asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia
-
Hill JM, Roberts J, Loeb E, Khan A, MacLellan A, Hill RW. l-Asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia. JAMA. 1967;202:882-8.
-
(1967)
JAMA
, vol.202
, pp. 882-888
-
-
Hill, J.M.1
Roberts, J.2
Loeb, E.3
Khan, A.4
MacLellan, A.5
Hill, R.W.6
-
137
-
-
0037085747
-
A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study
-
Avramis VI, Sencer S, Periclou AP, Sather H, Bostrom BC, Cohen LJ, et al. A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study. Blood. 2002;99:1986-94.
-
(2002)
Blood
, vol.99
, pp. 1986-1994
-
-
Avramis, V.I.1
Sencer, S.2
Periclou, A.P.3
Sather, H.4
Bostrom, B.C.5
Cohen, L.J.6
-
138
-
-
84893852306
-
Metabolic changes in cancer cells upon suppression of MYC
-
Anso E, Mullen AR, Felsher DW, Mates JM, Deberardinis RJ, Chandel NS, et al. Metabolic changes in cancer cells upon suppression of MYC. Cancer Metab. 2013;1:7.
-
(2013)
Cancer Metab
, vol.1
, pp. 7
-
-
Anso, E.1
Mullen, A.R.2
Felsher, D.W.3
Mates, J.M.4
Deberardinis, R.J.5
Chandel, N.S.6
-
139
-
-
84869027086
-
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation
-
Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, et al. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell. 2012. doi: 10.1016/j.ccr.2012.09.021.
-
(2012)
Cancer Cell
-
-
Qing, G.1
Li, B.2
Vu, A.3
Skuli, N.4
Walton, Z.E.5
Liu, X.6
-
140
-
-
59449083179
-
Targeting aspartate aminotransferase in breast cancer
-
Thornburg JM, Nelson KK, Clem BF, Lane AN, Arumugam S, Simmons A, et al. Targeting aspartate aminotransferase in breast cancer. Breast Cancer Res. 2008. doi: 10.1186/bcr2154.
-
(2008)
Breast Cancer Res
-
-
Thornburg, J.M.1
Nelson, K.K.2
Clem, B.F.3
Lane, A.N.4
Arumugam, S.5
Simmons, A.6
-
141
-
-
0022338261
-
Amino-oxyacetic acid as a palliative in tinnitus
-
Reed HT, Meltzer J, Crews P, Norris CH, Quine DB, Guth PS, et al. Amino-oxyacetic acid as a palliative in tinnitus. Arch Otolaryngo. 1985;111:803-5.
-
(1985)
Arch Otolaryngo
, vol.111
, pp. 803-805
-
-
Reed, H.T.1
Meltzer, J.2
Crews, P.3
Norris, C.H.4
Quine, D.B.5
Guth, P.S.6
-
142
-
-
0025134188
-
Evaluation of amino-oxyacetic acid as a palliative in tinnitus
-
Guth PS, Risey J, Briner W, Blair P, Reed HT, Bryant G, et al. Evaluation of amino-oxyacetic acid as a palliative in tinnitus. Ann Otol Rhinol Laryngol. 1990;1:74-9.
-
(1990)
Ann Otol Rhinol Laryngol
, vol.1
, pp. 74-79
-
-
Guth, P.S.1
Risey, J.2
Briner, W.3
Blair, P.4
Reed, H.T.5
Bryant, G.6
-
143
-
-
0018976229
-
Failure of aminooxyacetic acid therapy in Huntington disease
-
Perry TL, Wright JM, Hansen S, Allan BM, Baird PA, MacLeod PM, et al. Failure of aminooxyacetic acid therapy in Huntington disease. Neurology. 1980;30:772-5.
-
(1980)
Neurology
, vol.30
, pp. 772-775
-
-
Perry, T.L.1
Wright, J.M.2
Hansen, S.3
Allan, B.M.4
Baird, P.A.5
MacLeod, P.M.6
-
144
-
-
84899089555
-
Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations
-
Emadi A, Jun SA, Tsukamoto T, Fathi AT, Minden MD, Dang CV, et al. Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations. Exp Hematol. 2014. doi: 10.1016/j.exphem.2013.12.001.
-
(2014)
Exp Hematol
-
-
Emadi, A.1
Jun, S.A.2
Tsukamoto, T.3
Fathi, A.T.4
Minden, M.D.5
Dang, C.V.6
-
145
-
-
78549283855
-
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
-
Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010. doi: 10.1158/0008-5472.CAN-10-1666.
-
(2010)
Cancer Res
-
-
Seltzer, M.J.1
Bennett, B.D.2
Joshi, A.D.3
Gao, P.4
Thomas, A.G.5
Ferraris, D.V.6
-
146
-
-
84888002594
-
Liver as a target for oligonucleotide therapeutics
-
Sehgal A, Vaishnaw A, Fitzgerald K. Liver as a target for oligonucleotide therapeutics. J Hepatol. 2013. doi: 10.1016/j.jhep.2013.05.045.
-
(2013)
J Hepatol
-
-
Sehgal, A.1
Vaishnaw, A.2
Fitzgerald, K.3
-
148
-
-
84956792514
-
Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion
-
Tateishi K, Wakimoto H, Iafrate AJ, Tanaka S, Loebel F, Lelic N, et al. Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion. Cancer Cell. 2015;6:773-84.
-
(2015)
Cancer Cell
, vol.6
, pp. 773-784
-
-
Tateishi, K.1
Wakimoto, H.2
Iafrate, A.J.3
Tanaka, S.4
Loebel, F.5
Lelic, N.6
-
149
-
-
85017383110
-
Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair
-
Lu Y, Kwintkiewicz J, Liu Y, Tech K, Frady LN, Su YT, et al. Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair. Cancer Res. 2017;7:1709-18.
-
(2017)
Cancer Res
, vol.7
, pp. 1709-1718
-
-
Lu, Y.1
Kwintkiewicz, J.2
Liu, Y.3
Tech, K.4
Frady, L.N.5
Su, Y.T.6
-
150
-
-
0029986008
-
Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation
-
Luo H, Shan X, Wu J. Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation. J Cell Biochem. 1996. doi: 10.1002/(SICI)1097-4644(19960315)60:4<495:AID-JCB6>3.0.CO;2-N.
-
(1996)
J Cell Biochem
-
-
Luo, H.1
Shan, X.2
Wu, J.3
-
151
-
-
84890228415
-
Novel cases of d-2-hydroxyglutaric aciduria with IDH1 or IDH2 mosaic mutations identified by amplicon deep sequencing
-
Nota B, Hamilton EM, Sie D, Ozturk S, van Dooren SJ, Ojeda MR, et al. Novel cases of d-2-hydroxyglutaric aciduria with IDH1 or IDH2 mosaic mutations identified by amplicon deep sequencing. J Med Genet. 2013. doi: 10.1136/jmedgenet-2013-101961.
-
(2013)
J Med Genet
-
-
Nota, B.1
Hamilton, E.M.2
Sie, D.3
Ozturk, S.4
Dooren, S.J.5
Ojeda, M.R.6
-
152
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study
-
Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrozek K, Margeson D, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol. 2010. doi: 10.1200/JCO.2009.27.3730.
-
(2010)
J Clin Oncol
-
-
Marcucci, G.1
Maharry, K.2
Wu, Y.Z.3
Radmacher, M.D.4
Mrozek, K.5
Margeson, D.6
-
153
-
-
84876258128
-
Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia
-
Koszarska M, Bors A, Feczko A, Meggyesi N, Batai A, Csomor J, et al. Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia. Leuk Lymphoma. 2013. doi: 10.3109/10428194.2012.736981.
-
(2013)
Leuk Lymphoma
-
-
Koszarska, M.1
Bors, A.2
Feczko, A.3
Meggyesi, N.4
Batai, A.5
Csomor, J.6
|