-
1
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
DOI 10.1126/science.1133427
-
Sjöblom T, et al. The consensus coding sequences of human breast and colorectal cancers. Science. 2006;314(5797):268-274. (Pubitemid 44571966)
-
(2006)
Science
, vol.314
, Issue.5797
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
Mandelker, D.7
Leary, R.J.8
Ptak, J.9
Silliman, N.10
Szabo, S.11
Buckhaults, P.12
Farrell, C.13
Meeh, P.14
Markowitz, S.D.15
Willis, J.16
Dawson, D.17
Willson, J.K.V.18
Gazdar, A.F.19
Hartigan, J.20
Wu, L.21
Liu, C.22
Parmigiani, G.23
Park, B.H.24
Bachman, K.E.25
Papadopoulos, N.26
Vogelstein, B.27
Kinzler, K.W.28
Velculescu, V.E.29
more..
-
2
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321(5897):1807-1812.
-
(2008)
Science
, vol.321
, Issue.5897
, pp. 1807-1812
-
-
Parsons, D.W.1
-
3
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11):1058-1066.
-
(2009)
N Engl J Med
, vol.361
, Issue.11
, pp. 1058-1066
-
-
Mardis, E.R.1
-
4
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
Gross S, et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med. 2010;207(2):339-344.
-
(2010)
J Exp Med
, vol.207
, Issue.2
, pp. 339-344
-
-
Gross, S.1
-
5
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
-
Marcucci G, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(14):2348-2355.
-
(2010)
J Clin Oncol
, vol.28
, Issue.14
, pp. 2348-2355
-
-
Marcucci, G.1
-
6
-
-
84861407516
-
Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production
-
Ward PS, et al. Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. Oncogene. 2012;31(19):2491-2498.
-
(2012)
Oncogene
, vol.31
, Issue.19
, pp. 2491-2498
-
-
Ward, P.S.1
-
7
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274):739-744.
-
(2009)
Nature
, vol.462
, Issue.7274
, pp. 739-744
-
-
Dang, L.1
-
8
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17(3):225-234.
-
(2010)
Cancer Cell
, vol.17
, Issue.3
, pp. 225-234
-
-
Ward, P.S.1
-
9
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18(6):553-567.
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 553-567
-
-
Figueroa, M.E.1
-
10
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
-
Xu W, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19(1):17-30.
-
(2011)
Cancer Cell
, vol.19
, Issue.1
, pp. 17-30
-
-
Xu, W.1
-
11
-
-
77954697566
-
Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at a crossroads of cellular metabolism
-
Reitman ZJ, Yan H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst. 2010;102(13):932-941.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.13
, pp. 932-941
-
-
Reitman, Z.J.1
Yan, H.2
-
12
-
-
78649990315
-
Cancer-associated IDH mutations: Biomarker therapeutic opportunities
-
Yen KE, Bittinger MA, Su SM, Fantin VR. Cancer-associated IDH mutations: biomarker therapeutic opportunities. Oncogene. 2010;29(49):6409-6417.
-
(2010)
Oncogene
, vol.29
, Issue.49
, pp. 6409-6417
-
-
Yen, K.E.1
Bittinger, M.A.2
Su, S.M.3
Fantin, V.R.4
-
13
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765-773.
-
(2009)
N Engl J Med
, vol.360
, Issue.8
, pp. 765-773
-
-
Yan, H.1
-
14
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α
-
Zhao S, et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science. 2009;324(5924):261-265.
-
(2009)
Science
, vol.324
, Issue.5924
, pp. 261-265
-
-
Zhao, S.1
-
15
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012;483(7390):474-478.
-
(2012)
Nature
, vol.483
, Issue.7390
, pp. 474-478
-
-
Lu, C.1
-
16
-
-
0037099537
-
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
-
Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y. LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11) (q22;q23). Cancer Res. 2002;62(14):4075-4080. (Pubitemid 34791077)
-
(2002)
Cancer Research
, vol.62
, Issue.14
, pp. 4075-4080
-
-
Ono, R.1
Taki, T.2
Taketani, T.3
Taniwaki, M.4
Kobayashi, H.5
Hayashi, Y.6
-
17
-
-
0037350661
-
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;23) [3]
-
DOI 10.1038/sj.leu.2402834
-
Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11) (q22;q23). Leukemia. 2003;17(3):637-641. (Pubitemid 36395661)
-
(2003)
Leukemia
, vol.17
, Issue.3
, pp. 637-641
-
-
Lorsback, R.B.1
Moore, J.2
Mathew, S.3
Raimondi, S.C.4
Mukatira, S.T.5
Downing, J.R.6
-
18
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324(5929):930-935.
-
(2009)
Science
, vol.324
, Issue.5929
, pp. 930-935
-
-
Tahiliani, M.1
-
19
-
-
77956189495
-
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
-
Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010;466(7310):1129-1133.
-
(2010)
Nature
, vol.466
, Issue.7310
, pp. 1129-1133
-
-
Ito, S.1
D'Alessio, A.C.2
Taranova, O.V.3
Hong, K.4
Sowers, L.C.5
Zhang, Y.6
-
20
-
-
80052303426
-
TET family proteins and their role in stem cell differentiation and transformation
-
Cimmino L, Abdel-Wahab O, Levine RL, Aifantis I. TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell. 2011;9(3):193-204.
-
(2011)
Cell Stem Cell
, vol.9
, Issue.3
, pp. 193-204
-
-
Cimmino, L.1
Abdel-Wahab, O.2
Levine, R.L.3
Aifantis, I.4
-
21
-
-
79955538247
-
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
-
Guo JU, Su Y, Zhong C, Ming GL, Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011;145(3):423-434.
-
(2011)
Cell
, vol.145
, Issue.3
, pp. 423-434
-
-
Guo, J.U.1
Su, Y.2
Zhong, C.3
Ming, G.L.4
Song, H.5
-
22
-
-
79956302047
-
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
-
Williams K, et al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011;473(7347):343-348.
-
(2011)
Nature
, vol.473
, Issue.7347
, pp. 343-348
-
-
Williams, K.1
-
23
-
-
79956323623
-
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
-
Ficz G, et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature. 2011;473(7347):398-402.
-
(2011)
Nature
, vol.473
, Issue.7347
, pp. 398-402
-
-
Ficz, G.1
-
24
-
-
79956292024
-
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
-
Wu H, et al. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 2011;473(7347):389-393.
-
(2011)
Nature
, vol.473
, Issue.7347
, pp. 389-393
-
-
Wu, H.1
-
25
-
-
80052461558
-
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
Ito S, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011;333(6047):1300-1303.
-
(2011)
Science
, vol.333
, Issue.6047
, pp. 1300-1303
-
-
Ito, S.1
-
26
-
-
80052495940
-
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
-
He YF, et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science. 2011;333(6047):1303-1307.
-
(2011)
Science
, vol.333
, Issue.6047
, pp. 1303-1307
-
-
He, Y.F.1
-
27
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau F, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301.
-
(2009)
N Engl J Med
, vol.360
, Issue.22
, pp. 2289-2301
-
-
Delhommeau, F.1
-
28
-
-
67649876132
-
Acquired mutations in TET2 are common in myelodysplastic syndromes
-
Langemeijer SM, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet. 2009;41(7):838-842.
-
(2009)
Nat Genet
, vol.41
, Issue.7
, pp. 838-842
-
-
Langemeijer, S.M.1
-
29
-
-
67650588639
-
Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
-
Jankowska AM, et al. Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms. Blood. 2009;113(25):6403-6410.
-
(2009)
Blood
, vol.113
, Issue.25
, pp. 6403-6410
-
-
Jankowska, A.M.1
-
30
-
-
67651065502
-
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
-
Abdel-Wahab O, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 2009;114(1):144-147.
-
(2009)
Blood
, vol.114
, Issue.1
, pp. 144-147
-
-
Abdel-Wahab, O.1
-
31
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
Ko M, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010;468(7325):839-843.
-
(2010)
Nature
, vol.468
, Issue.7325
, pp. 839-843
-
-
Ko, M.1
-
32
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio K, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011;20(1):11-24.
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 11-24
-
-
Moran-Crusio, K.1
-
33
-
-
84865520089
-
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
-
Sasaki M, et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 2012;488(7413):656-659.
-
(2012)
Nature
, vol.488
, Issue.7413
, pp. 656-659
-
-
Sasaki, M.1
-
34
-
-
84875496294
-
-2-hydroxyglutarate is sufficient to promote leukemogenesis its effects are reversible
-
Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis its effects are reversible. Science. 2013;339(6127):1621-1625.
-
(2013)
Science
, vol.339
, Issue.6127
, pp. 1621-1625
-
-
Losman, J.A.1
-
35
-
-
84867355390
-
Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo
-
Popovici-Muller J, et al. Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo. ACS Med Chem Lett. 2012;3(10):850-855.
-
(2012)
ACS Med Chem Lett
, vol.3
, Issue.10
, pp. 850-855
-
-
Popovici-Muller, J.1
-
36
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
Wang F, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013;340(6132):622-626.
-
(2013)
Science
, vol.340
, Issue.6132
, pp. 622-626
-
-
Wang, F.1
-
37
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle D, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013;340(6132):626-630.
-
(2013)
Science
, vol.340
, Issue.6132
, pp. 626-630
-
-
Rohle, D.1
-
38
-
-
78149466021
-
IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders
-
Zou Y, Zeng Y, Zhang DF, Zou SH, Cheng YF, Yao YG. IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders. Biochem Biophys Res Commun. 2010;402(2):378-383.
-
(2010)
Biochem Biophys Res Commun
, vol.402
, Issue.2
, pp. 378-383
-
-
Zou, Y.1
Zeng, Y.2
Zhang, D.F.3
Zou, S.H.4
Cheng, Y.F.5
Yao, Y.G.6
-
39
-
-
79251510890
-
Acute myeloid leukemia with IDH1 or IDH2 mutation: Frequency clinicopathologic features
-
Patel KP, et al. Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency clinicopathologic features. Am J Clin Pathol. 2011;135(1):35-45.
-
(2011)
Am J Clin Pathol
, vol.135
, Issue.1
, pp. 35-45
-
-
Patel, K.P.1
-
40
-
-
84872021899
-
Screening for IDH mutations in chronic myelomonocytic leukemia
-
Ibáñez M, et al. Screening for IDH mutations in chronic myelomonocytic leukemia. Leuk Lymphoma. 2013;54(2):406-407.
-
(2013)
Leuk Lymphoma
, vol.54
, Issue.2
, pp. 406-407
-
-
Ibáñez, M.1
-
41
-
-
78650306174
-
IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia
-
Caramazza D, et al. IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. Leukemia. 2010;24(12):2120-2122.
-
(2010)
Leukemia
, vol.24
, Issue.12
, pp. 2120-2122
-
-
Caramazza, D.1
-
42
-
-
77954573304
-
IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
-
Pardanani A, Lasho TL, Finke CM, Mai M, McClure RF, Tefferi A. IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms. Leukemia. 2010;24(6):1146-1151.
-
(2010)
Leukemia
, vol.24
, Issue.6
, pp. 1146-1151
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.M.3
Mai, M.4
McClure, R.F.5
Tefferi, A.6
-
43
-
-
76549109434
-
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
-
Abdel-Wahab O, et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res. 2010;70(2):447-452.
-
(2010)
Cancer Res
, vol.70
, Issue.2
, pp. 447-452
-
-
Abdel-Wahab, O.1
-
44
-
-
84861082246
-
Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome
-
Zhang SJ, et al. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Blood. 2012;119(19):4480-4485.
-
(2012)
Blood
, vol.119
, Issue.19
, pp. 4480-4485
-
-
Zhang, S.J.1
-
45
-
-
84857997263
-
IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: Clinical evidence for leukemogenic collaboration with JAK2V617F
-
Tefferi A, et al. IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F. Leukemia. 2012;26(3):475-480.
-
(2012)
Leukemia
, vol.26
, Issue.3
, pp. 475-480
-
-
Tefferi, A.1
-
46
-
-
77952424259
-
Molecular alterations of the IDH1 gene in AML: A Children's Oncology Group and Southwest Oncology Group study
-
Ho PA, et al. Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study. Leukemia. 2010;24(5):909-913.
-
(2010)
Leukemia
, vol.24
, Issue.5
, pp. 909-913
-
-
Ho, P.A.1
-
47
-
-
79958864954
-
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group
-
Ho PA, et al. Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011;57(2):204-209.
-
(2011)
Pediatr Blood Cancer
, vol.57
, Issue.2
, pp. 204-209
-
-
Ho, P.A.1
-
48
-
-
80755140131
-
Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: A study of the AML-BFM and DCOG study groups
-
Damm F, et al. Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups. Leukemia. 2011;25(11):1704-1710.
-
(2011)
Leukemia
, vol.25
, Issue.11
, pp. 1704-1710
-
-
Damm, F.1
-
49
-
-
79751534999
-
IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies
-
Oki K, et al. IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies. Leukemia. 2011;25(2):382-384.
-
(2011)
Leukemia
, vol.25
, Issue.2
, pp. 382-384
-
-
Oki, K.1
-
50
-
-
84879431557
-
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A
-
Liang DC, et al. Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A. Blood. 2013;121(15):2988-2995.
-
(2013)
Blood
, vol.121
, Issue.15
, pp. 2988-2995
-
-
Liang, D.C.1
-
51
-
-
77957771067
-
IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
-
Schnittger S, Haferlach C, Ulke M, Alpermann T, Kern W, Haferlach T. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood. 2010;116(25):5486-5496.
-
(2010)
Blood
, vol.116
, Issue.25
, pp. 5486-5496
-
-
Schnittger, S.1
Haferlach, C.2
Ulke, M.3
Alpermann, T.4
Kern, W.5
Haferlach, T.6
-
52
-
-
79957593717
-
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
-
Makishima H, et al. CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood. 2011;117(21):e198-e206.
-
(2011)
Blood
, vol.117
, Issue.21
-
-
Makishima, H.1
-
53
-
-
84862819770
-
Isocitrate dehydrogenase mutation hot spots in acute lymphoblastic leukemia and oral cancer
-
Tang JY, Chang CC, Lin PC, Chang JG. Isocitrate dehydrogenase mutation hot spots in acute lymphoblastic leukemia and oral cancer. Kaohsiung J Med Sci. 2012;28(3):138-144.
-
(2012)
Kaohsiung J Med Sci
, vol.28
, Issue.3
, pp. 138-144
-
-
Tang, J.Y.1
Chang, C.C.2
Lin, P.C.3
Chang, J.G.4
-
54
-
-
84865683059
-
Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia
-
Zhang Y, et al. Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia. Genet Test Mol Biomarkers. 2012;16(8):991-995.
-
(2012)
Genet Test Mol Biomarkers
, vol.16
, Issue.8
, pp. 991-995
-
-
Zhang, Y.1
-
55
-
-
84876258128
-
Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia
-
Koszarska M, et al. Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia. Leuk Lymphoma. 2013;54(5):1028-1035.
-
(2013)
Leuk Lymphoma
, vol.54
, Issue.5
, pp. 1028-1035
-
-
Koszarska, M.1
-
56
-
-
77957286222
-
Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the Acute Leukemia French Association group
-
Boissel N, et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol. 2010;28(23):3717-3723.
-
(2010)
J Clin Oncol
, vol.28
, Issue.23
, pp. 3717-3723
-
-
Boissel, N.1
-
57
-
-
79960534917
-
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
-
Green CL, et al. The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood. 2011;118(2):409-412.
-
(2011)
Blood
, vol.118
, Issue.2
, pp. 409-412
-
-
Green, C.L.1
-
58
-
-
84857714230
-
Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients
-
Chotirat S, Thongnoppakhun W, Promsuwicha O, Boonthimat C, Auewarakul CU. Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients. J Hematol Oncol. 2012;5:5.
-
(2012)
J Hematol Oncol
, vol.5
, pp. 5
-
-
Chotirat, S.1
Thongnoppakhun, W.2
Promsuwicha, O.3
Boonthimat, C.4
Auewarakul, C.U.5
-
59
-
-
77956050251
-
Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
-
Thol F, et al. Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood. 2010;116(4):614-616.
-
(2010)
Blood
, vol.116
, Issue.4
, pp. 614-616
-
-
Thol, F.1
-
60
-
-
77950968519
-
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
-
Chou WC, et al. Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. Blood. 2010;115(14):2749-2754.
-
(2010)
Blood
, vol.115
, Issue.14
, pp. 2749-2754
-
-
Chou, W.C.1
-
61
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel JP, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
-
(2012)
N Engl J Med
, vol.366
, Issue.12
, pp. 1079-1089
-
-
Patel, J.P.1
-
62
-
-
77957192661
-
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value
-
Abbas S, et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood. 2010;116(12):2122-2126.
-
(2010)
Blood
, vol.116
, Issue.12
, pp. 2122-2126
-
-
Abbas, S.1
-
63
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel JP, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
-
(2012)
N Engl J Med
, vol.366
, Issue.12
, pp. 1079-1089
-
-
Patel, J.P.1
-
64
-
-
0034672269
-
Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study
-
Slovak ML, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood. 2000;96(13):4075-4083.
-
(2000)
Blood
, vol.96
, Issue.13
, pp. 4075-4083
-
-
Slovak, M.L.1
-
65
-
-
84856725273
-
Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: A Mayo Clinic study of 277 patients
-
Patnaik MM, et al. Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients. Leukemia. 2012;26(1):101-105.
-
(2012)
Leukemia
, vol.26
, Issue.1
, pp. 101-105
-
-
Patnaik, M.M.1
-
66
-
-
84857997263
-
IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: Clinical evidence for leukemogenic collaboration with JAK2V617F
-
Tefferi A, et al. IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F. Leukemia. 2012;26(3):475-480.
-
(2012)
Leukemia
, vol.26
, Issue.3
, pp. 475-480
-
-
Tefferi, A.1
-
67
-
-
84856298658
-
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
-
Borger DR, et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist. 2012;17(1):72-79.
-
(2012)
Oncologist
, vol.17
, Issue.1
, pp. 72-79
-
-
Borger, D.R.1
-
68
-
-
77954566882
-
Rapid targeted mutational analysis of human tumours: A clinical platform to guide personalized cancer medicine
-
Dias-Santagata D, et al. Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. EMBO Mol Med. 2010;2(5):146-158.
-
(2010)
EMBO Mol Med
, vol.2
, Issue.5
, pp. 146-158
-
-
Dias-Santagata, D.1
-
69
-
-
84870557152
-
Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response
-
Fathi AT, et al. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response. Blood. 2012;120(23):4649-4652.
-
(2012)
Blood
, vol.120
, Issue.23
, pp. 4649-4652
-
-
Fathi, A.T.1
-
70
-
-
77955885249
-
A single-tube, sensitive multiplex method for screening of isocitrate dehydrogenase 1 (IDH1) mutations
-
Chou WC, Huang YN, Huang CF, Tseng MH, Tien HF. A single-tube, sensitive multiplex method for screening of isocitrate dehydrogenase 1 (IDH1) mutations. Blood. 2010;116(3):495-496.
-
(2010)
Blood
, vol.116
, Issue.3
, pp. 495-496
-
-
Chou, W.C.1
Huang, Y.N.2
Huang, C.F.3
Tseng, M.H.4
Tien, H.F.5
-
71
-
-
84867397863
-
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting
-
Ibáñez M, et al. Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting. J Mol Diagn. 2012;14(6):594-601.
-
(2012)
J Mol Diagn
, vol.14
, Issue.6
, pp. 594-601
-
-
Ibáñez, M.1
-
72
-
-
82955198438
-
Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia an algorithmic approach using high-resolution melting curve analysis
-
Patel KP, et al. Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia an algorithmic approach using high-resolution melting curve analysis. J Mol Diagn. 2011;13(6):678-686.
-
(2011)
J Mol Diagn
, vol.13
, Issue.6
, pp. 678-686
-
-
Patel, K.P.1
-
73
-
-
84879374380
-
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
-
DiNardo CD, et al. Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Blood. 2013;121(24):4917-4924.
-
(2013)
Blood
, vol.121
, Issue.24
, pp. 4917-4924
-
-
DiNardo, C.D.1
-
74
-
-
84878366798
-
Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate
-
Balss J, et al. Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate. Acta Neuropathol. 2012;124(6):883-891.
-
(2012)
Acta Neuropathol
, vol.124
, Issue.6
, pp. 883-891
-
-
Balss, J.1
-
75
-
-
84872014953
-
2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: Predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels
-
Pollyea DA, et al. 2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels. Leuk Lymphoma. 2013;54(2):408-410.
-
(2013)
Leuk Lymphoma
, vol.54
, Issue.2
, pp. 408-410
-
-
Pollyea, D.A.1
-
76
-
-
77954658823
-
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
-
Tefferi A, et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia. 2010;24(7):1302-1309.
-
(2010)
Leukemia
, vol.24
, Issue.7
, pp. 1302-1309
-
-
Tefferi, A.1
|