Cytosolic NADP+-dependent isocitrate dehydrogenase status modulates oxidative damage to cells

Free Radical Biology and Medicine

Volumn 32, Issue 11, 2002, Pages 1185-1196

  Lee, Su Min ^a   Koh, Ho Jin ^a   Park, Dong Chan ^a   Song, Byoung J ^b   Huh, Tae Lin ^a   Park, Jeen Woo ^a  

^a Kyungpook National University   (South Korea)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Cellular redox state; Free radicals; Isocitrate dehydrogenase; NADPH; Reactive oxygen species

Indexed keywords

CATALASE; COMPLEMENTARY DNA; FREE RADICAL; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; ISOCITRATE DEHYDROGENASE; MENADIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ANTIOXIDANT; GLUTATHIONE; ISOCITRATE DEHYDROGENASE (NADP+);

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; LIPID PEROXIDATION; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; CELL STRAIN 3T3; CYTOSOL; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RABBIT;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMAL; ANTIOXIDANTS; APOPTOSIS; BASE SEQUENCE; BLOTTING, NORTHERN; CATALASE; CYTOSOL; DNA DAMAGE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; ISOCITRATE DEHYDROGENASE; LIPID PEROXIDATION; MICE; MOLECULAR SEQUENCE DATA; NADP; OXIDATION-REDUCTION; OXIDATIVE STRESS; RABBITS; REACTIVE OXYGEN SPECIES; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; VITAMIN K 3; ANIMALS;

EID: 0036614971     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00815-8     Document Type: Article

References (53)

1. Regulation of lymphocyte growth by antagonists of interleukin-2 or its cellular receptor
2. The biology of oxygen radicals
3. Oxidants, antioxidants, and the degenerative diseases of aging
4. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
5. Hydroperoxide metabolism in mammalian organs
6. Glutathione
7. Importance of glucose-6-phosphate dehydrogenase in the adaptive response to hydrogen peroxide in Saccharomyces cerevisiae
8. Thioredoxin-dependent peroxide reductase from yeast
9. Inhibition of metal-catalyzed oxidation systems by a yeast protector protein in the presence of thioredoxin
10. Superoxide radical: An endogenous toxicant
11. Thioredoxin
12. Catalase: A tetrameric enzyme with four tightly bound molecules of NADPH
13. Sensitivity of metabolic fluxes to covalent control
14. NADPH, not glutathione, status modulates oxidant sensitivity in normal and glucose-6-phosphate dehydrogenase-deficient erythrocytes
15. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress
16. Glucose-6-phosphate dehydrogenase: A "housekeeping" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress
17. The redox state of free nicotinamide- adenine dinucleotide phosphate in the cytoplasm of rat liver
18. Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA
19. Assignment of mitochondrial NAD(+)-specific isocitrate dehydrogenase beta subunit gene (IDH3B) to human chromosome band 20p13 by in situ hybridization and radiation hybrid mapping
20. Improved retroviral vectors for gene transfer and expression
21. Production of high-titer helper-free retroviruses by transient transfection
22. Characterization of two cDNA clones for pyruvate dehydrogenase E1 beta subunit and its regulation in tricarboxylic acid cycle-deficient fibroblast
23. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
24. Subcellular distribution of isocitrate dehydrogenases in neonatal and adult mouse brain
25. A spectrophotometric method for measuring breakdown of hydrogen peroxide by catalase
26. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
27. The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates
28. Epidermal growth factor rapidly activates the hexose monophosphate shunt in kidney cells
29. Paraquat-resistant HeLa cells: Increased cellular content of glutathione peroxidase
30. Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure
31. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples
32. Determination of glutathione and glutathione disulfide in biological samples
33. Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity
34. Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family
35. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
36. Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis
37. +-dependent isocitrate dehydrogenase
38. Purification and properties of NADP(+)-dependent isocitrate dehydrogenase from the corpus luteum
39. Cloning of a cDNA encoding bovine mitochondrial NADP(+)-specific isocitrate dehydrogenase and structural comparison with its isoenzymes from different species
40. Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization
41. Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues
42. The subcellular location of isozymes of NADP-isocitrate dehydrogenase in tissues from pig, ox and rat
43. +-dependent isocitrate dehydrogenase that is preferentially expressed in bovine corneal epithelium. A corneal epithelial crystallin
44. +-dependent isocitrate dehydrogenase
45. Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform
46. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
47. Effects of oxygen deprivation on cardiac redox systems
48. Reduction of glutathione disulfide and the maintenance of reducing equivalents in hypoxic hearts after the infusion of diamide
49. Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide
50. +-specific isocitrate dehydrogenases in Saccharomyces cerevisiae
51. Dependence of peroxisomal beta-oxidation on cytosolic sources of NADPH