메뉴 건너뛰기




Volumn 60, Issue 9, 2017, Pages 1630-1638

Metformin and ageing: improving ageing outcomes beyond glycaemic control

Author keywords

Ageing; Mechanisms of ageing; Metformin; Older adults; Review

Indexed keywords

METFORMIN; REACTIVE OXYGEN METABOLITE; ANTIDIABETIC AGENT;

EID: 85026748623     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-017-4349-5     Document Type: Review
Times cited : (107)

References (69)
  • 1
    • 85027570111 scopus 로고    scopus 로고
    • Ageing and health
    • Available from, Accessed 7 Mar 2017
    • World Health Organization (2015) Ageing and health. Fact sheet N404. Available from www.who.int/mediacentre/factsheets/fs404/en/. Accessed 7 Mar 2017
    • (2015) Fact sheet , vol.N404
  • 2
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: findings from the third National Health and nutrition examination survey
    • PID: 11790215
    • Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and nutrition examination survey. JAMA 287:356–359
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 3
    • 33846694838 scopus 로고    scopus 로고
    • Insulin resistance as estimated by homeostatis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study
    • PID: 17259501
    • Bonora E, Kiechl S, Willeit J et al (2007) Insulin resistance as estimated by homeostatis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study. Diabetes Care 30:318–324
    • (2007) Diabetes Care , vol.30 , pp. 318-324
    • Bonora, E.1    Kiechl, S.2    Willeit, J.3
  • 4
    • 84874076840 scopus 로고    scopus 로고
    • Insulin resistance and cancer: the role of insulin and IGFs
    • Djioque S, Nwabo Kamdje AH, Vecchio L et al (2013) Insulin resistance and cancer: the role of insulin and IGFs. Endocr Relat Cancer 20:R1–R17
    • (2013) Endocr Relat Cancer , vol.20 , pp. R1-R17
    • Djioque, S.1    Nwabo Kamdje, A.H.2    Vecchio, L.3
  • 5
    • 82855165012 scopus 로고    scopus 로고
    • Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine comorbidity
    • COI: 1:CAS:528:DC%2BC3MXhsFSkt7rE, PID: 22020230
    • Stuart MJ, Baune BT (2012) Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine comorbidity. Neurosci Biobehav Rev 36:658–676
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 658-676
    • Stuart, M.J.1    Baune, B.T.2
  • 6
    • 84903136322 scopus 로고    scopus 로고
    • Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
    • PID: 24931033
    • De Felice FG, Ferreira ST (2014) Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 63:2262–2272
    • (2014) Diabetes , vol.63 , pp. 2262-2272
    • De Felice, F.G.1    Ferreira, S.T.2
  • 7
    • 84859838208 scopus 로고    scopus 로고
    • Frailty transitions in the San Antonio longitudinal study of aging
    • PID: 22316162
    • Espinoza SE, Jung I, Hazuda H (2012) Frailty transitions in the San Antonio longitudinal study of aging. J Am Geriatr Soc 60:652–660
    • (2012) J Am Geriatr Soc , vol.60 , pp. 652-660
    • Espinoza, S.E.1    Jung, I.2    Hazuda, H.3
  • 8
    • 33750918489 scopus 로고    scopus 로고
    • (DPP research group). The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes
    • Crandall J et al (2006) (DPP research group). The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol 61:1075–1081
    • (2006) J Gerontol , vol.61 , pp. 1075-1081
    • Crandall, J.1
  • 9
    • 84919999231 scopus 로고    scopus 로고
    • (DPP research group). HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention Program: a randomized clinical trial
    • Knowler W et al (2014) (DPP research group). HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention Program: a randomized clinical trial. Diabetes Care 38:51–58
    • (2014) Diabetes Care , vol.38 , pp. 51-58
    • Knowler, W.1
  • 10
    • 84988360251 scopus 로고    scopus 로고
    • New definition of aging?: measuring regenerative capacity in patients
    • COI: 1:CAS:528:DC%2BC28XhsFWjtLnK, PID: 27635077
    • Losordo DW, Henry TD (2016) New definition of aging?: measuring regenerative capacity in patients. Circ Res 119:774–775
    • (2016) Circ Res , vol.119 , pp. 774-775
    • Losordo, D.W.1    Henry, T.D.2
  • 11
    • 84861885929 scopus 로고    scopus 로고
    • The critical role of metabolic pathways in aging
    • COI: 1:CAS:528:DC%2BC38XotlGqtLo%3D, PID: 22618766
    • Barzilai N, Huffman DM, Muzumdar RH, Bartke A (2012) The critical role of metabolic pathways in aging. Diabetes 61:1315–1322
    • (2012) Diabetes , vol.61 , pp. 1315-1322
    • Barzilai, N.1    Huffman, D.M.2    Muzumdar, R.H.3    Bartke, A.4
  • 12
    • 84927748959 scopus 로고    scopus 로고
    • Drivers of age-related inflammation and strategies for healthspan extension
    • COI: 1:CAS:528:DC%2BC2MXms1Sqtbk%3D, PID: 25879284
    • Goldberg EL, Dixit VD (2015) Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev 265:63–74
    • (2015) Immunol Rev , vol.265 , pp. 63-74
    • Goldberg, E.L.1    Dixit, V.D.2
  • 13
    • 84916634296 scopus 로고    scopus 로고
    • Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXhslOgt7%2FI, PID: 25305052
    • Harris RA, Tindale L, Cumming RC (2014) Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease. Biogerontology 15:559–577
    • (2014) Biogerontology , vol.15 , pp. 559-577
    • Harris, R.A.1    Tindale, L.2    Cumming, R.C.3
  • 14
    • 85027558516 scopus 로고    scopus 로고
    • Biology. In: Medina-Walpole A, Pacala JT (eds) Geriatrics review syllabus. 9th edn. American Geriatrics
    • Accessed 16 Mar 2017
    • Fedarko N, McNabney MK (2016) Biology. In: Medina-Walpole A, Pacala JT (eds) Geriatrics review syllabus. 9th edn. American Geriatrics Society. Available at https://geriatricscareonline.org/ProductAbstract/geriatrics-review-syllabus9th-edition/B023/. Accessed 16 Mar 2017
    • (2016) Society , vol.9
    • Fedarko, N.1    McNabney, M.K.2
  • 15
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • COI: 1:CAS:528:DC%2BD1MXht1GiurbK, PID: 19812404
    • Hoeijmakers JHJ (2009) DNA damage, aging, and cancer. N Engl J Med 361:1475–1485
    • (2009) N Engl J Med , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.J.1
  • 16
    • 84935514695 scopus 로고    scopus 로고
    • Xanthine oxidase inhibitors in heart failure: where do we go from here?
    • PID: 25986446
    • Tamariz L, Hare JM (2015) Xanthine oxidase inhibitors in heart failure: where do we go from here? Circulation 131:1741–1744
    • (2015) Circulation , vol.131 , pp. 1741-1744
    • Tamariz, L.1    Hare, J.M.2
  • 17
    • 0025832844 scopus 로고
    • Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone
    • COI: 1:CAS:528:DyaK3MXisVSmsbs%3D
    • Carney JM, Starke-Reed PE, Oliver CN et al (1991) Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc Natl Acad Sci US A 88:3633–3636
    • (1991) Proc Natl Acad Sci US A , vol.88 , pp. 3633-3636
    • Carney, J.M.1    Starke-Reed, P.E.2    Oliver, C.N.3
  • 18
    • 85016476904 scopus 로고    scopus 로고
    • Mutation and catastrophe in the aging genome
    • COI: 1:CAS:528:DC%2BC2sXlsFaisL0%3D, PID: 28263867
    • Milholland B, Suh Y, Vijg J (2017) Mutation and catastrophe in the aging genome. Exp Gerontol 94:34–40
    • (2017) Exp Gerontol , vol.94 , pp. 34-40
    • Milholland, B.1    Suh, Y.2    Vijg, J.3
  • 19
    • 34247578803 scopus 로고    scopus 로고
    • Geriatric syndromes: clinical, research and policy implications of a core geriatric concept
    • PID: 17493201
    • Inouye SK, Studenski S, Tinetti ME, Kuchel GA (2007) Geriatric syndromes: clinical, research and policy implications of a core geriatric concept. J Am Geriatr Soc 55:780–791
    • (2007) J Am Geriatr Soc , vol.55 , pp. 780-791
    • Inouye, S.K.1    Studenski, S.2    Tinetti, M.E.3    Kuchel, G.A.4
  • 20
    • 85018916698 scopus 로고    scopus 로고
    • Endocrinology and metabolism
    • Burton J, Lee A, Potter J, (eds), Springer, Switzerland
    • Valencia WM, Florez H (2017) Endocrinology and metabolism. In: Burton J, Lee A, Potter J (eds) Geriatrics for specialists. Springer, Switzerland, pp 269–282
    • (2017) Geriatrics for specialists , pp. 269-282
    • Valencia, W.M.1    Florez, H.2
  • 21
    • 84903524608 scopus 로고    scopus 로고
    • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
    • COI: 1:CAS:528:DC%2BC2cXpslGitLg%3D, PID: 24847880
    • Madiraju AK, Erion DM, Rahimi Y et al (2014) Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510:542–546
    • (2014) Nature , vol.510 , pp. 542-546
    • Madiraju, A.K.1    Erion, D.M.2    Rahimi, Y.3
  • 22
    • 77950506582 scopus 로고    scopus 로고
    • Inflammatory cytokines in heart failure: roles in aetiology and utility as biomarkers
    • COI: 1:CAS:528:DC%2BC3cXkt1Kktb0%3D, PID: 20172914
    • Tamariz L, Hare JM (2010) Inflammatory cytokines in heart failure: roles in aetiology and utility as biomarkers. Eur Heart J 31:768–770
    • (2010) Eur Heart J , vol.31 , pp. 768-770
    • Tamariz, L.1    Hare, J.M.2
  • 23
    • 84942115958 scopus 로고    scopus 로고
    • Metformin and inflammation: its potential beyond glucose-lowering effect
    • COI: 1:CAS:528:DC%2BC2MXhsFansrvP, PID: 25772174
    • Saisho Y (2015) Metformin and inflammation: its potential beyond glucose-lowering effect. Endocr Metab Immune Disord Drug Targets 15:196–205
    • (2015) Endocr Metab Immune Disord Drug Targets , vol.15 , pp. 196-205
    • Saisho, Y.1
  • 24
    • 84996807783 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation
    • COI: 1:CAS:528:DC%2BC28XhvFGjs7rN, PID: 27840174
    • Mancini SJ, White AD, Bijland S et al (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. Mol Cell Endocrinol 440:44–56
    • (2017) Mol Cell Endocrinol , vol.440 , pp. 44-56
    • Mancini, S.J.1    White, A.D.2    Bijland, S.3
  • 25
    • 84877822086 scopus 로고    scopus 로고
    • Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-kappa B activation
    • COI: 1:CAS:528:DC%2BC3sXovFKnsrc%3D, PID: 23521863
    • Moiseeva O, Deschenes-Simard X, St-Germain E et al (2013) Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-kappa B activation. Aging Cell 12:489–498
    • (2013) Aging Cell , vol.12 , pp. 489-498
    • Moiseeva, O.1    Deschenes-Simard, X.2    St-Germain, E.3
  • 26
    • 33746102508 scopus 로고    scopus 로고
    • The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin
    • COI: 1:CAS:528:DC%2BD28XmvFeisbc%3D, PID: 16732470
    • Batandier C, Guigas B, Detaille D et al (2006) The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin. J Bioenerg Biomembr 38:33–42
    • (2006) J Bioenerg Biomembr , vol.38 , pp. 33-42
    • Batandier, C.1    Guigas, B.2    Detaille, D.3
  • 27
    • 84863601677 scopus 로고    scopus 로고
    • Metformin reduces endogenous reactive oxygen species and associated DNA damage
    • COI: 1:CAS:528:DC%2BC38XntFOns7c%3D
    • Algire C, Moiseeva O, Deschenes-Simard X et al (2012) Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res 5:536–543
    • (2012) Cancer Prev Res , vol.5 , pp. 536-543
    • Algire, C.1    Moiseeva, O.2    Deschenes-Simard, X.3
  • 28
    • 84874925174 scopus 로고    scopus 로고
    • Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage-signaling
    • COI: 1:CAS:528:DC%2BC3sXjsVSitLs%3D, PID: 23363784
    • Halicka HD, Zhao H, Li J et al (2012) Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage-signaling. Aging 4:952–965
    • (2012) Aging , vol.4 , pp. 952-965
    • Halicka, H.D.1    Zhao, H.2    Li, J.3
  • 29
    • 84891560192 scopus 로고    scopus 로고
    • Metformin limits ceramide-induced senescence in C2C12 myoblasts
    • COI: 1:CAS:528:DC%2BC3sXhvF2rsL3P, PID: 24269881
    • Jadhav KS, Dungan CM, Williamson DL (2013) Metformin limits ceramide-induced senescence in C2C12 myoblasts. Mech Ageing Dev 134:548–559
    • (2013) Mech Ageing Dev , vol.134 , pp. 548-559
    • Jadhav, K.S.1    Dungan, C.M.2    Williamson, D.L.3
  • 30
    • 50849113473 scopus 로고    scopus 로고
    • Metformin slows down aging and extends lifespan of female SHR mice
    • COI: 1:CAS:528:DC%2BD1cXht1ymsLnL, PID: 18728386
    • Anisimov VN, Berstein LM, Egormin PA et al (2008) Metformin slows down aging and extends lifespan of female SHR mice. Cell Cycle 7:2769–2773
    • (2008) Cell Cycle , vol.7 , pp. 2769-2773
    • Anisimov, V.N.1    Berstein, L.M.2    Egormin, P.A.3
  • 31
    • 84875738351 scopus 로고    scopus 로고
    • Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
    • COI: 1:CAS:528:DC%2BC3sXltVeru7o%3D, PID: 23540700
    • Cabreiro F, Au C, Leung KY et al (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153:228–239
    • (2013) Cell , vol.153 , pp. 228-239
    • Cabreiro, F.1    Au, C.2    Leung, K.Y.3
  • 32
    • 84902603273 scopus 로고    scopus 로고
    • Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
    • PID: 24889636
    • De Haes W, Frooninckx L, Van Assche R et al (2014) Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci U S A 111:E2501–E2509
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E2501-E2509
    • De Haes, W.1    Frooninckx, L.2    Van Assche, R.3
  • 33
    • 84921601341 scopus 로고    scopus 로고
    • Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model
    • PID: 24993950
    • Takahashi N, Shibata R, Ouchi N, Sugimoto M, Murohara T, Komori K (2015) Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model. J Vasc Surg 61:489–496
    • (2015) J Vasc Surg , vol.61 , pp. 489-496
    • Takahashi, N.1    Shibata, R.2    Ouchi, N.3    Sugimoto, M.4    Murohara, T.5    Komori, K.6
  • 34
    • 85006372371 scopus 로고    scopus 로고
    • Metformin protects neurons against oxygen-glucose deprivation/reoxygenation -induced injury by down-regulating MAD2B
    • COI: 1:CAS:528:DC%2BC28XitFSmsbzN, PID: 27889750
    • Meng X, Chu G, Yang Z et al (2016) Metformin protects neurons against oxygen-glucose deprivation/reoxygenation -induced injury by down-regulating MAD2B. Cell Physiol Biochem 40:477–485
    • (2016) Cell Physiol Biochem , vol.40 , pp. 477-485
    • Meng, X.1    Chu, G.2    Yang, Z.3
  • 35
    • 40749133339 scopus 로고    scopus 로고
    • Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons
    • COI: 1:CAS:528:DC%2BD1cXitFWrtb4%3D, PID: 18040888
    • El-Mir MY, Detaille D, R-Villanueva G et al (2008) Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons. J Mol Neurosci 34:77–87
    • (2008) J Mol Neurosci , vol.34 , pp. 77-87
    • El-Mir, M.Y.1    Detaille, D.2    R-Villanueva, G.3
  • 36
    • 84964315943 scopus 로고    scopus 로고
    • Metformin impairs rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma
    • PID: 25365944
    • Kumar A, Al-Sammarraie N, DiPette DJ, Singh US (2014) Metformin impairs rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. Oncotarget 5:11709–11722
    • (2014) Oncotarget , vol.5 , pp. 11709-11722
    • Kumar, A.1    Al-Sammarraie, N.2    DiPette, D.J.3    Singh, U.S.4
  • 37
    • 79952439187 scopus 로고    scopus 로고
    • Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes
    • COI: 1:CAS:528:DC%2BC3MXjsFahur0%3D, PID: 21277873
    • Gupta A, Bisht B, Dey CS (2011) Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes. Neuropharmacology 60:910–920
    • (2011) Neuropharmacology , vol.60 , pp. 910-920
    • Gupta, A.1    Bisht, B.2    Dey, C.S.3
  • 38
    • 17144384777 scopus 로고    scopus 로고
    • Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes
    • COI: 1:STN:280:DC%2BD2M7lsFWjsQ%3D%3D, PID: 15787679
    • Johnson JA, Simpson SH, Toth EL, Majumdar SR (2005) Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes. Diabet Med 22:497–502
    • (2005) Diabet Med , vol.22 , pp. 497-502
    • Johnson, J.A.1    Simpson, S.H.2    Toth, E.L.3    Majumdar, S.R.4
  • 39
    • 85012875479 scopus 로고    scopus 로고
    • Differential effects of metformin on age related comorbidities in older men with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2sXhtFagurfK, PID: 28190681
    • Wang CP, Lorenzo C, Habib SL, Espinoza SE (2017) Differential effects of metformin on age related comorbidities in older men with type 2 diabetes. J Diabetes Complicat 31:679–686
    • (2017) J Diabetes Complicat , vol.31 , pp. 679-686
    • Wang, C.P.1    Lorenzo, C.2    Habib, S.L.3    Espinoza, S.E.4
  • 40
    • 85013412151 scopus 로고    scopus 로고
    • Metformin in adults with type 1 diabetes: design and methods of REducing with MetfOrmin vascular adverse lesions (REMOVAL): an international multicentre trial
    • COI: 1:CAS:528:DC%2BC2sXktlymurs%3D, PID: 27935183
    • Petrie JR, Chatuverdi N, Ford I et al (2017) Metformin in adults with type 1 diabetes: design and methods of REducing with MetfOrmin vascular adverse lesions (REMOVAL): an international multicentre trial. Diabetes Obes Metab 19:509–516
    • (2017) Diabetes Obes Metab , vol.19 , pp. 509-516
    • Petrie, J.R.1    Chatuverdi, N.2    Ford, I.3
  • 41
    • 84894900806 scopus 로고    scopus 로고
    • Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial
    • COI: 1:CAS:528:DC%2BC2cXosFSksb0%3D, PID: 24622715
    • Preiss D, Lloyd SM, Ford I et al (2014) Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial. Lancet Diabetes Endocrinol 2:116–124
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 116-124
    • Preiss, D.1    Lloyd, S.M.2    Ford, I.3
  • 42
    • 84865458808 scopus 로고    scopus 로고
    • Targeting the consequences of the metabolic syndrome in the diabetes prevention Program
    • COI: 1:CAS:528:DC%2BC38Xht1SmurbM, PID: 22895669
    • Goldberg RB, Mather K (2012) Targeting the consequences of the metabolic syndrome in the diabetes prevention Program. Arterioscler Thromb Vasc Biol 32:2077–2090
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2077-2090
    • Goldberg, R.B.1    Mather, K.2
  • 43
    • 84859442090 scopus 로고    scopus 로고
    • Weight change in people with type 2 diabetes: secular trends and the impact of alternative antihyperglycaemic drugs
    • COI: 1:CAS:528:DC%2BC38XotVSms70%3D, PID: 22192841
    • Morgan CL, Jenkins-Jones S, Evans M, Barnett AH, Poole CD, Currie CJ (2012) Weight change in people with type 2 diabetes: secular trends and the impact of alternative antihyperglycaemic drugs. Diabetes Obes Metab 14:424–432
    • (2012) Diabetes Obes Metab , vol.14 , pp. 424-432
    • Morgan, C.L.1    Jenkins-Jones, S.2    Evans, M.3    Barnett, A.H.4    Poole, C.D.5    Currie, C.J.6
  • 44
    • 17844366621 scopus 로고    scopus 로고
    • Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance
    • PID: 15855347
    • Haffner S, Temprosa M, Crandall J et al (2005) Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes 54:1566–1572
    • (2005) Diabetes , vol.54 , pp. 1566-1572
    • Haffner, S.1    Temprosa, M.2    Crandall, J.3
  • 45
    • 24144488274 scopus 로고    scopus 로고
    • Metformin improves endothelial function in patients with metabolic syndrome
    • COI: 1:CAS:528:DC%2BD2MXhtVOrtL7I, PID: 16115299
    • Vitale C, Mercuro G, Cornoldi A, Fini M, Volterrani M, Rosano GM (2005) Metformin improves endothelial function in patients with metabolic syndrome. J Intern Med 258:250–256
    • (2005) J Intern Med , vol.258 , pp. 250-256
    • Vitale, C.1    Mercuro, G.2    Cornoldi, A.3    Fini, M.4    Volterrani, M.5    Rosano, G.M.6
  • 46
    • 33746340623 scopus 로고    scopus 로고
    • Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance
    • PID: 16644641
    • de Aguiar LG, Bahia LR, Villela N et al (2006) Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance. Diabetes Care 29:1083–1089
    • (2006) Diabetes Care , vol.29 , pp. 1083-1089
    • de Aguiar, L.G.1    Bahia, L.R.2    Villela, N.3
  • 47
    • 33747879300 scopus 로고    scopus 로고
    • Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study
    • COI: 1:CAS:528:DC%2BD28XpsVWmtbs%3D, PID: 16949486
    • Jadhav S, Ferrell W, Greer IA, Petrie JR, Cobbe SM, Sattar N (2006) Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study. J Am Coll Cardiol 48:956–963
    • (2006) J Am Coll Cardiol , vol.48 , pp. 956-963
    • Jadhav, S.1    Ferrell, W.2    Greer, I.A.3    Petrie, J.R.4    Cobbe, S.M.5    Sattar, N.6
  • 48
    • 84873056313 scopus 로고    scopus 로고
    • Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon
    • COI: 1:CAS:528:DC%2BC3sXhslartrg%3D, PID: 23192487
    • Whittington HJ, Hall AR, McLaughlin CP, Hausenloy DJ, Yellon DM, Mocanu MM (2013) Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon. Cardiovasc Drugs Ther 27:5–16
    • (2013) Cardiovasc Drugs Ther , vol.27 , pp. 5-16
    • Whittington, H.J.1    Hall, A.R.2    McLaughlin, C.P.3    Hausenloy, D.J.4    Yellon, D.M.5    Mocanu, M.M.6
  • 49
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UKPDS Study Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854–865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 50
    • 63849328978 scopus 로고    scopus 로고
    • Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BD1MXksVOntrY%3D, PID: 19307526
    • Kooy A, de Jager J, Lehert P et al (2009) Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus. Arch Intern Med 169:616–625
    • (2009) Arch Intern Med , vol.169 , pp. 616-625
    • Kooy, A.1    de Jager, J.2    Lehert, P.3
  • 51
    • 84911209192 scopus 로고    scopus 로고
    • Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXhvVSjsbzI, PID: 24862430
    • Guo M, Mi J, Jiang QM et al (2014) Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus. Clin Exp Pharmacol Physiol 41:650–656
    • (2014) Clin Exp Pharmacol Physiol , vol.41 , pp. 650-656
    • Guo, M.1    Mi, J.2    Jiang, Q.M.3
  • 52
    • 84902239478 scopus 로고    scopus 로고
    • Long-term metformin usage and cognitive function among older adults with diabetes
    • COI: 1:CAS:528:DC%2BC2cXptVCgu7Y%3D, PID: 24577463
    • Ng TP, Feng L, Yap KB, Lee TS, Tan CH, Winblad B (2014) Long-term metformin usage and cognitive function among older adults with diabetes. J Alzheimers Dis 41:61–68
    • (2014) J Alzheimers Dis , vol.41 , pp. 61-68
    • Ng, T.P.1    Feng, L.2    Yap, K.B.3    Lee, T.S.4    Tan, C.H.5    Winblad, B.6
  • 53
    • 79956277464 scopus 로고    scopus 로고
    • Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
    • COI: 1:CAS:528:DC%2BC3MXmtFCmt74%3D, PID: 21297276
    • Hsu CC, Wahlqvist ML, Lee MS, Tsai HN (2011) Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin. J Alzheimers Dis 24:485–493
    • (2011) J Alzheimers Dis , vol.24 , pp. 485-493
    • Hsu, C.C.1    Wahlqvist, M.L.2    Lee, M.S.3    Tsai, H.N.4
  • 54
    • 84922222735 scopus 로고    scopus 로고
    • Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis
    • COI: 1:CAS:528:DC%2BC2sXns1ejs7g%3D, PID: 24899525
    • Cheng C, Lin CH, Tsai YW, Tsai CJ, Chou PH, Lan TH (2014) Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis. J Gerontol A Biol Sci Med Sci 69:1299–1305
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 1299-1305
    • Cheng, C.1    Lin, C.H.2    Tsai, Y.W.3    Tsai, C.J.4    Chou, P.H.5    Lan, T.H.6
  • 55
    • 84961773449 scopus 로고    scopus 로고
    • Metformin in amnestic mild cognitive impairment: results of a pilot randomized placebo controlled clinical trial
    • COI: 1:CAS:528:DC%2BC28XksFCjtbY%3D, PID: 26890736
    • Luchsinger JA, Perez T, Chang H et al (2016) Metformin in amnestic mild cognitive impairment: results of a pilot randomized placebo controlled clinical trial. J Alzheimers Dis 51:501–514
    • (2016) J Alzheimers Dis , vol.51 , pp. 501-514
    • Luchsinger, J.A.1    Perez, T.2    Chang, H.3
  • 56
    • 85015458873 scopus 로고    scopus 로고
    • Metformin in the diabetic brain: friend or foe?
    • PID: 25333029
    • Moreira PI (2014) Metformin in the diabetic brain: friend or foe? Ann Transl Med 2:54
    • (2014) Ann Transl Med , vol.2 , pp. 54
    • Moreira, P.I.1
  • 57
    • 84959464388 scopus 로고    scopus 로고
    • Metformin promotes tau aggregation and exacerbates abnormal behaviour in a mouse model of taupathy
    • PID: 26858121
    • Barini E, Antico O, Zhao Y et al (2016) Metformin promotes tau aggregation and exacerbates abnormal behaviour in a mouse model of taupathy. Mol Neurodegener 11:16
    • (2016) Mol Neurodegener , vol.11 , pp. 16
    • Barini, E.1    Antico, O.2    Zhao, Y.3
  • 59
    • 85021114575 scopus 로고    scopus 로고
    • Metformin, lifestyle intervention, and cognition in the Diabetes Prevention Program Outcomes Study
    • Luchsinger JA, Ma Y, Christophi CA et al (2017) Metformin, lifestyle intervention, and cognition in the Diabetes Prevention Program Outcomes Study. Diabetes Care 40:958–965
    • (2017) Diabetes Care , vol.40 , pp. 958-965
    • Luchsinger, J.A.1    Ma, Y.2    Christophi, C.A.3
  • 61
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • COI: 1:CAS:528:DC%2BD38XhtVWqurc%3D, PID: 11832527
    • Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. NEJM 346:393–403
    • (2002) NEJM , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 64
    • 3042798575 scopus 로고    scopus 로고
    • The phantom of lactic acidosis due to metformin in patients with diabetes
    • Misban RI (2004) The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 27:1791–1793
    • (2004) Diabetes Care , vol.27 , pp. 1791-1793
    • Misban, R.I.1
  • 65
    • 84959528193 scopus 로고    scopus 로고
    • Metformin associated lactic acidosis: current perspectives on causes and risk
    • COI: 1:CAS:528:DC%2BC2MXhslentL7J, PID: 26773926
    • DeFronzo R, Fleming GA, Chen K, Bicsak TA (2016) Metformin associated lactic acidosis: current perspectives on causes and risk. Metabolism 65:20–29
    • (2016) Metabolism , vol.65 , pp. 20-29
    • DeFronzo, R.1    Fleming, G.A.2    Chen, K.3    Bicsak, T.A.4
  • 66
    • 84920273088 scopus 로고    scopus 로고
    • Pharmacological treatment of diabetes in older people
    • COI: 1:CAS:528:DC%2BC2cXhvFShs7fO, PID: 25073699
    • Valencia WM, Florez H (2014) Pharmacological treatment of diabetes in older people. Diabetes Obes Metab 16:1192–1203
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1192-1203
    • Valencia, W.M.1    Florez, H.2
  • 67
    • 84906722201 scopus 로고    scopus 로고
    • Weight loss and physical activity for disease prevention in obese older adults: an important role for lifestyle management
    • PID: 25183491
    • Valencia WM, Stoutenberg M, Florez H (2014) Weight loss and physical activity for disease prevention in obese older adults: an important role for lifestyle management. Curr Diab Rep 14:539
    • (2014) Curr Diab Rep , vol.14 , pp. 539
    • Valencia, W.M.1    Stoutenberg, M.2    Florez, H.3
  • 68
    • 84994460732 scopus 로고    scopus 로고
    • Strategies and challenges in clinical trials targeting human aging
    • Newman JC, Milman S, Hashmi SK et al (2016) Strategies and challenges in clinical trials targeting human aging. J Gerontol A Biol Sci Med Sci 74:1424–1434
    • (2016) J Gerontol A Biol Sci Med Sci , vol.74 , pp. 1424-1434
    • Newman, J.C.1    Milman, S.2    Hashmi, S.K.3
  • 69
    • 85027570935 scopus 로고    scopus 로고
    • Early Prevention of Diabetes Complications in Europe
    • The ePREDICE Consortium (2016) Early Prevention of Diabetes Complications in Europe. Available from www.epredice.eu/en/the-project. Accessed 22 Feb 2017
    • (2016) Available from


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.