Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model

Journal of Vascular Surgery

Volumn 61, Issue 2, 2015, Pages 489-496

  Takahashi, Noriko ^a   Shibata, Rei ^a   Ouchi, Noriyuki ^a   Sugimoto, Masayuki ^a   Murohara, Toyoaki ^a   Komori, Kimihiro ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; CD31 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; METFORMIN; ANGIOGENIC FACTOR; NOS3 PROTEIN, MOUSE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CONTROLLED STUDY; CRITICAL LIMB ISCHEMIA; DOPPLER FLOWMETRY; DRUG EFFECT; HINDLIMB; IN VIVO STUDY; LIMB PERFUSION; MALE; MODULATION; MOUSE; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVASCULARIZATION; STOMACH TUBE; ANIMAL; BLOOD FLOW; BLOOD FLOW VELOCITY; C57BL MOUSE; CAPILLARY; CONVALESCENCE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; ISCHEMIA; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TIME; VASCULARIZATION;

ADENYLATE KINASE; ANGIOGENESIS INDUCING AGENTS; ANIMALS; ANTIGENS, CD31; BLOOD FLOW VELOCITY; CAPILLARIES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HINDLIMB; ISCHEMIA; MALE; METFORMIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RECOVERY OF FUNCTION; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84921601341     PISSN: 07415214     EISSN: 10976809     Source Type: Journal    
DOI: 10.1016/j.jvs.2013.09.061     Document Type: Article

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