The phantom of lactic acidosis due to metformin in patients with diabetes

Diabetes Care

Volumn 27, Issue 7, 2004, Pages 1791-1793

  Misbin, Robert I ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; METFORMIN; PHENFORMIN; SULFONYLUREA;

CLINICAL TRIAL; DIABETES MELLITUS; DRUG APPROVAL; DRUG CHOICE; DRUG INDICATION; DRUG LABELING; DRUG SAFETY; FOOD AND DRUG ADMINISTRATION; HUMAN; HYPOGLYCEMIA; LACTIC ACIDOSIS; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW;

ACIDOSIS, LACTIC; DIABETES MELLITUS; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN;

EID: 3042798575     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.27.7.1791     Document Type: Review

References (35)

1. Meadows M: Why drugs get pulled off the market [article online], 2002. Available from http://www.fda.gov/fdac/features/2002/102_drug.html.
2. Misbin RI: Phenformin associated lactic acidosis: pathogenesis and treatment. Ann Intern Med 87:591-595, 1977
3. University Group Diabetes Program: A study of the effects of hypoglycemic agents on vascular complication in patients with adult-onset diabetes. V. Evaluation of phenformin therapy. Diabetes 24 (Suppl. 1):65-184, 1975
4. Campbell I: Metformin and the sulfonylureas: the comparative risk. Horm Metab Res 15 (Suppl.):105-111, 1985
5. Colwell JA: Is it time to introduce metformin in the United States? Diabetes Care 16:653-655, 1993
6. Crofford OB: Metformin (Editorial). N Engl J Med 333:588-589, 1995
7. Public Citizen: Do not use Glucophage (metformin). Worst Pills, Best Pills 1:5, 1995
8. Bergman U, Boman G, Wiholm BE: Epidemiology of adverse drug reactions to phenformin and metformin. Br Med J 2:464-466, 1978
9. Wiholm BE, Myred M: Metformin-associated lactic acidosis in Sweden 1977-1991. Eur J Clin Pharmacol 44:589-591, 1993
10. Cryer DR, Mills DJ, Henry DH, Nicholas SP: Comparative Outcomes Study of Metformin Intervention Versus Conventional Approach: the COSMIC approach study (Abstract). Diabetes 53 (Suppl. 1):A115, 2003
11. UK Prospective Diabetes Study Group: Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854-865, 1998
12. Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
13. Misbin RI: Placebo-controlled trials in type 2 diabetes (Commentary). Diabetes Care 24:773-774, 2001
14. Salpeter S, Greyber E, Pasternak G, Salpeter E: Risk of fatal and non-fatal lactic acidosis with metformin in type 2 diabetes. Cochrane Database Syst Rev 2: CD002967, 2003
15. Salpeter S, Greyber E, Pasternak G, Salpeter E: Risk of fatal and non-fatal lactic acidosis with metformin in type 2 diabetes. Arch Intern Med 163:2294-2602, 2003
16. Misbin RI, Green L, Stadel BV, Gueriguian JL, Gubbi A, Fleming GA: Lactic acidosis in patients with diabetes treated with metformin (Letter). N Engl J Med 338:265-266, 1998
17. Stades AME, Heikens JT, Erkelens DW, Holleman F, Hoekstra JBL: Metformin and lactic acidosis: cause or coincidence? A review of case reports. J Int Med 255: 179-187, 2004
18. Pepper GM, Schwartz M: Lactic acidosis associated with Glucophage use in a man with normal renal and hepatic function (Letter). Diabetes Care 20:232-233, 1997
19. Dawson D, Conlon C: Case study: metformin-associated lactic acidosis: could orlistat be relevant? (Letter). Diabetes Care 26:2471-2472, 2003
20. Stacpoole PW, Harman EM, Curry SH, Baumgartner TG, Misbin RI: Treatment of lactic acidosis with dichloroacetate. N Engl J Med 309:390-396, 1983
21. Lactic Acidosis Study Group: Natural history and course of acquired lactic acidosis in adults. Am J Med 97:47-54, 1994
22. Brown JB, Pedula K, Barzilay J, Herson MK, Latare P: Lactic acidosis rates in type 2 diabetes. Diabetes Care 21:1659-1663, 1998
23. Stacpoole PW: Metformin and lactic acidosis: guilt by association (Editorial). Diabetes Care 21:1587-1588, 1998
24. Jones GC, Macklin JP, Alexander WD: Contraindications to the use of metformin: evidence suggests that it is time to amend the list. BMJ 326:4-5, 2003
25. Lalau JD, Race JM: Lactic acidosis in metformin-treated patients: prognostic value of arterial lactate levels and plasma metformin concentration. Drug Saf 20:377-384, 1999
26. Sulkin TV, Bosman D, Krentz AJ: Contra-indications to metformin therapy in patients with NIDDM. Diabetes Care 20: 925-928, 1997
27. Emslie-Smith AM, Boyle DIR, Evans JMM, Sullivan F, Morris AD: Contraindications to metformin in patients with type 2 diabetes: a population-based study on adherence to prescribing guidelines. Diabet Med 18:483-488, 2001
28. Horlen C, Malone R, Bryant B, Dennis B, Carey T, Pignone M, Rothman R: Frequency of inappropriate metformin prescriptions (Letter). JAMA 287:2504-2505, 2002
29. Holstein I, Nahrwold D, Hinze S, Egberts EH: Contra-indications to metformin therapy largely disregarded. Diabet Med 16:692-696, 1999
30. Rachmani R, Slavachevski I, Levy Z, Zadok B, Kedar Y, Ravid M: Metformin in patients with type 2 diabetes: reconsideration of traditional contraindications. Eur J Intern Med 13:428-433, 2002
31. Masoudi FA, Wang Y, Inzucchi SE, Setaro JF, Havranek EP, Foody J, Krumholz HM: Metformin and thiazolidinedione use in Medicare patients with heart failure. JAMA 290:81-85, 2003
32. Lalau JD, Mourlhon C, Bergeret A, LaCroix C: Consequences of metformin intoxication (Letter). Diabetes Care 21: 2036-2037, 1998
33. Chang CT, Chen YC, Fang JT, Huang CC: Metformin-associated lactic acidosis: case reports and literature review. J Nephrol 15:398-402, 2002
34. Medical officer's review of glucophage overdoses and lactic acidosis. Rockville, MD, Food and Drug Administration, 2004
35. DeFronzo RA, Goodman AM: Efficacy of metformin in patients with non-insulin dependent diabetes mellitus. N Engl J Med 333:541-549, 1995