Metformin impairs spatial memory and visual acuity in old male mice

Aging and Disease

Volumn 8, Issue 1, 2017, Pages 17-30

  Thangthaeng, Nopporn ^a   Rutledge, Margaret ^a   Wong, Jessica M ^a   Vann, Philip H ^a   Forster, Michael J ^a   Sumien, Nathalie ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Aging; Antidiabetic; Antioxidant enzymes; Cognition; Metformin; Redox stress; Visual function

Indexed keywords

GLUCOSE; GLUTAMATE CYSTEINE LIGASE; GLUTAREDOXIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; METFORMIN; SUPEROXIDE DISMUTASE; THIOREDOXIN REDUCTASE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE MONITORING; BODY WEIGHT; BRAIN CORTEX; COGNITION; CONDITIONED AVOIDANCE RESPONSE TEST; CONTROLLED STUDY; DISCRIMINATED AVOIDANCE TEST; ENZYME ACTIVITY; EXERCISE TEST; EXPERIMENTAL LOCOMOTOR ACTIVITY TEST; FLUID INTAKE; FOOD INTAKE; HIPPOCAMPUS; LOCOMOTION; MALE; MIDDLE AGED; MORRIS WATER MAZE TEST; MOUSE; MUSCLE REFLEX; NONHUMAN; SPATIAL LEARNING; SPATIAL MEMORY; T-MAZE TEST; VISUAL ACUITY; WIRE SUSPENSION TEST; YOUNG ADULT;

EID: 85014171130     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2016.1010     Document Type: Article

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