Multi-targeting andrographolide, a novel NF-κB inhibitor, as a potential therapeutic agent for stroke

International Journal of Molecular Sciences

Volumn 18, Issue 8, 2017, Pages

  Yang, Chih Hao ^a   Yen, Ting Lin ^a,b   Hsu, Chia Yuan ^c   Thomas, Philip Aloysius ^d   Sheu, Joen Rong ^a   Jayakumar, Thanasekaran ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b CATHAY GENERAL HOSPITAL   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d JOSEPH EYE HOSPITAL   (India)

Author keywords

Andrographolide; Multi targets; Neuroprotection; Signaling pathways; Stroke

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANDROGRAPHOLIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; CASPASE 3; CASPASE 8; CYCLOOXYGENASE 2; GAMMA INTERFERON; HEME OXYGENASE 2; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROSTAGLANDIN E2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; DITERPENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPROTECTIVE AGENT;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTERY THROMBOSIS; BLOOD BRAIN BARRIER; BRAIN HEMORRHAGE; BRAIN INJURY; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CELL VIABILITY; DEGENERATIVE DISEASE; DOWN REGULATION; HUMAN; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; CEREBROVASCULAR ACCIDENT; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; DITERPENES; HUMANS; NEUROPROTECTION; NEUROPROTECTIVE AGENTS; NF-KAPPA B; STROKE;

EID: 85026659833     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18081638     Document Type: Review

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