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Volumn 7, Issue 12, 2006, Pages 1571-1581

Neuroprotection and thrombolysis: Combination therapy in acute ischaemic stroke

Author keywords

Cerebral ischaemia; Combination therapy; Ischaemic cascade; Neuroprotection; Penumbra; Stroke; Thrombolysis

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4 PHOSPHONOMETHYLPIPECOLIC ACID; ACETYLSALICYLIC ACID; ALTEPLASE; CALCIUM CHANNEL BLOCKING AGENT; CEREBROLYSIN; CITICOLINE; CLOMETHIAZOLE; DISUFENTON SODIUM; DIZOCILPINE; FIBRINOGEN RECEPTOR ANTAGONIST; FIBRINOLYTIC AGENT; FOSPHENYTOIN SODIUM; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; LUBELUZOLE; MAGNESIUM SULFATE; MONOCLONAL ANTIBODY; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; NEUTROPHIL INHIBITORY FACTOR; NIMODIPINE; PLACEBO; SCAVENGER; SODIUM CHANNEL BLOCKING AGENT; TENECTEPLASE; TIRILAZAD; TISSUE PLASMINOGEN ACTIVATOR; UK 279276; UNCLASSIFIED DRUG; UNINDEXED DRUG; UROKINASE;

EID: 33747033469     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.7.12.1571     Document Type: Review
Times cited : (41)

References (67)
  • 1
    • 0026567697 scopus 로고
    • Epidemiology of stroke
    • BONITA R: Epidemiology of stroke. Lancet (1992) 339:342-344.
    • (1992) Lancet , vol.339 , pp. 342-344
    • Bonita, R.1
  • 2
    • 4544368193 scopus 로고    scopus 로고
    • Stroke-incidence, mortality, morbidity and risk
    • INGALL T: Stroke-incidence, mortality, morbidity and risk. J. Insur. Med. (2004) 36(2):143-152.
    • (2004) J. Insur. Med. , vol.36 , Issue.2 , pp. 143-152
    • Ingall, T.1
  • 3
    • 11144315361 scopus 로고    scopus 로고
    • What MONICA told us about stroke
    • ASPLUND K: What MONICA told us about stroke. Lancet Neurol. (2005) 4(1):64-68.
    • (2005) Lancet Neurol. , vol.4 , Issue.1 , pp. 64-68
    • Asplund, K.1
  • 4
    • 0031655731 scopus 로고    scopus 로고
    • tPA in acute ischemic stroke: United States experience and issues for the future
    • ALBERTS MJ: tPA in acute ischemic stroke: United States experience and issues for the future. Neurology (1998) 51(3 Suppl. 3):S53-S55.
    • (1998) Neurology , vol.51 , Issue.3 SUPPL. 3
    • Alberts, M.J.1
  • 5
    • 0037425137 scopus 로고    scopus 로고
    • Strategies to improve outcomes after acute stroke
    • DONNAN GA, DAVIS SM, LEVI CR: Strategies to improve outcomes after acute stroke. Med. J. Aust. (2003) 178(7):309-310.
    • (2003) Med. J. Aust. , vol.178 , Issue.7 , pp. 309-310
    • Donnan, G.A.1    Davis, S.M.2    Levi, C.R.3
  • 6
    • 4243813076 scopus 로고    scopus 로고
    • Australian survey of hospital services for stroke
    • OGDEN K CD, PEARCE D: Australian survey of hospital services for stroke. Cerebrovasc. Dis. (2001) 11(Suppl. 4):A93.
    • (2001) Cerebrovasc. Dis. , vol.11 , Issue.SUPPL. 4
    • Ogden, K.C.D.1    Pearce, D.2
  • 7
    • 20644462132 scopus 로고    scopus 로고
    • Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000
    • GROTTA JC, BURGIN WS, EL-MITWALLI A et al.: Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000. Arch. Neurol. (2001) 58(12):2009-2013.
    • (2001) Arch. Neurol. , vol.58 , Issue.12 , pp. 2009-2013
    • Grotta, J.C.1    Burgin, W.S.2    El-mitwalli, A.3
  • 8
    • 0033848141 scopus 로고    scopus 로고
    • Ischemic penumbra: Evidence from functional imaging in man
    • HEISS WD: Ischemic penumbra: evidence from functional imaging in man. J. Cereb. Blood Flow Metab. (2000) 20:1276-1293.
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 1276-1293
    • Heiss, W.D.1
  • 9
    • 0019822988 scopus 로고
    • Thresholds in cerebral ischemia - The ischemic penumbra
    • ASTRUP J, SIESJO BK, SYMON L: Thresholds in cerebral ischemia - the ischemic penumbra. Stroke (1981) 12(6):723-725.
    • (1981) Stroke , vol.12 , Issue.6 , pp. 723-725
    • Astrup, J.1    Siesjo, B.K.2    Symon, L.3
  • 10
    • 13944278763 scopus 로고    scopus 로고
    • Selection of thrombolytic therapy beyond 3 h using magnetic resonance imaging
    • DAVIS SM, DONNAN GA, BUTCHER KS, PARSONS M: Selection of thrombolytic therapy beyond 3 h using magnetic resonance imaging. Curr. Opin. Neurol. (2005) 18(1):47-52.
    • (2005) Curr. Opin. Neurol. , vol.18 , Issue.1 , pp. 47-52
    • Davis, S.M.1    Donnan, G.A.2    Butcher, K.S.3    Parsons, M.4
  • 11
    • 0038029709 scopus 로고    scopus 로고
    • Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy
    • DONNAN GA, DAVIS SM: Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy. Lancet Neurol. (2002) 1(7):417-425.
    • (2002) Lancet Neurol. , vol.1 , Issue.7 , pp. 417-425
    • Donnan, G.A.1    Davis, S.M.2
  • 12
  • 13
    • 0037224703 scopus 로고    scopus 로고
    • Adventures in the pathophysiology of brain ischemia: Penumbra, gene expression, neuroprotection: The 2002 Thomas Willis Lecture
    • GINSBERG MD: Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke (2003) 34(1):214-223.
    • (2003) Stroke , vol.34 , Issue.1 , pp. 214-223
    • Ginsberg, M.D.1
  • 14
    • 2942538277 scopus 로고    scopus 로고
    • Hypoxic tissue in ischaemic stroke: Persistence and clinical consequences of spontaneous survival
    • MARKUS R, REUTENS DC, KAZUI S et al.: Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival. Brain (2004) 127(Pt 6):1427-1436.
    • (2004) Brain , vol.127 , Issue.PART 6 , pp. 1427-1436
    • Markus, R.1    Reutens, D.C.2    Kazui, S.3
  • 15
    • 0036327385 scopus 로고    scopus 로고
    • Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients
    • WINTERMARK M, REICHHART M, CUISENAIRE O et al.: Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients. Stroke (2002) 33(8):2025-2031.
    • (2002) Stroke , vol.33 , Issue.8 , pp. 2025-2031
    • Wintermark, M.1    Reichhart, M.2    Cuisenaire, O.3
  • 16
    • 33645817175 scopus 로고    scopus 로고
    • Perfusion-CT assessment of infarct core and penumbra: Receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke
    • WINTERMARK M, FLANDERS AE, VELTHUIS B et al.: Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke (2006) 37(4):979-985.
    • (2006) Stroke , vol.37 , Issue.4 , pp. 979-985
    • Wintermark, M.1    Flanders, A.E.2    Velthuis, B.3
  • 17
    • 1542315556 scopus 로고    scopus 로고
    • Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
    • HACKE W, DONNAN G, FIESCHI C et al.: Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet (2004) 363:768-774.
    • (2004) Lancet , vol.363 , pp. 768-774
    • Hacke, W.1    Donnan, G.2    Fieschi, C.3
  • 18
    • 1842586172 scopus 로고    scopus 로고
    • Cerebral ischemia and reperfusion: The pathophysiologic concept as a basis for clinical therapy
    • SCHALLER B, GRAF R: Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J. Cereb. Blood Flow Metab. (2004) 24(4):351-371.
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , Issue.4 , pp. 351-371
    • Schaller, B.1    Graf, R.2
  • 19
    • 5444233626 scopus 로고    scopus 로고
    • Pathophysiology of stroke: Lessons from animal models
    • MERGENTHALER P, DIRNAGL U, MEISEL A: Pathophysiology of stroke: lessons from animal models. Metab. Brain Dis. (2004) 19(3-4):151-167.
    • (2004) Metab. Brain Dis. , vol.19 , Issue.3-4 , pp. 151-167
    • Mergenthaler, P.1    Dirnagl, U.2    Meisel, A.3
  • 20
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • DIRNAGL U, IADECOLA C, MOSKOWITZ MA: Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. (1999) 22(9):391-397.
    • (1999) Trends Neurosci. , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 21
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • LO EH, DALKARA T, MOSKOWITZ MA: Mechanisms, challenges and opportunities in stroke. Nat. Rev. Neurosci. (2003) 4(5):399-415.
    • (2003) Nat. Rev. Neurosci. , vol.4 , Issue.5 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 22
    • 0034983276 scopus 로고    scopus 로고
    • Trends in acute ischemic stroke trials through the 20th century
    • KIDWELL CS, LIEBESKIND DS, STARKMAN S, SAVER JL: Trends in acute ischemic stroke trials through the 20th century. Stroke (2001) 32(6):1349-1359.
    • (2001) Stroke , vol.32 , Issue.6 , pp. 1349-1359
    • Kidwell, C.S.1    Liebeskind, D.S.2    Starkman, S.3    Saver, J.L.4
  • 23
    • 0035134255 scopus 로고    scopus 로고
    • Very Early Nimodipine Use in Stroke (VENUS): A randomized, double-blind, placebo-controlled trial
    • HORN J, DE HAAN RJ, VERMEULEN M, LIMBURG M: Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial. Stroke (2001) 32(2):461-465.
    • (2001) Stroke , vol.32 , Issue.2 , pp. 461-465
    • Horn, J.1    De Haan, R.J.2    Vermeulen, M.3    Limburg, M.4
  • 25
    • 0031438509 scopus 로고    scopus 로고
    • Lubeluzole treatment of acute ischemic stroke
    • The US and Canadian Lubeluzole Ischemic Stroke Study Group
    • GROTTA J: Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group. Stroke (1997) 28(12):2338-2346.
    • (1997) Stroke , vol.28 , Issue.12 , pp. 2338-2346
    • Grotta, J.1
  • 26
    • 0033766740 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
    • DIENER HC, CORTENS M, FORD G et al.: Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. Stroke (2000) 31(11):2543-2551.
    • (2000) Stroke , vol.31 , Issue.11 , pp. 2543-2551
    • Diener, H.C.1    Cortens, M.2    Ford, G.3
  • 27
    • 0034780566 scopus 로고    scopus 로고
    • Combination Therapy Stroke Trial: Recombinant tissue-type plasminogen activator with/without lubeluzole
    • GROTTA J: Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole. Cerebrovasc Dis. (2001) 12(3):258-263.
    • (2001) Cerebrovasc Dis. , vol.12 , Issue.3 , pp. 258-263
    • Grotta, J.1
  • 28
    • 0032953495 scopus 로고    scopus 로고
    • Clomethiazole acute stroke study (CLASS): Results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients
    • WAHLGREN NG, RANASINHA KW, ROSOLACCI T et al.: Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients. Stroke (1999) 30(1):21-28.
    • (1999) Stroke , vol.30 , Issue.1 , pp. 21-28
    • Wahlgren, N.G.1    Ranasinha, K.W.2    Rosolacci, T.3
  • 29
    • 18244392468 scopus 로고    scopus 로고
    • Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): Final results
    • LYDEN P, SHUAIB A, NG K et al.: Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results. Stroke (2002) 33(1):122-128.
    • (2002) Stroke , vol.33 , Issue.1 , pp. 122-128
    • Lyden, P.1    Shuaib, A.2    Ng, K.3
  • 30
    • 0043204506 scopus 로고    scopus 로고
    • A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS): The RANTTAS Investigators
    • A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS): the RANTTAS Investigators. Stroke (1996) 27(9):1453-1458.
    • (1996) Stroke , vol.27 , Issue.9 , pp. 1453-1458
  • 31
    • 0031781078 scopus 로고    scopus 로고
    • High-dose tirilazad for acute stroke (RANTTAS II) RANTTAS II Investigators
    • HALEY EC Jr: High-dose tirilazad for acute stroke (RANTTAS II) RANTTAS II Investigators. Stroke (1998) 29(6):1256-1257.
    • (1998) Stroke , vol.29 , Issue.6 , pp. 1256-1257
    • Haley Jr., E.C.1
  • 32
    • 0037039233 scopus 로고    scopus 로고
    • The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke
    • VAN DER WORP HB, KAPPELLE LJ, ALGRA A et al.: The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. Neurology (2002) 58(1):133-135.
    • (2002) Neurology , vol.58 , Issue.1 , pp. 133-135
    • Van Der Worp, H.B.1    Kappelle, L.J.2    Algra, A.3
  • 33
    • 0037319241 scopus 로고    scopus 로고
    • Tolerability of NXY-059 at higher target concentrations in patients with acute stroke
    • LEES KR, BARER D, FORD GA et al.: Tolerability of NXY-059 at higher target concentrations in patients with acute stroke. Stroke (2003) 34(2):482-487.
    • (2003) Stroke , vol.34 , Issue.2 , pp. 482-487
    • Lees, K.R.1    Barer, D.2    Ford, G.A.3
  • 34
    • 0034745231 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke
    • LEES KR, SHARMA AK, BARER D et al.: Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke. Stroke (2001) 32(3):675-680.
    • (2001) Stroke , vol.32 , Issue.3 , pp. 675-680
    • Lees, K.R.1    Sharma, A.K.2    Barer, D.3
  • 35
    • 32144453826 scopus 로고    scopus 로고
    • NXY-059 for acute ischemic stroke
    • LEES KR, ZIVIN JA, ASHWOOD T et al.: NXY-059 for acute ischemic stroke. N. Engl. J. Med. (2006) 354(6):588-600.
    • (2006) N. Engl. J. Med. , vol.354 , Issue.6 , pp. 588-600
    • Lees, K.R.1    Zivin, J.A.2    Ashwood, T.3
  • 36
    • 0033951941 scopus 로고    scopus 로고
    • Selfotel in acute ischemic stroke: Possible neurotoxic effects of an NMDA antagonist
    • DAVIS SM, LEES KR, ALBERS GW et al.: Selfotel in acute ischemic stroke: possible neurotoxic effects of an NMDA antagonist. Stroke (2000) 31(2):347-354.
    • (2000) Stroke , vol.31 , Issue.2 , pp. 347-354
    • Davis, S.M.1    Lees, K.R.2    Albers, G.W.3
  • 37
    • 2942700683 scopus 로고    scopus 로고
    • Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): Randomised controlled trial
    • MUIR KW, LEES KR, FORD I, DAVIS S: Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet (2004) 363(9407):439-445.
    • (2004) Lancet , vol.363 , Issue.9407 , pp. 439-445
    • Muir, K.W.1    Lees, K.R.2    Ford, I.3    Davis, S.4
  • 38
    • 2342535001 scopus 로고    scopus 로고
    • Prehospital neuroprotective therapy for acute stroke: Results of the Field Administration of Stroke Therapy - Magnesium (FAST - MAG) pilot trial
    • SAVER JL, KIDWELL C, ECKSTEIN M, STARKMAN S: Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy - Magnesium (FAST - MAG) pilot trial. Stroke (2004) 35(5):e106-e108.
    • (2004) Stroke , vol.35 , Issue.5
    • Saver, J.L.1    Kidwell, C.2    Eckstein, M.3    Starkman, S.4
  • 39
    • 0030760430 scopus 로고    scopus 로고
    • A randomized dose-response trial of citicoline in acute ischemic stroke patients
    • Citicoline Stroke Study Group
    • CLARK WM, WARACH SJ, PETTIGREW LC, GAMMANS RE, SABOUNJIAN LA: A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group. Neurology (1997) 49(3):671-678.
    • (1997) Neurology , vol.49 , Issue.3 , pp. 671-678
    • Clark, W.M.1    Warach, S.J.2    Pettigrew, L.C.3    Gammans, R.E.4    Sabounjian, L.A.5
  • 40
    • 0032709479 scopus 로고    scopus 로고
    • A randomized efficacy trial of citicoline in patients with acute ischemic stroke
    • CLARK WM, WILLIAMS BJ, SELZER KA et al.: A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke (1999) 30(12):2592-2597.
    • (1999) Stroke , vol.30 , Issue.12 , pp. 2592-2597
    • Clark, W.M.1    Williams, B.J.2    Selzer, K.A.3
  • 41
    • 0035856456 scopus 로고    scopus 로고
    • A Phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients
    • CLARK WM, WECHSLER LR, SABOUNJIAN LA, SCHWIDERSKI UE: A Phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology (2001) 57(9):1595-602.
    • (2001) Neurology , vol.57 , Issue.9 , pp. 1595-1602
    • Clark, W.M.1    Wechsler, L.R.2    Sabounjian, L.A.3    Schwiderski, U.E.4
  • 42
    • 0033757829 scopus 로고    scopus 로고
    • Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging
    • Citicoline 010 Investigators
    • WARACH S, PETTIGREW LC, DASHE JF et al.: Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators. Ann. Neurol. (2000) 48(5):713-722.
    • (2000) Ann. Neurol. , vol.48 , Issue.5 , pp. 713-722
    • Warach, S.1    Pettigrew, L.C.2    Dashe, J.F.3
  • 43
    • 0035940577 scopus 로고    scopus 로고
    • Use of anti-ICAM-1 therapy in ischemic stroke: Results of the Enlimomab Acute Stroke Trial
    • ENLIMOMAB ACUTE STROKE TRIAL INVESTIGATORS:
    • ENLIMOMAB ACUTE STROKE TRIAL INVESTIGATORS: Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial. Neurology (2001) 57(8):1428-1434.
    • (2001) Neurology , vol.57 , Issue.8 , pp. 1428-1434
  • 44
    • 20944431799 scopus 로고    scopus 로고
    • Neuroprotective treatment with cerebrolysin in patients with acute stroke: A randomised controlled trial
    • LADURNER G, KALVACH P, MOESSLER H: Neuroprotective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. J. Neural Transm. (2005) 112(3):415-428.
    • (2005) J. Neural Transm. , vol.112 , Issue.3 , pp. 415-428
    • Ladurner, G.1    Kalvach, P.2    Moessler, H.3
  • 45
    • 3242787149 scopus 로고    scopus 로고
    • Cooling for Acute Ischemic Brain Damage (COOL AID): A feasibility trial of endovascular cooling
    • DE GEORGIA MA, KRIEGER DW, ABOU-CHEBL A et al.: Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology (2004) 63(2):312-317.
    • (2004) Neurology , vol.63 , Issue.2 , pp. 312-317
    • De Georgia, M.A.1    Krieger, D.W.2    Abou-chebl, A.3
  • 46
    • 10344226664 scopus 로고    scopus 로고
    • Vascular aspects of neuroprotection
    • TAKAHASHI M, MACDONALD RL: Vascular aspects of neuroprotection. Neurol. Res. (2004) 26(8):862-869.
    • (2004) Neurol. Res. , vol.26 , Issue.8 , pp. 862-869
    • Takahashi, M.1    Macdonald, R.L.2
  • 47
    • 0031723801 scopus 로고    scopus 로고
    • Spontaneous reperfusion after ischemic stroke is associated with improved outcome
    • BARBER PA, DAVIS SM, INFELD B et al.: Spontaneous reperfusion after ischemic stroke is associated with improved outcome. Stroke (1998) 29(12):2522-2528.
    • (1998) Stroke , vol.29 , Issue.12 , pp. 2522-2528
    • Barber, P.A.1    Davis, S.M.2    Infeld, B.3
  • 48
    • 0026652877 scopus 로고
    • Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats
    • XUE D, SLIVKA A, BUCHAN AM: Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats. Stroke (1992) 23(6):894-899.
    • (1992) Stroke , vol.23 , Issue.6 , pp. 894-899
    • Xue, D.1    Slivka, A.2    Buchan, A.M.3
  • 49
    • 0036158487 scopus 로고    scopus 로고
    • Re: Stroke Therapy Academic Industry Roundtable II (STAIR-II)
    • BATH P: Re: Stroke Therapy Academic Industry Roundtable II (STAIR-II). Stroke (2002) 33(2):639-640.
    • (2002) Stroke , vol.33 , Issue.2 , pp. 639-640
    • Bath, P.1
  • 50
    • 9444284316 scopus 로고    scopus 로고
    • Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model
    • ZHANG L, ZHANG ZG, ZHANG C, ZHANG RL, CHOPP M: Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model. Stroke (2004) 35(12):2890-2895.
    • (2004) Stroke , vol.5 , Issue.12 , pp. 2890-2895
    • Zhang, L.1    Zhang, Z.G.2    Zhang, C.3    Zhang, R.L.4    Chopp, M.5
  • 51
    • 0032985429 scopus 로고    scopus 로고
    • Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model
    • ANDERSEN M, OVERGAARD K, MEDEN P, BOYSEN G, CHOI SC: Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model. Stroke (1999) 30(7):1464-1471.
    • (1999) Stroke , vol.30 , Issue.7 , pp. 1464-1471
    • Andersen, M.1    Overgaard, K.2    Meden, P.3    Boysen, G.4    Choi, S.C.5
  • 52
    • 0034055662 scopus 로고    scopus 로고
    • Evaluating the efficacy of citicoline in embolic ischemic stroke in rats: Neuroprotective effects when used alone or in combination with urokinase
    • SHUAIB A, YANG Y, LI Q: Evaluating the efficacy of citicoline in embolic ischemic stroke in rats: neuroprotective effects when used alone or in combination with urokinase. Exp. Neurol. (2000) 161(2):733-739.
    • (2000) Exp. Neurol. , vol.161 , Issue.2 , pp. 733-739
    • Shuaib, A.1    Yang, Y.2    Li, Q.3
  • 53
    • 0028911203 scopus 로고
    • Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy
    • BOWES MP, ROTHLEIN R, FAGAN SC, ZIVIN JA: Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy. Neurology (1995) 45(4):815-819.
    • (1995) Neurology , vol.45 , Issue.4 , pp. 815-819
    • Bowes, M.P.1    Rothlein, R.2    Fagan, S.C.3    Zivin, J.A.4
  • 54
    • 0001373003 scopus 로고    scopus 로고
    • Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain
    • ZHANG RL, ZHANG ZG, CHOPP M, ZIVIN JA: Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain. Stroke (1999) 30(3):624-629.
    • (1999) Stroke , vol.30 , Issue.3 , pp. 624-629
    • Zhang, R.L.1    Zhang, Z.G.2    Chopp, M.3    Zivin, J.A.4
  • 55
    • 0031474759 scopus 로고    scopus 로고
    • Neutoprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model
    • LEKIEFFRE D, BENAVIDES J, SCATTON B, NOWICKI JP: Neutoprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model. Brain Res. (1997) 776(1-2):88-95.
    • (1997) Brain Res. , vol.776 , Issue.1-2 , pp. 88-95
    • Lekieffre, D.1    Benavides, J.2    Scatton, B.3    Nowicki, J.P.4
  • 56
    • 0027431207 scopus 로고
    • Neuroprotection by excitatory amino acid antagonist augments the benefit of thrombolysis in embolic stroke in rats
    • SEREGHY T, OVERGAARD K, BOYSEN G: Neuroprotection by excitatory amino acid antagonist augments the benefit of thrombolysis in embolic stroke in rats. Stroke (1993) 24(11):1702-1708.
    • (1993) Stroke , vol.24 , Issue.11 , pp. 1702-1708
    • Sereghy, T.1    Overgaard, K.2    Boysen, G.3
  • 57
    • 0025165826 scopus 로고
    • Background review and current concepts of reperfusion injury
    • HALLENBECK JM, DUTKA AJ: Background review and current concepts of reperfusion injury. Arch. Neurol. (1990) 47(11):1245-1254.
    • (1990) Arch. Neurol. , vol.47 , Issue.11 , pp. 1245-1254
    • Hallenbeck, J.M.1    Dutka, A.J.2
  • 58
    • 7644223379 scopus 로고    scopus 로고
    • Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption
    • WARACH S, LATOUR LL: Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke (2004) 35(11 Suppl. 1):2659-2661.
    • (2004) Stroke , vol.35 , Issue.11 SUPPL. 1 , pp. 2659-2661
    • Warach, S.1    Latour, L.L.2
  • 59
    • 0036895552 scopus 로고    scopus 로고
    • Late secondary ischemic injury in patients receiving intraarterial thrombolysis
    • KIDWELL CS, SAVER JL, STARKMAN S et al.: Late secondary ischemic injury in patients receiving intraarterial thrombolysis. Ann. Neurol. (2002) 52(6):698-703.
    • (2002) Ann. Neurol. , vol.52 , Issue.6 , pp. 698-703
    • Kidwell, C.S.1    Saver, J.L.2    Starkman, S.3
  • 60
    • 0242694372 scopus 로고    scopus 로고
    • Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): An adaptive dose-response study of UK-279,276 in acute ischemic stroke
    • KRAMS M, LEES KR, HACKE W et al.: Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke. Stroke (2003) 34(11):2543-2548.
    • (2003) Stroke , vol.34 , Issue.11 , pp. 2543-2548
    • Krams, M.1    Lees, K.R.2    Hacke, W.3
  • 61
    • 0035833953 scopus 로고    scopus 로고
    • The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): Final results
    • LYDEN P, JACOBY M, SCHIM J et al.: The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results. Neurology (2001) 57(7):1199-205.
    • (2001) Neurology , vol.57 , Issue.7 , pp. 1199-1205
    • Lyden, P.1    Jacoby, M.2    Schim, J.3
  • 64
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • Tissue plasminogen activator for acute ischemic stroke: the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N. Engl. J. Med. (1995) 333(24):1581-1587.
    • (1995) N. Engl. J. Med. , vol.333 , Issue.24 , pp. 1581-1587
  • 65
    • 0035942340 scopus 로고    scopus 로고
    • Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility
    • BARBER PA, ZHANG J, DEMCHUK AM, HILL MD, BUCHAN AM: Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology (2001) 56(8):1015-1020.
    • (2001) Neurology , vol.56 , Issue.8 , pp. 1015-1020
    • Barber, P.A.1    Zhang, J.2    Demchuk, A.M.3    Hill, M.D.4    Buchan, A.M.5
  • 66
    • 0037425148 scopus 로고    scopus 로고
    • Time to hospital admission for acute stroke: An observational study
    • BROADLEY SA, THOMPSON PD: Time to hospital admission for acute stroke: an observational study. Med. J. Aust. (2003) 178(7):329-331.
    • (2003) Med. J. Aust. , vol.178 , Issue.7 , pp. 329-331
    • Broadley, S.A.1    Thompson, P.D.2
  • 67
    • 0023611671 scopus 로고
    • Role of neutrophils in ischemia-reperfusion-induced microvascular injury
    • HERNANDEZ LA, GRISHAM MB, TWOHIG B et al.: Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am. J. Physiol. (1987) 253(3 Pt 2):H699-H703.
    • (1987) Am. J. Physiol. , vol.253 , Issue.3 PART 2
    • Hernandez, L.A.1    Grisham, M.B.2    Twohig, B.3


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