메뉴 건너뛰기




Volumn 28, Issue 5, 2007, Pages 601-608

JNK pathway: Diseases and therapeutic potential

Author keywords

Diseases; Inhibitors; JNK pathway; Signal transduction

Indexed keywords

1,3 BENZOTHIAZOL 2 YL[2 [[2 (3 PYRIDINYL)ETHYL]AMINO] 4 PYRIDINYL]ACETONITRILE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; AS 601245; CEP 1347; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 34247580832     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00579.x     Document Type: Review
Times cited : (146)

References (75)
  • 1
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000 103 : 239 5.
    • (2000) Cell , vol.103 , pp. 239-5
    • Davis, R.J.1
  • 2
  • 3
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001 22 : 153 83.
    • (2001) Endocr Rev , vol.22 , pp. 153-83
    • Pearson, G.1    Robinson, F.2    Beers Gibson, T.3    Xu, B.E.4    Karandikar, M.5    Berman, K.6
  • 5
    • 0038004740 scopus 로고    scopus 로고
    • Targeting JNK for therapeutic benefit: From junk to gold
    • Manning AM, Davis RJ. Targeting JNK for therapeutic benefit: from junk to gold Nat Rev Drug Discov 2003 2 : 554 65.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 554-65
    • Manning, A.M.1    Davis, R.J.2
  • 6
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001 81 : 807 69.
    • (2001) Physiol Rev , vol.81 , pp. 807-69
    • Kyriakis, J.M.1    Avruch, J.2
  • 7
    • 0024997935 scopus 로고
    • Pp54 microtubule-associated protein 2 kinase. a novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine
    • Kyriakis JM, Avruch, J. pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine. J Biol Chem 1990 265 : 17355 63.
    • (1990) J Biol Chem , vol.265 , pp. 17355-63
    • Kyriakis, J.M.1    Avruch, J.2
  • 9
    • 0033231020 scopus 로고    scopus 로고
    • From receptors to stress-activated MAP kinase
    • Ichijo H. From receptors to stress-activated MAP kinase. Oncogene 1999 18 : 6087 93.
    • (1999) Oncogene , vol.18 , pp. 6087-93
    • Ichijo, H.1
  • 10
    • 0030780804 scopus 로고    scopus 로고
    • Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    • Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997 389 : 865 70.
    • (1997) Nature , vol.389 , pp. 865-70
    • Yang, D.D.1    Kuan, C.Y.2    Whitmarsh, A.J.3    Rincon, M.4    Zheng, T.S.5    Davis, R.J.6
  • 11
    • 0032692497 scopus 로고    scopus 로고
    • CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC 12 cells from death evoked by three distinct insults
    • Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, et al. CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC 12 cells from death evoked by three distinct insults. J Neurochem 1999 73 : 1901 12.
    • (1999) J Neurochem , vol.73 , pp. 1901-12
    • Maroney, A.C.1    Finn, J.P.2    Bozyczko-Coyne, D.3    O'Kane, T.M.4    Neff, N.T.5    Tolkovsky, A.M.6
  • 13
    • 0036498974 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons
    • Trotter L, Panton W, Hajimohamadreza I, Petalidis L, Ward R, Fleming Y, et al. Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Neurosci Lett 2002 320 : 29 32.
    • (2002) Neurosci Lett , vol.320 , pp. 29-32
    • Trotter, L.1    Panton, W.2    Hajimohamadreza, I.3    Petalidis, L.4    Ward, R.5    Fleming, Y.6
  • 14
    • 0037439170 scopus 로고    scopus 로고
    • POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis
    • Xu Z, Kukekov NV, Greene LA. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J 2003 15 22 : 252 61.
    • (2003) EMBO J , vol.15 , Issue.22 , pp. 252-61
    • Xu, Z.1    Kukekov, N.V.2    Greene, L.A.3
  • 15
    • 27644568141 scopus 로고    scopus 로고
    • Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop
    • Xu Z, Kukekov NV, Greene LA. Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop. Mol Cell Biol 2005 25 : 9949 59.
    • (2005) Mol Cell Biol , vol.25 , pp. 9949-59
    • Xu, Z.1    Kukekov, N.V.2    Greene, L.A.3
  • 16
    • 33644855733 scopus 로고    scopus 로고
    • Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis
    • Xu Z, Sproul A, Wang W, Kukekov N, Greene LA. Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis. J Biol Chem 2006 281 : 303 12.
    • (2006) J Biol Chem , vol.281 , pp. 303-12
    • Xu, Z.1    Sproul, A.2    Wang, W.3    Kukekov, N.4    Greene, L.A.5
  • 17
    • 32144434256 scopus 로고    scopus 로고
    • Activation of the apoptotic JNK pathway through the Rac1-binding scaffold protein POSH
    • Xu Z, Greene LA. Activation of the apoptotic JNK pathway through the Rac1-binding scaffold protein POSH. Methods Enzymol 2006 406 : 479 89.
    • (2006) Methods Enzymol , vol.406 , pp. 479-89
    • Xu, Z.1    Greene, L.A.2
  • 21
    • 33744950092 scopus 로고    scopus 로고
    • Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs
    • Kukekov NV, Xu Z, Greene LA. Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. J Biol Chem 2006 281 : 15517 24.
    • (2006) J Biol Chem , vol.281 , pp. 15517-24
    • Kukekov, N.V.1    Xu, Z.2    Greene, L.A.3
  • 22
    • 0029885419 scopus 로고    scopus 로고
    • Selective interaction of JNK protein kinase isoforms with transcription factors
    • Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 1996 15 : 2760 70.
    • (1996) EMBO J , vol.15 , pp. 2760-70
    • Gupta, S.1    Barrett, T.2    Whitmarsh, A.J.3    Cavanagh, J.4    Sluss, H.K.5    Derijard, B.6
  • 23
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994 76 : 1025 37.
    • (1994) Cell , vol.76 , pp. 1025-37
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6
  • 24
    • 0028905076 scopus 로고
    • Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • Gupta S, Campbell D, Derijard B, Davis RJ. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 1995 267 : 389 93.
    • (1995) Science , vol.267 , pp. 389-93
    • Gupta, S.1    Campbell, D.2    Derijard, B.3    Davis, R.J.4
  • 26
    • 0030706186 scopus 로고    scopus 로고
    • Nuclear accumulation of NFAT4 opposed by the JNK signaling pathway
    • Chow CW, Rico MN, Cavanagh J, Dickens M, Davis RJ. Nuclear accumulation of NFAT4 opposed by the JNK signaling pathway. Science 1997 278 : 1638 41.
    • (1997) Science , vol.278 , pp. 1638-41
    • Chow, C.W.1    Rico, M.N.2    Cavanagh, J.3    Dickens, M.4    Davis, R.J.5
  • 27
    • 0034745050 scopus 로고    scopus 로고
    • Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcription activities in response to stress
    • Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, et al. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcription activities in response to stress. Mol Cell Biol 2001 21 : 2743 54.
    • (2001) Mol Cell Biol , vol.21 , pp. 2743-54
    • Buschmann, T.1    Potapova, O.2    Bar-Shira, A.3    Ivanov, V.N.4    Fuchs, S.Y.5    Henderson, S.6
  • 28
    • 0034607702 scopus 로고    scopus 로고
    • Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    • Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000 288 : 870 4.
    • (2000) Science , vol.288 , pp. 870-4
    • Tournier, C.1    Hess, P.2    Yang, D.D.3    Xu, J.4    Turner, T.K.5    Nimnual, A.6
  • 29
    • 15644381250 scopus 로고    scopus 로고
    • Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress- activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1
    • Maundrell K, Antonsson B, Magnenat E, Camps M, Muda M, Chabert C, et al. Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. J Biol Chem 1997 272 : 25238 42.
    • (1997) J Biol Chem , vol.272 , pp. 25238-42
    • Maundrell, K.1    Antonsson, B.2    Magnenat, E.3    Camps, M.4    Muda, M.5    Chabert, C.6
  • 30
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol cell Biol 1999 19 : 8469 78.
    • (1999) Mol Cell Biol , vol.19 , pp. 8469-78
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 31
    • 0034614658 scopus 로고    scopus 로고
    • Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage
    • Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, et al. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem 2000 275 : 322 7.
    • (2000) J Biol Chem , vol.275 , pp. 322-7
    • Kharbanda, S.1    Saxena, S.2    Yoshida, K.3    Pandey, P.4    Kaneki, M.5    Wang, Q.6
  • 32
    • 0037174934 scopus 로고    scopus 로고
    • JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery
    • Donovan N, Becker EB, Konishi Y, Bonni A. JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 2002 277 : 40944 9.
    • (2002) J Biol Chem , vol.277 , pp. 40944-9
    • Donovan, N.1    Becker, E.B.2    Konishi, Y.3    Bonni, A.4
  • 33
    • 0037418238 scopus 로고    scopus 로고
    • JNK phosphorylation of Bim-related members of the Bcl-2 family induces Bax-dependent apoptosis
    • Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl-2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA 2003 100 : 2432 7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2432-7
    • Lei, K.1    Davis, R.J.2
  • 34
    • 25844458239 scopus 로고    scopus 로고
    • Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies
    • Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribe E, Dalfo E, et al. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Curr Alzheimer Res 2005 2 : 3 18.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 3-18
    • Ferrer, I.1    Gomez-Isla, T.2    Puig, B.3    Freixes, M.4    Ribe, E.5    Dalfo, E.6
  • 35
    • 0036580703 scopus 로고    scopus 로고
    • Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
    • Savage MJ, Lin YG, Ciallella JR, Flood DG, Scott RW, et al. Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition. J Neurosci 2002 22 : 3376 85.
    • (2002) J Neurosci , vol.22 , pp. 3376-85
    • Savage, M.J.1    Lin, Y.G.2    Ciallella, J.R.3    Flood, D.G.4    Scott, R.W.5
  • 36
    • 33747177369 scopus 로고    scopus 로고
    • Signaling mechanisms underlying Abeta toxicity: Potential therapeutic targets for Alzheimer's disease
    • Smith WW, Gorospe M, Kusiak JW. Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease. CNS Neurol Disord Drug Targets 2006 5 : 355 61.
    • (2006) CNS Neurol Disord Drug Targets , vol.5 , pp. 355-61
    • Smith, W.W.1    Gorospe, M.2    Kusiak, J.W.3
  • 37
    • 0346374790 scopus 로고    scopus 로고
    • JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease
    • Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, et al. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci USA 2004 101 : 665 70.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 665-70
    • Hunot, S.1    Vila, M.2    Teismann, P.3    Davis, R.J.4    Hirsch, E.C.5    Przedborski, S.6
  • 38
    • 0035964358 scopus 로고    scopus 로고
    • Gene transfer of the JNK interacting protein-1 protects dopam-inergic neurons in the MPTP model of Parkinson's disease
    • Xia XG, Harding T, Weller M, Bieneman A, Uney JB, Schulz JB. Gene transfer of the JNK interacting protein-1 protects dopam-inergic neurons in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001 98 : 10433 8.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10433-8
    • Xia, X.G.1    Harding, T.2    Weller, M.3    Bieneman, A.4    Uney, J.B.5    Schulz, J.B.6
  • 39
    • 20844450752 scopus 로고    scopus 로고
    • Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy
    • Kuan CY, Burke RE. Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. Curr Drug Targets CNS Neurol Disord 2005 4 : 63 7.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 63-7
    • Kuan, C.Y.1    Burke, R.E.2
  • 40
    • 0032527879 scopus 로고    scopus 로고
    • Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
    • Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, et al. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci 1998 18 : 5124 35.
    • (1998) J Neurosci , vol.18 , pp. 5124-35
    • Herdegen, T.1    Claret, F.X.2    Kallunki, T.3    Martin-Villalba, A.4    Winter, C.5    Hunter, T.6
  • 43
    • 0141593385 scopus 로고    scopus 로고
    • Repression of phospho-JNK and infarct volume in ischemic brain of JIP 1-deficient mice
    • Im JY, Lee KW, Kim MH, Lee SH, Ha HY, Cho IH, et al. Repression of phospho-JNK and infarct volume in ischemic brain of JIP 1-deficient mice. J Neurosci Res 2003 74 : 326 32.
    • (2003) J Neurosci Res , vol.74 , pp. 326-32
    • Im, J.Y.1    Lee, K.W.2    Kim, M.H.3    Lee, S.H.4    Ha, H.Y.5    Cho, I.H.6
  • 44
    • 27644433927 scopus 로고    scopus 로고
    • Knockdown of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield
    • Zhang QG, Wang RM, Yin XH, Pan J, Xu TL, Zhang GY. Knockdown of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield. J Neurochem 2005 95 : 784 95.
    • (2005) J Neurochem , vol.95 , pp. 784-95
    • Zhang, Q.G.1    Wang, R.M.2    Yin, X.H.3    Pan, J.4    Xu, T.L.5    Zhang, G.Y.6
  • 45
    • 0030041536 scopus 로고    scopus 로고
    • Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in radiation-induced apoptosis
    • Chen YR, Meyer CF, Tan TH. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in radiation-induced apoptosis. J Biol Chem 1996 27 : 631 4.
    • (1996) J Biol Chem , vol.27 , pp. 631-4
    • Chen, Y.R.1    Meyer, C.F.2    Tan, T.H.3
  • 46
    • 33644845569 scopus 로고    scopus 로고
    • Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance
    • Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka TA, Matsuhisa M, et al. Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol 2006 38 : 782 93.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 782-93
    • Kaneto, H.1    Nakatani, Y.2    Kawamori, D.3    Miyatsuka, T.4    Matsuoka, T.A.5    Matsuhisa, M.6
  • 47
    • 0037153158 scopus 로고    scopus 로고
    • Hotanisligil, a central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, et al. Hotanisligil, a central role for JNK in obesity and insulin resistance. Nature 2002 420 : 333 6.
    • (2002) Nature , vol.420 , pp. 333-6
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3    Gorgun, C.Z.4    Uysal, K.T.5    Maeda, K.6
  • 48
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 2000 275 : 9047 54.
    • (2000) J Biol Chem , vol.275 , pp. 9047-54
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 49
    • 4043073652 scopus 로고    scopus 로고
    • An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
    • Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev 2004 18 : 1976 80.
    • (2004) Genes Dev , vol.18 , pp. 1976-80
    • Jaeschke, A.1    Czech, M.P.2    Davis, R.J.3
  • 50
  • 51
    • 0033850451 scopus 로고    scopus 로고
    • The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells
    • Ammendrup A, Maillard A, Nielsen K, Aabenhus Andersen N, Serup P, Dragsbaek Madsen O, et al. The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes 2000 49 : 1468 76.
    • (2000) Diabetes , vol.49 , pp. 1468-76
    • Ammendrup, A.1    Maillard, A.2    Nielsen, K.3    Aabenhus Andersen, N.4    Serup, P.5    Dragsbaek Madsen, O.6
  • 52
    • 0035152487 scopus 로고    scopus 로고
    • Cell-permeable peptide inhibitors of JNK: Novel blockers of beta-cell death
    • Bonny A, Oberson S, Negri C, Sauser X, Schorderet DF. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 2001 50 : 77 82.
    • (2001) Diabetes , vol.50 , pp. 77-82
    • Bonny, A.1    Oberson, S.2    Negri, C.3    Sauser, X.4    Schorderet, D.F.5
  • 53
    • 7044249537 scopus 로고    scopus 로고
    • Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure
    • Abdelli S, Ansite J, Roduit R, Borsello T, Matsumoto I, Sawada T, et al. Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 2004 53 : 2815 23.
    • (2004) Diabetes , vol.53 , pp. 2815-23
    • Abdelli, S.1    Ansite, J.2    Roduit, R.3    Borsello, T.4    Matsumoto, I.5    Sawada, T.6
  • 54
    • 0037119417 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    • Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 2002 277 : 30010 8.
    • (2002) J Biol Chem , vol.277 , pp. 30010-8
    • Kaneto, H.1    Xu, G.2    Fujii, N.3    Kim, S.4    Bonner-Weir, S.5    Weir, G.C.6
  • 57
    • 15144358619 scopus 로고    scopus 로고
    • Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis (alkoxymethyl)-K-252a derivatives
    • Kaneko M, Saito Y, Saito H, Matsumoto T, Matsuda Y, Vaught JL, et al. Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis (alkoxymethyl)-K-252a derivatives. J Med Chem 1997 40 : 1863 9.
    • (1997) J Med Chem , vol.40 , pp. 1863-9
    • Kaneko, M.1    Saito, Y.2    Saito, H.3    Matsumoto, T.4    Matsuda, Y.5    Vaught, J.L.6
  • 58
    • 0022500301 scopus 로고
    • K-252a, a potent inhibitor of protein kinase C from microbial origin
    • Kase H, Iwahashi K, Matsuda Y. K-252a, a potent inhibitor of protein kinase C from microbial origin. J Antibiot (Tokyo) 1986 39 : 1059 65.
    • (1986) J Antibiot (Tokyo) , vol.39 , pp. 1059-65
    • Kase, H.1    Iwahashi, K.2    Matsuda, Y.3
  • 59
    • 17344374130 scopus 로고    scopus 로고
    • Motoneuron apoptosis is blocked by CEP-1347 (KT7515), a novel inhibitor of the JNK signaling pathway
    • Maroney AC, Glicksman MA, Basma AN, Walton KM, Knight E, Murphy CA, et al. Motoneuron apoptosis is blocked by CEP-1347 (KT7515), a novel inhibitor of the JNK signaling pathway. J Neurosci 1998 18 : 104 11.
    • (1998) J Neurosci , vol.18 , pp. 104-11
    • Maroney, A.C.1    Glicksman, M.A.2    Basma, A.N.3    Walton, K.M.4    Knight, E.5    Murphy, C.A.6
  • 60
    • 0033029823 scopus 로고    scopus 로고
    • CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
    • Saporito MS, Brown EM, Miller MS, Carswell S. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. J Pharmacol Exp Ther 1999 288 : 421 7.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 421-7
    • Saporito, M.S.1    Brown, E.M.2    Miller, M.S.3    Carswell, S.4
  • 62
    • 0033994234 scopus 로고    scopus 로고
    • Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation
    • Pirvola U, Liang XQ, Virkkala J, Saarma M, Murakata C, Camoratto AM, et al. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 2000 20 : 43 50.
    • (2000) J Neurosci , vol.20 , pp. 43-50
    • Pirvola, U.1    Liang, X.Q.2    Virkkala, J.3    Saarma, M.4    Murakata, C.5    Camoratto, A.M.6
  • 63
    • 0035985743 scopus 로고    scopus 로고
    • Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced co-chlear and vestibular hair cell death
    • Ylikoski J, Liang XQ, Virkkala J, Pirvola U. Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced co-chlear and vestibular hair cell death. Hear Res 2002 166 : 33 43.
    • (2002) Hear Res , vol.166 , pp. 33-43
    • Ylikoski, J.1    Liang, X.Q.2    Virkkala, J.3    Pirvola, U.4
  • 65
    • 0035006390 scopus 로고    scopus 로고
    • IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibro-blasts through c-Jun NH2-terminal kinase-dependent pathway
    • Hashimoto S, Gon Y, Takeshita I, Maruoka S, Horie T. IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibro-blasts through c-Jun NH2-terminal kinase-dependent pathway. J Allergy Clin Immunol 2001 107 : 1001 8.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 1001-8
    • Hashimoto, S.1    Gon, Y.2    Takeshita, I.3    Maruoka, S.4    Horie, T.5
  • 67
    • 9144220172 scopus 로고    scopus 로고
    • SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease
    • Wang W, Shi L, Xie L, Ma C, Li W, Su X, et al. SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neurosci Res 2004 48 : 195 202.
    • (2004) Neurosci Res , vol.48 , pp. 195-202
    • Wang, W.1    Shi, L.2    Xie, L.3    Ma, C.4    Li, W.5    Su, X.6
  • 68
    • 25444511529 scopus 로고    scopus 로고
    • Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia
    • Chialda L, Zhang M, Brune K, Pahl A. Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia. Respir Res 2005 15 : 6 36.
    • (2005) Respir Res , vol.15 , pp. 6-36
    • Chialda, L.1    Zhang, M.2    Brune, K.3    Pahl, A.4
  • 69
    • 3042694681 scopus 로고    scopus 로고
    • AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): A c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties
    • Carboni S, Hiver A, Szyndralewiez C, Gaillard P, Gotteland JP, Vitte PA. AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther 2004 301 : 25 32.
    • (2004) J Pharmacol Exp Ther , vol.301 , pp. 25-32
    • Carboni, S.1    Hiver, A.2    Szyndralewiez, C.3    Gaillard, P.4    Gotteland, J.P.5    Vitte, P.A.6
  • 70
    • 14844333103 scopus 로고    scopus 로고
    • Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurons following global transient ischaemia
    • Carboni S, Antonsson B, Gaillard P, Gotteland JP, Gillon JY, Vitte PA. Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurons following global transient ischaemia. J Neurochem 2005 92 : 1054 60.
    • (2005) J Neurochem , vol.92 , pp. 1054-60
    • Carboni, S.1    Antonsson, B.2    Gaillard, P.3    Gotteland, J.P.4    Gillon, J.Y.5    Vitte, P.A.6
  • 71
    • 3843090683 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats
    • Ferrandi C, Ballerio R, Gaillard P, Giachetti C, Carboni S, Vitte PA, et al. Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. Br J Pharmacol 2004 142 : 953.
    • (2004) Br J Pharmacol , vol.142 , pp. 953
    • Ferrandi, C.1    Ballerio, R.2    Gaillard, P.3    Giachetti, C.4    Carboni, S.5    Vitte, P.A.6
  • 72
    • 22244479745 scopus 로고    scopus 로고
    • Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase
    • Gaillard P, Jeanclaude-Etter I, Ardissone V, Arkinstall S, Cambet Y, Camps M, et al. Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J Med Chem 2005 48 : 4596 607.
    • (2005) J Med Chem , vol.48 , pp. 4596-607
    • Gaillard, P.1    Jeanclaude-Etter, I.2    Ardissone, V.3    Arkinstall, S.4    Cambet, Y.5    Camps, M.6
  • 73
    • 0037192843 scopus 로고    scopus 로고
    • Identification of the critical features of a small peptide inhibitor of JNK activity
    • Barr RK, Kendrick TS, Bogoyevitch MA. Identification of the critical features of a small peptide inhibitor of JNK activity. J Biol Chem 2002 277 : 10 987 97.
    • (2002) J Biol Chem , vol.277 , Issue.10 , pp. 987-97
    • Barr, R.K.1    Kendrick, T.S.2    Bogoyevitch, M.A.3
  • 74
    • 0141457877 scopus 로고    scopus 로고
    • A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss
    • Wang J, van De Water TR, Bonny C, De Ribaupierre F, Puel JL, Zine A. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 2003 23 : 8596 607.
    • (2003) J Neurosci , vol.23 , pp. 8596-607
    • Wang, J.1    Van De Water, T.R.2    Bonny, C.3    De Ribaupierre, F.4    Puel, J.L.5    Zine, A.6
  • 75
    • 3042694907 scopus 로고    scopus 로고
    • D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia
    • Hirt L, Badaut J, Thevenet J, Granziera C, Regli L, Maurer F, et al. D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia. Stroke 2004 35 : 1738 43.
    • (2004) Stroke , vol.35 , pp. 1738-43
    • Hirt, L.1    Badaut, J.2    Thevenet, J.3    Granziera, C.4    Regli, L.5    Maurer, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.