A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: The pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP

Journal of Molecular Medicine

Volumn 89, Issue 12, 2011, Pages 1261-1273

  Lu, Wan Jung ^a   Lee, Jie Jen ^b   Chou, Duen Suey ^a   Jayakumar, Thanasekaran ^a   Fong, Tsorng Han ^a   Hsiao, George ^a   Sheu, Joen Rong ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Andrographolide; cGMP; eNOS; p38 MAPK; Platelet activation; PLC 2

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE DIPHOSPHATE; ANDROGRAPHOLIDE; CALCIUM ION; COLLAGEN; CYCLIC AMP; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYL RADICAL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE B; PROTEIN KINASE C; THROMBOXANE A2; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IN VIVO STUDY; LUNG EMBOLISM; MORTALITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION INHIBITION;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; CALCIUM; COLLAGEN; CYCLIC GMP; DITERPENES; HUMANS; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PULMONARY EMBOLISM; THROMBOXANE A2;

EID: 84655169528     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0800-0     Document Type: Article

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