Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: Regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade

Biochemical Pharmacology

Volumn 84, Issue 7, 2012, Pages 914-924

  Lu, Wan J ^a   Lin, Kuan H ^a,b   Hsu, Ming J ^a   Chou, Duen S ^a   Hsiao, George ^a   Sheu, Joen R ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Andrographolide; ERK2; Hydroxyl radical; NF B; P38 MAPK; Platelet

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANDROGRAPHOLIDE; COLLAGEN; HYDROXYL RADICAL; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KT 5823; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; SYNAPTOTAGMIN I;

ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION;

BLOOD PLATELETS; COLLAGEN; CYCLIC GMP; DITERPENES; EIF-2 KINASE; GENE EXPRESSION REGULATION; HUMANS; HYDROXYL RADICAL; I-KAPPA B KINASE; MITOGEN-ACTIVATED PROTEIN KINASE 1; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; SIGNAL TRANSDUCTION;

EID: 84865518873     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.030     Document Type: Article

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