Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-κB inactivation

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 21, 2008, Pages 10265-10272

  Yun, Kyung Jin ^a   Koh, Duck Jae ^a   Kim, Shi Hye ^a   Park, Seung Jae ^a   Ryu, Jong Hoon ^a   Kim, Deog Gon ^a   Lee, Jin Yong ^a   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Cyclooxygenase 2; Cytokines; Inducible nitric oxide synthase; Nuclear factor b; Sinapic acid

Indexed keywords

ANTIINFLAMMATORY AGENT; AUTACOID; COUMARIC ACID; CYCLOOXYGENASE 2; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; SINAPIC ACID;

ANIMAL; ARTICLE; CELL LINE; CHEMICALLY INDUCED DISORDER; DOWN REGULATION; DRUG EFFECT; EDEMA; GENE EXPRESSION; GENE SILENCING; GENETICS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MOUSE; PROTEIN TRANSPORT; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; COUMARIC ACIDS; CYCLOOXYGENASE 2; CYTOKINES; DOWN-REGULATION; EDEMA; GENE EXPRESSION; GENE SILENCING; HUMANS; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 58149343686     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf802095g     Document Type: Article

References (30)

1. Oberyszyn, T. M. Inflammation and wound healing. Front. Biosci. 2007, 12, 2993-2999.
2. Paul, P. T.; Gary, S. F. NF-κB: A key role in inflammatory diseases. J. Clin. Invest. 2001, 107, 7-11.
3. Baeuerle, P. A. IkappaB-NF-kappaB structures: At the interface of inflammation control. Cell 1998, 95, 729-731.
4. Baeuerle, P. A.; Baltimore, D. NF-kappa B: Ten years after. Cell 1996, 87, 13-20.
5. Vane, J. R.; Mitchell, J. A.; Appleton, I.; Tomlinson, A.; Bishop-Bailey, D.; Croxtall, J.; Willoughby, D. A. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Pharmacology 1994, 91, 2046-2050.
6. Yun, H. Y.; Dawson, T. T.; Dawson, T. M. Neurobiology of nitric oxide. Crit. Rev. Neurobiol. 1996, 10, 291-316.
7. Hinz, B.; Brune, K. Cyclooxygenase-2-10 years later. J. Pharmacol. Exp. Ther. 2002, 300, 367-375.
8. Beutler, B.; Cerami, A. The biology of cachectin/TNF-α primary mediator of the host response. Annu. Rev. Immunol. 1989, 7, 625-655.
9. Molloy, R. G.; Mannick, J. A.; Rodrick, M. L. Cytokines, sepsis and immunomodulation. Br. J. Surg. 1993, 80, 289-297.
10. West, M. A.; Seatter, S. C.; Bellingham, J.; Clair, L. Mechanisms of reprogrammed macrophage endotoxin signal transduction after lipopolysaccharide pretreatment. Surgery 1995, 118, 220-228.
11. Dendorfer, U. Molecular biology of cytokines. Artif. Organs 1996, 20, 437-444.
12. Andreasen, M. F.; Landbo, A. K.; Christensen, L. P.; Hansen, A.; Meyer, A. S. Antioxidant effects of phenolic rye (Secale cereale L.) extracts, monomeric hydroxycinnamates. and ferulic acid dehydrodimers on human low-density lipoproteins. J. Agric. Food. Chem 2001, 49, 4090-4096.
13. Lu, C.; Yao, S.; Lin, N. Studies on reactions of oxidizing sulfulsulful three-electron-bond complexes and reducing alphaamino radicals derived from OH reaction with methionine in aqueous solution. Biochim. Biophys. Acta 2001, 16, 89-96.
14. Zou, Y.; Kim, A. R.; Kim, J. E.; Choi, J. S.; Chung, H. Y. Peroxynitrite scavenging activity of sinapic acid (3, 5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea. J. Agric. Food. Chem. 2002, 9, 5884-5890.
15. Yoon, B. H.; Jung, J. W.; Lee, J. J.; Cho. Y. W.; Jang. C. G.; Jin, C; Oh, T. H.; Ryu, J. H. Anxiolytic-like effects of sinapic acid in mice. Life. Sci. 2007, 81, 234-240.
16. Shin, K. M.; Kim, 1. T.; Park, Y. M.; Ha, J.; Choi, J. W.; Park, H. J.; Lee, Y. S.; Lee, K. T. Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-alpha production. Biochem. Pharmacol. 2004, 68, 2327-2336.
17. Recio, M. C.; Prieto, M.; Bonucelli, M.; Orsi, C.; Manez, S.; Giner, R. M.; Cerda-Nicolas, M.; Rios, J. L. Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. Planta Med. 2004, 70, 414-420.
18. Eddy, N. B.; Leimback, D. J. Synthetic analgesics. II. Dithienbutenyl- and dithienbutenylamines. Pharmacol. Exp. Ther. 1953, 107, 385-393.
19. Coffey, M.; Phare, S.; Peters-Golden, M. Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages. Exp. Lung Res. 2004, 30, 615-633.
20. Freeman, B. D.; Natanson, C. Anti-inflammatory therapies and sepsis and septic shock. Exp. Opin. Invest. Drugs 2000, 9, 1651-1663.
21. Feldmann, M.; Brennan, F. M.; Maini, R. Cytokines in autoimmune disorders. Int. Rev. Immunol. 1998, 17, 217-228.
22. Dinarello, C. A. Cytokines as endogenous pyrogens. J. Infect. Dis. 1999, 179, 294-304.
23. Mannel, D. N.; Echtenacher, B. TNF in the inflammatory response. Chem. Immunol. 2000, 74, 141-161.
24. Zhang, W. H; Wang, X. L.; Zhou, J.; An, L. Z.; Xie, X. D. Association of interleukin-1B (IL-1B) gene polymorphisms with risk of gastric cancer in Chinese population. Cytokine 2005, 30, 378-381.
25. May, M. J.; Ghosh, S. IkappaB kinases: Kinsmen with different crafts. Science 1999, 284, 271-273.
26. Karin, M.; Ben-Neriah, Y. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu. Rev. Immunol. 2000, 18, 621-663.
27. Schimedtje, J. F.; Ji, Y. S.; Liu, W. L.; Dubois, R. N.; Runge, M. S. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 1997, 272, 601-608.
28. Henkel, T.; Machleidt, T.; Nantermet, P. V.; Alkalay, I.; Kronke, M.; Ben-Neriah, Y.; Baeuerle, P. A. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature 1993, 365, 182-185.
29. Omote. K; Hazama, K; Kawamata, T.; Kawamata, M.; Nakayaka, Y.; Toriyabe, M.; Namiki, A. Peripheral nitric oxide in carrageenan-induced inflammation. Brain Res. 2001, 912, 171-175.
30. Cunha, F. Q.; Poole, S.; Lorenzetti, B. B.; Ferreira, S. H. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 1992, 107, 660-664.