Miyabenol A inhibits LPS-induced NO production via IKK/IκB inactivation in RAW 264.7 macrophages: Possible involvement of the p38 and PI3K pathways

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 19, 2008, Pages 8911-8918

  Ku, Kuei Ting ^a   Huang, Yu Ling ^b   Huang, Yu Jou ^a   Chiou, Wen Fei ^a,b  

^a NATIONAL TAITUNG UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

I B; IKK ; iNOS; Miyabenol A; NF B; NO; p38 MAPK; PI3K Akt; Vitis thunbergii

Indexed keywords

BENZOFURAN DERIVATIVE; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MIYABENOL A; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; STILBENE DERIVATIVE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; GRAPE; ISOLATION AND PURIFICATION; MACROPHAGE; METABOLISM; PHOSPHORYLATION; PLANT ROOT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BENZOFURANS; CELL LINE; GENE EXPRESSION; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT ROOTS; STILBENES; VITIS;

VITACEAE; VITIS THUNBERGII;

EID: 54349128159     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf8019369     Document Type: Article

References (30)

1. Chiu, N. Y.; Chang, K. H. The Illustrated Medicinal Plants of Taiwan; SMC Publisher: Taipei, 1995; Vol. 4, pp 147-149.
2. Birrell, M. A.; McCluskie, K.; Wong, S.; Donnelly, L. E.; Barnes, P. J.; Belvisi, M. G. Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-κB-independent mechanism. FASEB J. 2005, 19, 840-841.
3. Leiro, J.; Ivarez, E.A'.; Arranz, J. A.; Laguna, R.; Uriarte, E.; Orallo, F. Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes. J. Leukocyte Biol 2004, 75, 1156-1165.
4. Huang, Y. L.; Tsai, W. J.; Shen, C. C.; Chen, C. C. Resveratrol derivatives from the roots of Vitis thunbergii. J. Nat. Prod. 2005, 68, 217-220.
5. Xie, Q. W.; Whisnant, R.; Nathan, C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp. Med. 1993, 177, 1779-1784.
6. Petros, A.; Bennett, D.; Vallance, P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991, 338, 1557-1558.
7. Giuliani, C.; Napolitano, G.; Bucci, I.; Montani, V.; Monaco, F. NF-κB transcription factor: role in the pathogenesis of inflammatory, autoimmune and neoplastic diseases and therapy implications. Clin. Ther. 2001, 152, 249-253.
8. Hayden, M. S.; Ghosh, S. Signaling to NF-kappaB. Genes Dev. 2004, 18, 2195-2224.
9. Chen, C. C.; Tsai, P. C.; Wei, B. L.; Chiou, W. F. 8-Prenyl-kaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages. Eur. J. Pharmacol. 2008, 590, 430-436.
10. Don, M. J.; Liao, J. F.; Lin, L. Y.; Chiou, W. F. Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of PI3K signaling pathway. Br. J. Pharmacol. 2007, 151, 638-646.
11. Ko, H. C.; Kuo, Y. H.; Wei, B. L.; Chiou, W. F. Laxifolone A suppresses LPS/IFN-γ-induced NO synthesis by attenuating NF-κB translocation: role of NF-κB p105 level in RAW264.7 macrophages. Planta Med. 2005, 71, 514-519.
12. Janssen-Heininger, Y. M.; Poynter, M. E.; Baeuerle, P. A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radical Biol. Med 2000, 28, 1317-1327.
13. Ghosh, S.; Karin, M. Missing pieces in the NF-κB puzzle. Cell 2002, 109, S81-S96.
14. Bian, Z. M.; Einer, S. G.; Yoshida, A.; Einer, V. M. Human RPE-monocyte coculture induces chemokine gene expression through activation of MAPK and NIK cascade. Exp. Eye Res. 2003, 76, 573-583.
15. Vanden Berghe, W.; Plaisance, S.; Boone, E.; De Bosscher, K.; Schmitz, M. L.; Fiers, W.; Haegeman, G. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 1998, 273, 3285-3290.
16. Sizemore, N.; Leung, S.; Stark, G. R. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol. Cell. Biol. 1999, 19, 4798-4805.
17. Naseem, K. M. The role of nitric oxide in cardiovascular diseases. Mol. Aspects Med. 2005, 26, 33-65.
18. Pannu, R.; Singh, I. Pharmacological strategies for the regulation of inducible nitric oxide synthase: Neurodegenerative versus neuroprotective mechanisms. Neurochem. Int. 2006, 49, 170-182.
19. Tinker, A. C.; Wallace, A. V. Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases. Curr. Top. Med. Chem. 2006, 6, 77-92.
20. 1 phosphorylation. Planta Med. 2008, 74, 156-162.
21. Zandi, E.; Rothwarf, D. M.; Delhase, M.; Hayakawa, M.; Karin, M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF kappaB activation. Cell 1997, 91, 243-252.
22. Yun, K. J.; Kim, J. Y.; Kim, J. B.; Lee, K. W.; Jeong, S. Y.; Park, H. J.; Jung, H. J.; Cho, Y. W.; Yun, K.; Lee, K. T. Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways. Int. Immunopharmacol. 2008, 8, 431-441.
23. Paul, A.; Cuenda, A.; Bryant, C. E.; Murray, J.; Chilvers, E. R.; Cohen, P. Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages. Cell. Signalling 1999, 11, 491-497.
24. Kim, S. H.; Kim, J.; Sharma, R. P. Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression. Pharmacol. Res. 2004, 49, 433-439.
25. Choi, C. Y.; Park, K. R.; Lee, J. H.; Jeon, Y. J.; Liu, K. H.; Oh, S.; Kim, D. E.; Yea, S. S. 2007 Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-κB, ERK1/2, and p38 kinase. Eur. J. Pharmacol. 2007, 576, 151-159.
26. Madrid, L. V.; Mayo, M. W.; Reuther, J. Y.; Baldwin, A. S. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogenactivated protein kinase p38. J. Biol. Chem. 2001, 276, 18934-18940.
27. Li, X.; Stark, G. R. NF-κB-dependent signaling pathways. Exp. Hematol. 2002, 30, 285-296.
28. Ajizian, S. J.; English, B. K.; Meals, E. A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J. Infect. Dis. 1999, 179, 939-944.
29. Underwood, D. C.; Osborn, R. R.; Bochnowicz, S.; Webb, E. F.; Rieman, D. J.; Lee, J. C. SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am. J. Physiol. Lung Cell Mol. Physiol 2000, 279, L895-L902.
30. Schindler, J. F.; Monahan, J. B.; Smith, W. G. p38 pathway kinases as anti-inflammatory drug targets. J. Dent. Res. 2007, 86, 800-811.