Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

Journal of Neuroinflammation

Volumn 7, Issue , 2010, Pages

  Maddahi, Aida ^a   Edvinsson, Lars ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 [4 [3 (3 METHOXY 5 METHYL 2 PYRAZINYLSULFAMOYL) 2 PYRIDYL]PHENYL] 2,2 DIMETHYLPROPIONIC ACID; ANGIOTENSIN 1 RECEPTOR; CANDESARTAN; CYTOKINE; ENDOTHELIN A RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; 1,3 BUTADIENE DERIVATIVE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NITRILE; PYRAZINE DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN SIZE; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BLOCKING; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION; ANIMAL; BRAIN; CEREBRAL ARTERY DISEASE; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; NEUROLOGIC EXAMINATION; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TIME; WISTAR RAT;

ANIMALS; BRAIN; BUTADIENES; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MAP KINASE KINASE KINASES; NEUROLOGIC EXAMINATION; NITRIC OXIDE SYNTHASE TYPE II; NITRILES; PYRAZINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SULFONAMIDES; TIME FACTORS;

EID: 77949396869     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-7-14     Document Type: Article

References (35)

1. Tsuchidate R, He QP, Smith ML, Siesjo BK. Regional cerebral blood flow during and after 2 hours of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1997, 17:1066-1073. 10.1097/00004647-199710000-00008, 9346431.
2. Memezawa H, Minamisawa H, Smith ML, Siesjo BK. Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 1992, 89:67-78. 10.1007/BF00229002, 1601103.
3. Rosenberg GA, Estrada EY, Dencoff JE. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke 1998, 29:2189-2195.
4. Ross AM, Hurn P, Perrin N, Wood L, Carlini W, Potempa K. Evidence of the peripheral inflammatory response in patients with transient ischemic attack. J Stroke Cerebrovasc Dis 2007, 16:203-207. 10.1016/j.jstrokecerebrovasdis.2007.05.002, 2570354, 17845917.
5. Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. Surg Neurol 2006, 66:232-245. 10.1016/j.surneu.2005.12.028, 16935624.
6. Correale J, Villa A. The neuroprotective role of inflammation in nervous system injuries. J Neurol 2004, 251:1304-1316. 10.1007/s00415-004-0649-z, 15592725.
7. Diamond P, McGinty A, Sugrue D, Brady HR, Godson C. Regulation of leukocyte trafficking by lipoxins. Clin Chem Lab Med 1999, 37:293-297. 10.1515/CCLM.1999.051, 10353475.
8. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol 2005, 6:1191-1197. 10.1038/ni1276, 16369558.
9. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG. Energy on demand. Science 1999, 283:496-497. 10.1126/science.283.5401.496, 9988650.
10. Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG. Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. J Cereb Blood Flow Metab 2006, 26:865-877. 10.1038/sj.jcbfm.9600263, 16407855.
11. Yamamoto Y, Gaynor RB. IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 2004, 29:72-79. 10.1016/j.tibs.2003.12.003, 15102433.
12. Shohami E, Ginis I, Hallenbeck JM. Dual role of tumor necrosis factor alpha in brain injury. Cytokine Growth Factor Rev 1999, 10:119-130. 10.1016/S1359-6101(99)00008-8, 10743503.
13. Stenman E, Jamali R, Henriksson M, Maddahi A, Edvinsson L. Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat. Eur J Pharmacol 2007, 570:142-148. 10.1016/j.ejphar.2007.05.049, 17597600.
14. Maddahi A, Edvinsson L. Enhanced expression of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway. BMC Neurosci 2008, 00:00.
15. Menzies SA, Hoff JT, Betz AL. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery 1992, 31:100-106. 10.1097/00006123-199207000-00014, 1641086.
16. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986, 17:472-476.
17. Vikman P, Beg S, Khurana T, Hansen-Schwartz J, Edvinsson L. Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat. J Neurosurg 2006, 105:438-444. 10.3171/jns.2006.105.3.438, 16961140.
18. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 1998, 273:18623-18632. 10.1074/jbc.273.29.18623, 9660836.
19. Stenman E, Malmsjo M, Uddman E, Gido G, Wieloch T, Edvinsson L. Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat. Stroke 2002, 33:2311-2316. 10.1161/01.STR.0000028183.04277.32, 12215604.
20. Stenman E, Edvinsson L. Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats. Stroke 2004, 35:970-974. 10.1161/01.STR.0000121642.53822.58, 15001791.
21. Namura S, Iihara K, Takami S, Nagata I, Kikuchi H, Matsushita K, Moskowitz MA, Bonventre JV, Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci USA 2001, 98:11569-11574. 10.1073/pnas.181213498, 58770, 11504919.
22. Vikman P, Ansar S, Henriksson M, Stenman E, Edvinsson L. Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Exp Brain Res 2007, 183:499-510. 10.1007/s00221-007-1062-5, 17828393.
23. Yun HY, Gonzalez-Zulueta M, Dawson VL, Dawson TM. Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proc Natl Acad Sci USA 1998, 95:5773-5778. 10.1073/pnas.95.10.5773, 20455, 9576960.
24. Ansar S, Edvinsson L. Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Stroke 2008, 39:185-190. 10.1161/STROKEAHA.107.487827, 18032736.
25. Henriksson M, Stenman E, Vikman P, Edvinsson L. MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia. Exp Brain Res 2007, 178:470-476. 10.1007/s00221-006-0753-7, 17091294.
26. Beg SA, Hansen-Schwartz JA, Vikman PJ, Xu CB, Edvinsson LI. ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat. J Cereb Blood Flow Metab 2006, 26:846-856. 10.1038/sj.jcbfm.9600236, 16251886.
27. Wang ZQ, Wu DC, Huang FP, Yang GY. Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia. Brain Res 2004, 996:55-66. 10.1016/j.brainres.2003.09.074, 14670631.
28. Wang X, Xu L, Wang H, Young PR, Gaestel M, Feuerstein GZ. Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice. J Biol Chem 2002, 277:43968-43972. 10.1074/jbc.M206837200, 12215446.
29. Wang H, Xu L, Venkatachalam S, Trzaskos JM, Friedman SM, Feuerstein GZ, Wang X. Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral ischemia in mice. Biochem Biophys Res Commun 2001, 286:869-874. 10.1006/bbrc.2001.5482, 11527379.
30. Patel TR, Galbraith SL, McAuley MA, Doherty AM, Graham DI, McCulloch J. Therapeutic potential of endothelin receptor antagonists in experimental stroke. J Cardiovasc Pharmacol 1995, 26(Suppl 3):S412-415.
31. Nishimura Y, Ito T, Saavedra JM. Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke 2000, 31:2478-2486.
32. Hansen-Schwartz J, Hoel NL, Zhou M, Xu CB, Svendgaard NA, Edvinsson L. Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries. Neurosurgery 2003, 52:1188-1194. 10.1227/01.NEU.0000058467.82442.64, 12699564.
33. Chuquet J, Benchenane K, Toutain J, MacKenzie ET, Roussel S, Touzani O. Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat. Stroke 2002, 33:3019-3025. 10.1161/01.STR.0000039401.48915.9F, 12468806.
34. Moller S, Uddman E, Welsh N, Edvinsson L, Adner M. Analysis of the time course for organ culture-induced endothelin ET B receptor upregulation in rat mesenteric arteries. Eur J Pharmacol 2002, 454:209-215. 10.1016/S0014-2999(02)02499-8, 12421649.
35. Ansar S, Vikman P, Nielsen M, Edvinsson L. Cerebrovascular ETB, 5-HT1B and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol 2008, 294:H3750-H3758.